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Division of Pulmonary, Allergy and Critical Care Medicine Heersink School of Medicine

Division of Pulmonary, Allergy and Critical Care Medicine

Publications

  • 2022 Publications

    Bronchodilators in Tobacco-Exposed Persons with Symptoms and Preserved Lung Function. Han MK, Ye W, Wang D, White E, Arjomandi M, Barjaktarevic IZ, Brown SA, Buhr RG, Comellas AP, Cooper CB, Criner GJ, Dransfield MT, Drescher F, Folz RJ, Hansel NN, Kaner RJ, Kanner RE, Krishnan JA, Lazarus SC, Maddipati V, Martinez FJ, Mathews A, Meldrum C, McEvoy C, Nyunoya T, Rogers L, Stringer WW, Wendt CH, Wise RA, Wisniewski SR, Sciurba FC, Woodruff PG; RETHINC Study Group. N Engl J Med. 2022 Sep 4. doi: 10.1056/NEJMoa2204752. Online ahead of print. PMID: 36066078

    Towards the elimination of chronic obstructive pulmonary disease: a Lancet Commission. Stolz D, Mkorombindo T, Schumann DM, Agusti A, Ash SY, Bafadhel M, Bai C, Chalmers JD, Criner GJ, Dharmage SC, Franssen FME, Frey U, Han M, Hansel NN, Hawkins NM, Kalhan R, Konigshoff M, Ko FW, Parekh TM, Powell P, Rutten-van Mölken M, Simpson J, Sin DD, Song Y, Suki B, Troosters T, Washko GR, Welte T, Dransfield MT. Lancet. 2022 Sep 5:S0140-6736(22)01273-9. doi: 10.1016/S0140-6736(22)01273-9. Online ahead of print. PMID: 36075255 Review. No abstract available.

    Time-Dependent Risk of Cardiovascular Events Following an Exacerbation in Patients With Chronic Obstructive Pulmonary Disease: Post Hoc Analysis From the IMPACT Trial. Dransfield MT, Criner GJ, Halpin DMG, Han MK, Hartley B, Kalhan R, Lange P, Lipson DA, Martinez FJ, Midwinter D, Singh D, Wise R, Kunisaki KM. J Am Heart Assoc. 2022 Sep 14:e024350. doi: 10.1161/JAHA.121.024350. Online ahead of print. PMID: 36102236

    Mitochondrial uncoupling protein-2 reprograms metabolism to induce oxidative stress and myofibroblast senescence in age-associated lung fibrosis. Rangarajan S, Locy ML, Chanda D, Kurundkar A, Kurundkar D, Larson-Casey JL, Londono P, Bagchi RA, Deskin B, Elajaili H, Nozik ES, Deshane JS, Zmijewski JW, Eickelberg O, Thannickal VJ. Aging Cell. 2022 Sep;21(9):e13674. doi: 10.1111/acel.13674. Epub 2022 Aug 7. PMID: 35934931

    Role of hair follicles in the pathogenesis of arsenical-induced cutaneous damage. Srivastava RK, Wang Y, Khan J, Muzaffar S, Lee MB, Weng Z, Croutch C, Agarwal A, Deshane J, Athar M. Ann N Y Acad Sci. 2022 Sep;1515(1):168-183. doi: 10.1111/nyas.14809. Epub 2022 Jun 9. PMID: 35678766

    Bronchodilators in Tobacco-Exposed Persons with Symptoms and Preserved Lung Function. Han MK, Ye W, Wang D, White E, Arjomandi M, Barjaktarevic IZ, Brown SA, Buhr RG, Comellas AP, Cooper CB, Criner GJ, Dransfield MT, Drescher F, Folz RJ, Hansel NN, Kalhan R, Kaner RJ, Kanner RE, Krishnan JA, Lazarus SC, Maddipati V, Martinez FJ, Mathews A, Meldrum C, McEvoy C, Nyunoya T, Rogers L, Stringer WW, Wendt CH, Wise RA, Wisniewski SR, Sciurba FC, Woodruff PG; RETHINC Study Group. N Engl J Med. 2022 Sep 29;387(13):1173-1184. doi: 10.1056/NEJMoa2204752. Epub 2022 Sep 4. PMID: 36066078 Clinical Trial.

    Acute Infection with a Tobramycin-Induced Small Colony Variant of Staphylococcus aureus Causes Increased Inflammation in the Cystic Fibrosis Rat Lung. Bollar GE, Keith JD, Oden AM, Kiedrowski MR, Birket SE. Infect Immun. 2022 Sep 27:e0023722. doi: 10.1128/iai.00237-22. Online ahead of print. PMID: 36165627

    Clinical Markers Associated with Risk of Suicide or Drug Overdose Among Heavy Smokers - A Longitudinal Follow-Up Study of the COPDGene Cohort. Adviento BA, Regan EA, Make BJ, Han MK, Foreman MG, Iyer AS, Bhatt SP, Kim V, Bon J, Soler X, Kinney GL, Hanania NA, Lowe KE, Holm KE, Yohannes AM, Shinozaki G, Hoth KF, Fiedorowicz JG; COPDGene Investigators. Chest. 2022 Sep 24:S0012-3692(22)03891-0. doi: 10.1016/j.chest.2022.09.022. Online ahead of print. PMID: 36167120

    Roflumilast May Increase Risk of Exacerbations When Used to Treat Poorly Controlled Asthma in People with Obesity. Dixon AE, Que LG, Kalhan R, Dransfield MT, Rogers L, Gerald LB, Kraft M, Krishnan JA, Johnson O, Hazucha H, Roy G, Holbrook JT, Wise RA.Ann Am Thorac Soc. 2022 Sep 28. doi: 10.1513/AnnalsATS.202204-368OC. Online ahead of print.PMID: 36170654

    Two-bronchoscope technique for cryoextraction: An alternative approach for the removal of endobronchial thrombi in children. Simpson R, Virella-Lowell I, Batra H, Ale GB. Pediatr Pulmonol. 2022 Oct;57(10):2558-2561. doi: 10.1002/ppul.26043. Epub 2022 Jul 4. PMID: 35751167 No abstract available.

    Aging, Cellular Senescence, and Alzheimer’s Disease. Liu, RM (2022). International Journal of Molecular Sciences 23(4): 1989.

    Fibrinogen Mediates Cadmium-induced Macrophage Activation and Serves as a Predictor of Cadmium Exposure in Chronic Obstructive Pulmonary Disease.  Li, FJ., Surolia, R., Singh, P., Dsouza, K., Stephens, C., Wang, Z., Liu, RM., Bae, S., YI., Kim, Athar, M., Dransfield, M., and Antony, V (2022). American Journal of Physiology: Lung Cellular and Molecular Physiology 322:L593-L606.

    Effect of Fluid Bolus Administration on Cardiovascular Collapse Among Critically Ill Patients Undergoing Tracheal Intubation: A Randomized Clinical Trial. Russell DW, Casey JD, Gibbs KW, Ghamande S, Dargin JM, Vonderhaar DJ, Joffe AM, Khan A, Prekker ME, Brewer JM, Dutta S, Landsperger JS, White HD, Robison SW, Wozniak JM, Stempek S, Barnes CR, Krol OF, Arroliga AC, Lat T, Gandotra S, Gulati S, Bentov I, Walters AM, Dischert KM, Nonas S, Driver BE, Wang L, Lindsell CJ, Self WH, Rice TW, Janz DR, Semler MW; PREPARE II Investigators and the Pragmatic Critical Care Research Group. JAMA. 2022 Jun 16. doi: 10.1001/jama.2022.9792. Online ahead of print. PMID: 35707974

    Cui, H., Xie, H., Banerjee, S., Dey, T., Gomez, JL., Liu, R-M., Antony, V., Sanders, YY., Thannickal, VJ., Kaminski, N., Liu, G. (2022). CD38 mediates lung fibrosis by promoting alveolar epithelial cell aging.  American Journal of Respiratory and Critical Care Medicine (in press)
     
    Depressive and anxiety symptoms in patients with COPD: A network analysis.
    Yohannes AM, Murri MB, Hanania NA, Regan EA, Iyer A, Bhatt SP, Kim V, Kinney GL, Wise RA, Eakin MN, Hoth KF; COPDGene Investigators.
    Respir Med. 2022 Jul;198:106865. doi: 10.1016/j.rmed.2022.106865. Epub 2022 May 7.
    PMID: 35576775

    Lung function impairment and risk of incident heart failure: the NHLBI Pooled Cohorts Study.
    Eckhardt CM, Balte PP, Barr RG, Bertoni AG, Bhatt SP, Cuttica M, Cassano PA, Chaves P, Couper D, Jacobs DR, Kalhan R, Kronmal R, Lange L, Loehr L, London SJ, O'Connor GT, Rosamond W, Sanders J, Schwartz JE, Shah A, Shah SJ, Smith L, White W, Yende S, Oelsner EC.
    Eur Heart J. 2022 Jun 14;43(23):2196-2208. doi: 10.1093/eurheartj/ehac205.
    PMID: 35467708

    Role of hair follicles in the pathogenesis of arsenical-induced cutaneous damage.
    Srivastava RK, Wang Y, Khan J, Muzaffar S, Lee MB, Weng Z, Croutch C, Agarwal A, Deshane J, Athar M.
    Ann N Y Acad Sci. 2022 Jun 9. doi: 10.1111/nyas.14809. Online ahead of print.
    PMID: 35678766

    DNA methylation in pulmonary fibrosis and lung cancer.
    Duan J, Zhong B, Fan Z, Zhang H, Xu M, Zhang X, Sanders YY.
    Expert Rev Respir Med. 2022 Jun 8:1-10. doi: 10.1080/17476348.2022.2085091. Online ahead of print.
    PMID: 35673969

    I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations.
    Files DC, Matthay MA, Calfee CS, Aggarwal NR, Asare AL, Beitler JR, Berger PA, Burnham EL, Cimino G, Coleman MH, Crippa A, Discacciati A, Gandotra S, Gibbs KW, Henderson PT, Ittner CAG, Jauregui A, Khan KT, Koff JL, Lang J, LaRose M, Levitt J, Lu R, McKeehan JD, Meyer NJ, Russell DW, Thomas KW, Eklund M, Esserman LJ, Liu KD; ISPY COVID Adaptive Platform Trial Network; undefined.
    BMJ Open. 2022 Jun 6;12(6):e060664. doi: 10.1136/bmjopen-2021-060664.
    PMID: 35667714 Clinical Trial.

    "Stick a Fork in Me; I'm Done": Epithelial Cell Expression of ORMDL Sphingolipid Biosynthesis Regulator 3 Mediates Autophagic Cell Death.
    Curtiss ML, Deshane JS.
    Am J Respir Cell Mol Biol. 2022 Jun;66(6):593-595. doi: 10.1165/rcmb.2022-0023ED.
    PMID: 35377833 Free PMC article. No abstract available.
    A Randomized Trial of a Nurse-Led Palliative Care Intervention for Patients with Newly Diagnosed Lung Cancer.
    Reinke LF, Sullivan DR, Slatore C, Dransfield MT, Ruedebusch S, Smith P, Rise PJ, Tartaglione EV, Vig EK, Au DH.
    J Palliat Med. 2022 Jun 1. doi: 10.1089/jpm.2022.0008. Online ahead of print.
    PMID: 35649214

    Clinical Trial of Losartan for Pulmonary Emphysema: Pulmonary Trials Cooperative LEEP Trial.
    Wise RA, Holbrook JT, Brown RH, Criner GJ, Dransfield MT, He J, Henderson RJ, Kaminsky DA, Kaner RJ, Lazarus SC, Make BJ, McCormack MC, Neptune ER, Que LG; American Lung Association Airways Clinical Research Centers and Pulmonary Trials Cooperative.
    Am J Respir Crit Care Med. 2022 Jun 1. doi: 10.1164/rccm.202201-0206OC. Online ahead of print.
    PMID: 35649189

    A Metabolomic Severity Score for Airflow Obstruction and Emphysema.
    Godbole S, Labaki WW, Pratte KA, Hill A, Moll M, Hastie AT, Peters SP, Gregory A, Ortega VE, DeMeo D, Cho MH, Bhatt SP, Wells JM, Barjaktarevic I, Stringer KA, Comellas A, O'Neal W, Kechris K, Bowler RP.
    Metabolites. 2022 Apr 19;12(5):368. doi: 10.3390/metabo12050368.
    PMID: 35629872 Free PMC article.

    Emergency Tracheal Intubation: A Procedure in Need of Better Evidence.
    Seitz KP, Gandotra S, Casey JD.
    Am J Respir Crit Care Med. 2022 May 17. doi: 10.1164/rccm.202204-0792ED. Online ahead of print.
    PMID: 35579619 No abstract available.

    Depressive and anxiety symptoms in patients with COPD: A network analysis.
    Yohannes AM, Murri MB, Hanania NA, Regan EA, Iyer A, Bhatt SP, Kim V, Kinney GL, Wise RA, Eakin MN, Hoth KF; COPDGene Investigators.
    Respir Med. 2022 May 7;198:106865. doi: 10.1016/j.rmed.2022.106865. Online ahead of print.
    PMID: 35576775

    Pathophysiological Role of Vimentin Intermediate Filaments in Lung Diseases.
    Surolia R, Antony VB.
    Front Cell Dev Biol. 2022 Apr 28;10:872759. doi: 10.3389/fcell.2022.872759. eCollection 2022.
    PMID: 35573702 Free PMC article. Review.

    Screening for Chronic Obstructive Pulmonary Disease: Challenges and Opportunities.
    Bhatt SP, O'Connor GT.
    JAMA. 2022 May 10;327(18):1768-1770. doi: 10.1001/jama.2022.3823.
    PMID: 35536275 No abstract available.

    Ex Vivo Culture Models of Hidradenitis Suppurativa for Defining Molecular Pathogenesis and Treatment Efficacy of Novel Drugs.
    Goliwas KF, Kashyap MP, Khan J, Sinha R, Weng Z, Oak ASW, Jin L, Atigadda V, Lee MB, Elmets CA, Mukhtar MS, Raman C, Deshane JS, Athar M.
    Inflammation. 2022 Jun;45(3):1388-1401. doi: 10.1007/s10753-022-01629-w. Epub 2022 Mar 17.
    PMID: 35301634


    Survival after inpatient or outpatient pulmonary rehabilitation in patients with fibrotic interstitial lung disease: a multicentre retrospective cohort study.
    Guler SA, Hur SA, Stickland MK, Brun P, Bovet L, Holland AE, Bondarenko J, Hambly N, Wald J, Makhdami N, Kreuter M, Gloeckl R, Jarosch I, Tan B, Johannson KA, McBride SA, De Boer K, Sandoz JS, Sun K, Assayag D, Bhatt SP, Morisset J, Ferraro V, Garvey C, Camp PG, Ryerson CJ.
    Thorax. 2022 Jun;77(6):589-595. doi: 10.1136/thoraxjnl-2021-217361. Epub 2021 Aug 30.
    PMID: 34462346 Clinical Trial.
                
    Screening for Chronic Obstructive Pulmonary Disease: Challenges and Opportunities.
    Bhatt SP, O'Connor GT.
    JAMA. 2022 May 10;327(18):1768-1770. doi: 10.1001/jama.2022.3823.
    PMID: 35536275 No abstract available.

    Pneumococcal Phasevarions Control Multiple Virulence Traits, Including Vaccine Candidate Expression.
    Phillips ZN, Trappetti C, Van Den Bergh A, Martin G, Calcutt A, Ozberk V, Guillon P, Pandey M, von Itzstein M, Swords WE, Paton JC, Jennings MP, Atack JM.
    Microbiol Spectr. 2022 May 10:e0091622. doi: 10.1128/spectrum.00916-22. Online ahead of print.
    PMID: 35536022

    The Role of Palliative Care in COPD.
    Iyer AS, Sullivan DR, Lindell KO, Reinke LF.
    Chest. 2022 May;161(5):1250-1262. doi: 10.1016/j.chest.2021.10.032. Epub 2021 Nov 3.
    PMID: 34740592 Review.

    The Glycobiology of Pulmonary Arterial Hypertension.
    Vang S, Cochran P, Sebastian Domingo J, Krick S, Barnes JW.
    Metabolites. 2022 Apr 1;12(4):316. doi: 10.3390/metabo12040316.
    PMID: 35448503 Review.

    Ficolin-2 Lectin Complement Pathway Mediates Capsule-Specific Innate Immunity Against Invasive Pneumococcal Disease.
    Nahm MH, Yu J, Calix JJ, Ganaie F.
    Front Immunol. 2022 Mar 28;13:841062. doi: 10.3389/fimmu.2022.841062. eCollection 2022.
    PMID: 35418983 Free PMC article.

