Alzheimers disease center

UAB researchers found that blocking sortilin binding significantly improves progranulin gene therapy for frontotemporal dementia, boosting protein delivery, reducing brain inflammation and advancing potential treatments for a disease with no cure.

This finding suggests that therapy to remodel synapses could help memory in old age and dementia patients.

These findings could lead to non-invasive, low-cost tests and the early diagnosis of the disease, which progresses for decades before symptoms of dementia emerge.