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Dr. Jan Jansen

Associate Vice Chair for Clinical Trials
Director of Research, Division of Trauma & Acute Care Surgery
Director, UAB Center for Injury Science

Areas of Interest
trauma, critical care medicine, clinical trials


Dr. Jansen joined the Division of Trauma & Acute Care Surgery faculty in August 2017. He trained in the United Kingdom where he obtained his medical degree and an intercalated Bachelor of Science degree in anatomy. He also holds a Doctorate of Medicine from the University of Berlin and a Ph.D. from the University of Aberdeen.

 Dr. Jansen completed his general surgery residency in Scotland, with trauma and critical care medicine fellowships in Johannesburg and Toronto. He is a fellow of the Royal College of Surgeons of England and a fellow of the Faculty of Intensive Care Medicine of the Royal College of Anaesthetists. Dr. Jansen served in the British Army as a reservist and was awarded a Queen’s Commendation for his service in Afghanistan.

Dr. Jansen’s principal research interest is clinical trials. He has particular expertise in the evaluation of complex interventions, and Bayesian trial designs. He was the chief investigator of the "UK Resuscitative Endovascular Balloon Occlusion of the Aorta" (UK-REBOA) trial, and is the principal investigator of the "Trauma Resuscitation with Group O Whole Blood Or Products" (TROOP) and "Trauma And Prothrombin Complex Concentrate" (TAP) trials. He serves as director of research for the UAB Division of Acute Care Surgery, director of the UAB Center for Injury Science, and associate vice chair for clinical trials for the UAB Department of Surgery.

Selected Publications

Jansen JO, Hudson J, Cochran C, Maclennan G, Lendrum R, Sadek S, Gillies K, Cotton S, Kennedy C, Boyers D, Ferry G, Lawrie L, Nath M, Wileman S, Forrest M, Brohi K, Harris T, Lecky F, Moran C, Morrison JJ, Norrie J, Paterson A, Tai N, Welch N, Campbell MK; and the UK-REBOA Study Group. Emergency Department Resuscitative Endovascular Balloon Occlusion of the Aorta in Trauma Patients with Exsanguinating Hemorrhage: The UK-REBOA Randomized Clinical Trial. JAMA 2023;330(19):1-10

Lammers D, Richman J, Holcomb JB, Jansen JO. Use of Bayesian Statistics to reanalyze data from the Pragmatic Randomized Optimal Platelet and Plasma Ratios trial. JAMA Netw Open 2023; 6(2): e230421

Jansen JO, Cochran C, Boyers D, Gillies K, Lendrum R, Sadek S, Lecky F, Maclennan G, Campbell MK, and the UK-REBOA Trial Grantholders. The effectiveness and cost-effectiveness of resuscitative endovascular balloon occlusion of the aorta (REBOA) for trauma patients with uncontrolled torso haemorrhage: study protocol for a randomised clinical trial (the UK-REBOA trial). Trials 2022; 23(1): 384

Lawrie L, Duncan EM, Jansen JO, Campbell MK, Brunsdon D, Skea Z, Coffey T, Cochran C, Gillies K. Behavioural optimization to address trial conduct challenges: case study in the UK-REBOA trial. Trials 2022; 23(1): 398

Tolles J, Beiling M, Schreiber MA, Del Junco DJ, McMullan JT, Guyette FX, Wang H, Jansen JO, Meurer WJ, Mainali S, Yadav K, Lewis RJ. An adaptive platform trial for evaluating treatments in patients with life-threatening hemorrhage from traumatic injuries: rationale and proposal Transfusion 2022;62(Suppl 1):S231-S241

Abraham PJ, Gonzales-Sigler I, Reynolds L, Griffin RL, Kerby JD, Holcomb JB, Jansen JO. Balancing Enrollment and Mortality in Hemorrhage Control Trials: A Secondary Analysis of the PROPPR Trial Journal of Trauma and Acute Care Surgery 2022:92(6):1054-1060

Jansen JO, Stephens SW, Inaba K, Goldkind SF, Holcomb JB. Interative media-based community consultation for exception from informed consent trials: How representative should (and can) it be? Journal of Trauma 2022;92(3):e41-e46

