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Matthew Macaluso, D.O.

Treatment-resistant depression • Mood disorders • Psychopharmacology

Media contact: Brianna Hoge,  

candice dye experts2017Matthew Macaluso, D.O.

Marnix E. Heersink School of Medicine

Department of Psychiatry and Behavioral Neurobiology



Areas of expertise:

  • Treatment-resistant depression
  • Mood disorders
  • Psychopharmacology



Macaluso is the Bee McWane Reid Professor in the Department of Psychiatry and Behavioral Neurobiology, as well as the clinical director of the UAB Depression and Suicide Center. His research focus is on clinical psychopharmacology and its translation to clinical practice with a focus on treatment-resistant major depression.

As clinical director, Macaluso oversees clinical trials of novel mechanism of action drugs, devices and biologics to treat patients with severe forms of depression that are not responsive to currently marketed treatments. He is a highly experienced investigator in complex clinical trials and the translational neuroscience of mood disorders and has contributed most significantly in the area of novel treatment development.



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