    Lung-kidney interactions and their role in chronic kidney disease-associated pulmonary diseases.
    Bollenbecker S, Czaya B, Gutiérrez OM, Krick S.
    Am J Physiol Lung Cell Mol Physiol. 2022 May 1;322(5):L625-L640. doi: 10.1152/ajplung.00152.2021. Epub 2022 Mar 10.
    PMID: 35272496 Review.
            
    Nontypeable Haemophilus influenzae Infection Impedes Pseudomonas aeruginosa Colonization and Persistence in Mouse Respiratory Tract.
    Lindgren NR, Novak L, Hunt BC, McDaniel MS, Swords WE.
    Infect Immun. 2022 Feb 17;90(2):e0056821. doi: 10.1128/IAI.00568-21. Epub 2021 Nov 15.
    PMID: 34780275

    Ficolin-2 Lectin Complement Pathway Mediates Capsule-Specific Innate Immunity Against Invasive Pneumococcal Disease.
    Nahm MH, Yu J, Calix JJ, Ganaie F.
    Front Immunol. 2022 Mar 28;13:841062. doi: 10.3389/fimmu.2022.841062. eCollection 2022.
    PMID: 35418983 Free PMC article.

    Heart Rate Variability on 10-Second Electrocardiogram and Risk of Acute Exacerbation of COPD: A Secondary Analysis of the BLOCK-COPD Trial.
    MacDonald DM, Mkorombindo T, Ling SX, Adabag S, Casaburi R, Connett JE, Helgeson ES, Porszasz J, Rossiter HB, Stringer WW, Voelker H, Zhao D, Dransfield MT, Kunisaki KM.
    Chronic Obstr Pulm Dis. 2022 Apr 9. doi: 10.15326/jcopdf.2021.0264. Online ahead of print.
    PMID: 35403415

    Characterizing COPD Symptom Variability in the Stable State Utilizing the Evaluating Respiratory Symptoms in COPD Questionnaire.
    Krishnan JK, Ancy KM, Oromendia C, Hoffman KL, Easthausen I, Leidy NK, Han MK, Bowler RP, Christenson SA, Couper DJ, Criner GJ, Curtis JL, Dransfield MT, Hansel NN, Iyer AS, Paine Iii R, Peters SP, Wedzicha JA, Woodruff PG, Ballman KV, Martinez FJ; SPIROMICS Investigators.
    Chronic Obstr Pulm Dis. 2022 Apr 9. doi: 10.15326/jcopdf.2021.0263. Online ahead of print.
    PMID: 35403414

    Mucus Clearance Strategies in Mechanically Ventilated Patients.
    Goetz RL, Vijaykumar K, Solomon GM.
    Front Physiol. 2022 Mar 23;13:834716. doi: 10.3389/fphys.2022.834716. eCollection 2022.
    PMID: 35399263 Free PMC article. Review.

    Plasma Exosome Hemoglobin Released During Surgery Is Associated with Cardiac Injury in Animal Model.
    Eudailey KW, Pat B, Oh JY, Powell PC, Collawn JF, Mobley JA, Gaggar A, Lewis CT, Davies JE, Patel R, Dell'Italia LJ.
    Ann Thorac Surg. 2022 Apr 6:S0003-4975(22)00483-0. doi: 10.1016/j.athoracsur.2022.02.084. Online ahead of print.
    PMID: 35398036

    Fibrinogen mediates cadmium-induced macrophage activation and serves as a predictor of cadmium exposure in chronic obstructive pulmonary disease.
    Li FJ, Surolia R, Singh P, Dsouza KG, Stephens CT, Wang Z, Liu RM, Bae S, Kim YI, Athar M, Dransfield MT, Antony VB.
    Am J Physiol Lung Cell Mol Physiol. 2022 Apr 1;322(4):L593-L606. doi: 10.1152/ajplung.00475.2021. Epub 2022 Feb 24.
    PMID: 35200041

    Impact of the COVID-19 Pandemic on Treatment Patterns for Patients With Metastatic Solid Cancer in the United States.
    Parikh RB, Takvorian SU, Vader D, Paul Wileyto E, Clark AS, Lee DJ, Goyal G, Rocque GB, Dotan E, Geynisman DM, Phull P, Spiess PE, Kim RY, Davidoff AJ, Gross CP, Neparidze N, Miksad RA, Calip GS, Hearn CM, Ferrell W, Shulman LN, Mamtani R, Hubbard RA; PRACTICE Investigators.
    J Natl Cancer Inst. 2022 Apr 11;114(4):571-578. doi: 10.1093/jnci/djab225.
    PMID: 34893865

    Longitudinal Association Between Muscle Loss and Mortality in Ever Smokers.
    Mason SE, Moreta-Martinez R, Labaki WW, Strand MJ, Regan EA, Bon J, San Jose Estepar R, Casaburi R, McDonald ML, Rossiter HB, Make B, Dransfield MT, Han MK, Young K, Curtis JL, Stringer K, Kinney G, Hokanson JE, San Jose Estepar R, Washko GR; COPDGene Investigators.
    Chest. 2022 Apr;161(4):960-970. doi: 10.1016/j.chest.2021.10.047. Epub 2021 Nov 14.
    PMID: 34785234

    Significance of FEV3/FEV6 in Recognition of Early Airway Disease in Smokers at Risk of Development of COPD: Analysis of the SPIROMICS Cohort.
    Yee N, Markovic D, Buhr RG, Fortis S, Arjomandi M, Couper D, Anderson WH, Paine R 3rd, Woodruff PG, Han MK, Martinez FJ, Barr RG, Wells JM, Ortega VE, Hoffman EA, Kim V, Drummond MB, Bowler RP, Curtis JL, Cooper CB, Tashkin DP, Barjaktarevic IZ.
    Chest. 2022 Apr;161(4):949-959. doi: 10.1016/j.chest.2021.10.046. Epub 2021 Nov 10.
    PMID: 34767825

    Lung Function and the Risk of Exacerbation in the BLOCK COPD Trial.
    Parekh TM, Helgeson ES, Connett J, Voelker H, Ling SX, Lazarus SC, Bhatt SP, MacDonald DM, Mkorombindo T, Kunisaki KM, Fortis S, Kaminsky D, Dransfield MT.
    Ann Am Thorac Soc. 2022 Apr 1. doi: 10.1513/AnnalsATS.202109-1042OC. Online ahead of print.
    PMID: 35363600

    Mammalian peroxidasin (PXDN): From physiology to pathology.
    Cheng G, Shi R.
    Free Radic Biol Med. 2022 Mar;182:100-107. doi: 10.1016/j.freeradbiomed.2022.02.026. Epub 2022 Feb 24.
    PMID: 35219848 Review.

    Poly (acetyl, arginyl) glucosamine disrupts Pseudomonas aeruginosa biofilms and enhances bacterial clearance in a rat lung infection model.
    Garcia BA, McDaniel MS, Loughran AJ, Johns JD, Narayanaswamy V, Fernandez Petty C, Birket SE, Baker SM, Barnaby R, Stanton BA, Foote JB, Rowe SM, Swords WE.
    Microbiology (Reading). 2022 Jan;168(1):001121. doi: 10.1099/mic.0.001121.
    PMID: 35077346 Free PMC article.

    Does UCP2 Couple Hyperoxia to Lung Injury?
    Larson-Casey JL, Carter AB.
    Am J Respir Cell Mol Biol. 2022 Mar;66(3):250-251. doi: 10.1165/rcmb.2021-0480ED.
    PMID: 34905723 Free PMC article. No abstract available.

    Targeting Cpt1a-Bcl-2 interaction modulates apoptosis resistance and fibrotic remodeling.
    Gu L, Surolia R, Larson-Casey JL, He C, Davis D, Kang J, Antony VB, Carter AB.
    Cell Death Differ. 2022 Jan;29(1):118-132. doi: 10.1038/s41418-021-00840-w. Epub 2021 Aug 20.
    PMID: 34413485 Free PMC article.

    How To Prescribe And Troubleshoot Continuous Renal Replacement Therapy: A Case-Based Review.
    Neyra JA, Yessayan L, Thompson Bastin ML, Wille KM, Tolwani AJ.
    Kidney360. 2020 Dec 14;2(2):371-384. doi: 10.34067/KID.0004912020. eCollection 2021 Feb 25.
    PMID: 35373031 Free PMC article. Review.

    The Changing Landscape of Nutrition in Cystic Fibrosis: The Emergence of Overweight and Obesity.
    Bailey J, Krick S, Fontaine KR.
    Nutrients. 2022 Mar 13;14(6):1216. doi: 10.3390/nu14061216.
    PMID: 35334873 Free PMC article. Review.

    Chronotropic index during 6-minute walk and acute respiratory events in COPDGene.
    Macdonald DM, Palzer EF, Abbasi A, Baldomero AK, Bhatt SP, Casaburi R, Connett JE, Dransfield MT, Gaeckle NT, Mkorombindo T, Rossiter HB, Stringer WW, Tiller NB, Wendt CH, Zhao D, Kunisaki KM.
    Respir Med. 2022 Apr;194:106775. doi: 10.1016/j.rmed.2022.106775. Epub 2022 Feb 18.
    PMID: 35203009

    Ex Vivo Culture Models of Hidradenitis Suppurativa for Defining Molecular Pathogenesis and Treatment Efficacy of Novel Drugs.
    Goliwas KF, Kashyap MP, Khan J, Sinha R, Weng Z, Oak ASW, Jin L, Atigadda V, Lee MB, Elmets CA, Mukhtar MS, Raman C, Deshane JS, Athar M.
    Inflammation. 2022 Mar 17. doi: 10.1007/s10753-022-01629-w. Online ahead of print.
    PMID: 35301634

    An in vivo model for extracellular vesicle-induced emphysema.
    Margaroli C, Madison MC, Viera L, Russell DW, Gaggar A, Genschmer KR, Blalock JE.
    JCI Insight. 2022 Jan 25;7(4):e153560. doi: 10.1172/jci.insight.153560.
    PMID: 35077395 Free PMC article.

    Recombinant Myeloperoxidase as a New Class of Antimicrobial Agents.
    Cao Z, Cheng G.
    Microbiol Spectr. 2022 Feb 23;10(1):e0052221. doi: 10.1128/spectrum.00522-21. Epub 2022 Jan 12.
    PMID: 35019674 Free PMC article.

    Extracellular Vesicles as Central Mediators of COPD Pathophysiology.
    Russell DW, Genschmer KR, Blalock JE.
    Annu Rev Physiol. 2022 Feb 10;84:631-654. doi: 10.1146/annurev-physiol-061121-035838. Epub 2021 Nov 1.
    PMID: 34724435 Review.

    Effects of Exercise on Nutritional Status in People with Cystic Fibrosis: A Systematic Review.
    Nicolson WB, Bailey J, Alotaibi NZ, Krick S, Lowman JD.
    Nutrients. 2022 Feb 22;14(5):933. doi: 10.3390/nu14050933.
    PMID: 35267909 Free PMC article.

    Aging, Cellular Senescence, and Alzheimer's Disease.
    Liu RM.
    Int J Mol Sci. 2022 Feb 11;23(4):1989. doi: 10.3390/ijms23041989.
    PMID: 35216123 Free PMC article. Review.

    HLA-C and KIR permutations influence chronic obstructive pulmonary disease risk.
    Mkorombindo T, Tran-Nguyen TK, Yuan K, Zhang Y, Xue J, Criner GJ, Kim YI, Pilewski JM, Gaggar A, Cho MH, Sciurba FC, Duncan SR.
    JCI Insight. 2021 Oct 8;6(19):e150187. doi: 10.1172/jci.insight.150187.
    PMID: 34464355 Free PMC article.

    Effects of Exercise on Nutritional Status in People with Cystic Fibrosis: A Systematic Review.
    Nicolson WB, Bailey J, Alotaibi NZ, Krick S, Lowman JD.
    Nutrients. 2022 Feb 22;14(5):933. doi: 10.3390/nu14050933.
    PMID: 35267909 Review.

    Modulation of H4K16Ac levels reduces pro-fibrotic gene expression and mitigates lung fibrosis in aged mice.
    Zhang X, Liu H, Zhou JQ, Krick S, Barnes JW, Thannickal VJ, Sanders YY.
    Theranostics. 2022 Jan 1;12(2):530-541. doi: 10.7150/thno.62760. eCollection 2022.
    PMID: 34976199 Free PMC article.

    Comparative Impact of Depressive Symptoms and FEV1% on Chronic Obstructive Pulmonary Disease.
    O'Toole J, Woo H, Putcha N, Cooper CB, Woodruff P, Kanner RE, Paine R, Bowler RP, Comellas A, Hoth KF, Krishnan JA, Han M, Dransfield M, Iyer AS, Couper D, Peters SP, Criner G, Kim V, Barr RG, Martinez FJ, Hansel NN, Eakin MN; SPIROMICS Investigators.
    Ann Am Thorac Soc. 2022 Feb;19(2):171-178. doi: 10.1513/AnnalsATS.202009-1187OC.
    PMID: 34410883

    Mammalian peroxidasin (PXDN): From physiology to pathology.
    Cheng G, Shi R.
    Free Radic Biol Med. 2022 Feb 24:S0891-5849(22)00079-X. doi: 10.1016/j.freeradbiomed.2022.02.026. Online ahead of print.
    PMID: 35219848 Review.

    Use of inhaled epoprostenol with high flow nasal oxygen in non-intubated patients with severe COVID-19.
    Chiles JW 3rd, Vijaykumar K, Darby A, Goetz RL, Kane LE, Methukupally AR, Gandotra S, Russell DW, Whitson MR, Kelmenson D.
    J Crit Care. 2022 Feb 22;69:153989. doi: 10.1016/j.jcrc.2022.153989. Online ahead of print.
    PMID: 35217371 Free PMC article.

    Aging, Cellular Senescence, and Alzheimer's Disease.
    Liu RM.
    Int J Mol Sci. 2022 Feb 11;23(4):1989. doi: 10.3390/ijms23041989.
    PMID: 35216123 Free PMC article. Review.

    The Air We Breathe: Respiratory Impact of Indoor Air Quality in Chronic Obstructive Pulmonary Disease.
    Mkorombindo T, Balmes JR, Custovic A, Dransfield MT.
    Am J Respir Crit Care Med. 2022 Feb 15;205(4):378-380. doi: 10.1164/rccm.202112-2822ED.
    PMID: 35007496 Free PMC article. No abstract available.
     
    Ozone-induced changes in the murine lung extracellular vesicle small RNA landscape.
    Smith GJ, Tovar A, Kanke M, Wang Y, Deshane JS, Sethupathy P, Kelada SNP.
    Physiol Rep. 2021 Sep;9(18):e15054. doi: 10.14814/phy2.15054.
    PMID: 34558223 Free PMC article.

    Chronotropic index during 6-minute walk and acute respiratory events in COPDGene.
    Macdonald DM, Palzer EF, Abbasi A, Baldomero AK, Bhatt SP, Casaburi R, Connett JE, Dransfield MT, Gaeckle NT, Mkorombindo T, Rossiter HB, Stringer WW, Tiller NB, Wendt CH, Zhao D, Kunisaki KM.
    Respir Med. 2022 Feb 18;194:106775. doi: 10.1016/j.rmed.2022.106775. Online ahead of print.
    PMID: 35203009

    Fibrinogen Mediates Cadmium-induced Macrophage Activation and Serves as a Predictor of Cadmium Exposure in Chronic Obstructive Pulmonary Disease.
    Li FJ, Surolia R, Singh P, Dsouza KG, Stephens CT, Wang Z, Liu RM, Bae S, Kim YI, Athar M, Dransfield MT, Antony VB.
    Am J Physiol Lung Cell Mol Physiol. 2022 Feb 24. doi: 10.1152/ajplung.00475.2021. Online ahead of print.
    PMID: 35200041

    End-of-Life Preferences in Older US Adults-Bridging the "What Matters" Chasm.
    Iyer AS, Brown CJ.
    JAMA Netw Open. 2022 Jan 4;5(1):e2142279. doi: 10.1001/jamanetworkopen.2021.42279.
    PMID: 34985522 No abstract available.

    Pneumococcal Antibody Function for Immunologic Evaluation: Normal Results in Older Adults, and a Novel Analytical Model for Vaccine Response.
    LaFon D, Kim YI, Burton R, Dransfield M, Nahm M.
    J Clin Immunol. 2021 Nov;41(8):1964-1968. doi: 10.1007/s10875-021-01126-z. Epub 2021 Aug 30.
    PMID: 34462839 Clinical Trial. No abstract available.

    Advances in molecular pathogenesis of hidradenitis suppurativa: Dysregulated keratins and ECM signaling.
    Kashyap MP, Khan J, Sinha R, Jin L, Atigadda V, Deshane JS, Ahmed AR, Kilic A, Raman C, Mukhtar MS, Elmets CA, Athar M.
    Semin Cell Dev Biol. 2022 Feb 4:S1084-9521(22)00014-3. doi: 10.1016/j.semcdb.2022.01.006. Online ahead of print.
    PMID: 35131152 Review.