Farley P, Stephens SW, Crowley B, Collins SP, Wong MD, Panas AB, Dennis BM, Richond N, Inaba K, Brown KN, Holcomb JB, Jansen JO. Exception from Informed Consent Trials: Social Media Based Community Consultation Campaigns are Representative of Target Communities. Trauma Surgery and Acute Care Open 2021;6:e000830

 Stephens SW, Farley P**, Collins SP, Wong MD, Panas AB, Dennis BM, Richond N, Inaba K, Brown KN, Holcomb JB, Jansen JO. Multicenter social media community consultation/public disclosure for an exception from informed consent trial of the XSTAT device. Journal of Trauma and Acute Care Surgery 2022;92(2):442-446

 Gunn AJ, Raborn JR*, Stephens SW, Griffin RL, Richman J, Jansen JO. A pilot randomized controlled trial of coils versus plugs for proximal splenic artery embolization in high-grade splenic trauma. Abdominal Radiology 2021;46(6):2823-2832

 Holcomb JB, Moore EE, Sperry JL, Jansen JO, Schreiber MA, del Junco DJ, Spinella PC, Sauaia A, Brohi K, Bulger EM, Cap AP, Hess JR, Jenkins D, Lewis R, Neal MD, Newgard C, Pati S, Pusateri AE, Rizoli S, Russell RT, Shackelford DM, Steiner M, Wang H, Ward KR, Young P. Evidence Based and Clinically Relevant Outcomes for Hemorrhage Control Trauma Trials. Annals of Surgery 2021;273(3):395-401

Jansen JO, MacLennan G, Campbell MK. Bayesian clinical trial designs: another option for trauma trials? Submitted to Journal of Trauma and Acute Care Surgery (in press/available online)

Emerson P, Dodds N, Green DR, Jansen JO. Geographical access to critical care services in Scotland. Journal of the Intensive Care Society (in press/available online)

Zhang GX, Fan JKM, Chan FSY, Leung GKK, Lo CM, Yu YM, Zhang H, Brundage SI, Jansen JO. An exploratory analysis of the geographical distribution of trauma incidents in Shenzhen, China. World Journal of Surgery 2017;41(9):2207-2214

Madurska MJ, Jansen JO, Reva VA, Mirghani M, Morrison JJ. The compatibility of CT scanning and partial REBOA: a large animal pilot study. Journal of Trauma and Acute Care Surgery 2017;83(8):557-561

Dodds N, Emerson P, Phillips S, Green DR, Jansen JO. Analysis of aeromedical retrieval coverage using elliptical isochrones: An evaluation of helicopter fleet size configurations in Scotland. Journal of Trauma and Acute Care Surgery 2017; 82(3): 550-556

Wang H, Jin Y, Jansen JO. Data-driven surrogate-assisted multi-objective evolutionary optimization of a trauma system. IEEE Transactions on Evolutionary Computation 2016; 20(6): 939-952

Jansen JO, Lendrum R, Morrison JJ. Trauma care in Scotland: The role of major trauma centres, trauma units, and local emergency hospitals. Surgeon 2016; 14: 241-244

Roberts N, Lorencatto F, Manson J, Brundage S, Jansen JO. What helps or hinders the transformation from a Major Tertiary Center to a Major Trauma Center? Identifying Barriers and Enablers Using the Theoretical Domains Framework. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2016; 24(1): 30

Jansen JO, Morrison JJ, Smyth L, Campbell MK. Using population-based critical care data to evaluate trauma outcomes. Surgeon 2016; 14(1): 7-12

Morrison JJ, Yapp L, Beattie A, Devlin E, Samarage M, McCaffer C, Jansen JO. The epidemiology of Scottish trauma: A comparison of pre-hospital and in-hospital deaths, 2000 to 2011. Surgeon 2016; 14(1): 1-6

Morrison JJ, Galgon RE, Jansen JO, Rasmussen TE, Eliason JL. A systematic review of the use of resuscitative endovascular balloon occlusion of the aorta in the management of hemorrhagic shock. Journal of Trauma 2016; 80(2): 324-34

Jansen JO, Morrison JJ, Wang H, He S, Lawrenson R, Hutchison JD, Campbell MK. Access to specialist care: Optimising the geographical configuration of trauma care networks. Journal of Trauma and Acute Care Surgery 2015; 79(5): 756-65

