AlarconJane Knight Lowe
Emeritus Professor of Medicine

 

Address: 

Faculty Office Towers, room 830
510 20th Street South
Birmingham, Alabama 35294-3408



Telephone:(205) 422-0983
Email: galarcon@uab.edu

 

Education


BS, Facultad de Ciencias, Universidad Nacional Mayor de San Marcos. Lima, Perú, 1961
MD, Facultad de Medicina, Universidad Peruana Cayetano Heredia. Lima, Perú, 1967
Fellowship (Clinical), Department of Medicine, Johns Hopkins University, School of Medicine. Baltimore City Hospitals, Baltimore, MD, 1969
Master in Public Health (M.P.H.), Johns Hopkins University, School of Hygiene and Public Health, Baltimore, MD, 1972
Doctor in Medicine, Universidad Peruana Cayetano Heredia. Lima, Perú, 1972
Fellowship (Research), Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, 1981

 

Selected Honors and Awards


1964

Diploma presented by the Peruvian Government recognizing voluntary work at the Sierra Indian Communities of Cuzco, Per&uacute

1971- 1972

Recipient of Merck, Sharp & Dohme Scholarship, Master of Public Health, Johns Hopkins University. Baltimore, MD

1980

American Rheumatism Association Senior Rheumatology Scholar Award

1988

Mexican Society of Rheumatology, Professor of the Year

1997

Virginia Engalichteff Award for Impact on Quality of Life, Arthritis Foundation. Denver, CO

2003

Outstanding Faculty-The University of Alabama at Birmingham Women's Center

2004

Pfizer Visiting Professor - Vanderbilt University- Nashville, TN

2006

Keynote Speaker,  Pan American League of Associations of Rheumatologists. Lima, Perú

2008

ACR Master, ACR Annual Scientifie Meeting, San Francisco, CA

2008

PANLAR Master, PANLAR Scientific Meeting, Guatemala City, Guatemala

2009

Dean's Award for Academic Execellence. The University of Alabama at Birmingham, Birmingham, Alabama

2000 & 2010

Visiting Professor, Argentinean Society of Rheumatology

2011

Mexican Society of Rheumatology: Honoring Latin American Masters of the American College of Rheumatology; Cancún, Mexico
Speaker, Universidad Peruana Cayetano Heredia, 50th year Anniversary. Lima, Perú
Evelyn Hess Award for Excellence in Lupus Research. Lupus Foundation of America. Chicago, IL

2012

Leader of Peruvian Rheumatology. Sociedad Peruana de Reumatología; Lima, Perú

2013

Visiting Professor. University of Washington; Seattle, WA.
Dr. Honoris Causa. Universidad Nacional de Asunción; Asunción, Paraguay.
Associate member, Peruvian Academy of Medicine

2014

Visiting Professor (38th Annual Michael Einbender Distinguished Lectureship. University Missouri; Columbus, MO
American College of Rheumatology Distinguished Rheumatology Investigator Award, Boston, MA

2015

Peruvian College of Physicians: Recognition as Leader of Peruvian Rheumatology
The Servicio de Inmuno-Reumatología, at Hospital Nacional Cayetano Heredia from Universidad Peruana Cayetano Heredia is named: Graciela S. Alarcón

2016

The University of Alabama at Birmingham establishes the Graciela S. Alarcón, MD, MPH Lupus Research Fund
The Halsted R. Holman Award for Excellence on Clinical Research in Lupus. LUPUS 2016, Armonk, NY.
Distinguished Service Award for promoting the goals of the Global Alliance for Musculoskeletal Health.

 

Clinical, Research and Education Interests


I joined the Faculty at UAB in 1981 after being a Research Fellow for about 18 months. I am currently Emeritus Professor and although not in Birmingham, I am still involved in mentoring fellows and collaborating with the LFA, LCTC, GLADEL as the need arises. During my stay at UAB and prior to that at my alma mater (Universidad Peruana Cayetano Heredia in Lima, Perú), I have been involved in the training of clinical and research fellows. In fact, after my US training (1968-1972), I started the first training program in Rheumatology and the first Rheumatology Unit in Perú. Whether in Perú or in the US, I have attended their clinics, have rounded with them, and foremost I have been stimulating them to always keep an open and inquisitive mind in dealing with their day-to-day activities being those in the clinic or in the research setting. I can say that over 60% of the fellows graduating from UAB between 1981 and the early 2000's, when I became more involved in the training of clinical research fellows (vide infra), have had the opportunity to publish their clinical experience under my mentorship and with my unconditional support. Of course, not all of them have become academicians or researchers in their own right, but I have been quick to point out to all of them that the proper appreciation of what research entails or the amount of work that goes into a published paper, can only come from personally going through the same experience.

