Project 1: Role of Innate Immune Cells in Human Parkinson Disease - P50 in Parkinson’s

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Udall Center of Excellence in Parkinson’s Disease Research Heersink School of Medicine

Is there is evidence for a systemic inflammatory response at the earliest stages of PD?
- Studies of blood monocytes
- Signaling pathways (LRRK2 and JAK/STAT)
- Analysis of PET imaging with [18F]-DPA-714
- Clinical change, especially in cognitive function
Do the inflammatory changes present in the brain and body at the earliest stages of PD predict disease progression?