Barnard EBG, Morrison JJ, Madureira RM, Lendrum R, Fragoso-Inguinez M, Lecky F, Bouamra O, Jansen JO. Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA): A population-based gap analysis of trauma patients in England and Wales. Emergency Medicine Journal 2015; 32: 926-932

Hetherington JJ, Ford I, Ashcroft GP, Jansen JO. Intraoperative changes in platelet function in relation to moderate haemorrhage. Thrombosis Research 2015; 135(6): 1198-202

Jansen JO, Morrison JJ, Wang H, He S, Lawrenson R, Campbell MK, Green DR. Feasibility and utility of population-level geospatial injury profiling: prospective, national cohort study. Journal of Trauma and Acute Care Surgery 2015; 78(50): 962-9

Jansen JO, Morrison JJ, Tai NRM, Midwinter MJ. A survey of major trauma centre staffing in England. Journal of the Royal Army Medical Corps 2015; 161(4): 341-4

O’Reilly DJ, Morrison JJ, Jansen JO, Apodaca AN, Rasmussen TE, Midwinter MJ. Prehospital blood transfusion in the en route management of severe combat trauma: a matched cohort study. Journal of Trauma and Acute Care Surgery 2014; 77 (3 Supp 2): S114-20

O’Reilly DJ, Morrison JJ, Jansen JO, Nordman G, Rasmussen TE, Midwinter MJ. Special report: initial UK experience of prehospital blood transfusion in combat casualties. Journal of Trauma and Acute Care Surgery 2014; 77 (Supp 3): S66-70

Yeap EE, Morrison JJ, Apodaca AN, Egan H, Jansen JO. Trauma care in Scotland: Effect of rurality on ambulance travel times and destination healthcare facility. European Journal of Trauma and Emergency Surgery 2014: 40(3): 295-302

Jansen JO, Morrison JJ, Wang H, He S, Lawrenson R, Egan G, Campbell MK. Optimizing Trauma System Design: The GEOS (Geospatial Evaluation of Systems of Trauma Care) Approach. Journal of Trauma and Acute Care Surgery 2014; 76(4): 1035-40

Morrison JJ, Lendrum R, Jansen JO. Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA): a bridge to definitive haemorrhage control for trauma patients in Scotland? Surgeon 2014: 12(3): 119-120

Morrison JJ, Ross JD, Rasmussen T, Midwinter MJ, Jansen JO. Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA): A gap analysis of severely injured UK combat casualties. Shock 2014; 41(5): 388-93

Jansen JO, Morrison JJ, Midwinter MJ, Doughty H. Changes in blood transfusion practices in the UK role 3 medical treatment facility in Afghanistan, 2008-2011. Transfusion Medicine 2014: 24(3): 154-161

Jacobs N, Rourke K, Hicks A, Smith S, Templeton P, Adams SA, Jansen JO. Traumatic lower extremity amputation caused by improvised explosive devices: “Bastion” classification. Injury 2014; 45(9): 1422-1428

Jansen JO, Campbell MK, on behalf of the GEOS Study Investigators. The GEOS study: designing a geospatially optimised trauma system for Scotland. Surgeon 2014; 12(2): 61-3

Jansen JO, Lord JM, Thickett DR, Midwinter MJ, McAuley DF, Gao F. Statins and trauma: systematic review. Critical Care 2013, 17: 227

Starkey K, Keene D, Morrison JJ, Doughty H, Midwinter MJ, Woolley T, Jansen JO. Impact of high ratios of plasma-to-red-cell-concentrate on the incidence of acute respiratory distress syndrome in UK transfused combat casualties. Shock 2013; 40(1): 15-20

Morrison JJ, Ross JD, Poon H, Midwinter MJ, Jansen JO. Intra-operative correction of acidosis, coagulopathy and hypothermia in combat casualties with severe haemorrhagic shock. Anaesthesia 2013; 68(8): 846-50

Wohlgemut JM, Morrison JJ, Apodaca A, Egan G, Sponseller PD, Driver CP, Jansen JO. Demographic and geographic characteristics of pediatric trauma in Scotland. Journal of Pediatric Surgery 2013; 48(7): 1593-7