Although I have been involved in mentoring Junior Faculty and clinical research fellows in the past, it has been only since 2002 that I have had the opportunity to LUMINAcollaboratorshave the funding to support them for the conduct of research in lupus. These fellows have used the very rich database from LUMINA, a multi-ethnic cohort of lupus patients established in collaboration with Drs. John Reveille (UT-Houston, TX) and Luis Vilá (U- Puerto Rico, San Juan, PR) in the early 1990's. Participating in the training of these young physicians while continuing to mentor Junior Faculty and clinical fellows, as time permits, has been, and continues to be, one of the most rewording but also challenging experiences of my academic life as a rheumatologist. For the most part, these trainees have come with limited research experience; despite that, they have performed spectacularly well. In addition to participating in data collection on patients from the cohort, they have generated their own sub-projects and taken them to completion including the Gladel 2publication of their findings in prestigious rheumatology journals. The fruits of LUMINA have been summarized in a special article published in the Journal Lupus in 2008. Moreover, the salient finding from the LUMINA study were highlighted in an article published in The Rheumatologist in the Spring of 2011. At the present time, I continue to be involved in the work of the fellows that trained with me over the last few years (Drs. Durán-Barragán, González, Pons-Estel and Burgos) who are conducting research in lupus in their country of origin. In parallel I am assisting the LCTC in the establishment of a national registry of lupus patients (US and Canada). Finally, over the last few years I have developed a very close relationship with GLADEL (for Grupo Latinoamericano de Estudio de Lupus or Latin American Group for the Study of Lupus), assisting them in the utilization of their rich database. This group with the support of PANLAR is now developing the Latin American treatment guidelines for lupus, effort in which I am quite involved.

 

Selected Publications


Fernandez M, Alarcón GS, Apte M, Andrade R, Vila LM, Reveille JD. 2007. Systemic Lupus erythematosus in a multiethnic U.S. cohort (LUMINA) XLIII: The significance of thrombocytopenia as a prognostic factor. Arthritis Rheum 56:614-21. PMID: 17921793


Andrade RM, Alarcón GS, Fernández M, Apte M, Vilá LM, Reveille JD. 2007. Accelerated damage accrual among men with systemic lupus erythematosus: XLIV. Results from a multiethnic US cohort. Arthritis Rheum 56:622-30. PMID: 17265497


Alarcón GS, McGwin G, Jr., Bertoli AM, Fessler BJ, Calvo-Alén J, Bastian HM, Vilá LM, Reveille JD, for the LUMINA Study Group:  Effect of hydroxychloroquine in the survival of patients with systemic lupus erythematosus.  Data from LUMINA, a multiethnic US cohort (LUMINA L). 2007. Ann Rheum Dis 66:1168-72. PMID: 17389655


González LA, McGwin G Jr, Durán S, Pons-Estel GJ, Apte M, Vilá LM, Reveille JD, Alarcón GS. 2008. Predictors of Premature Gonadal Failure in Patients with Systemic Lupus Erythematosus. Results from LUMINA, a Multiethnic US Cohort (LUMINA LVIII). Ann Rheum Dis 67:1170-3. PMID: 18299303


Durán-Barragan S, McGwin G, Jr. Vilá LM, ReveilleJD, Alarcón GS. 2008. Angiotensin-converting enzyme inhibitors delay the occurrence of renal involvement and are associated with a decreased risk of disease activity in patients with systemic lupus erythematosus.  Results from LUMINA (LIX): A multiethnic US cohort.  Rheumatology 47:1093-6. PMID: 18511474


Danila M, Pons-Estel GJ, Zhang J, Vilá LM, Reveille JD, Alarcón GS . 2008. Renal damage is the most important predictor of mortality within the damage index: data from LUMINA, a multiethnic US cohort. Rheumatology 48:542-5. PMID: 19233884


Burgos PI, Perkins EL, Pons-Estel GJ, Kendrick SA, Liu JM, Kendrick WT, Cook WJ, Julian BA, Alarcón GS, Kew II CE. 2009. Risk Factors and Impact of Recurrent Lupus Nephritis in Transplanted Patients with Systemic Lupus Erythematosus:  Data from a Single US Institution. Arthritis Rheum 60:2757-66. PMID: 19714623


Uribe AG, Romero Diaz J, Apte M, Fernandez M, Burgos PI, Reveille JD, Sanchez-   Guerrero J, Alarcón GS. 2009. Impact of immigration on the clinical espression of systemic lupus erythematosus: A comparative study of Hispanic patients residing in the US and Mexico. Rheumatology 48: 1392-7. PMID: 19717548


Pons-Estel GJ, Alarcón GS, McGwin G Jr, Danila MI, Zhang J, Bastian HM, Reveille JD, Vilá LM. 2009. Lumina Study Group. Protective effect of hydroxychloroquine on renal damage in patients with lupus nephritis: LXV, data from a multiethnic US cohort. Arthritis Rheum. 2009 61:830-9. PMID: 19479701


Craig SM, Yu F, Curtis JR, Alarcón GS,Conn DL, Jonas B, Callahan LF, Smith EA, Moreland LW, Bridges SL Jr, Mikuls TR. 2010. Vitamin D status and its associations with disease activity and severity in African Americans with recent-onset rheumatoid arthritis. J Rheumatol. 37(2):275-81 PMID: 20032100


Shinjo SK, Bonfá E, Wojdyla D, Borba EF, Ramirez LA, Scherbarth HR, Brenol JC, Chacón-Diaz R, Neira OJ, Berbotto GA, De La Torre IG, Acevedo-Vázquez EM, Massardo L, Barile-Fabris LA, Caeiro F, Silveira LH, Sato EI, Buliubasich S, Alarcón GS, Pons-Estel BA; Grupo Latino Americano de Estudio del Lupus Eritematoso (Gladel). 2010. Antimalarial treatment may have a time-dependent effect on lupus survival: data from a multinational Latin American inception cohort. Arthritis Rheum. 62(3):855-62. PMID: 20131238


