Acute Care Surgery Research

The UAB Division of Trauma & Acute Care Surgery is committed to improving the fields of trauma, burn care and surgical critical care. Our faculty are actively involved in a number of research areas, such as those listed below, as well as the Crash Injury Research Engineering Network (CIREN) Program funded by the National Highway Traffic Safety Administration and the Center for Injury Science

Acute Care Surgery


This program fosters research and instruction in the areas of hemorrhage to translate these experimental studies to the bedside using novel treatment modalities so that complications and mortality rates in such trauma patients can be decreased.

Along with the Center for Phase I Studies have now been contracted to the tune of $10 million dollars to obtain IND approval from the FDA and then conduct the Phase I studies of EE-3-SO4. More specifically, the contract titled “Surviving Blood Loss: First In Human Studies To Assess Safety And Physiological Effects Of Synthetic Ethinyl Estradiol-3-Sulfate (EE-3-SO4) In Healthy Subjects Both Euvolemic And Following 10-20% Inatrogenic Blood Loss” has been awarded since September, 2015 to complete the preclinical studies and then perform the Phase I studies of EE-3-SO4.


Surgical Education Research Program

The Surgical Education Research Program studies the process by which we train future surgeons and surgical leaders. Our focus areas include surgical simulation, conflict management, robotic surgical curriculum, and surgery work hours as well as other educational interests. 



Traumatic Hemorrhage and Fluid Resuscitation

This research program is focused on understanding the role of the endothelial glycocalyx in regulating injury severity and outcomes in trauma patients. In combination with established animal models of trauma-hemorrhage and resuscitation (THR), we utilize custom-designed bioengineered cell culture systems to study the effect of hemodynamic forces on THR-related endotheliopathy, microvascular dysfunction and organ injury. Our research efforts are aimed at the identification of therapeutic strategies to prevent glycocalyx damage or restore loss of glycocalyx function caused by THR.