Parnaby CN, Ramsay G, Macleod CS, Hope NR, Jansen JO, McAdam TK. Complications after laparoscopic and open subtotal colectomy for inflammatory colitis: a case-matched comparison. Colorectal Disease 2013; 15(11): 1399-405

Morrison JJ, Stannard A, Rasmussen TE, Jansen JO, Tai NRM, Midwinter MJ. Injury pattern and mortality of non-compressible torso haemorrhage in UK combat casualties. Journal of Trauma and Acute Care Surgery 2013; 75: S263-S268

Poon H, Morrison JJ, Clasper JC, Midwinter MJ, Jansen JO. Use and complications of operative control of arterial inflow in combat casualties with traumatic lower extremity amputations caused by improvised explosive devices. Journal of Trauma and Acute Care Surgery 2013; 75: S233-S237

Peach CM, Morrison JJ, Apodaca AN, Egan G, Watson HG, Jansen JO. Destination healthcare facility of shocked trauma patients in Scotland: Analysis of transfusion and surgical capability of receiving hospitals. Surgeon 2013; 11(5): 272-7

Brown C, Cooper J, Denison A, Jansen JO. Coeliac Axis Dissection Secondary to Blunt Abdominal Trauma: A Case report and review of the literature. Injury Extra 2014; 45(3): 19-28

Jansen JO, Luke D, Davies E, Spencer P, Kirkman E, Midwinter M. Temporal changes in ROTEM measured coagulability of citrated blood samples from coagulopathic trauma patients. Injury 2013; 44(1): 36-9

Sudlow A, McConnell N, Egan G, Jansen JO. Destination healthcare facility of patients with suspected traumatic brain injury in Scotland: analysis of pre-hospital data. Injury 2013; 44(9): 1237-40

Jansen JO, Inaba K, Reznick S, Fraga G, Starling S, Rizoli S, Boffard KD, Demetriades D. Selective non-operative management of abdominal gunshot wounds: survey of practice. Injury 2013; 44(5): 639-44

Morrison JJ, McConnell N, Orman JA, Egan G, Jansen JO. Rural and urban distribution of trauma incidents in Scotland. British Journal of Surgery 2013; 100(3): 351-9

Jansen JO, Tai NRM, Midwinter MJ. Planning trauma care services in the UK: surgical workforce development remains a challenge. British Medical Journal 2013; 346: f738

Morrison JJ, Ross JD, Dubose JJ, Williams K, Jansen JO, Midwinter MJ, Rasmussen TE. Cryoprecipitate and tranexamic acid improve mortality following wartime injury. JAMA Surgery 2013; 148(3): 218-25

Jansen JO, Morrison JJ. Mortality from trauma in Scotland. Injury 2013; 100(3): 351-9

Jansen JO, Champion HR. Trauma care in Scotland: The importance of functional outcomes and quality of life. Surgeon 2012; 10(5): 247-248

Tarmey N, Doran C, Easby D, Jansen JO, Woolley T, Midwinter M. Evolution of coagulopathy monitoring in military resuscitation. Journal of Trauma and Acute Care Surgery 2012; 73(6): S417-S422

Morrison JJ, Poon H, Garner J, Midwinter MJ, Jansen JO. Non-therapeutic laparotomy in combat casualties. Journal of Trauma and Acute Care Surgery 2012; 73(6): S479-S482

Jansen JO, Thomas GOR, Adams SA, Tai NRM, Morrison JJ, Russell R, Clasper J, Midwinter M. Early management of proximal traumatic lower extremity amputation and pelvic injury caused by improvised explosive devices (IEDs). Injury 2012; 43(7): 976-979

Jansen JO, Inaba K, Rizoli S, Boffard K, Demetriades D. Selective non-operative management of penetrating abdominal injury in Great Britain and Ireland: Survey of practice. Injury 2012; 43(11): 1799-1804

Morrison J, Dickson E, Jansen JO, Midwinter M. Utility of admission physiology in the surgical triage of isolated ballistic battlefield torso trauma. Journal of Emergencies, Trauma and Shock 2012; 5(3): 233-23

Morrison J, Hunt N, Midwinter M, Jansen JO. Prevalence of torso and head injuries in combat casualties with traumatic lower extremity amputations. British Journal of Surgery 2012; 99(3): 362-366