    Journal Club-Respiratory Impairment With A Preserved Spirometric Ratio.
    Mkorombindo T, Balkissoon R.
    Chronic Obstr Pulm Dis. 2022 Jan 27;9(1):103-110. doi: 10.15326/jcopdf.2022.0285.
    PMID: 35090103 No abstract available.

    Genetic European Ancestry and Incident Diabetes in Black Individuals: Insights From the SPRINT Trial.
    Parcha V, Heindl B, Kalra R, Bress A, Rao S, Pandey A, Gower B, Irvin MR, McDonald MN, Li P, Arora G, Arora P.
    Circ Genom Precis Med. 2022 Jan 28:CIRCGEN121003468. doi: 10.1161/CIRCGEN.121.003468. Online ahead of print.
    PMID: 35089798

    Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease.
    Lakshman Kumar P, Wilson AC, Rocco A, Cho MH, Wan E, Hobbs BD, Washko GR, Ortega VE, Christenson SA, Li X, Wells JM, Bhatt SP, DeMeo DL, Lutz SM, Rossiter H, Casaburi R, Rennard SI, Lomas DA, Labaki WW, Tal-Singer R, Bowler RP, Hersh CP, Tiwari HK, Dransfield M, Thalacker-Mercer A, Meyers DA, Silverman EK, McDonald MN; COPDGene, ECLIPSE and SPIROMICS investigators.
    J Cachexia Sarcopenia Muscle. 2021 Dec;12(6):1803-1817. doi: 10.1002/jcsm.12782. Epub 2021 Sep 15.
    PMID: 34523824 Free PMC article.

    Predictors of In-Hospital Death in Patients with Lung Cancer Admitted for Acute Radiation Pneumonitis: A Healthcare Cost and Utilization Project (HCUP) Analysis.
    Kirkland RS, Kole AJ, Batra H, Boggs DH, Spencer SA, Dobelbower MC, Willey CD, Thachuthara-George JT, Wei B, McDonald AM, Kenzik KM, Stahl JM.
    Clin Lung Cancer. 2021 Sep;22(5):e716-e722. doi: 10.1016/j.cllc.2021.01.016. Epub 2021 Feb 3.
    PMID: 33658160

    Recent developments in the pathobiology of lung myofibroblasts.
    Jiang D, Dey T, Liu G.
    Expert Rev Respir Med. 2021 Feb;15(2):239-247. doi: 10.1080/17476348.2021.1829972. Epub 2020 Oct 19.
    PMID: 32981357 Free PMC article. Review.

    Poly (acetyl, arginyl) glucosamine disrupts Pseudomonas aeruginosa biofilms and enhances bacterial clearance in a rat lung infection model.
    Garcia BA, McDaniel MS, Loughran AJ, Johns JD, Narayanaswamy V, Fernandez Petty C, Birket SE, Baker SM, Barnaby R, Stanton BA, Foote JB, Rowe SM, Swords WE.
    Microbiology (Reading). 2022 Jan;168(1). doi: 10.1099/mic.0.001121.
    PMID: 35077346

    Correction to: Single-Inhaler Triple Therapy and Health-Related Quality of Life in COPD: The IMPACT Study.
    Tabberer M, Jones CE, Kilbride S, Halpin DMG, Lomas DA, Pascoe S, Singh D, Wise RA, Criner GJ, Lange P, Dransfield MT, Han MK, Martinez FJ, Kaisermann MC, Lipson DA.
    Adv Ther. 2022 Jan 21. doi: 10.1007/s12325-021-02019-8. Online ahead of print.
    PMID: 35060093 No abstract available.

    Capsule Promotes Intracellular Survival and Vascular Endothelial Cell Translocation during Invasive Pneumococcal Disease.
    Brissac T, Martínez E, Kruckow KL, Riegler AN, Ganaie F, Im H, Bakshi S, Arroyo-Diaz NM, Spencer BL, Saad JS, Nahm MH, Orihuela CJ.
    mBio. 2021 Oct 26;12(5):e0251621. doi: 10.1128/mBio.02516-21. Epub 2021 Oct 12.
    PMID: 34634940 Free PMC article.

    AICAR decreases acute lung injury by phosphorylating AMPK and upregulating heme oxygenase-1.
    Ahmad I, Molyvdas A, Jian MY, Zhou T, Traylor AM, Cui H, Liu G, Song W, Agarwal A, Jilling T, Aggarwal S, Matalon S.
    Eur Respir J. 2021 Dec 23;58(6):2003694. doi: 10.1183/13993003.03694-2020. Print 2021 Dec.
    PMID: 34049949

    Long term clinical effectiveness of ivacaftor in people with the G551D CFTR mutation.
    Guimbellot JS, Baines A, Paynter A, Heltshe SL, VanDalfsen J, Jain M, Rowe SM, Sagel SD; GOAL-e2 Investigators.
    J Cyst Fibros. 2021 Mar;20(2):213-219. doi: 10.1016/j.jcf.2020.11.008. Epub 2020 Nov 25.
    PMID: 33249004

    Nontypeable Haemophilus influenzae Redox Recycling of Protein Thiols Promotes Resistance to Oxidative Killing and Bacterial Survival in Biofilms in a Smoke-Related Infection Model.
    Hunt BC, Xu X, Gaggar A, Swords WE.
    mSphere. 2022 Jan 19:e0084721. doi: 10.1128/msphere.00847-21. Online ahead of print.
    PMID: 35044805

    Prolyl endopeptidase contributes to early neutrophilic inflammation in acute myocardial transplant rejection.
    Payne GA, Sharma NS, Lal CV, Song C, Guo L, Margaroli C, Viera L, Kumar S, Li J, Xing D, Bosley M, Xu X, Wells JM, George JF, Tallaj J, Leesar M, Blalock JE, Gaggar A.
    JCI Insight. 2021 Mar 22;6(6):e139687. doi: 10.1172/jci.insight.139687.
    PMID: 33571164 Free PMC article.

    Recombinant Myeloperoxidase as a New Class of Antimicrobial Agents.
    Cao Z, Cheng G.
    Microbiol Spectr. 2022 Jan 12:e0052221. doi: 10.1128/spectrum.00522-21. Online ahead of print.
    PMID: 35019674

    First Maintenance Therapy for Chronic Obstructive Pulmonary Disease: Retrospective Analyses of US and UK Healthcare Databases.
    Bloom CI, Montonen J, Jöns O, Garry EM, Bhatt SP.
    Pulm Ther. 2022 Jan 10. doi: 10.1007/s41030-021-00179-0. Online ahead of print.
    PMID: 35015270

    Treatment Transitions in Chronic Obstructive Pulmonary Disease: Retrospective Analyses of US and UK Healthcare Databases.
    Bloom CI, Montonen J, Jöns O, Garry EM, Bhatt SP.
    Pulm Ther. 2022 Jan 10. doi: 10.1007/s41030-021-00180-7. Online ahead of print.
    PMID: 35015269

    Expanding Implementation of Tele-Pulmonary Rehabilitation: The New Frontier.
    Bhatt SP, Rochester CL.
    Ann Am Thorac Soc. 2022 Jan;19(1):3-5. doi: 10.1513/AnnalsATS.202109-1082ED.
    PMID: 34971356 No abstract available.

    Effect of Use of a Bougie vs Endotracheal Tube With Stylet on Successful Intubation on the First Attempt Among Critically Ill Patients Undergoing Tracheal Intubation: A Randomized Clinical Trial.

    Driver BE, Semler MW, Self WH, Ginde AA, Trent SA, Gandotra S, Smith LM, Page DB, Vonderhaar DJ, West JR, Joffe AM, Mitchell SH, Doerschug KC, Hughes CG, High K, Landsperger JS, Jackson KE, Howell MP, Robison SW, Gaillard JP, Whitson MR, Barnes CM, Latimer AJ, Koppurapu VS, Alvis BD, Russell DW, Gibbs KW, Wang L, Lindsell CJ, Janz DR, Rice TW, Prekker ME, Casey JD; BOUGIE Investigators and the Pragmatic Critical Care Research Group.
    JAMA. 2021 Dec 28;326(24):2488-2497. doi: 10.1001/jama.2021.22002.
    PMID: 34879143 Clinical Trial.

    Emphysema Progression and Lung Function Decline Among Angiotensin Converting Enzyme Inhibitors and Angiotensin-Receptor Blockade Users in the COPDGene Cohort.
    Tejwani V, Fawzy A, Putcha N, Castaldi PJ, Cho MH, Pratte KA, Bhatt SP, Lynch DA, Humphries SM, Kinney GL, D'Alessio FR, Hansel NN; COPDGene Investigators.
    Chest. 2021 Oct;160(4):1245-1254. doi: 10.1016/j.chest.2021.05.007. Epub 2021 May 21.
    PMID: 34029566

    End-of-Life Preferences in Older US Adults-Bridging the "What Matters" Chasm.
    Iyer AS, Brown CJ.
    JAMA Netw Open. 2022 Jan 4;5(1):e2142279. doi: 10.1001/jamanetworkopen.2021.42279.
    PMID: 34985522 No abstract available.

    Modulation of H4K16Ac levels reduces pro-fibrotic gene expression and mitigates lung fibrosis in aged mice.
    Zhang X, Liu H, Zhou JQ, Krick S, Barnes JW, Thannickal VJ, Sanders YY.
    Theranostics. 2022 Jan 1;12(2):530-541. doi: 10.7150/thno.62760. eCollection 2022.
    PMID: 34976199 Free PMC article.

    Higher COPD Assessment Test Score Associated With Greater Exacerbations Risk: A Post Hoc Analysis of the IMPACT Trial.
    Thomashow B, Stiegler M, Criner GJ, Dransfield MT, Halpin DMG, Han MK, Lange P, Martinez FJ, Midwinter D, Singh D, Tabberer M, Wise RA, Lipson DA, Jones P.
    Chronic Obstr Pulm Dis. 2021 Dec 22. doi: 10.15326/jcopdf.2021.0259. Online ahead of print.
    PMID: 34972260

    Expanding Implementation of Tele-Pulmonary Rehabilitation: The New Frontier.
    Bhatt SP, Rochester CL.
    Ann Am Thorac Soc. 2022 Jan;19(1):3-5. doi: 10.1513/AnnalsATS.202109-1082ED.
    PMID: 34971356 No abstract available.

    Reply to: Intraosseous Versus Intravenous Resuscitation During In-Hospital Cardiac Arrest.
    Schwalbach KT, Chad Wade R, Barney J.
    Resuscitation. 2021 Dec;169:203-204. doi: 10.1016/j.resuscitation.2021.09.036. Epub 2021 Oct 8.
    PMID: 34627865 No abstract available.

    Noninvasive Ventilation in Seriously Ill Older Adults at the End of Life-The Evidence Remains Elusive.
    Iyer AS.
    JAMA Intern Med. 2021 Jan 1;181(1):102-103. doi: 10.1001/jamainternmed.2020.5648.
    PMID: 33074308 Free PMC article. No abstract available.


  • 2021 Publications

    Cui, H., Xie, H., Banerjee, S., Dey, T., Gomez, JL., Liu, R-M., Antony, V., Sanders, YY., Thannickal, VJ., Kaminski, N., Liu, G. (2021). CD38 mediates lung fibrosis by promoting alveolar epithelial cell aging (in press)

    Cui, H., Xie, N., Banerjee, S., Ge, J., Jiang, D., Dey, T., Matthews, Q. L., Liu, R-M., Liu, G. (2021). Lung myofibroblasts promote macrophage pro-fibrotic activity through lactate-induced histone lactylation. American Journal of Respiratory Cell and Molecular Biology 64 (1) 115-125. PMID: 33074715

    Jiang, C., Liu, G., Cai, L., Deshane, J., Antony, V., Thannickal, VJ., and Liu, R-M* (2021). Divergent regulation of ATII cell and fibroblast apoptosis by PAI-1 in lung fibrosis. American Journal of Pathology 191 (7):1227-1239. PMID: 33887217

    N-myc-interactor mediates microbiome induced epithelial to mesenchymal transition and is associated with chronic lung allograft dysfunction. Banday MM, Kumar A, Vestal G, Sethi J, Patel KN, O'Neill EB, Finan J, Cheng F, Lin M, Davis NM, Goldberg H, Coppolino A, Mallidi HR, Dunning J, Visner G, Gaggar A, Seyfang A, Sharma NS. J Heart Lung Transplant. 2021 Mar 2:S1053-2498(21)02199-9. doi: 10.1016/j.healun.2021.02.014. Online ahead of print. PMID: 33781665

    Functional and Transcriptional Adaptations of Blood Monocytes Recruited to the Cystic Fibrosis Airway Microenvironment In Vitro. Ford BD, Moncada Giraldo D, Margaroli C, Giacalone VD, Brown MR, Peng L, Tirouvanziam R. Int J Mol Sci. 2021 Mar 3;22(5):2530. doi: 10.3390/ijms22052530. PMID: 33802410

    Prognostic value of clinically important deterioration in COPD: IMPACT trial analysis. Han MK, Criner GJ, Dransfield MT, Halpin DMG, Jones CE, Kilbride S, Lange P, Lettis S, Lipson DA, Lomas DA, Martin N, Martinez FJ, Wise RA, Naya IP, Singh D. ERJ Open Res. 2021 Mar 8;7(1):00663-2020. doi: 10.1183/23120541.00663-2020. PMID: 33718490 Free PMC article.

    Binge Drinking Moderates the Association Between Chronic Lung Disease and E-Cigarette Use. Alqahtani MM, Alanazi AM, Pavela G, Dransfield MT, Wells JM, Lein DH Jr, Hendricks PS. Respir Care. 2021 Mar 9:respcare.08559. doi: 10.4187/respcare.08559. Online ahead of print. PMID: 33688091

    Clinical Development of Mepolizumab for the Treatment of Severe Eosinophilic Asthma: On the Path to Personalized Medicine. Pavord ID, Menzies-Gow A, Buhl R, Chanez P, Dransfield M, Lugogo N, Keene ON, Bradford ES, Yancey SW. J Allergy Clin Immunol Pract. 2021 Mar;9(3):1121-1132.e7. doi: 10.1016/j.jaip.2020.08.039. Epub 2020 Sep 2. PMID: 32889223

    The presence of emphysema on chest imaging and mid-life cognition. Henkle BE, Colangelo LA, Dransfield MT, Hou L, Jacobs DR Jr, Joyce BT, Pistenmaa CL, Putman RK, Sidney S, Thyagarajan B, Washko GR, Yaffe K, Kalhan R, Kunisaki KM. ERJ Open Res. 2021 Mar 15;7(1):00048-2021. doi: 10.1183/23120541.00048-2021. eCollection 2021 Jan. PMID: 33748259 Free PMC article.

