Project 3: LRRK2 mediated macrophage responses in PD - P50 in Parkinson’s

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Udall Center of Excellence in Parkinson’s Disease Research Heersink School of Medicine

Focus is on role of LRRK2 in PD-related inflammatory processes
- Does LRRK2 inhibition in the periphery block α-syn driven pro-inflammation and neurodegeneration?
- Do macrophages from LRRK2 mutation carriers and early PD patients demonstrate enhanced pro-inflammatory responses to α-syn?
- What is the role of LRRK2 activity in these responses?