Kelley JM, Hughes LB, Malik A, Danila MI, Edberg Y, Alarcón GS, Conn DL, Jonas BL, Callahan LF, Smith EA, Brasington RD, Edberg JC, Kimberly RP, Moreland LW, Bridges SL. 2010. Genetic variants of STAT4 associated with rheumatoid arthritis in persons of Asian and European ancestry do not replicate in African Americans.Ann Rheum Dis. 69(4):625-6. PMID: 20237121


Burgos PI, Causey ZL, Tamhane A, Kelley JM, Brown EE, Hughes LB, Danila MI, van Everdingen A, Conn DL, Jonas BL, Callahan LF, Smith EA, Brasington RD Jr, Moreland LW, van der Heijde DM, Alarcón GS, Bridges SL Jr. 2010. Association of IL4R single-nucleotide polymorphisms with rheumatoid nodules in African Americans with rheumatoid arthritis.Arthritis Res Ther. 12(3):R75. PMID: 20444266


Bridges SL Jr, Causey ZL, Burgos PI, Huynh BQ, Hughes LB, Danila MI, van Everdingen A, Ledbetter S, Conn DL, Tamhane A, Westfall AO, Jonas BL, Callahan LF, Smith EA, Brasington R, Moreland LW, Alarcón GS, van der Heijde DM. 2010. Radiographic severity of rheumatoid arthritis in African Americans: results from a multicenter observational study. Arthritis Care Res (Hoboken). 62(5):624-31. PMID: 20461784


Freedman BI, Edberg JC, Comeau ME, Murea M, Bowden DW, Divers J, Alarcón GS, Brown EE, McGwin G Jr, Kopp JB, Winkler CA, Nelson GW, Illei G, Petri M, Ramsey-Goldman R, Reveille JD, Vilá LM, Langefeld CD, Kimberly RP. 2010. The Non-Muscle Myosin Heavy Chain 9 Gene (MYH9) Is Not Associated with Lupus Nephritis in African Americans. Am J Nephrol. 2010;32(1):66-72 PMID: 20523037


Burgos PI, McGwin G Jr, Pons-Estel GJ, Reveille JD, Alarcón GS, Vilá LM.2010. US patients of Hispanic and African ancestry develop lupus nephritis early in the disease course: data from LUMINA, a multiethnic US cohort (LUMINA LXXIV). Ann Rheum Dis. 70(2):393-394 PMID: 20627945


Harley IT, Niewold TB, Stormont RM, Kaufman KM, Glenn SB, Franek BS, Kelly JA, Kilpatrick JR, Hutchings D, Divers J, Bruner GR, Edberg JC, McGwin G Jr, Petri MA, Ramsey-Goldman R, Reveille JD, Vilá-Pérez LM, Merrill JT, Gilkeson GS, Vyse TJ, Alarcón-Riquelme ME, Cho SK, Jacob CO, Alarcón GS, Moser KL, Gaffney PM, Kimberly RP, Bae SC, Langefeld CD, Harley JB, Guthridge JM, James JA. 2010. The role of genetic variation near interferon-kappa in systemic lupus erythematosus. J Biomed Biotechnol. 2010;2010. pii: 706825. Epub 2010 Jul 15. PMID: 20706608


Isenberg DA, Allen E, Farewell V, D'Cruz D, Alarcón GS, Aranow C, Bruce IN, Dooley MA, Fortin PR, Ginzler EM, Gladman DD, Hanly JG, Inanc M, Kalunian K, Khamashta M, Merrill JT, Nived O, Petri M, Ramsey-Goldman R, Sturfelt G, Urowitz M, Wallace DJ, Gordon C, Rahman A. 2011. An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA. Ann Rheum Dis. 70(1):54-9.  PMID: 20833737


Ruperto N, Hanrahan L, Alarcón G, Belmont H, Brey R, Brunetta P, Buyon J, Costner M, Cronin M, Dooley M, Filocamo G, Fiorentino D, Fortin P, Franks A Jr, Gilkeson G, Ginzler E, Gordon C, Grossman J, Hahn B, Isenberg D, Kalunian K, Petri M, Sammaritano L, Sánchez-Guerrero J, Sontheimer R, Strand V, Urowitz M, von Feldt J, Werth V, Merrill J. 2011. International consensus for a definition of disease flare in lupus. Lupus. 20(5):453-462. PMID: 21148601


Hanly JG, Urowitz MB, Jackson D, Bae SC, Gordon C, Wallace DJ, Clarke A, Bernatsky S, Vasudevan A, Isenberg D, Rahman A, Sanchez-Guerrero J, Romero-Diaz J, Merrill JT, Fortin PR, Gladman DD, Bruce IN, Steinsson K, Khamashta M, Alarcón GS, Fessler B, Petri M, Manzi S, Nived O, Sturfelt G, Ramsey-Goldman R, Dooley MA, Aranow C, Van Vollenhoven R, Ramos-Casals M, Zoma A, Kalunian K, Farewell V; for the Systemic Lupus International Collaborating Clinics (SLICC). 2011. SF-36 summary and subscale scores are reliable outcomes of neuropsychiatric events in systemic lupus erythematosus. Ann Rheum Dis. 70(6):961-967. PMID: 21342917


Ippolito A, Wallace DJ, Gladman D, Fortin PR, Urowitz M, Werth V, Costner M, Gordon C, Alarcón GS, Ramsey-Goldman R, Maddison P, Clarke A, Bernatsky S, Manzi S, Bae SC, Merrill JT, Ginzler E, Hanly JG, Nived O, Sturfelt G, Sanchez-Guerrero J, Bruce I, Aranow C, Isenberg D, Zoma A, Magder LS, Buyon J, Kalunian K, Dooley MA, Steinsson K, van Vollenhoven RF, Stoll T, Weisman M, Petri M. 2011. Autoantibodies in systemic lupus erythematosus: comparison of historical and current assessment of seropositivity. Lupus. 20(3):250-5. PMID: 21362750