Jansen JO, Scarpelini S, Pinto R, Tien H, Callum J, Rizoli S. Hypoperfusion in severely injured trauma patients is associated with reduced coagulation factor activity. Journal of Trauma 2011; 71(5): S435-S440

Rizoli SB, Scarpelini S, Callum J, Nascimento B, Mann KG, Pinto R, Jansen JO, Tien H. Clotting factor deficiency in early trauma-associated coagulopathy. Journal of Trauma and Acute Care Surgery 2011; 71(5): S427-S434

Jansen JO, Turner S, Johnston A. Nutritional management of critically ill trauma patients in the deployed military setting. Journal of the Royal Army Medical Corps 2011; 157(3): 344-349

Bowley DM, Jansen JO, Nott D, Sapsford W, Streets CG, Tai N. Difficult decisions: surgical care of military casualties with major torso trauma. Journal of the Royal Army Medical Corps 2011; 157(3): 324-333

Jansen JO (on behalf of the Torso Trauma Working Group of the Academic Department of Surgery and Trauma, Royal Centre for Defence Medicine). Selective non-operative management of abdominal injury in the military setting (consensus statement). Journal of the Royal Army Medical Corps 2011; 157(3): 237-242

Morrison JJ, Midwinter MJ, Jansen JO. Decision making in ballistic thoracoabdominal trauma management: Analysis of recent military experience. World Journal of Surgery 2010; 35(6): 1396-1401

Jansen JO. Regionalisation of trauma services in England and Wales: Implications for Scotland. Surgeon 2010; 8: 237-238

Wood A, Trimble K, Loudon MA, Jansen JO. Selective non-operative management of ballistic abdominal solid organ injury in the deployed military setting. Journal of the Royal Army Medical Corps 2010; 156(1): 21-24

Jansen JO, Cuthbertson BH. Detecting critical illness outside the ICU: the role of track and trigger systems. Current Opinion in Critical Care 2010; 16(3): 184-190

Jansen JO, Thomas R, Loudon MA, Brooks A. Damage control resuscitation for patients with major trauma. British Medical Journal 2009; 338: 1436-1440

Andrews JMS, Dickson EJ, Loudon MA. Jansen JO. Protocol-driven trauma resuscitation: survey of UK practice. Emergency Medicine Journal 2009;26(12):864-86

Jansen JO, Yule SR, Loudon MA. Investigation of blunt abdominal trauma. British Medical Journal 2008; 336: 938-942

Jansen JO, Loudon MA. Damage control surgery in a non-trauma setting. British Journal of Surgery 2007; 94: 789-790

Jansen JO, Driver CP, Duncan JL. Unusual hindgut malrotation and associated mesenteric vascular abnormality presenting as large bowel obstruction in an adult. Surgeon 2007; 5(2): 109-110

Jansen JO, Logie JRC. Diagnostic peritoneal lavage – an obituary. British Journal of Surgery 2005; 92(5): 517-518

King PM, Suttie S, Jansen JO, Watson AJM. Perforation of the terminal ileum: a possible complication of nicorandil therapy Surgeon 2004; 2(1): 56-57

Jansen JO, Gardiner DS, MacDonald A. Small bowel obstruction secondary to traction from a large stromal tumour. Scottish Medical Journal 2004; 49: 160-161

O’Kelly TJ, Jansen JO. Non-restorative surgery for rectal cancer: indications in 2003. Surgeon 2003; 1(6): 342-346

Jansen JO, Grant IC. Communication with GPs after Accident & Emergency department attendance: computer-generated letters are often deficient. Emergency Medicine Journal 2003; 20(3): 256-257

Jansen JO, O’Kelly TJ, Krukowski ZH, Keenan RA. Right hemicolectomy: mechanical bowel preparation is not required. Journal of the Royal College of Surgeons of Edinburgh 2002; 47(3): 557-560


Medical School
United Medical and Dental School of Guy’s and St Thomas’s Hospitals, London, UK

North of Scotland Higher Surgical Training Program
General Surgery

Johannesburg Hospital, South Africa
Sunnybrook Health Sciences Centre, Toronto, Canada
Critical Care Medicine


Campus Address
BDB 625

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