    Bioenergetic maladaptation and release of HMGB1 in calcineurin inhibitor nephrotoxicity. Zmijewska AA, Zmijewski JW, Becker EJ Jr, Benavides GA, Darley-Usmar V, Mannon RB. Am J Transplant. 2021 Mar 16. doi: 10.1111/ajt.16561. PMID: 33724664

    Citrullinated vimentin mediates development and progression of lung fibrosis. Li FJ, Surolia R, Li H, Wang Z, Liu G, Kulkarni T, Massicano AVF, Mobley JA, Mondal S, de Andrade JA, Coonrod SA, Thompson PR, Wille K, Lapi SE, Athar M, Thannickal VJ, Carter AB, Antony VB. Sci Transl Med. 2021 Mar 17;13(585):eaba2927. doi: 10.1126/scitranslmed.aba2927. PMID: 33731433

    A Phase 3 Open-Label Study of ELX/TEZ/IVA in Children 6 Through 11 Years of Age With CF and at Least One F508del Allele. Zemanick ET, Taylor-Cousar JL, Davies J, Gibson RL, Mall MA, McKone EF, McNally P, Ramsey BW, Rayment JH, Rowe SM, Tullis E, Ahluwalia N, Chu C, Ho T, Moskowitz SM, Noel S, Tian S, Waltz D, Weinstock TG, Xuan F, Wainwright CE, McColley SA; VX18-445-106 Study Group. Am J Respir Crit Care Med. 2021 Mar 18. doi: 10.1164/rccm.202102-0509OC. Online ahead of print. PMID: 33734030

    Atrial Arrhythmia Related Outcomes in Critically Ill COVID-19 Patients. Colon CM, Barrios JG, Chiles JW, Brown TM, Pogwizd SM, McElwee SK, Gandotra S, Russell DW, McElderry HT, Maddox WR. Pacing Clin Electrophysiol. 2021 Mar 18. doi: 10.1111/pace.14221. Online ahead of print. PMID: 33738812

    Tezacaftor/ivacaftor in people with cystic fibrosis who stopped lumacaftor/ivacaftor due to respiratory adverse events. Schwarz C, Sutharsan S, Epaud R, Klingsberg RC, Fischer R, Rowe SM, Audhya PK, Ahluwalia N, You X, Ferro TJ, Duncan ME, Bruinsma BG. J Cyst Fibros. 2021 Mar;20(2):228-233. doi: 10.1016/j.jcf.2020.06.001. Epub 2020 Jun 23. PMID: 32586736

    Safety and efficacy of the cystic fibrosis transmembrane conductance regulator potentiator icenticaftor (QBW251). Kazani S, Rowlands DJ, Bottoli I, Milojevic J, Alcantara J, Jones I, Kulmatycki K, Machineni S, Mostovy L, Nicholls I, Nick JA, Rowe SM, Simmonds NJ, Vegesna R, Verheijen J, Danahay H, Gosling M, Ayalavajjala PS, Salman M, Strieter R. J Cyst Fibros. 2021 Mar;20(2):250-256. doi: 10.1016/j.jcf.2020.11.002. Epub 2020 Dec 6. PMID: 33293212

    Long term clinical effectiveness of ivacaftor in people with the G551D CFTR mutation. Guimbellot JS, Baines A, Paynter A, Heltshe SL, VanDalfsen J, Jain M, Rowe SM, Sagel SD; GOAL-e2 Investigators. J Cyst Fibros. 2021 Mar;20(2):213-219. doi: 10.1016/j.jcf.2020.11.008. Epub 2020 Nov 25. PMID: 33249004

    Prolyl endopeptidase contributes to early neutrophilic inflammation in acute myocardial transplant rejection. Payne GA, Sharma NS, Lal CV, Song C, Guo L, Margaroli C, Viera L, Kumar S, Li J, Xing D, Bosley M, Xu X, Wells JM, George JF, Tallaj J, Leesar M, Blalock JE, Gaggar A. JCI Insight. 2021 Mar 22;6(6):139687. doi: 10.1172/jci.insight.139687. PMID: 33571164

    Effect of Age on the Efficacy and Safety of Once-Daily Single-Inhaler Triple-TSpatial mapping of SARS-CoV-2 and H1N1 Lung Injury Identifies Differential Transcriptional Signatures. Margaroli C, Benson P, Sharma NS, Madison MC, Robison SW, Arora N, Ton K, Liang Y, Zhang L, Patel RP, Gaggar A. Cell Rep Med. 2021 Mar 23:100242. doi: 10.1016/j.xcrm.2021.100242. Online ahead of print. PMID: 33778787 Free PMC article.

    Navigational Bronchoscopy with Interventional Pulmonologists and Thoracic Surgeons. Muñoz-Largacha JA, Batra H, Wei B. Innovations (Phila). 2021 Mar 23:1556984521997421. doi: 10.1177/1556984521997421. Online ahead of print. PMID: 33754842 No abstract available.

    Patient and family perceptions of telehealth as part of the cystic fibrosis care model during COVID-19. Jaclyn D, Andrew N, Ryan P, Julianna B, Christopher S, Nauman C, Powers M, Gregory S S, George M S. J Cyst Fibros. 2021 Mar 25:S1569-1993(21)00058-8. doi: 10.1016/j.jcf.2021.03.009. Online ahead of print.  PMID: 33775604 Free PMC article.

    Distribution and Geographic Accessibility of Lung Cancer Screening Centers in the US. Niranjan SJ, Opoku-Agyeman W, Carroll NW, Dorsey A, Tipre M, Baskin ML, Dransfield MT. Ann Am Thorac Soc. 2021 Mar 30. doi: 10.1513/AnnalsATS.202010-1313RL. Online ahead of print. PMID: 33784236

    Chronotropic Index and Acute Exacerbations of COPD: A Secondary Analysis of BLOCK COPD. MacDonald DM, Helgeson ES, Adabag S, Casaburi R, Connett JE, Stringer WW, Voelker H, Dransfield MT, Kunisaki KM. Ann Am Thorac Soc. 2021 Mar 30. doi: 10.1513/AnnalsATS.202008-1085OC. Online ahead of print. PMID: 33784233

    Effect of Age on the Efficacy and Safety of Once-Daily Single-Inhaler Triple-Therapy Fluticasone Furoate/Umeclidinium/Vilanterol in Patients With COPD: A Post Hoc Analysis of the Informing the Pathway of COPD Treatment Trial. Hanania NA, Mannino DM, Criner GJ, Dransfield MT, Han MK, Jones CE, Kilbride S, Lomas DA, Martin N, Martinez FJ, Singh D, Wise RA, Halpin DMG, Lima R, Lipson DA. Chest. 2021 Mar;159(3):985-995. doi: 10.1016/j.chest.2020.09.253. Epub 2020 Oct 5. PMID: 33031829

    The Immunological Response Among COVID-19 Patients with Acute Respiratory Distress Syndrome. Abdulaziz S. Almutairi, Hassan Abunurah, Abdulkarim Alenazi, Faraj Alenazi, Hassan Nag, Nafea Almutairi, Michael Wells, Abdullah Alawam, and Mohammed M. Alqahtania. J Infect Public Health. 2021 May 26 doi: 10.1016/j.jiph.2021.05.007 [Epub ahead of print]. PMCID: PMC8153960

    BOugie or stylet in patients UnderGoing Intubation Emergently (BOUGIE): protocol and statistical analysis plan for a randomised clinical trial. Driver B, Semler MW, Self WH, Ginde AA, Gandotra S, Trent SA, Smith LM, Gaillard JP, Page DB, Whitson MR, Vonderhaar DJ, Joffe AM, West JR, Hughes C, Landsperger JS, Howell MP, Russell DW, Gulati S, Bentov I, Mitchell S, Latimer A, Doerschug K, Koppurapu V, Gibbs KW, Wang L, Lindsell CJ, Janz D, Rice TW, Prekker ME, Casey JD; BOUGIE Investigators# and the Pragmatic Critical Care Research Group. BMJ Open. 2021 May 25;11(5): e047790. doi: 10.1136/bmjopen-2020-047790. PMID: 34035106

    NETosis in the pathogenesis of acute lung injury following cutaneous chemical burns. Surolia R, Li FJ, Wang Z, Kashyap M, Srivastava RK, Traylor AM, Singh P, Dsouza KG, Kim H, Pittet JF, Zmijewski JW, Agarwal A, Athar M, Ahmad A, Antony VB. JCI Insight. 2021 May 24;6(10):147564. doi: 10.1172/jci.insight.147564. PMID: 34027893

    NOX4 regulates macrophage apoptosis resistance to induce fibrotic progression. Larson-Casey JL, Gu L, Kang J, Dhyani A, Carter AB. J Biol Chem. 2021 May 20:100810. doi: 10.1016/j.jbc.2021.100810. Online ahead of print. PMID: 34023385

    Pulmonary Artery Enlargement is Associated with Exacerbations and Mortality in Ever-Smokers with Preserved Ratio Impaired Spirometry (PRISm). Wade RC, Simmons JP, Boueiz A, Gregory A, Wan ES, Regan EA, Bhatt SP, Han MK, Bowler RP, Crapo JD, Silverman EK, Washko GR, Dransfield MT, Wells JM. Am J Respir Crit Care Med. 2021 May 20. doi: 10.1164/rccm.202103-0619LE. Online ahead of print. PMID: 34014810 No abstract available.

    Risk of Exacerbation and Pneumonia with Single-Inhaler Triple versus Dual Therapy in IMPACT. Mark T. Dransfield, Courtney Crim, Gerard J. Criner, Nicola C. Day, David M. G. Halpin, MeiLan K. Han, C. Elaine Jones, Sally Kilbride, David LaFon, David A. Lipson, David A. Lomas, Neil Martin, Fernando J. Martinez, Dave Singh, Robert A. Wise, and Peter Lange. Ann Am Thorac Soc. 2021 May; 18(5): 788–798. doi: 10.1513/AnnalsATS.202002-096OC. PMCID: PMC8086537 PMID: 33108212

    Racial Segregation and Respiratory Outcomes among Urban Black Residents with and at Risk of COPD. Woo H, Brigham EP, Allbright K, Ejike C, Galiatsatos P, Jones MR, Oates GR, Krishnan JA, Cooper CB, Kanner RE, Bowler RP, Hoffman EA, Comellas AP, Criner G, Barr RG, Martinez FJ, Han MK, Ortega VE, Parekh TM, Christenson S, Belz D, Raju S, Gassett A, Paulin LM, Putcha N, Kaufman JD, Hansel NN. Am J Respir Crit Care Med. 2021 May 10. doi: 10.1164/rccm.202009-3721OC. Online ahead of print. PMID: 33971109

    Atrial arrhythmia related outcomes in critically ill COVID-19 patients. Colon CM, Barrios JG, Chiles JW, Brown TM, Pogwizd SM, McElwee SK, Gandotra S, Russell DW, McElderry HT, Maddox WR. Pacing Clin Electrophysiol. 2021 May;44(5):814-823. doi: 10.1111/pace.14221. PMID: 33738812

    InforMing the PAthway of COPD Treatment (IMPACT) trial: fibrinogen levels predict risk of moderate or severe exacerbations. Singh D, Criner GJ, Dransfield MT, Halpin DMG, Han MK, Lange P, Lettis S, Lipson DA, Mannino D, Martin N, Martinez FJ, Miller BE, Wise R, Zhu CQ, Lomas D. Respir Res. 2021 Apr 28;22(1):130. doi: 10.1186/s12931-021-01706-y. PMID: 33910578

    Association between Cardiorespiratory Fitness and Bronchiectasis at CT: A Long-term Population-based Study of Healthy Young Adults Aged 18-30 Years in the CARDIA Study. Diaz AA, Colangelo LA, Okajima Y, Yen A, Sala MA, Dransfield MT, Tino G, Ross JC, San José Estépar R, Washko GR, Kalhan R. Radiology. 2021 Apr 27:203874. doi: 10.1148/radiol.2021203874. Online ahead of print. PMID: 33904771

    PXDN reduces autophagic flux in insulin-resistant cardiomyocytes via modulating FoxO1. Li C, Liu Z, Xu Q, Peng H, Cao J, Zhou H, Zhang G, Cheng G, Shi R. Cell Death Dis. 2021 Apr 26;12(5):418. doi: 10.1038/s41419-021-03699-4. PMID: 33903591

    Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort. Zhang WZ, Hoffman KL, Schiffer KT, Oromendia C, Rice MC, Barjaktarevic I, Peters SP, Putcha N, Bowler RP, Wells JM, Couper DJ, Labaki WW, Curtis JL, Han MK, Paine R 3rd, Woodruff PG, Criner GJ, Hansel NN, Diaz I, Ballman KV, Nakahira K, Choi ME, Martinez FJ, Choi AMK, Cloonan SM. Respir Res. 2021 Apr 26;22(1):126. doi: 10.1186/s12931-021-01707-x. PMID: 33902556.

    Auranofin-Mediated NRF2 Induction Attenuates Interleukin 1 Beta Expression in Alveolar Macrophages. Wall SB, Li R, Butler B, Burg AR, Tse HM, Larson-Casey JL, Carter AB, Wright CJ, Rogers LK, Tipple TE. Antioxidants (Basel). 2021 Apr 21;10(5):632. doi: 10.3390/antiox10050632. PMID: 33919055

    Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium. Kasela S, Ortega VE, Martorella M, Garudadri S, Nguyen J, Ampleford E, Pasanen A, Nerella S, Buschur KL, Barjaktarevic IZ, Barr RG, Bleecker ER, Bowler RP, Comellas AP, Cooper CB, Couper DJ, Criner GJ, Curtis JL, Han MK, Hansel NN, Hoffman EA, Kaner RJ, Krishnan JA, Martinez FJ, McDonald MN, Meyers DA, Paine R 3rd, Peters SP, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Israel E, Jarjour NN, Levy BD, Li X, Moore WC, Wenzel SE, Zein J; NHLBI SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS); NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Langelier C, Woodruff PG, Lappalainen T, Christenson SA. Genome Med. 2021 Apr 21;13(1):66. doi: 10.1186/s13073-021-00866-2. PMID: 33883027

    Spatial mapping of SARS-CoV-2 and H1N1 lung injury identifies differential transcriptional signatures. Margaroli C, Benson P, Sharma NS, Madison MC, Robison SW, Arora N, Ton K, Liang Y, Zhang L, Patel RP, Gaggar A. Cell Rep Med. 2021 Apr 20;2(4):100242. doi: 10.1016/j.xcrm.2021.100242. Epub 2021 Mar 23. PMID: 33778787.

    Divergent Regulation of Alveolar Type 2 Cell and Fibroblast Apoptosis by Plasminogen Activator Inhibitor 1 in Lung Fibrosis. Jiang C, Liu G, Cai L, Deshane J, Antony V, Thannickal VJ, Liu RM. Am J Pathol. 2021 Apr 20:S0002-9440(21)00154-1. doi: 10.1016/j.ajpath.2021.04.003. Online ahead of print. PMID: 33887217

    Astegolimab (anti-ST2) efficacy and safety in adults with severe asthma: a randomized clinical trial. Kelsen SG, Agache IO, Soong W, Israel E, Chupp GL, Cheung DS, Theess W, Yang X, Staton TL, Choy DF, Fong A, Dash A, Dolton M, Pappu R, Brightling CE. J Allergy Clin Immunol. 2021 Apr 16: S0091-6749(21)00609-6. doi: 10.1016/j.jaci.2021.03.044. Online ahead of print. PMID: 33872652

    Update in Chronic Obstructive Pulmonary Disease in 2020. Ritchie AI, Baker JR, Parekh TM, Allinson JP, Bhatt SP, Donnelly LE, Donaldson GC. Am J Respir Crit Care Med. 2021 Apr 15. doi: 10.1164/rccm.202102-0253UP. Online ahead of print. PMID: 33856972

    Cystic Fibrosis Lung Disease in the Aging Population. Künzi L, Easter M, Hirsch MJ, Krick S. Front Pharmacol. 2021 Apr 15;12:601438. doi: 10.3389/fphar.2021.601438. eCollection 2021. PMID: 33935699 Free PMC article. Review.

    Mucus Plugs and Emphysema in the Pathophysiology of Airflow Obstruction and Hypoxemia in Smokers. mDunican EM, Elicker BM, Henry T, Gierada DS, Schiebler ML, Anderson W, Barjaktarevic I, Barr RG, Bleecker ER, Boucher RC, Bowler R, Christenson SA, Comellas A, Cooper CB, Couper D, Criner GJ, Dransfield M, Doerschuk CM, Drummond MB, Hansel NN, Han MK, Hastie AT, Hoffman EA, Krishnan JA, Lazarus SC, Martinez FJ, McCulloch CE, O'Neal WK, Ortega VE, Paine R 3rd, Peters S, Schroeder JD, Woodruff PG, Fahy JV. Am J Respir Crit Care Med. 2021 Apr 15;203(8):957-968. doi: 10.1164/rccm.202006-2248OC. PMID: 33180550

    Computational Simulation of Exosome Transport in Tumor Microenvironment. Koomullil R, Tehrani B, Goliwas K, Wang Y, Ponnazhagan S, Berry J, Deshane J. Front Med (Lausanne). 2021 Apr 13;8:643793. doi: 10.3389/fmed.2021.643793. eCollection 2021. PMID: 33928104 Free PMC article.

    A mechanism for matrikine regulation in acute inflammatory lung injury. Robison SW, Li J, Viera L, Blackburn JP, Patel RP, Blalock JE, Gaggar A, Xu X. JCI Insight. 2021 Apr 8;6(7):140750. doi: 10.1172/jci.insight.140750. PMID: 33830084

    Age-Dependent Associations Between 25-Hydroxy Vitamin D Levels and COPD Symptoms: Analysis of SPIROMICS. Burkes RM, Couper DJ, Barjaktarevic IZ, Cooper CB, Labaki WW, Han MK, Woodruff PG, Lazarus SC, Parekh TM, Paine Iii R, Comellas AP, Bowler RP, Loehr LR, Putcha N, Wise RA, Brown TT, Drummond MB. Chronic Obstr Pulm Dis. 2021 Apr 6. doi: 10.15326/jcopdf.2020.0180. Online ahead of print. PMID: 33829714

    Moving Immune Therapy Forward Targeting TME. Goliwas KF, Deshane JS, Elmets CA, Athar M. Physiol Rev. 2021 Apr 1;101(2):417-425. doi: 10.1152/physrev.00008.2020. Epub 2020 Aug 13. PMID: 32790578

    Inclusion of Performance Parameters and Patient Context in the Clinical Practice Guidelines for Heart Failure. Parag Goyal, Ozan Unlu, Peter J Kennel, Ross C Schumacher, Lauren G Gilstrap, Ashok Krishnaswami, Larry A Allen, Mathew S Maurer, Michael W Rich, Anil Makam. J Card Fail. 2021 Feb;27(2):190-197. doi: 10.1016/j.cardfail.2020.09.473. Epub 2020 Oct 14. PMID: 33065263 DOI: 10.1016/j.cardfail.2020.09.473

    Defining Resilience to Smoking Related Lung Disease: A Modified Delphi Approach from SPIROMICS.