Hughes T, Kim-Howard X, Kelly JA, Kaufman KM, Langefeld CD, Ziegler J, Sanchez E, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Martin J, Brown EE, Vilá LM, Alarcón GS, James JA, Gilkeson GS, Moser KL, Gaffney PM, Merrill JT, Vyse TJ, Alarcón-Riquelme ME; on behalf of the BIOLUPUS network, Nath SK, Harley JB, Sawalha AH. 2011. Fine mapping and trans-ethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21. Arthritis Rheum. 2011 Mar 18. doi: 10.1002/art.30320. [Epub ahead of print] PMID: 21425124


Vinet E, Clarke AE, Gordon C, Urowitz MB, Hanly JG, Pineau CA, Isenberg D, Rahman A, Wallace D, Alarcón GS, Bruce I, Petri M, Dooley MA, Kalunian K, Maddison P, Aranow C, van Vollenhoven R, Bernatsky S. 2011. Decreased live births in women with systemic lupus erythematosus. Arthritis Care Res (Hoboken). 2011 Mar 18. doi: 10.1002/acr.20466. [Epub ahead of print] PMID: 21425248


Ramos PS, Williams AH, Ziegler JT, Comeau ME, Guy RT, Lessard CJ, Edberg JC, Zidovetzki R, Criswell LA, Gaffney PM, Graham DC, Graham RR, Kelly JA, Kaufman KM, Brown EE, Alarcón GS, Petri MA, Reveille JD, McGwin G, Vilá LM, Ramsey-Goldman R, Jacob CO, Vyse TJ, Tsao BP, Harley JB, Kimberly RP, Alarcón-Riquelme ME, Langefeld CD, Moser KL. 2011. Genetic analyses of interferon pathway-related genes reveals multiple new loci associated with systemic lupus erythematosus (SLE). Arthritis Rheum. 2011 Mar 24. doi: 10.1002/art.30356. [Epub ahead of print] PMID: 21437871


Costenbader KH, Desai A, Alarcón GS, Hiraki L, Shaykevich T, Brookhart MA, Massarotti E, Lu B, Solomon DH, Winkelmayer WC. 2011. Trends in the incidence, demographics and outcomes of end-stage renal disease due to lupus nephritis in the U.S., 1995-2006. Arthritis Rheum. 2011 Mar 28. doi: 10.1002/art.30293. [Epub ahead of print] PMID: 21445962


Hiraki LT, Lu B, Alexander SR, Shaykevich T, Alarcón GS, Solomon DH, Winkelmayer W, Costenbader KH. 2011. End-stage renal disease due to lupus nephritis among children in the U.S., 1995-2006. Arthritis Rheum. 2011 Mar 28. doi: 10.1002/art.30350. [Epub ahead of print] PMID: 21445963


Santiago-Casas Y, Vilá LM, McGwin G Jr, Cantor RS, Petri M, Ramsey-Goldman R, Reveille JD, Kimberly RP, Alarcón GS, Brown EE. 2012. Association of discoid lupus with clinical manifestations and damage accrual in Profile: A multiethnic lupus cohort. Arthritis Care Res  64: 704-12.


Devlin A, Waikar SS, Solomon DH, Lu B, Shaykevich T, Alarcón GS, Winkelmayer WC, Costenbader KH. 2011. Variation in initial kidney replacement therapy for end-stage renal disease due to lupus nephritis in the United States. Arthritis Care Res. 63: 1642-53.


Willis R, Seif, McGwin G Jr, Martinez-Martinez LA, Gonzales EB, Papalardo E, Liu J, Vila L, Reveille JD, Alarcon GS, Pierangelli S. 2012. Effect of hydroxychloroquine on pro-inflammatory cytokines and disease activity in SLE patients. Data from LUMINA (LXXV), a multiethnic US cohort. Lupus.  21: 830-5.


Pons-Estel GJ, Alarcón GS, Hachuel L, Boggio G, Wojdyla D, Pascual-Ramos V, Soriano ER, Saurit V, Cavalcanti FS, Guzman RA, Guibert-Toledano M, Sauza Del Pozo MJ, Amigo MC, Alva M, Esteva-Spinetti MH, Pons-Estel BA; on behalf of GLADEL. 2012. Anti-malarials exert a protective effect while Mestizo patients are at increased risk of developing SLE renal disease: data from a Latin-American cohort. Rheumatology (Oxford).  51: 1293-1298.


Hiraki LT, Feldman CH, Liu J, Alarcón GS, Fischer MA, Winkelmayer WC, Costenbader KH. P2012. revalence, incidence and demographics of systemic lupus erythematosus and lupus nephritis from 2000 to 2004 among children in the US Medicaid beneficiary population. Arthritis Rheum.  64: 2669-76.


