ZmijewskiPhoto

Associate Professor of Medicine 

Division of Pulmonary, Allergy & Critical Care Medicine
1530 3rd Avenue So, THT-422
University of Alabama at Birmingham
Birmingham, AL 35294

Contact Information

Campus Address:

 BMR2 304

Academic Office location:

 BMR2 304

Office Phone:

 205-934-7792

Office Fax:

 205-934-0950

Email Address:

 zmijewsk@uab.edu

Brief Bio
Dr. Jaroslaw Zmijewski completed his undergraduate education in Biology, graduating from the University of Gdansk. He than completed his PhD training in University of Gdansk Department of Biotechnology, a department dedicated to the research integration between the University of Gdansk and Medical School in Gdansk. Dr. Zmijewski undertook postdoctoral training in the Department of Pathology at UAB and thereafter joined the Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine as an Assistant Professor and subsequently Associate Professor.

Dr. Zmijewski is also a member of the Center for Free Radical Biology at UAB, an editorial board member of the American Journal of Clinical and Experimental Immunology, and research Director of the Translational Program for Acute Respiratory Syndrome (TP-ARDS) at UAB. Dr. Zmijewski has broad expertise in molecular biology and biochemistry, protein interaction, redox signalling, assessment of numerous enzymatic activities, metabolism, ubiquitin/proteasome systems, and mitochondrial function in cultured cells and experimental models of lung injury. He is also a mentor/co-mentor of our department's students, postdoctoral trainees, and junior faculty.

Academic & Research Interests
Dr. Zmijewski's research interests concern the molecular mechanisms underlying the development of inflammatory conditions frequently associated with lung injury, normal resolution or progressive non-resolving lung fibrosis. The importance of metabolic pathways in regulating the immune and tissue homeostasis is an emerging concept of my research related to ARDS, COPD, asthma and IPF. His research investigates how metabolic switches, including AMP-activated protein kinase AMPK a major sensor and regulator of cellular redox and bioenergetics, affect development of lung injury that is triggered by sterile and abdominal polymicrobial sepsis. His research determined how inflammatory mediators, including human resistin, HMGB1 and other DAMPs, diminish AMPK anti-inflammatory action in inflammatory settings.

Several potential therapeutic strategies are developed in our laboratory to prevent AMPK inactivation and to increase efficacy of AMPK activators in pre-clinical models of sepsis. We are testing if AMPK activators prevent and/or restore normal redox and mitochondrial bioenergetic homeostasis in lung epithelial and immune cells. AMPK activators are also used to determine their potential to compensate the aging-dependent decline in AMPK activity and increased susceptibility to pneumonia and formation of non-resolving fibrosis. Our results suggest that independently from anti-inflammatory action, AMPK activation prevents and possibly reverses the adverse myofibroblast activation. These exciting findings let us examine the effects of AMPK activators in setting of Idiopathic Pulmonary Fibrosis, a progressive and devastating pulmonary disorder.

Key Publications
Jiang S, Park DW, Gao Y, Ravi S, Darley-Usmar V, Abraham E, Zmijewski JW. Participation of proteasome-ubiquitin protein degradation in autophagy and the activation of AMP-activated protein kinase. Cell Signal. 2015 Jun;27(6):1186-97.

Rangarajan S, Kurundkar A, Kurundkar D, Bernard K, Sanders YY, Ding Q, Antony VB, Zhang J, Zmijewski JW, Thannickal VJ.Novel Mechanisms for the Anti-Fibrotic Action of Nintedanib. Am J Respir Cell Mol Biol. 2015 Jun 13.

Deshane JS, Redden DT, Zeng M, Spell ML, Zmijewski JW, Anderson JT, Deshane RJ, Gaggar A, Siegal GP, Abraham E, Dransfield MT, Chaplin DD.Subsets of airway myeloid-derived regulatory cells distinguish mild asthma from chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2015 Feb;135(2):413-424.