    Oh AL, Mularski RA, Barjaktarevic I, Barr RG, Bowler RP, Comellas AP, Cooper CB, Criner GJ, Han MK, Hansel NN, Hoffman EA, Kanner RE, Krishnan JA, Paine R 3rd, Parekh TM, Peters SP, Christenson SA, Woodruff PG; SPIROMICS Investigators. Ann Am Thorac Soc. 2021 Feb 25. doi: 10.1513/AnnalsATS.202006-757OC. Online ahead of print. PMID: 33631079

      

    Novel Correctors and Potentiators Enhance Functional Rescue of CFTR Nonsense Mutation Translational Readthrough. Am J Respir Cell Mol Biol. 2021 Feb 22. doi: 10.1165/rcmb.2019-0291OC. Online ahead of print. Venkateshwar Mutyam, Jyoti Sharma, Yao Li, Ning Peng, Jianguo Chen, Li Ping Tang, Emily Falk Libby, Ashvani K Singh, Katja Conrath, Steven M Rowe. PMID: 33616476. DOI: 10.1165/rcmb.2019-0291OC

    Extracorporeal membrane oxygenation in patients with severe respiratory failure from COVID-19.

    Shaefi S, Brenner SK, Gupta S, O'Gara BP, Krajewski ML, Charytan DM, Chaudhry S, Mirza SH, Peev V, Anderson M, Bansal A, Hayek SS, Srivastava A, Mathews KS, Johns TS, Leonberg-Yoo A, Green A, Arunthamakun J, Wille KM, Shaukat T, Singh H, Admon AJ, Semler MW, Hernán MA, Mueller AL, Wang W, Leaf DE; STOP-COVID Investigators. Intensive Care Med. 2021 Feb;47(2):208-221. doi: 10.1007/s00134-020-06331-9. Epub 2021 Feb 2. PMID: 33528595 Free PMC article.

    Appropriateness of Long-Term Acute Care Hospital Transfer: A Multicenter Study of Medicare ACO Beneficiaries. Ross C Schumacher, Michael Chiu, Jean de Leon, Kate Krause, Anil N Makam. J Am Med Dir Assoc. 2021 Feb 19;S1525-8610(21)00118-3. doi: 10.1016/j.jamda.2021.01.067. Online ahead of print. PMID: 33617790 DOI: 10.1016/j.jamda.2021.01.067

    Reciprocal Links Between Physical Health and Coping Among Adolescents with Cystic Fibrosis. J Pediatr Psychol. 2021 Feb 19;46(2):231-240. doi: 10.1093/jpepsy/jsaa103. Christina M D'Angelo, Sylvie Mrug, Daniel Grossoehme, Kevin Leon, Lacrecia Thomas, Bradley Troxler. PMID: 33306793. PMCID: PMC7896275 (available on 2021-12-11). DOI: 10.1093/jpepsy/jsaa103

    MicroRNA 219-5p inhibits alveolarization by reducing platelet derived growth factor receptor-alpha. Respir Res. 2021 Feb 17;22(1):57. doi: 10.1186/s12931-021-01654-7. Amelia Freeman, Luhua Qiao, Nelida Olave, Gabriel Rezonzew, Samuel Gentle, Brian Halloran, Gloria S Pryhuber, Amit Gaggar, Trent E Tipple, Namasivayam Ambalavanan, Charitharth Vivek Lal. PMID: 33596914. PMCID: PMC7891005. DOI: 10.1186/s12931-021-01654-7

    Pulmonary Arterial Pruning and Longitudinal Change in Percent Emphysema and Lung Function: the COPDGene Study.  Chest. 2021 Feb 16; S0012-3692(21)00278-6. doi: 10.1016/j.chest.2021.01.084. Online ahead of print. CL Pistenmaa, P Nardelli, SY Ash, CE Come, AA Diaz, FN Rahaghi, RG Barr, KA Young, GL Kinney, JP Simmons, RC Wade, JM Wells, JE Hokanson, GR Washko, Estépar R San José, COPDGene Investigators

    Recent developments in the pathobiology of lung myofibroblasts. Expert Rev Respir Med. 2021 Feb;15(2):239-247. doi: 10.1080/17476348.2021.1829972. Epub 2020 Oct 19. Dingyuan Jiang, Tapan Dey, Gang Liu. PMID: 32981357. PMCID: PMC7870526 (available on 2022-02-01). DOI: 10.1080/17476348.2021.1829972

     Respiratory exacerbations are associated with muscle loss in current and former smokers.  Mason SE, Moreta-Martinez R, Labaki WW, Strand M, Baraghoshi D, Regan EA, Bon J, San Jose Estepar R, Casaburi R, McDonald MN, Rossiter H, Make BJ, Dransfield MT, Han MK, Young KA, Kinney G, Hokanson JE, San Jose Estepar R, Washko GR; COPDGene Investigators; COPDGene® Investigators. Thorax. 2021 Feb 11: thoraxjnl-2020-215999. doi: 10.1136/thoraxjnl-2020-215999. Online ahead of print. PMID: 33574123

    Twelve tips for teaching in the ICU. Doyle S, Sharp M, Winter G, Khan MMKS, Holden R, Djondo D, Bosslet G, Lenz P. Med Teach. 2021 Feb 9:1-10. doi: 10.1080/0142159X.2020.1859097. Online ahead of print. PMID: 33563060

      

    Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort. Opron K, Begley LA, Erb-Downward JR, Freeman C, Madapoosi S, Alexis NE, Barjaktarevic I, Graham Barr R, Bleecker ER, Bowler RP, Christenson SA, Comellas AP, Cooper CB, Couper DJ, Doerschuk CM, Dransfield MT, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kaner RJ, Krishnan J, O'Neal WK, Ortega VE, Paine R 3rd, Peters SP, Michael Wells J, Woodruff PG, Martinez FJ, Curtis JL, Huffnagle GB, Huang YJ. NPJ Biofilms Microbiomes. 2021 Feb 5;7(1):14. doi: 10.1038/s41522-021-00185-9. PMID: 33547327

    A novel locus for exertional dyspnoea in childhood asthma. Eur Respir J. 2021 Feb 4;57(2):2001224. doi: 10.1183/13993003.01224-2020. Print 2021 Feb. Sanghun Lee, Jessica Ann Lasky-Su, Christoph Lange, Wonji Kim, Preeti Lakshman Kumar, Merry-Lynn N McDonald, Carlos A Vaz Fragoso, Cecelia Laurie, Benjamin A Raby, Juan C Celedón, Michael H Cho, Sungho Won, Scott T Weiss, Julian Hecker, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium

    Chitinase 3-like-1 protects airway function despite promoting type 2 inflammation during fungal-associated allergic airway inflammation. Am J Physiol Lung Cell Mol Physiol. 2021 Feb 3. doi: 10.1152/ajplung.00528.2020. Online ahead of print. Joseph J Mackel, Jaleesa M Garth, MaryJane Jones, Diandra A Ellis, Jonathan P Blackburn, Zhihong Yu, Sadis Matalon, Miranda Curtiss, Frances E Lund, Annette T Hastie, Deborah A Meyers, Chad Steele. PMID: 33533316. DOI: 10.1152/ajplung.00528.2020

    Ratio of Forced Expiratory Volume in 1 second /Slow Vital Capacity (FEV1/SVC) <0.7 is associated with clinical, functional, and radiologic features of obstructive lung disease in smokers with preserved lung function. Fortis S, Comellas A, Bhatt SP, Hoffman EA, Han MK, Bhakta NR, Paine R 3rd, Ronish B, Kanner RE, Dransfield M, Hoesterey D, Buhr RG, Barr RG, Dolezal B, Ortega VE, Drummond MB, Arjomandi M, Kaner RJ, Kim V, Curtis JL, Bowler RP, Martinez F, Labaki WW, Cooper CB, O'Neal WK, Criner G, Hansel NN, Krishnan JA, Woodruff P, Couper D, Tashkin D, Barjaktarevic I. Chest. 2021 Feb 1: S0012-3692(21)00229-4. doi: 10.1016/j.chest.2021.01.067. Online ahead of print.

    PMID: 33539837               

    Inhaled high molecular weight hyaluronan ameliorates respiratory failure in acute COPD exacerbation: a pilot study. Respir Res. 2021 Feb 1;22(1):30. doi: 10.1186/s12931-020-01610-x. Flavia Galdi 1, Claudio Pedone, Christopher A McGee, Margaret George, Annette B Rice, Shah S Hussain, Kadambari Vijaykumar, Evan R Boitet, Guillermo J Tearney, John A McGrath, Audrey R Brown, Steven M Rowe, Raffaele A Incalzi, Stavros Garantziotis. PMID: 33517896. PMCID: PMC7847749. DOI: 10.1186/s12931-020-01610-x

    Obstructive sleep apnea is more severe in men but not women with refractory hypertension compared with controlled resistant hypertension. J Hypertens. 2021 Feb 1;39(2):286-291. doi: 10.1097/HJH.0000000000002631. S Justin Thomas, Mohammed Siddiqui, Eric Judd, David Moore, Susan M Harding, Suzanne Oparil, David Calhoun. PMID: 33031172. DOI: 10.1097/HJH.0000000000002631

    Portable, Consumer-grade Pulse Oximeters are Accurate for Home and Medical Use: Implications for their Use in COVID-19 Patients. Ann Am Thorac Soc. 2021 Feb 22. doi: 10.1513/AnnalsATS.202012-1555LE. Online ahead of print. Walter A Schrading, David B Page. PMID: 33617739. DOI: 10.1513/AnnalsATS.202012-1555LE

    Favorable Clinician Acceptability of Telehealth as Part of the Cystic Fibrosis Care Model during the COVID-19 Pandemic.  Ann Am Thorac Soc. 2021 Feb 26. doi: 10.1513/AnnalsATS.202012-1484RL. Online ahead of print. Ryan C Perkins, Jaclyn Davis, Andrew NeSmith, Julianna Bailey, Michael R Powers, Nauman Chaudary, Christopher Siracusa, Ahmet Uluer, George M Solomon, Gregory S Sawicki. PMID: 33636092. DOI: 10.1513/AnnalsATS.202012-1484RL

    Elevated plasma level of Pentraxin 3 is associated with emphysema and mortality in smokers.  Zhang Y, Tedrow J, Nouraie M, Li X, Chandra D, Bon J, Kass DJ, Fuhrman CR, Leader JK, Duncan SR, Kaminski N, Sciurba FC.Thorax. 2021 Jan 21:thoraxjnl-2020-215356. doi: 10.1136/thoraxjnl-2020-215356. Online ahead of print. PMID: 33479043

    Structural airway imaging metrics are differentially associated with persistent chronic bronchitis.  Bhatt SP, Bodduluri S, Kizhakke Puliyakote AS, Oelsner EC, Nakhmani A, Lynch DA, Wilson CG, Fortis S, Kim V. Thorax. 2021 Jan 6:thoraxjnl-2020-215853. doi: 10.1136/thoraxjnl-2020-215853. Online ahead of print. PMID: 33408194

    RANKL-Targeted Combination Therapy with Osteoprotegerin Variant Devoid of TRAIL Binding Exerts Biphasic Effects on Skeletal Remodeling and Antitumor Immunity. Hong Wang, Reading Ashton, Jonathan A. Hensel, Joo Hyoung Lee, Vinayak Khattar, Yong Wang, Jessy S. Deshane and Selvarangan Ponnazhagan. Large Molecule Therapeutics. DOI: 10.1158/1535-7163.MCT-20-0378. December 2020

    Identification of a Repair-Supportive Mesenchymal Cell Population during Airway Epithelial Regeneration.  Moiseenko A, Vazquez-Armendariz AI, Kheirollahi V, Chu X, Tata A, Rivetti S, Günther S, Lebrigand K, Herold S, Braun T, Mari B, De Langhe S, Kwapiszewska FG, Günther A, Chen C, Seeger W, Tata PR, Zhang JS, Bellusci S, El Agha E. Cell Rep. 2020 Dec 22;33(12):108549. doi: 10.1016/j.celrep.2020.108549. PMID: 33357434

    Reciprocal Links Between Physical Health and Coping Among Adolescents With Cystic Fibrosis.  D'Angelo CM, Mrug S, Grossoehme D, Leon K, Thomas L, Troxler B. J Pediatr Psychol. 2020 Dec 11:jsaa103. doi: 10.1093/jpepsy/jsaa103. Online ahead of print.PMID: 33306793

    A Patient Charter for Chronic Obstructive Pulmonary Disease. Hurst JR, Winders T, Worth H, Bhutani M, Gruffydd-Jones K, Stolz D, Dransfield MT. Adv Ther. 2020 Nov 27. doi: 10.1007/s12325-020-01577-7. Online ahead of print. PMID: 33245531

    Long term clinical effectiveness of ivacaftor in people with the G551D CFTR mutation.  Guimbellot JS, Baines A, Paynter A, Heltshe SL, VanDalfsen J, Jain M, Rowe SM, Sagel SD; GOAL-e2 Investigators. J Cyst Fibros. 2020 Nov 25:S1569-1993(20)30911-5. doi: 10.1016/j.jcf.2020.11.008. Online ahead of print. PMID: 33249004

    Technical advance: The use of tree shrews as a model of pulmonary fibrosis.  Larson-Casey JL, He C, Che P, Wang M, Cai G, Kim YI, El Hamdaoui M, Grytz R, Ding Q, Carter AB. PLoS One. 2020 Nov 3;15(11):e0241323. doi: 10.1371/journal.pone.0241323. eCollection 2020. PMID: 33141839

    The Effect of Inhaled Corticosteroid Withdrawal and Baseline Inhaled Treatment on Exacerbations in the IMPACT Study. A Randomized, Double-Blind, Multicenter Clinical Trial.  Han MK, Criner GJ, Dransfield MT, Halpin DMG, Jones CE, Kilbride S, Lange P, Lettis S, Lipson DA, Lomas DA, Martin N, Wise RA, Singh D, Martinez FJ. Am J Respir Crit Care Med. 2020 Nov 1;202(9):1237-1243. doi:10.1164/rccm.201912-2478OC.  PMID: 32584168 Free PMC article. Clinical Trial.

    Neutrophilic inflammation during lung development disrupts elastin assembly and predisposes adult mice to COPD. Benjamin JT, Plosa E, Sucre J, van der Meer R, Dave S, Gutor SS, Nichols D, Gulleman P, Jetter C, Han W, Xin MK, Dinella PC, Catanzarite A, Kook S, Dolma K, Lal CV, Gaggar A, Blalock JE, Newcomb DC, Richmond BW, Kropski JA, Young LR, Guttentag S, Blackwell TS. J Clin Invest. 2020 Oct 27:139481. doi: 10.1172/JCI139481. Online ahead of print. PMID: 33108351

    Risk of Exacerbation and Pneumonia with Single Inhaler Triple Versus Dual Therapy in IMPACT.  Dransfield MT, Crim C, Criner GJ, Day NC, Halpin DMG, Han MK, Jones CE, Kilbride S, LaFon D, Lipson DA, Lomas DA, Martin N, Martinez FJ, Singh D, Wise RA, Lange P.

    Ann Am Thorac Soc. 2020 Oct 27. doi: 10.1513/AnnalsATS.202002-096OC. Online ahead of print. PMID: 33108212

    Trends and Geographic Variation in Acute Respiratory Failure and ARDS Mortality in the United States.  Parcha V, Kalra R, Bhatt SP, Berra L, Arora G, Arora P. Chest. 2020 Oct 22:S0012-3692(20)34937-0. doi: 10.1016/j.chest.2020.10.042. Online ahead of print. PMID: 33393472 Free PMC article.

    Plasma Cathelicidin is Independently Associated with Reduced Lung Function in COPD: Analysis of the Subpopulations and Intermediate Outcome Measures in COPD Study Cohort.  Burkes RM, Ceppe AS, Couper DJ, Comellas AP, Wells JM, Peters SP, Criner GJ, Kanner RE, Paine R 3rd, Christenson SA, Cooper CB, Barjaktarevic IZ, Krishnan JA, Labaki WW, Han MK, Curtis JL, Hansel NN, Wise RA, Drummond MB; SPIROMICS collaborators. Chronic Obstr Pulm Dis. 2020 Oct;7(4):370-381. doi: 10.15326/jcopdf.7.4.2020.0142. PMID: 33108110

    ATF4 Mediates Mitochondrial Unfolded Protein Response in Alveolar Epithelial Cells.