Petri M, Orbai AM, Alarcón GS, Gordon C, Merrill JT, Fortin PR, Bruce IN, Isenberg D, Wallace DJ, Nived O, Sturfelt G, Ramsey-Goldman R, Bae SC, Hanly JG, Sánchez-Guerrero J, Clarke A, Aranow C, Manzi S, Urowitz M, Gladman D, Kalunian K, Costner M, Werth VP, Zoma A, Bernatsky S, Ruiz-Irastorza G, Khamashta MA, Jacobsen S, Buyon JP, Maddison P, Dooley MA, van Vollenhoven RF, Ginzler E, Stoll T, Peschken C, Jorizzo JL, Callen JP, Lim SS, Fessler BJ, Inanc M, Kamen DL, Rahman A, Steinsson K, Franks AG Jr, Sigler L, Hameed S, Fang H, Pham N, Brey R, Weisman MH, McGwin G Jr, Magder LS.2012.  Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum  64: 2677-86.


Urowitz MB, Gladman DD, Ibañez D, Fortin PR, Bae SC, Gordon C, Clarke A, Bernatsky S, Hanly JG, Isenberg D, Rahman A, Sanchez-Guerrero J, Wallace DJ, Ginzler E, Alarcón GS, Merrill JT, Bruce IN, Sturfelt G, Nived O, Steinsson K, Khamashta M, Petri M, Manzi S, Ramsey-Goldman R, Dooley MA, van Vollenhoven RF, Ramos M, Stoll T, Zoma A, Kalunian K, Aranow C. 2012. Evolution of disese burden over five years in a multicenter inception lupus erythematosus cohort. Arthritis Care Res.  64:132-7.


Feldman CH, Hiraki LT, Liu J, Fischer MA, Solomon DH, Alarcón GS, Winkelmayer WC, Costenbader KH. 2013. Epidemiology and sociodemographics of systemic lupus erythematosus and lupus nephritis among U.S. adults with Medicaid coverage, 2000-2004. Arthritis Rheum.  65: 753-63.


Sánchez E, Rasmussen A, Riba L, Acevedo E, Kelly JA, Langefeld CD, García-De La Torre I, Maradiaga-Ceceña MA, Cardiel MH, Esquivel-Valerio JA, Rodriguez-Amado J, Moctezuma JF, Miranda P, Perandones C, Castel C, Laborde HA, Alba P, Musuruana J, Goecke A, Anaya JM, Kaufman KM, Adler A, Brown EE, Alarcón GS, Kimberly RP, Edberg JC, Criswell LA, Gilkeson GS, Niewold TB, Martin J, Vyse TJ, Ramsey-Goldman R, Petri M, Merrill JT, Reveille JD, Tsao BP, Orozco L, Baca V, James JA, Harley JB, Tusié-Luna T, Pons-Estel BA, Jacob CO, Alarcón-Riquelme ME. 2012. Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in Amerindian-European populations. Arthritis Rheum.  64: 3687-94.


Parker B, Urowitz MB, Gladman DD, Lunt M, Bae SC, Sanchez-Guerrero J, Romero-Diaz J, Gordon C, Wallace DJ, Clarke AE, Bernatsky S, Ginzler EM, Isenberg DA, Rahman A, Merrill JT, Alarcón GS, Fessler BJ, Fortin PR, Hanly JG, Petri M, Steinsson K, Dooley MA, Manzi S, Khamashta M, Ramsey-Goldman R, Zoma A, Sturfelt G, Nived O, Aranow C, MackayM, Ramos-Casals M, van Vollenhoven RF, Kalunian K, Ruiz-Irastorza G, Lim S, Kamen DL, Peschken CA, Inanc M, Bruce 2013. IN. Clinical associations of the metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort. Ann Rheum Dis  72: 1308-1314. Erratum: 2014; 73:320.


Pons-Estel GJ, Saurit V, Alarcón GS, Hachuel L, Boggio G, Wojdyla D, Alvaro-Lozano JL, Garcia de la Torre I, Massardo L, Esteva-Spinetti MH, Guibert-Toledano M, Ramirez Gomez LA, Lavras Costallat LT, Sauza Del Pozo MJ, Silveira LH, Cavalcanti FS, Pons-Estel BA. 2012. The impact of rural residency on the expression and outcome of systemic lupus erythematosus: data from a multiethnic Latin American cohort. Lupus  21: 1397-404.


Bernatsky S, Ramsey-Goldman R, Labrecque J, Joseph L, Boivin JF, Petri M, Zoma A, Manzi S, Urowitz MB, Gladman D, Fortin PR, Ginzler E, Yelin E, Bae SC, Wallace DJ, Edworthy S, Jacobsen S, Gordon C, Dooley MA, Peschken CA, Hanly JG, Alarcón GS, Nived O, Ruiz-Irastorza G, Isenberg D, Rahman A, Witte T, Aranow C, Kamen DL, Steinsson K, Askanase A, Barr S, Criswell LA, Sturfelt G, Patel NM, Senécal JL, Zummer M, Pope JE, Ensworth S, El-Gabalawy H, McCarthy T, Dreyer L, Sibley J, St Pierre Y, Clarke AE. 2013. Cancer risk in systemic lupus: An updated international multi-centre study. J Autoimmun.  42: 130-5.


Pons-Estel GJ, Alarcón GS, Burgos PI, Hachuel L, Boggio G, Wojdyla D, Nieto R, Alvarellos A, Catoggio LJ, Guibert-Toledano M, Sarano J, Massardo L, Vásquez GM, Iglesias-Gamarra A, Lavras Costallat LT, Da Silva NA, Alfaro JL, Abadi I, Segami MI, Huerta G, Cardiel MH, Pons-Estel BA; Grupo Latino Americano de Estudio de Lupus (GLADEL). 2013.  Mestizos with systemic lupus erythematosus develop renal disease early while antimalarials retard its appearance. Data from a Latin American lupus cohort. Lupus. 22: 899-907.