Park DW, Jiang S, Liu Y, Siegal GP, Inoki K, Abraham E, Zmijewski JW.GSK3β-dependent inhibition of AMPK potentiates activation of neutrophils and macrophages and enhances severity of acute lung injury.  Am J Physiol Lung Cell Mol Physiol. 2014 Nov 15;307(10)

Jiang S, Park DW, Tadie JM, Gregoire M, Deshane J, Pittet JF, Abraham E, Zmijewski JW.Human resistin promotes neutrophil proinflammatory activation and neutrophil extracellular trap formation and increases severity of acute lung injury. J Immunol. 2014 May 15;192(10):4795-803.

Carles M, Wagener BM, Lafargue M, Roux J, Iles K, Liu D, Rodriguez CA, Anjum N, Zmijewski JW, Ricci JE, Pittet JF.Heat-shock response increases lung injury caused by Pseudomonas aeruginosa via an interleukin-10-dependent mechanism in mice.  Anesthesiology. 2014 Jun;120(6):1450-62

Park DW, Jiang S, Tadie JM, Stigler WS, Gao Y, Deshane J, Abraham E, Zmijewski JW.Activation of AMPK enhances neutrophil chemotaxis and bacterial killing.  Mol Med. 2013 Nov 8;19:387-98.

Jiang S, Park DW, Stigler WS, Creighton J, Ravi S, Darley-Usmar V, Zmijewski JW.Mitochondria and AMP-activated protein kinase-dependent mechanism of efferocytosis.  J Biol Chem. 2013 Sep 6;288(36):26013-26.

Bae HB, Tadie JM, Jiang S, Park DW, Bell CP, Thompson LC, Peterson CB, Thannickal VJ, Abraham E, Zmijewski JW.Vitronectin inhibits efferocytosis through interactions with apoptotic cells as well as with macrophages. J Immunol. 2013 Mar 1;190(5):2273-81.

Tadie JM, Bae HB, Jiang S, Park DW, Bell CP, Yang H, Pittet JF, Tracey K, Thannickal VJ, Abraham E, Zmijewski JW.HMGB1 promotes neutrophil extracellular trap formation through interactions with Toll-like receptor 4. Am J Physiol Lung Cell Mol Physiol. 2013 Mar 1;304(5):L342-9.

Tadié JM, Bae HB, Banerjee S, Zmijewski JW, Abraham E. Differential activation of RAGE by HMGB1 modulates neutrophil-associated NADPH oxidase activity and bacterial killing.  Am J Physiol Cell Physiol. 2012 Jan 1;302(1):C249-56.

Tadie JM, Bae HB, Deshane JS, Bell CP, Lazarowski ER, Chaplin DD, Thannickal VJ, Abraham E, Zmijewski JW. Toll-like receptor 4 engagement inhibits adenosine 5'-monophosphate-activated protein kinase activation through a high mobility group box 1 protein-dependent mechanism. Mol Med. 2012 May 9;18:659-68

Zmijewski JW, Bae HB, Deshane JS, Peterson CB, Chaplin DD, Abraham E.Inhibition of neutrophil apoptosis by PAI-1. Am J Physiol Lung Cell Mol Physiol. 2011 Aug;301(2):L247-54

Zmijewski JW, Banerjee S, Bae H, Friggeri A, Lazarowski ER, Abraham E.Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinase.  J Biol Chem. 2010 Oct 22;285(43):33154-64.

Zmijewski JW, Lorne E, Zhao X, Tsuruta Y, Sha Y, Liu G, Siegal GP, Abraham E.Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injury. Am J Respir Crit Care Med. 2008 Jul 15;178(2):168-79.

Zhao X, Zmijewski JW, Lorne E, Liu G, Park YJ, Tsuruta Y, Abraham E.Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury.  Am J Physiol Lung Cell Mol Physiol. 2008 Sep;295(3):L497-504.

Zmijewski JW, Lorne E, Zhao X, Tsuruta Y, Sha Y, Liu G, Abraham E.Antiinflammatory effects of hydrogen peroxide in neutrophil activation and acute lung injury. Am J Respir Crit Care Med. 2009 Apr 15;179(8):694-704.

Bosworth CA, Toledo JC Jr, Zmijewski JW, Li Q, Lancaster JR Jr. Dinitrosyliron complexes and the mechanism(s) of cellular protein nitrosothiol formation from nitric oxide. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4671-6.

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