    Jiang D, Cui H, Xie N, Banerjee S, Liu RM, Dai H, Thannickal VJ, Liu G. Am J Respir Cell Mol Biol. 2020 Oct;63(4):478-489. doi: 10.1165/rcmb.2020-0107OC. PMID: 32551949

    Obstructive sleep apnea is more severe in men but not women with refractory hypertension compared with controlled resistant hypertension. Thomas SJ, Siddiqui M, Judd E, Moore D, Harding SM, Oparil S, Calhoun D. J Hypertens. 2020 Oct 6. doi: 10.1097/HJH.0000000000002631. Online ahead of print. PMID: 33031172

    COPD: COagulation-associated Pulmonary Disease? Mkorombindo T, Dransfield MT. Respirology. 2021 Jan 11. doi: 10.1111/resp.14000. Online ahead of print. PMID: 33432655 No abstract available.

    Noninvasive Ventilation in Seriously Ill Older Adults at the End of Life-The Evidence Remains Elusive.  Iyer AS. JAMA Intern Med. 2020 Oct 19. doi: 10.1001/jamainternmed.2020.5648. Online ahead of print. PMID: 33074308 No abstract available.

  • 2020 Publications

    January 2020

    Al Alam D, Danopoulos S, Grubbs B, Ali NABM, MacAogain M, Chotirmall SH, Warburton D, Gaggar A, Ambalavanan N, Lal CV. Am J Respir Crit Care Med. 2020 Jan 3;doi: 10.1164/rccm.201911-2127LE. [Epub ahead of print].Human Fetal Lungs Harbor a Microbiome Signature.

    Liu RM, Liu G. Exp Gerontol. 2020 Jan 17:110836. doi: 10.1016/j.exger.2020.110836. Cell senescence and fibrotic lung diseases.

    Hwangpo T, Wang Z, Ghably J, Bhatt SP, Cui X, Schroeder HW Jr. Use of FEF25-75% to Guide IgG Dosing to Protect Pulmonary Function in CVID [published online ahead of print, 2020 Jan 3]. J Clin Immunol. 2020;10.1007/s10875-019-00730-4. doi:10.1007/s10875-019-00730-4

    Larson-Casey JL, He C, Carter AB. Mitochondrial quality control in pulmonary fibrosis [published online ahead of print, 2020 Jan 8]. Redox Biol. 2020;101426. doi:10.1016/j.redox.2020.101426.

    Hough KP, Deshane JS. Cutting edge approaches for rapid characterization of airway exosomes [published online ahead of print, 2020 Jan 14]. Methods. 2020;S1046-2023(19)30275-0. doi:10.1016/j.ymeth.2020.01.003

    Hurst JR, Skolnik N, Hansen GJ, Anzueto A, Donaldson GC, Dransfield MT, Varghese P. Understanding the impact of chronic obstructive pulmonary disease exacerbations on patient health and quality of life. Eur J Intern Med. 2020 Jan 16;S0953-6205(19)30443-1. doi: 10.1016/j.ejim.2019.12.014. [Epub ahead of print]. PMID: 31954592.

    Kato K, Logsdon NJ, Shin YJ, Palumbo S, Knox A, Irish JD, Rounseville SP, Rummel SR, Mohamed M, Ahmad K, Trinh JM, Kurundkar D, Knox KS, Thannickal VJ, Hecker L. Impaired Myofibroblast Dedifferentiation Contributes to Non-Resolving Fibrosis in Aging. Am J Respir Cell Mol Biol. 2020 Jan 21;10.1165/rcmb.2019-0092OC. doi: 10.1165/rcmb.2019-0092OC. [Epub ahead of print]. PMID: 31962055.

    Hurst JR, Skolnik N, Hansen GJ, Anzueto A, Donaldson GC, Dransfield MT, Varghese P. Understanding the impact of chronic obstructive pulmonary disease exacerbations on patient health and quality of life. Eur J Intern Med. 2020 Jan 16;S0953-6205(19)30443-1. doi: 10.1016/j.ejim.2019.12.014. [Epub ahead of print]. PMID: 31954592.

    Konstan MW, VanDevanter DR, Rowe SM, Wilschanski M, Kerem E, Sermet-Gaudelus I, DiMango E, Melotti P, McIntosh J, De Boeck K; ACT CF Study Group. Efficacy and safety of ataluren in patients with nonsense-mutation cystic fibrosis not receiving chronic inhaled aminoglycosides: The international, randomized, double-blind, placebo-controlled Ataluren Confirmatory Trial in Cystic Fibrosis (ACT CF). J Cyst Fibros. 2020 Jan 23;S1569-1993(20)30030-8. doi: 10.1016/j.jcf.2020.01.007. [Epub ahead of print]. PMID: 31983658.

    March 2020

    Dransfield MT, Garner JL, Bhatt SP, Slebos DJ, Klooster K, Sciurba FC, Shah PL, Marchetti NT, Sue RD, Wright S, Rivas-Perez H, Wiese TA, Wahidi MM, de Oliveira HG, Armstrong B, Radhakrishnan S, Shargill NS, Criner GJ. Effect of Zephyr Endobronchial Valves on Dyspnea, Activity Levels and Quality of Life at One Year. Ann Am Thorac Soc. 2020 Mar 30;. doi: 10.1513/AnnalsATS.201909-666OC. [Epub ahead of print] PubMed PMID: 32223724.

    Brown KK, Martinez FJ, Walsh SLF, Thannickal VJ, Prasse A, Schlenker-Herceg R, Goeldner RG Clerisme-Beaty E, Tetzlaff K, Cottin V, Wells AU.The natural history of progressive fibrosing interstitial lung diseases. Eur Respir J. 2020 Mar 26. pii: 2000085. doi: 10.1183/13993003.00085-2020. [Epub ahead of print]

    Shlobin OA, Kouranos V, Barnett SD, Alhamad EH, Culver DA, Barney J, Cordova FC, Carmona EM, Scholand MB, Wijsenbeek M, Ganesh S, Lower EE, Engel PJ, Wort J, Price L, Wells AU, Nathan SD, Baughman RP.Physiological Predictors of Survival in Patients with Sarcoidosis Associated Pulmonary Hypertension: Results from an International Registry. Eur Respir J. 2020 Mar 26. pii: 1901747. doi: 10.1183/13993003.01747-2019.

    Regal-McDonald K, Somarathna M, Lee T, Litovsky SH, Barnes J, Peretik JM, Traylor JG Jr, Orr AW, Patel RP.Assessment of ICAM-1 N-glycoforms in mouse and human models of endothelial dysfunction. PLoS One. 2020 Mar 24;15(3):e0230358. doi: 10.1371/journal.pone.0230358. eCollection 2020.

    Krina P, Raju, SV. Evaluation of secondhand smoke effects on CFTR function in vivo. Lawrence W. Rasmussen,Denise Stanford. Respir Res. 2020; 21: 70. Published online 2020 Mar 20.doi:10.1186/s12931-020-1324-3 PMCID:PMC7082971 PMID:32192506

    Guo Q, Quan M, Dong J, Bai J, Wang J, Han R, Wang W, Cai Y, Lv YQ, Chen Q, Xu H, Lyu HD, Deng L, Zhou D, Xiao X, De Langhe S, Billadeau DD, Lou Z, Zhang JS.The WW domains dictate isoform-specific regulation of YAP1 stability and pancreatic cancer cell malignancy. Theranostics. 2020 Mar 15;10(10):4422-4436. doi: 10.7150/thno.42795. eCollection 2020

    Bhatt SP. COPD exacerbations: finally, a more than ACCEPTable risk score. Lancet Respir Med. 2020 Mar 13;. doi: 10.1016/S2213-2600(20)30049-7. [Epub ahead of print] PubMed PMID: 32178778.

    Lipson DA, Crim C, Criner GJ, Day NC, Dransfield MT, Halpin DMG, Han MK, Jones CE, Kilbride S, Lange P, Lomas DA, Lettis S, Manchester P, Martin N, Midwinter D, Morris A, Pascoe SJ, Singh D, Wise RA, Martinez FJ; IMPACT investigators.Reduction in All-Cause Mortality with Fluticasone Furoate/Umeclidinium/Vilanterol in COPD Patients. Am J Respir Crit Care Med. 2020 Mar 12. doi: 10.1164/rccm.201911-2207OC. [Epub ahead of print]

    Otoupalova E, Smith S, Cheng G, Thannickal VJ. Oxidative Stress in Pulmonary Fibrosis. Compr Physiol. 2020 Mar 12;10(2):509-547. doi: 10.1002/cphy.c19001

    McDonald KR, Hernandez-Nichols AL, Barnes JW, Patel RP.Hydrogen peroxide regulates endothelial surface N-glycoforms to control inflammatory monocyte rolling and adhesion. Redox Biol. 2020 Mar 6:101498. doi: 10.1016/j.redox.2020.101498. [Epub ahead of print]

    Bernard K, Thannickal VJ. NADPH Oxidase Inhibition in Fibrotic Pathologies. Antioxid Redox Signal. 2020 Mar 4. doi: 10.1089/ars.2020.8032. [Epub ahead of print]

    Yuan T, Klinkhammer K, Lyu H, Gao S, Yuan J, Hopkins S, Zhang JS, De Langhe SP. Temporospatial Expression of Fgfr1 and 2 During Lung Development, Homeostasis, and Regeneration. Front Pharmacol. 2020 Mar 2;11:120. doi: 10.3389/fphar.2020.00120. ECollection 2020

    April 2020

    Pleasants RA, Rivera MP, Tilley SL, Bhatt SP. Both Duration and Pack-years of Tobacco Smoking Should be Used for Clinical Practice and Research. Ann Am Thorac Soc. 2020 Apr 29;. doi: 10.1513/AnnalsATS.202002-133VP. [Epub ahead of print] PubMed PMID: 32348693.

    Iyer, AS, Curtis, JR, Meier, DE. Proactive Integration of Geriatrics and Palliative Care Principles Into Practice for Chronic Obstructive Pulmonary Disease. April 27, 2020

    Barnes JW, Aarnio-Peterson M, Norris J, Haskins M, Flanagan-Steet H, Steet R.Upregulation of Sortilin, a Lysosomal Sorting Receptor, Corresponds with Reduced Bioavailability of Latent TGFβ in Mucolipidosis II Cells. Biomolecules. 2020 Apr 26;10(5). pii: E670. doi: 10.3390/biom10050670.

    Manzoor S, Mariappan N, Zafar I, Wei CC, Ahmad A, Surolia R, Foote JB, Agarwal A, Ahmad S, Athar M, Antony VB, Ahmad A.Cutaneous lewisite exposure causes acute lung injury. Ann N Y Acad Sci. 2020 Apr 24. doi: 10.1111/nyas.14346. [Epub ahead of print]

    Iyer AS, Dionne-Odom JN, Khateeb DM, O'Hare L, Tucker RO, Brown CJ, Dransfield MT, Bakitas MA.A Qualitative Study of Pulmonary and Palliative Care Clinician Perspectives on Early Palliative Care in Chronic Obstructive Pulmonary Disease. J Palliat Med. 2020 Apr;23(4):513-526. doi: 10.1089/jpm.2019.0355.

    Tran-Nguyen TK, Xue J, Feghali-Bostwick C, Sciurba FC, Kass DJ, Duncan SR. CD70 Activation Decreases Pulmonary Fibroblast Production of Extracellular Matrix Proteins. Am J Respir Cell Mol Biol. 2020 Apr 22. doi: 10.1165/rcmb.2019-0450OC. [Epub ahead of print]

    Wade C, Wells JM. Practical recommendations for the use of beta-blockers in chronic obstructive pulmonary disease.Expert Rev Respir Med. 2020 Apr 19:1-8. doi: 10.1080/17476348.2020.1752671. [Epub ahead of print]

    Halpin DMG, Dransfield MT, Han MK, Jones CE, Kilbride S, Lange P, Lipson DA, Lomas DA, Martinez FJ, Pascoe S, Singh D, Wise R, Criner GJ.The Effect of Exacerbation History on Outcomes in the IMPACT Trial. Eur Respir J. 2020 Apr 16. pii: 1901921. doi: 10.1183/13993003.01921-2019.

    Cornelius T, Schwartz JE, Balte P, Bhatt SP, Cassano PA, Currow D, Jacobs DR Jr, Johnson M, Kalhan R, Kronmal R, Loehr L, O'Connor GT, Smith B, White WB, Yende S, Oelsner EC. A Dyadic Growth Modeling Approach to Examine Associations Between Weight Gain and Lung Function Decline: The NHLBI Pooled Cohorts Study. Am J Epidemiol. 2020 Apr 14;. doi: 10.1093/aje/kwaa059. [Epub ahead of print] PubMed PMID: 32286615.

    Parekh TM, Cherrington AL, Bhatia S, Turan B, Patel SB, Kim YI, Turan JM, Dransfield MT. The Association of Low Income and High Stress with Acute Care Use in COPD Patients.Chronic Obstr Pulm Dis. 2020 Apr;7(2):107-117. doi: 10.15326/jcopdf.7.2.2019.0165.

    AbuNurah HY, Russell DW, Lowman JD. The validity of surface EMG of extra-diaphragmatic muscles in assessing respiratory responses during mechanical ventilation: A systematic review. Pulmonology. 2020 Apr 2. pii: S2531-0437(20)30034-9. doi: 10.1016/j.pulmoe.2020.02.008. [Epub ahead of print]

    Dransfield MT, Helgeson ES, Connett JE; BLOCK COPD Investigators.Metoprolol for the Prevention of Exacerbations of COPD. Reply. N Engl J Med. 2020 Apr 2;382(14):1375-1376. doi: 10.1056/NEJMc2000638.

    May 2020

    George R. Washko ,Pietro Nardelli ,Samuel Y. Ash,Farbod N. Rahaghi,Gonzalo Vegas Sanchez-Ferrero,Carolyn E Come,Mark T Dransfield,Ravi Kalhan,MeiLan K Han,Surya P. Bhatt ,J Michael Wells,Carrie L. Pistenmaa,Alejandro A Diaz ,James C. Ross,Stephen Rennard,Gabriela Querejeta Roca ,Amil M Shah,Kendra Young,Gregory L Kinney,John E. Hokanson ,Alvar Agustí, Raúl San José Estépar,COPDGene Investigators Smaller Left Ventricle Size at Noncontrast CT Is Associated With Lower Mortality in COPDGene Participants. Radiology. 2020 May 5;191793.

    Wilson AC, Kumar PL, Lee S, Parker MM, Arora I, Morrow JD, Wouters EFM, Casaburi R, Rennard SI, Lomas DA, Agusti A, Tal-Singer R, Dransfield MT, Wells JM, Bhatt SP, Washko G, Thannickal VJ, Tiwari HK, Hersh CP, Castaldi PJ, Silverman EK, McDonald MN. Heme metabolism genes Downregulated in COPD Cachexia. Respir Res. 2020 May 1;21(1):100. doi: 10.1186/s12931-020-01336-w. PubMed PMID: 32354332.

    Liu, Rui-Ming, Chong, Zechen, and Chen, Jiu-Chiuan. ‘Ozone and Particulate Matter Exposure and Alzheimer’s Disease: A Review of Human and Animal Studies’. 1 Jan. 2020 : 807 – 824.

    Liu, RM, Chong, Z, and Chen, JC (2020). Ozone and particulate matter exposure and Alzheimer’s disease: A review of human and animal studies. J Alzheimer’s Disease 77 (2): 701-714. PMID: 32568209

    Sharma NS, Vestal G, Wille K, Patel KN, Cheng F, Tipparaju S, Tousif S, Banday MM, Xu X, Wilson L, Nair VS, Morrow C, Hayes D Jr, Seyfang A, Barnes S Deshane JS, Gaggar A. Differences in airway microbiome and metabolome of single lung transplant recipients. Respir Res. 2020 May 6;21(1):104. doi: 10.1186/s12931-020-01367-3.

    Stanford D, Kim H, Bodduluri S, LaFontaine J, Byzek SA, Schoeb TR, Harris ES, Nath HP, Bhatt SP, Raju SV, Rowe SM.Airway Remodeling in Ferrets with Cigarette Smoke Induced COPD using µCT Imaging. Am J Physiol Lung Cell Mol Physiol. 2020 May 6. doi: 10.1152/ajplung.00328.2019. [Epub ahead of print]

    Adewale AT, Falk Libby E, Fu L, Lenzie A, Boitet ER, Birket SE, Petty CF, Johns JD, Mazur M, Tearney GJ, Copeland D, Durham C, Rowe SM. Novel Therapy of Bicarbonate, Glutathione and Ascorbic Acid Improves Cystic Fibrosis Mucus Transport. Am J Respir Cell Mol Biol. 2020 May 6. doi: 10.1165/rcmb.2019-0287OC. [Epub ahead of print]

    Halliday SJ, Casey JD, Rice TW, Semler MW, Janz DR, Russell DW, Dargin J, Vonderhaar DJ, West JR, Churpek MM; Pragmatic Critical Care Research Group. Risk Factors for Cardiovascular Collapse During Tracheal Intubation of Critically Ill Adults. Ann Am Thorac Soc. 2020 May 4. doi: 10.1513/AnnalsATS.201912-894RL. [Epub ahead of print].