Freedman BI, Langefeld CD, Andringa KK, Croker JA, Williams AH, Garner NE, Birmingham DJ, Hebert LA, Hicks PJ, Segal MS, Edberg JC, Brown EE, Alarcón GS, Costenbader KH, Comeau ME, Criswell LA, Harley JB, James JA, Kamen DL, Lim SS, Merrill JT, Sivils KL, Niewold TB, Patel NM, Petri M, Ramsey-Goldman R, Reveille JD, Salmon JE, Tsao BP, Gibson KL, Byers JR, Vinnikova AK, Lea JP, Julian BA, Kimberly RP; on behalf of the Lupus Nephritis-ESKD Consortium. 2014. End-stage kidney disease in African Americans with lupus nephritis associates with APOL1. Arthritis Rheum.  66: 390-6.


Lu M, Bernatsky S, Ramsey-Goldman R, Petri M, Manzi S, Urowitz MB, Gladman D, Fortin PR, Ginzler EM, Yelin E, Bae SC, Wallace DJ, Jacobsen S, Dooley MA, Peschken CA, Alarcón GS Nived O, Gottesman L, Criswell LA, Sturfelt G, Dreyer L, Lee JL, Clarke AE. 2013.  Non-lymphoma hematological malignancies in systemic lupus erythematosus. Oncology.  85:235-240.


Ugarte-Gil MF, Acevedo-Vásquez E, Alarcón GS, Pastor-Asurza CA, Alfaro-Lozano JL, Cucho-Venegas JM, Segami MI, Wojdyla D, Soriano ER, Drenkard C, Brenol JC, de Oliveira E Silva Montandon AC, Lavras Costallat LT, Massardo L, Molina-Restrepo JF, Guibert-Toledano M, Silveira LH, Amigo MC, Barile-Fabris LA, Chacón-Díaz R, Esteva-Spinetti MH, Pons-Estel GJ, McGwin G Jr, Pons-Estel BA; on behalf of GLADEL. 2014. The number of flares patients experience impacts on damage accrual in systemic lupus erythematosus: data from a multiethnic Latin American cohor. Ann Rheum Dis  74: 1019-23.


García MA, Alarcón GS, Boggio G, Hachuel L, Marcos AI, Marcos JC, Gentiletti S, Caeiro F, Sato EI, Borba EF, Brenol JC, Massardo L, Molina-Restrepo JF, Vásquez G, Guibert-Toledano M, Barile-Fabris L, Amigo MC, Huerta-Yáñez GF, Cucho-Venegas JM, Chacón-Diaz R, Pons-Estel BA; on behalf of the Grupo Latino Americano de Estudio del Lupus Eritematoso (GLADEL). 2014. Primary cardiac disease in systemic lupus erythematosus patients from a multi-ethnic Latin American cohor. Rheumatology 53: 1431-8.


Urowitz M, Gladman DD, Ibañez D, Sanchez-Guerrero J, Bae SC, Gordon C, Fortin PR, Clarke A, Bernatsky S, Hanly JG, Wallace DJ, Isenberg D, Rahman A, Merrill J, Ginzler E, Alarcón GS, Fessler B, Khamashta M, Steinsson K, Petri M, Dooley M, Bruce IN, Manzi S, Sturfelt G, Nived O, Ramsey-Goldman R, Zoma A, Maddison P, Kalunian K, van Vollenhoven R, Aranow C, Romero-Diaz J, Stoll T. 2014. Changes in quality of life in the first five years of disease in a multicenter cohort of patients with systemic lupus erythemathosus (SLE). Arthritis Care Res . 66:1374-9.


Parker B, Urowitz MB, Gladman DD, Lunt M, Donn R, Bae SC, Sanchez-Guerrero J, Romero-Diaz J, Gordon C, Wallace DJ, Clarke AE, Bernatsky S, Ginzler EM, Isenberg DA, Rahman A, Merrill JT, Alarcón GS, Fessler BJ, Fortin PR, Hanly JG, Petri M, Steinsson K, Dooley MA, Manzi S, Khamashta MA, Ramsey-Goldman R, Zoma AA, Sturfelt GK, Nived O, Aranow C, Mackay M, Ramos-Casals M, van Vollenhoven RF, Kalunian KC, Ruiz-Irastorza G, Lim SS, Kamen DL, Peschken CA, Inanc M, Bruce IN.2014.  Impact of early disease factors on metabolic syndrome in systemic lupus erythemathosus: data from an international inception cohort. Ann Rheum Dis 74:1530-6.


Urowitz MB, Gladman DD, Ibañez D, Sanchez-Guerrero J, Romero-Diaz J, Gordon C, Bae SC, Clarke AE, Bernatsky S, Fortin PR, Hanly JG, Isenberg D, Rahman A, Wallace DJ, Ginzler E, Petri M, Bruce IN, Merrill JT, Nived O, Sturfelt G, Dooley MA, Alarcón GS, Fessler B, Steinsson K, Ramsey-Goldman R, Zoma A, Khamashta M, Manzi S, van Vollenhoven R, Ramos-Casals M, Aranow C, Stoll T. 2014. American College of Rheumatology criteria at inception, and accrual over 5 years in the SLICC inception cohort. J Rheumatol.  41:875-80.


