UAB neurologist edits first textbook on newly defined disease process

anthony nicholas bookAnthony Nicholas, M.D., associate professor in the Department of Neurology at the University of Alabama at Birmingham, is a co-editor of the first textbook on the subject of protein deimination in human health and disease.

Deimination is a process by which selected positively charged arginine amino acids are converted to neutral citrulline amino acids by the peptidyl arginine deiminase family of enzymes. The book is a comprehensive look at this rapidly developing field and illustrates the connection between deimination and numerous illnesses, including autoimmune diseases, Alzheimer’s, Parkinson’s, Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, cancer, periodontitis, glaucoma, spinal cord trauma and peripheral nerve injury.

Authors for each chapter of the book, titled “Protein Deimination in Human Health and Disease,” are international experts from the United States, Canada, Europe and Asia.

The publisher, Springer Publishing, said “‘Protein Deimination in Human Health and Disease’ is the first publication to compile this knowledge and the growing amount of new information now known about the presence of deiminated proteins in the eye, skin, hair, gums, lungs and nervous system, as well. Chronicling the earliest studies of deimination up to the present, this volume distills what is currently known about citrullination of proteins in the human body and is the first book of its kind on the topic.”

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