    Wilson AC, Kumar PL, Lee S, Parker MM, Arora I, Morrow JD, Wouters EFM, Casaburi R, Rennard SI, Lomas DA, Agusti A, Tal-Singer R, Dransfield MT, Wells JM, Bhatt SP, Washko G, Thannickal VJ, Tiwari HK, Hersh CP, Castaldi PJ, Silverman EK, McDonald MN.Heme metabolism genes Downregulated in COPD Cachexia. Respir Res. 2020 May 1;21(1):100. doi: 10.1186/s12931-020-01336-w.

    Pleasants RA, Rivera MP, Tilley SL, Bhatt SP.Both Duration and Pack-years of Tobacco Smoking Should be Used for Clinical Practice and Research. Ann Am Thorac Soc. 2020 Apr 29. doi: 10.1513/AnnalsATS.202002-133VP. [Epub ahead of print]

    May 2020

    Adewale AT, Falk Libby E, Fu L, Lenzie A, Boitet ER, Birket SE, Petty CF, Johns JD, Mazur M, Tearney GJ, Copeland D, Durham C, Rowe SM.Novel Therapy of Bicarbonate, Glutathione and Ascorbic Acid Improves Cystic Fibrosis Mucus Transport. Am J Respir Cell Mol Biol. 2020 May 6. doi: 10.1165/rcmb.2019-0287OC. [Epub ahead of print]

    Stanford D, Kim H, Bodduluri S, LaFontaine J, Byzek SA, Schoeb TR, Harris ES, Nath HP, Bhatt SP, Raju SV, Rowe SM.Airway Remodeling in Ferrets with Cigarette Smoke Induced COPD using µCT Imaging.Am J Physiol Lung Cell Mol Physiol. 2020 May 6. doi: 10.1152/ajplung.00328.2019. [Epub ahead of print]

    Hunninghake GM, Quesada-Arias LD, Carmichael NE, Martinez Manzano JM1, Poli De Frías S1, Baumgartner MA, DiGianni L, Gampala-Sagar SN, Leone DA, Gulati S, El-Chemaly S, Goldberg HJ, Putman RK, Hatabu H, Raby BA, Rosas IO1,6.Interstitial Lung Disease in Relatives of Patients with Pulmonary Fibrosis. Am J Respir Crit Care Med. 2020 May 15;201(10):1240-1248. doi: 10.1164/rccm.201908-1571OC.

    Fernando Sergio Leitao Filho, Andre Mattman, Robert Schellenberg, Gerard J Criner, Prescott Woodruff , Stephen C Lazarus, Richard K Albert, John Connett ,Meilan K Han, Steven E Gay, Fernando J Martinez, Anne L Fuhlbrigge, James K Stoller, Neil R MacIntyre, Richard Casaburi, Philip Diaz ,Ralph J Panos, J Allen Cooper Jr, William C Bailey, David C LaFon, Frank C Sciurba, Richard E Kanner, Roger D Yusen, David H Au, Kenneth C Pike, Vincent S Fan, Janice M Leung, Shu-Fan Paul Man,Shawn D Aaron, Robert M Reed, Don D Sin. Serum IgG Levels and Risk of COPD Hospitalization: A Pooled Meta-Analysis. Chest. 2020 May 18;S0012-3692(20)31409-4. doi: 10.1016/j.chest.2020.04.058. Online ahead of print.

    June 2020

    Necroptosis inhibition prevents long-term cardiac damage during pneumococcal pneumonia and invasive disease. Beno SM, Riegler AN, Gilley RP, Brissac T, Wang Y, Kruckow KL, Jadapalli JK, Wright GM, Shenoy AT, Stoner SN, Restrepo MI, Deshane JS, Halade GV, Gonzalez-Juarbe N, Orihuela CJ.J Infect Dis. 2020 Jun 3. pii: jiaa295. doi: 10.1093/infdis/jiaa295. [Epub ahead of print] PMID: 32492702 [PubMed - as supplied by publisher]

    Human Nasal Epithelial Organoids for Therapeutic Development in Cystic Fibrosis. Liu Z, Anderson JD, Deng L, Mackay S, Bailey J, Kersh L, Rowe SM, Guimbellot JS. Genes (Basel). 2020 May 29;11(6). pii: E603. doi: 10.3390/genes11060603. PMID: 32485957 [PubMed - in process] Free Article

    Airway Remodeling in Asthma. Hough KP, Curtiss ML, Blain TJ, Liu RM, Trevor J, Deshane JS, Thannickal VJ. Front Med (Lausanne). 2020 May 21;7:191. doi: 10.3389/fmed.2020.00191. eCollection 2020. Review. PMID: 32509793 [PubMed] Free PMC Article

    Single-inhaler triple therapy fluticasone furoate/umeclidinium/vilanterol versus fluticasone furoate/vilanterol and umeclidinium/vilanterol in patients with COPD: results on cardiovascular safety from the IMPACT trial. Day NC, Kumar S, Criner G, Dransfield M, Halpin DMG, Han MK, Jones CE, Kaisermann MC, Kilbride S, Lange P, Lomas DA, Martin N, Martinez FJ, Singh D, Wise R, Lipson DA. Respir Res. 2020 Jun 5;21(1):139. doi: 10.1186/s12931-020-01398-w. PMID: 32503599 [PubMed - in process] Free PMC Article

    Increased flux through the mevalonate pathway mediates fibrotic repair without injury. Larson-Casey JL, Vaid M, Gu L, He C, Cai GQ, Ding Q, Davis D, Berryhill TF, Wilson LS, Barnes S, Neighbors JD, Hohl RJ, Zimmerman KA, Yoder BK, Longhini ALF, Hanumanthu VS, Surolia R, Antony VB, Carter AB. J Clin Invest. 2019 Nov 1;129(11):4962-4978. doi: 10.1172/JCI127959. PMID: 31609245 [PubMed - indexed for MEDLINE] Free PMC Article

    Combined Forced Expiratory Volume in 1 Second and Forced Vital Capacity Bronchodilator Response, Exacerbations, and Mortality in Chronic Obstructive Pulmonary Disease. Fortis S, Comellas A, Make BJ, Hersh CP, Bodduluri S, Georgopoulos D, Kim V, Criner GJ, Dransfield MT, Bhatt SP; COPDGene Investigators–Core Units: Administrative Center, COPDGene Investigators–Clinical Centers: Ann Arbor VA. Ann Am Thorac Soc. 2019 Jul;16(7):826-835. doi: 10.1513/AnnalsATS.201809-601OC. PMID: 30908927 [PubMed - indexed for MEDLINE]

    The Effect of ICS Withdrawal and Baseline Inhaled Treatment on Exacerbations in the IMPACT Study: A Randomized, Double-blind Multicenter Trial.
    Han MK, Criner GJ, Dransfield MT, Halpin DMG, Jones CE, Kilbride S, Lange P, Lettis S, Lipson DA, Lomas DA, Martin N, Wise RA, Singh D, Martinez FJ.
    Am J Respir Crit Care Med. 2020 Jun 25. doi: 10.1164/rccm.201912-2478OC. [Epub ahead of print] PMID: 32584168 [PubMed - as supplied by publisher]

    Elixir of Youth: Lipid Signaling Chaperones Synthesized in the Liver. Thannickal VJ. Dev Cell. 2020 Jun 22;53(6):625-626. doi: 10.1016/j.devcel.2020.06.001. PMID: 32574591 [PubMed - in process]

    Ozone and Particulate Matter Exposure and Alzheimer's Disease: A Review of Human and Animal Studies. Liu RM, Chong Z, Chen JC. J Alzheimers Dis. 2020 Jun 15. doi: 10.3233/JAD-200435. [Epub ahead of print] Review. PMID: 32568209 [PubMed - as supplied by publisher]

    Deep neural network analyses of spirometry for structural phenotyping of chronic obstructive pulmonary disease. Bodduluri S, Nakhmani A, Reinhardt JM, Wilson CG, McDonald MN, Rudraraju R, Jaeger BC, Bhakta NR, Castaldi PJ, Sciurba FC, Zhang C, Bangalore PV, Bhatt SP.JCI Insight. 2020 Jun 18. pii: 132781. doi: 10.1172/jci.insight.132781. [Epub ahead of print] PMID: 32554922

    Mechanical strain induces phenotypic changes in breast cancer cells and promotes immunosuppression in the tumor microenvironment. Wang Y, Goliwas KF, Severino PE, Hough KP, Van Vessem D, Wang H, Tousif S, Koomullil RP, Frost AR, Ponnazhagan S, Berry JL, Deshane JS. Lab Invest. 2020 Jun 22. doi: 10.1038/s41374-020-0452-1. Online ahead of print. PMID: 32572176

    Metabolomics to Predict Antiviral Drug Efficacy in COVID-19. Migaud M, Gandotra S, Chand HS, Gillespie MN, Thannickal VJ, Langley RJ. Am J Respir Cell Mol Biol. 2020 Jun 23. doi: 10.1165/rcmb.2020-0206LE. Online ahead of print. PMID: 32574504

    Single-Inhaler Triple Therapy and Health-Related Quality of Life in COPD: The IMPACT Study. Tabberer M, Jones CE, Kilbride S, Halpin DMG, Lomas DA, Pascoe S, Singh D, Wise RA, Criner GJ, Lange P, Dransfield MT, Han MK, Martinez FJ, Kaisermann MC, Lipson DA. Adv Ther. 2020 Jul 9. doi: 10.1007/s12325-020-01409-8. Online ahead of print. PMID: 32647911

    Clinical Effectiveness of Lumacaftor/Ivacaftor in Cystic Fibrosis Patients Homozygous for F508del-CFTR. Sagel SD, Khan U, Heltshe SL, Clancy JP, Borowitz D, Gelfond D, Donaldson SH, Moran A, Ratjen F, VanDalfsen JM, Rowe SM; PROSPECT Investigators of the Cystic Fibrosis Foundation Therapeutics Development Network. Ann Am Thorac Soc. 2020 Jul 9. doi: 10.1513/AnnalsATS.202002-144OC. Online ahead of print. PMID: 32644818

    The Effect of ICS Withdrawal and Baseline Inhaled Treatment on Exacerbations in the IMPACT Study: A Randomized, Double-blind Multicenter Trial. Han MK, Criner GJ, Dransfield MT, Halpin DMG, Jones CE, Kilbride S, Lange P, Lettis S, Lipson DA, Lomas DA, Martin N, Wise RA, Singh D, Martinez FJ. Am J Respir Crit Care Med. 2020 Jun 25. doi: 10.1164/rccm.201912-2478OC. Online ahead of print. PMID: 32584168

    Ivacaftor Reverses Airway Mucus Abnormalities in a Rat Model Harboring a Humanized G551D-CFTR. Birket SE, Davis JM, Fernandez-Petty CM, Henderson AG, Oden AM, Tang L, Wen H, Hong J, Fu L, Chambers A, Fields A, Zhao G, Tearney GJ, Sorscher EJ, Rowe SM. Am J Respir Crit Care Med. 2020 Jun 25. doi: 10.1164/rccm.202002-0369OC. Online ahead of print. PMID: 32584141

    Tezacaftor/ivacaftor in people with cystic fibrosis who stopped lumacaftor/ivacaftor due to respiratory adverse events. Schwarz C, Sutharsan S, Epaud R, Klingsberg RC, Fischer R, Rowe SM, Audhya PK, Ahluwalia N, You X, Ferro TJ, Duncan ME, Bruinsma BG. J Cyst Fibros. 2020 Jun 23:S1569-1993(20)30730-X. doi: 10.1016/j.jcf.2020.06.001. Online ahead of print. PMID: 32586736 Free article.

    Zheng Z, Nakamura K, Gershbaum S, Wang X, Thomas S, Bessler M, Schrope B, Krikhely A, Liu RM, Ozcan L, López JA, Tabas I. Interacting hepatic PAI-1/tPA gene regulatory pathways influence impaired fibrinolysis severity in obesity. J Clin Invest. 2020 Jul 13. pii: 135919. doi: 10.1172/JCI135919. [Epub ahead of print]

    Lavin KM, Ge Y, Sealfon SC, Nair VD, Wilk K, McAdam JS, Windham ST, Kumar PL, McDonald MN, Bamman MM. Rehabilitative Impact of Exercise Training on Human Skeletal Muscle Transcriptional Programs in Parkinson's Disease. Front Physiol. 2020 Jun 17;11:653. doi: 10.3389/fphys.2020.00653. eCollection 2020.

    New Clue: Prediction from Cell-Free DNA. Sanders YY. J Clin Med. 2020 Jul 21;9(7):E2307. doi: 10.3390/jcm9072307. PMID: 32708076

    Lung-Specific Risk Factors Associated With Incident Hip Fracture in Current and Former Smokers. Bon J, Nouraie SM, Smith KJ, Dransfield MT, McDonald ML, Hoffman EA, Newell JD Jr, Comellas AP, Saha PK, Bowler RP, Regan EA. J Bone Miner Res. 2020 Aug 4. doi: 10.1002/jbmr.4103. Online ahead of print.
    PMID: 32754944

    Am J Respir Crit Care Med. 2020 Aug 5.doi: 10.1164/rccm.202004-0951OC. Online ahead of print.CT-based Airway Surface Area to Volume Ratio for Phenotyping Airway Remodeling in Chronic Obstructive Pulmonary Disease. Sandeep Bodduluri, Abhilash Kizhakke Puliyakote, Arie Nakhmani, Jean-Paul Charbonnier, Joseph M Reinhardt, Surya P Bhatt. PMID: 32755486

    Clinical Effectiveness of Lumacaftor/Ivacaftor in Cystic Fibrosis Patients Homozygous for F508del-CFTR. Sagel SD, Khan U, Heltshe SL, Clancy JP, Borowitz D, Gelfond D, Donaldson SH, Moran A, Ratjen F, VanDalfsen JM, Rowe SM; PROSPECT Investigators of the Cystic Fibrosis Foundation Therapeutics Development Network. Ann Am Thorac Soc. 2020 Jul 9. doi: 10.1513/AnnalsATS.202002-144OC. Online ahead of print.PMID: 32644818

    Oxidative cross-linking of fibronectin confers protease resistance and inhibits cellular migration. Locy ML, Rangarajan S, Yang S, Johnson MR, Bernard K, Kurundkar A, Bone NB, Zmijewski JW, Byun J, Pennathur S, Zhou Y, Thannickal VJ. Sci Signal. 2020 Aug 11;13(644):eaau2803. doi: 10.1126/scisignal.aau2803. PMID: 32788339

    Extracellular Vesicles: Bidirectional Accelerators of Cellular Senescence in Fibrosis? Goliwas KF, Deshane JS. Am J Respir Cell Mol Biol. 2020 Aug 11. doi: 10.1165/rcmb.2020-0313ED. Online ahead of print. PMID: 32780980

    A novel tree shrew model of pulmonary fibrosis. Che P, Wang M, Larson-Casey JL, Hu RH, Cheng Y, El Hamdaoui M, Zhao XK, Grytz R, Brent Carter A, Ding Q. Lab Invest. 2020 Aug 9. doi: 10.1038/s41374-020-00476-3. Online ahead of print. PMID: 32773774

    The "Good" Home Death in Pulmonary Disease: Avoiding the "Bad" and the "Ugly". Iyer AS. Chest. 2020 Aug;158(2):449-450. doi: 10.1016/j.chest.2020.04.005. PMID: 32768060

    Understanding the andromeda strain - The role of cytokine release, coagulopathy and antithrombin III in SARS-CoV2 critical illness. Mir N, D'Amico A, Dasher J, Tolwani A, Valentine V. Blood Rev. 2020 Jul 3:100731. doi: 10.1016/j.blre.2020.100731. Online ahead of print. PMID: 32829961

    Fibroblast Growth Factor Receptor 4 Deficiency Mediates Airway Inflammation in the Adult Healthy Lung?
    Molly Easter, Jaleesa Garth, Elex S Harris, Ren-Jay Shei, Eric S Helton, Yuhua Wei, Rebecca Denson, Rennan Zaharias, Steven M Rowe, Patrick Geraghty, Christian Faul, Jarrod W Barnes, Stefanie Krick.
    Front Med (Lausanne). 2020 Jul 24;7:317. doi: 10.3389/fmed.2020.00317. eCollection 2020.

    July 2020
    Zheng Z., Nakamura, K., Gershbaum, D., Wang X., Thomas, S., Bessler, M., Schrope, B., Krikhely, A., Liu, RM., Ozcan, L., Lopez, J., Tabas, IA (2020). Interacting PAI-1 and tPA gene regulatory pathways in hepatocytes influence the degree of impaired fibrinolysis in obesity. JCI 130 (8):4348-4359. PMID: 32657780

    August 2020

    The Innate Lymphoid System Is a Critical Player in the Manifestation of Mucoinflammatory Airway Disease in Mice. Brandon W Lewis, Ishita Choudhary, Kshitiz Paudel, Yun Mao, Rahul Sharma, Yong Wang, Jessy S Deshane, Richard C Boucher, Sonika Patial, Yogesh Saini. J Immunol. 2020 Aug 17;ji2000530. doi: 10.4049/jimmunol.2000530. Online ahead of print.