Ugarte-Gil MF, Gamboa- Cárdenas RV, Zevallos F, Medina M, Cucho-Venegas JM, Perich-Campos RA, Alfaro-Lozano JL, Rodriguez-Bellido Z, Alarcón GS, Pastor-Asurza CA. 2014. High prolactin levels are independently associated with damage accrual in systemic lupus erythematosus patients. Lupus.  23: 969-74.


Willis R, Seif AM, McGwin G Jr, Martinez-Martinez LA, Gonzales EB, Doan E, Dong N, Papalardo E, Lui J, Vila LM, Reveille JD, Alarcón GS, Pieranglelli SS. 2014. Effects of statins on proinflammatory/prothrombotic biomarkers and on disease activity score in SLE patients: data from LUMINA (LXXVI) a multiethnic US cohort. Clin Exp Rheumatol.  32: 162-7.


Bruce IN, O'Keeffe AG, Farewell V, Hanly JG, Manzi S, Su L, Gladman DD, Bae SC, Sanchez-Guerrero J, Romero-Diaz J, Gordon C, Wallace DJ, Clarke AE, Bernatsky S, Ginzler EM, Isenberg DA, Rahman A, Merrill JT, Alarcón GS, Fessler BJ, Fortin PR, Petri M, Steinsson K, Dooley MA, Khamashta MA, Ramsey-Goldman R, Zoma AA, Sturfelt GK, Nived O, Aranow C, Mackay M, Ramos-Casals M, van Vollenhoven RF, Kalunian KC, Ruiz-Irastorza G, Lim S, Kamen DL, Peschken CA, Inanc M, Urowitz MB. 2015. Factors associated with damage accrual in patients with systemic lupus erythematosus: results from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort. Ann Rheum Dis. 74:1706-13.


Bourré-Tessier J, Urowitz MB, Clarke AE, Bernatsky S, Krantz MJ, Huynh T, Joseph L, Belisle P, Bae SC, Hanly JG, Wallace DJ, Gordon C, Isenberg D, Rahman A, Gladman DD, Fortin PR, Merrill JT, Romero-Diaz J, Sanchez-Guerrero J, Fessler B, Alarcón GS, Steinsson K, Bruce IN, Ginzler E, Dooley MA, Nived O, Sturfelt G, Kalunian K, Ramos-Casals M, Petri M, Zoma A, Pineau CA. 2015. Electrocardiographic findings in systemic lupus erythematosus: data from an international inception cohort. Arthritis Care Res (Hoboken).  67:128-35


Ugarte-Gil MF, Sánchez-Zúñiga C, Gamboa-Cárdenas RV, Aliaga-Zamudio M, Zevallos F, Tineo-Pozo G, Cucho-Venegas JM, Mosqueira-Riveros A, Perich-Campos RA, Alfaro-Lozano JL, Medina M, Rodríguez-Bellido Z, Alarcón GS, Pastor-Asurza CA. 2015. Circulating naive and memory CD4+ T cells and metabolic syndrome in patients with systemic lupus erythematosus: data from a primarily Mestizo population. Rheumatology (Oxford).  54:1302-7.


Gómez-Puerta JA, Barbhaiya M, Guan H, Feldman CH, Alarcón GS, Costenbader KH. 2015. Racial/Ethnic variation in all-cause mortality among United States Medicaid recipients with systemic lupus erythematosus: A Hispanic and Asian paradox. Arthritis Rheumatol.  67:752-60.


Gómez-Puerta JA, Feldman CH, Alarcón GS, Guan H, Winkelmayer WC, Costenbader KH. 2015. Racial and ethnic differences in mortality and cardiovascular events among patients with end-stage renal disease due to lupus nephritis. Arthritis Care Res (Hoboken).  67:1453-62.


Wang SS, Vajdic CM, Linet MS, Slager SL, Voutsinas J, Nieters A, de Sanjose S, Cozen W, Alarcón GS, Martinez-Maza O, Brown EE, Bracci PM, Lightfoot T, Turner J, Hjalgrim H, Spinelli JJ, Zheng T, Morton LM, Birmann BM, Flowers CR, Paltiel O, Becker N, Holly EA, Kane E, Weisenburger D, Maynadie M, Cocco P, Foretova L, Staines A, Davis S, Severson R, Cerhan JR, Breen EC, Lan Q, Brooks-Wilson A, De Roos AJ, Smith MT, Roman E, Boffetta P, Kricker A, Zhang Y, Skibola C, Chanock SJ, Rothman N, Benavente Y, Hartge P, Smedby KE. 2015. Associations of non-Hodgkin Lymphoma (NHL) risk with autoimmune conditions according to putative NHL loci. Am J Epidemiol.  181:406-21.


Hanly JG, Su L, Urowitz MB, Romero-Diaz J, Gordon C, Bae SC, Bernatsky S, Clarke AE, Wallace DJ, Merrill JT, Isenberg DA, Rahman A, Ginzler EM, Petri M, Bruce IN, Dooley MA, Fortin P, Gladman DD, Sanchez-Guerrero J, Steinsson K, Ramsey-Goldman R, Khamashta MA, Aranow C, Alarcón GS, Fessler BJ, Manzi S, Nived O, Sturfelt GK, Zoma AA, van Vollenhoven RF, Ramos-Casals M, Ruiz-Irastorza G, Lim SS, Kalunian KC, Inanc M, Kamen DL, Peschken CA, Jacobsen S, Askanase A, Theriault C, Thompson K, Farewell V. 2015. Mood disorders in systemic lupus erythematosus: Results from an international inception cohort study. Arthritis Rheumatol.  67:1837-47.


