Pre-clinical Studies of AKI

The Pre-Clinical Studies of AKI Core (Core B) provides skills and expertise to:

1) Study murine models of AKI
2) Small animal imaging
3) Determine renal physiological changes in AKI

This core specifically provides 
  • Expertise in development and training in the use of rodent models of AKI, specifically in the setting of ischemia/reperfusion (I/R) injury, sepsis and renal transplantation
  • Multi-modality small animal imaging sub-core that provides state-of-the-art molecular imaging (functional, structural and metabolic imaging)
    • MRI/ Spectroscopy
    • high frequency ultrasonography
    • microCT
    • gamma-ray imaging (gamma camera, microSPECT/CT, microPET/CT)
    • optical imaging (bioluminescence, fluorescnece)
  • Physiology sub-core that provides expertise and training for studying renal function on whole kidney and at the single nephron level
    • Micropuncture techniques
    • GFR
    • microanalysis of tubular fluid and reabsorbtion
    • renal hemodynamics (assessment of tubuloglomerular feedback)
    • metabolic assessments of kidney O2 consumption
  • Technical expertise in isolation of primary renal and vascular cell in culture

Director

Sanders 2

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Professor of Medicine
Division of Nephrology
UAB


Co-Directors

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Professor of Radiology
UAB



BlzntzThis email address is being protected from spambots. You need JavaScript enabled to view it.
Professor of Medicine
Division of Nephrology
UCSD School of Medicine


GeorgeThis email address is being protected from spambots. You need JavaScript enabled to view it.
Professor of Medicine
Division of Surgery
UAB


VallonThis email address is being protected from spambots. You need JavaScript enabled to view it.
Professor of Medicine
Division of Nephrology
UCSD School of Medicine