Arroyo-Ávila M, Santiago-Casas Y, McGwin G Jr, Cantor RS, Petri M, Ramsey-Goldman R, Reveille JD, Kimberly RP, Alarcón GS, Vilá LM, Brown EE. 2015. Clinical associations of anti-Smith antibodies in PROFILE: a multi-ethnic lupus cohort. Clin Rheumatol.  34:1217-23.


Hanly JG, O'Keeffe AG, Su L, Urowitz MB, Romero-Diaz J, Gordon C, Bae SC, Bernatsky S, Clarke AE, Wallace DJ, Merrill JT, Isenberg DA, Rahman A, Ginzler EM, Fortin P, Gladman DD, Sanchez-Guerrero J, Petri M, Bruce IN, Dooley MA, Ramsey-Goldman R, Aranow C, Alarcón GS, Fessler BJ, Steinsson K, Nived O, Sturfelt GK, Manzi S, Khamashta MA, van Vollenhoven RF, Zoma AA, Ramos-Casals M, Ruiz-Irastorza G, Lim SS, Stoll T, Inanc M, Kalunian KC, Kamen DL, Maddison P, Peschken CA, Jacobsen S, Askanase A, Theriault C, Thompson K, Farewell V. 2016. The frequency and outcome of lupus nephritis: Results from an international inception cohort study. Rheumatology (Oxford).  55:255-62.


González-Naranjo LA, Betancur OM, Alarcón GS, Ugarte-Gil MF, Jaramillo-Arroyave D, Wojdyla D, Pons-Estel GJ, Rondón-Herrera F, Vásquez-Duque GM, Quintana-López G, Da Silva NA, Tavares Brenol JC, Reyes-Llerena G, Pascual-Ramos V, Amigo MC, Massardo L, Alfaro-Lozano J, Segami MI, Esteva-Spinetti MH, Iglesias-Gamarra A, Pons-Estel BA. 2016. Features associated with hematological abnormalities and their impact in patients with systemic lupus erythematosus. Semin Arthritis Rheum  45: 675-83.


Ugarte-Gil M, Sánchez-Zúñiga C, Gamboa-Cárdenas RV, Aliaga-Zamudio M, Zevallos F, Tineo-Pozo G, Cucho-Venegas JM, Mosqueira-Riveros A, Medina M, Perich-Campos RA, Alfaro-Lozano JL, Rodriguez-Bellido Z, Alarcón GS, Pastor-Asurza CA. 2016.  Circulating CD4+CD28null extra-thymic CD4+CD8+double positive T cells are independently associated with disease damage in systemic lupus erythematosus. Lupus  25: 323-40.


Catoggio LJ, Soriano ER, Imamura PM, Wojdyla D, Jacobelli S, Massardo L, Chacón Díaz R, Guibert-Toledano M, Alvarellos A, Saurit V, Manni JA, Pascual-Ramos V, Silva de Sauza AW, Bonfa E, Tavares Brenol JC, Ramirez LA, Barile-Fabris LA, De La Torre IG, Alarcón GS, Pons-Estel BA; Grupo Latino Americano De Estudio del Lupus (GLADEL). 2015. Late-onset systemic lupus erythematosus in Latin America: A distinct subgroup? Lupus 24: 788-95.


Al Sawah S, Daly RP, Foster S, Naegeli A, Benjamin K, Doll H, Bond G, Moshkovich O and Alarcón GS. 2016. The caregiver burden in lupus: Findings from UNVEIL, a national online lupus survey in the United States. Lupus [Epub ahead of print]


Muñoz-Grajales C, González LA, Alarcón GS, Acosta-Reyes J. 2016. Gender differences in disease activity and clinical features in newly diagnosed systemic lupus erythematosus patients. Lupus  [Epub ahead of print]


Hanly JG for the Systemic Lupus International Collaborating Clinics, Su L, Urowitz M, Romero-Diaz J, Gordon C, Bae S-C, Bernatsky SR, Clarke AE, Wallace DJ, Merrill JT, Isenberg DA, Rahman A, Ginzler EM, Fortin P, Gladman DD, Sanchez-Guerrero J, Petri1 MA, Bruce I, Dooley MA, Ramsey-Goldman R, Aranow C, Alarcon GS, Fessler BJ, Steinsson K, Nived O, Sturfelt GK, Manzi S, Khamashta MA. van Vollenhoven RF, Zoma A, Ramos-Casals M, Ruiz-Irastorza G, Lim S, Stoll T, Inanc M, Kalunian KC, Kamen DL, Maddison P, Peschken CA, Jacobsen S, Askanase A, Buyon JP, Theriault C, Thompson K and Farewel V. 2016. A longitudinal analysis of change in lupus nephritis in an international inception cohort using a multistate Markov model approach. Arthritis Rheumatol.  68: 1932-44.


Ugarte-Gil MF, Pons-Estel GJ, Molineros J, Wojdyla D, McGwin G Jr, Nath SK, Pons-Estel BA, Alarcón-Riquelme M, Alarcón GS. 2016. Disease features and outcomes in United States lupus patients of Hispanic origin and their Mestizo counterparts in Latin America: A commentary. Rheumatology (Oxford).  55: 436-40.


Alarcón GS. The Evelyn Hess Memorial Lecture. J Clin Rheum. 22: 372-5.

 

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