    Haemophilus influenzae persists in biofilm communities in a smoke-exposed ferret model of COPD Benjamin C Hunt, Denise Stanford, Xin Xu, Jindong Li, Amit Gaggar, Steven M Rowe, S Vamsee Raju, W Edward Swords. ERJ Open Res. 2020 Aug 11;6(3):00200-2020. doi: 10.1183/23120541.00200-2020. eCollection 2020 Jul.

    Extracellular Vesicles as Mediators of Cellular Cross Talk in the Lung Microenvironment. Sabine Bartel, Jessy Deshane, Tom Wilkinson,Susanne Gabrielsson. Front Med (Lausanne) . 2020 Aug 4;7:326. doi: 10.3389/fmed.2020.00326. eCollection 2020.
    Novel Respiratory Disability Score Predicts COPD Exacerbations and Mortality in the SPIROMICS Cohort.

    Cooper CB, Paine R, Curtis JL, Kanner RE, Martinez CH, Meldrum CA, Bowler R, O'Neal W, Hoffman EA, Couper D, Quibrera M, Criner G, Dransfield MT, Han MK, Hansel NN, Krishnan JA, Lazarus SC, Peters SP, Barr RG, Martinez FJ, Woodruff PG; SPIROMICS investigators. Int J Chron Obstruct Pulmon Dis. 2020 Aug 4;15:1887-1898. doi: 10.2147/COPD.S250191. ECollection 2020. PMID: 32821092

    Comparative Analysis of Streptococcus pneumoniae Type I Restriction-Modification Loci: Variation in hsdS Gene Target Recognition Domains.  Oliver MB, Swords WE. Pathogens. 2020 Aug 29;9(9):E712. doi: 10.3390/pathogens9090712. PMID: 32872494

    A Novel Locus for Exertional Dyspnea in Childhood Asthma.  Lee S, Lasky-Su JA, Lange C, Kim W, Kumar PL, McDonald MN, Fragoso CAV, Laurie C, Raby BA, Celedón JC, Cho MH, Won S, Weiss ST, Hecker J. Eur Respir J. 2020 Aug 27:2001224. doi: 10.1183/13993003.01224-2020. Online ahead of print. PMID: 32855217

    September 2020

    Novel Respiratory Disability Score Predicts COPD Exacerbations and Mortality in the SPIROMICS Cohort. Cooper CB, Paine R, Curtis JL, Kanner RE, Martinez CH, Meldrum CA, Bowler R, O'Neal W, Hoffman EA, Couper D, Quibrera M, Criner G, Dransfield MT, Han MK, Hansel NN, Krishnan JA, Lazarus SC, Peters SP, Barr RG, Martinez FJ, Woodruff PG; SPIROMICS investigators. Int J Chron Obstruct Pulmon Dis. 2020 Aug 4;15:1887-1898. doi: 10.2147/COPD.S250191. ECollection 2020. PMID: 32821092

    Extracellular Vesicles as Mediators of Cellular Cross Talk in the Lung Microenvironment Sabine Bartel, Jessy Deshane, Tom Wilkinson,Susanne Gabrielsson.
    Front Med (Lausanne) . 2020 Aug 4;7:326. doi: 10.3389/fmed.2020.00326. eCollection 2020.

    Haemophilus influenzae persists in biofilm communities in a smoke-exposed ferret model of COPD Benjamin C Hunt, Denise Stanford, Xin Xu, Jindong Li, Amit Gaggar, Steven M Rowe, S Vamsee Raju, W Edward Swords. ERJ Open Res. 2020 Aug 11;6(3):00200-2020. doi: 10.1183/23120541.00200-2020. eCollection 2020 Jul.

    The Innate Lymphoid System Is a Critical Player in the Manifestation of Mucoinflammatory Airway Disease in Mice. Brandon W Lewis, Ishita Choudhary, Kshitiz Paudel, Yun Mao, Rahul Sharma, Yong Wang, Jessy S Deshane, Richard C Boucher, Sonika Patial, Yogesh Saini.. J Immunol. 2020 Aug 17;ji2000530. doi: 10.4049/jimmunol.2000530. Online ahead of print.

    A Novel Locus for Exertional Dyspnea in Childhood Asthma. Lee S, Lasky-Su JA, Lange C, Kim W, Kumar PL, McDonald MN, Fragoso CAV, Laurie C, Raby BA, Celedón JC, Cho MH, WonF S, Weiss ST, Hecker J. Eur Respir J. 2020 Aug 27:2001224. doi: 10.1183/13993003.01224-2020. Online ahead of print. PMID: 32855217

    Comparative Analysis of Streptococcus pneumoniae Type I Restriction-Modification Loci: Variation in hsdS Gene Target Recognition Domains.Oliver MB, Swords WE.Pathogens. 2020 Aug 29;9(9):E712. doi: 10.3390/pathogens9090712. PMID: 32872494

    Transparency and diversity in cystic fibrosis research - Authors' reply. McCoy KS, Heijerman H, Taylor-Cousar JL, Waltz D, Sosnay PR, Ramsey BW, Rowe S, Welter J. Lancet. 2020 Aug 29;396(10251):602. doi: 10.1016/S0140-6736(20)30897-7. PMID: 32861305.

    A Risk Prediction Model for Mortality Among Smokers in the COPDGene® Study. Strand M, Austin E, Moll M, Pratte KA, Regan EA, Hayden LP, Bhatt SP, Boriek AM, Casaburi R, Silverman EK, Fortis S, Ruczinski I, Koegler H, Rossiter HB, Occhipinti M, Hanania NA, Gebrekristos HT, Lynch DA, Kunisaki KM, Young KA, Sieren JC, Ragland M, Hokanson JE, Lutz SM, Make BJ, Kinney GL,Cho MH, Massimo Pistolesi M,DeMeo DL,Frank C Sciurba, Comellas AP, Diaz AA, Barjaktarevic I, Bowler RP, Kanner RE, Peters SP, Ortega VE, Dransfield MT, Crapo JD. Chronic Obstr Pulm Dis . 2020 Sep 2;7(4). doi: 10.15326/jcopdf.7.4.2020.0146. Online ahead of print

    Targeting Aging Pathways in Chronic Obstructive Pulmonary Disease. Easter M, Bollenbecker S, Barnes JW, Krick S. Int J Mol Sci. 2020 Sep 21;21(18):E6924. doi: 10.3390/ijms21186924. PMID: 32967225 Review.

    "A National Survey of Burnout and Depression Among Fellows Training in Pulmonary and Critical Care Medicine: A Special Report by the APCCMPD. Sharp M, Burkart KM, Adelman MH, Ashton RW, Biddison LD, Bosslet GT, Doyle ST, Eckmann T, Khurram S Khan MM, Lenz PH, McCallister JW, O'Toole J, Rand CS, Riekert KA, Soffler MI, Winter GR, Zaeh S, Eakin MN.  Chest. 2020 Sep 18:S0012-3692(20)34511-6. doi: 10.1016/j.chest.2020.08.2117. Online ahead of print. PMID: 32956717

    Protocol and statistical analysis plan for the PREventing cardiovascular collaPse with Administration of fluid REsuscitation during Induction and Intubation (PREPARE II) randomised clinical trial. Russell DW, Casey JD, Gibbs KW, Dargin JM, Vonderhaar DJ, Joffe AM, Ghamande S, Khan A, Dutta S, Landsperger JS, Robison SW, Bentov I, Wozniak JM, Stempek S, White HD, Krol OF, Prekker ME, Driver BE, Brewer JM, Wang L, Lindsell CJ, Self WH, Rice TW, Semler MW, Janz D; PREPARE II Investigators.  BMJ Open. 2020 Sep 18;10(9):e036671. doi: 10.1136/bmjopen-2019-036671. PMID: 32948554

    October 2020

    Contribution of Individual and Neighborhood Factors to Racial Disparities in Respiratory Outcomes.  Ejike CO, Woo H, Galiatsatos P, Paulin LM, Krishnan JA, Cooper CB, Couper DJ, Kanner RE, Bowler RP, Hoffman EA, Comellas AP, Criner GJ, Barr RG, Martinez FJ, Han MK, Martinez CH, Ortega VE, Parekh TM, Christenson SA, Thakur N, Baugh A, Belz DC, Raju S, Gassett AJ, Kaufman JD, Putcha N, Hansel NN. Am J Respir Crit Care Med. 2020 Oct 2. doi: 10.1164/rccm.202002-0253OC. Online ahead of print. PMID: 33007162

    Jiang, D., Cui, H., Xie, N., Banerjee, S., Liu, RM., Dai, H., Thannickal, VJ., Liu, G (2020). ATF4 Mediates Mitochondrial Unfolded Protein Response (UPRmt) in Alveolar Epithelial Cells. American Journal of Respiratory Cell and Molecular Biology 63(4):478-489. PMID: 32551949

    Tobacco smoke exposure limits the therapeutic benefit of tezacaftor/ivacaftor in pediatric patients with cystic fibrosis. Baker E, Harris WT, Rowe SM, Rutland SB, Oates GR. J Cyst Fibros. 2020 Oct 3:S1569-1993(20)30870-5. doi: 10.1016/j.jcf.2020.09.011. Online ahead of print. PMID: 33023836

    Effect of Age on the Efficacy and Safety of Once-Daily Single-Inhaler Triple Therapy Fluticasone Furoate/Umeclidinium/Vilanterol in Patients With Chronic Obstructive Pulmonary Disease: A Post Hoc Analysis of the IMPACT Trial. Hanania NA, Mannino DM, Criner GJ, Dransfield MT, Han MK, Jones CE, Kilbride S, Lomas DA, Martin N, Martinez FJ, Singh D, Wise RA, Halpin DMG, Lima R, Lipson DA. Chest. 2020 Oct 5:S0012-3692(20)34846-7. doi: 10.1016/j.chest.2020.09.253. Online ahead of print. PMID: 33031829

     
     

    A CT-based Automated Algorithm for Airway Segmentation using Freeze-and-Grow Propagation and Deep Learning. Syed Ahmed Nadeem, Eric A Hoffman, Jessica C Sieren, Alejandro P Comellas, Surya P Bhatt, Igor Z Barjaktarevic, Fereidoun Abtin, Punam K Saha. IEEE Trans Med Imaging. 2020 Oct 6;PP. doi: 10.1109/TMI.2020.3029013. Online ahead of print.

    A conserved aromatic moiety in the ectodomain is a key determinant for structural integrity and protein trafficking of TNFR superfamily. Wang H, Hyoung Lee J, Wang Y, Seo HS, Wang J, Deshane JS, Ponnazhagan S. FASEB J. 2020 Oct 13. doi: 10.1096/fj.202000341R. Epub ahead of print. PMID: 33047892.

    Noninvasive Ventilation in Seriously Ill Older Adults at the End of Life-The Evidence Remains Elusive. Iyer AS. JAMA Intern Med. 2020 Oct 19. doi: 10.1001/jamainternmed.2020.5648. Online ahead of print. PMID: 33074308 No abstract available.         

    Variation in Intensive Care Unit Intubation Practices in Pulmonary Critical Care Medicine Fellowship Anna K. Brady, Wade Brown, Joshua L. Denson, Gretchen Winter, Abesh Niroula, Lekshmi Santhosh, and W. Graham Carlos. ATS Scholar. Published October 21, 2020

    Neutrophilic inflammation during lung development disrupts elastin assembly and predisposes adult mice to COPD. Benjamin JT, Plosa E, Sucre J, van der Meer R, Dave S, Gutor SS, Nichols D, Gulleman P, Jetter C, Han W, Xin MK, Dinella PC, Catanzarite A, Kook S, Dolma K, Lal CV, Gaggar A, Blalock JE, Newcomb DC, Richmond BW, Kropski JA, Young LR, Guttentag S, Blackwell TS.  J Clin Invest. 2020 Oct 27:139481. doi: 10.1172/JCI139481. Online ahead of print. PMID: 33108351

    Efficacy and Safety of the CFTR Potentiator Icenticaftor (QBW251) in COPD: Results from a Phase 2 Randomized Trial.  Rowe SM, Jones I, Dransfield MT, Haque N, Gleason S, Hayes KA, Kulmatycki K, Yates DP, Danahay H, Gosling M, Rowlands DJ, Grant SS.  Int J Chron Obstruct Pulmon Dis. 2020 Oct 5;15:2399-2409. doi: 10.2147/COPD.S257474. eCollection 2020. PMID: 33116455

    Plasma Cathelicidin is Independently Associated with Reduced Lung Function in COPD: Analysis of the Subpopulations and Intermediate Outcome Measures in COPD Study Cohort. Burkes RM, Ceppe AS, Couper DJ, Comellas AP, Wells JM, Peters SP, Criner GJ, Kanner RE, Paine R 3rd, Christenson SA, Cooper CB, Barjaktarevic IZ, Krishnan JA, Labaki WW, Han MK, Curtis JL, Hansel NN, Wise RA, Drummond MB; SPIROMICS collaborators. Chronic Obstr Pulm Dis. 2020 Oct;7(4):370-381. doi: 10.15326/jcopdf.7.4.2020.0142. PMID: 33108110

    Defining Chronic Mucus Hypersecretion Using the CAT in the SPIROMICS Cohort. Marni Stott-Miller, Hana Müllerová , Bruce Miller, Maggie Tabberer , Céline El Baou, Tom Keeley, Fernando J Martinez, Meilan Han, Mark Dransfield, Nadia N Hansel, Christopher B Cooper, Prescott Woodruff, Victor E Ortega, Alejandro P Comellas, Robert Paine Iii, Richard E Kanner, Wayne Anderson, M Bradley Drummond, Victor Kim, Ruth Tal-Singer, Aili L Lazaar. Int J Chron Obstruct Pulmon Dis. 2020 Oct 13;15:2467-2476. doi: 10.2147/COPD.S267002. eCollection 2020. PMID: 33116455

  • 2019 Publications

    December 2019

    Iyer AS, Goodrich CA, Dransfield MT, Alam SS, Brown CJ, Landefeld CS, Bakitas MA, Brown JR. End-of-Life Spending and Healthcare Utilization Among Older Adults with Chronic Obstructive Pulmonary Disease. Am J Med. 2019 Dec 26;S0002-9343(19)31105-2. doi: 10.1016/j.amjmed.2019.11.024. [Epub ahead of print]. PMID: 31883772.

    Raju SV. What doesn't kill you makes you weaker. Am J Physiol Lung Cell Mol Physiol. 2019;317(6):L891–L892. doi:10.1152/ajplung.00432.2019

    November 2019

    Parekh TM, Bhatia S, Cherrington A, Kim YI, Lambert A, Iyer A, Regan EA, DeMeo DL, Han M, Dransfield MT.Respir Med. 2019 Nov 15;161:105820. doi: 10.1016/j.rmed.2019.105820.Factors influencing decline in quality of life in smokers without airflow obstruction: The COPDGene study.

    David C. LaFon, Surya P. Bhatt, Wassim W. Labaki, Farbod N. Rahaghi, Matthew Moll, Russ P. Bowler, Elizabeth A. Regan, Barry J. Make, James D. Crapo, Raul San Jose Estepar, Alejandro A. Diaz, Edwin K. Silverman, MeiLan K. Han, Brian Hobbs, Michael H. Cho, George R. Washko, Mark T. Dransfield, J. Michael Wells for the COPDGene Investigators. European Respiratory Journal 2019; DOI: 10.1183/13993003.01812-2019. Pulmonary artery enlargement and mortality risk in moderate to severe COPD: results from COPDGene

    Wells JM, Xing D, Viera L, Burkes RM, Wu Y, Bhatt SP, Dransfield MT, Couper DJ, O'Neal W, Hoffman EA, Gaggar A, Barjaktarevic I, Curtis JL, Labaki WW, Han MLK, Freeman CM, Putcha N, Schlange T, Blalock JE; SPIROMICS Investigators,. The matrikine acetyl-proline-glycine-proline and clinical features of COPD: findings from SPIROMICS. Respir Res. 2019 Nov 12;20(1):254. doi: 10.1186/s12931-019-1230-8. PMID: 31718676; PMCID: PMC6852714.

    Middleton PG, Mall MA, Dřevínek P, Lands LC, McKone EF, Polineni D, Ramsey BW, Taylor-Cousar JL, Tullis E, Vermeulen F, Marigowda G, McKee CM, Moskowitz SM, Nair N, Savage J, Simard C, Tian S, Waltz D, Xuan F, Rowe SM, Jain R; VX17-445-102 Study Group. Elexacaftor-Tezacaftor-Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele. N Engl J Med. 2019 Nov 7;381(19):1809-1819. doi: 10.1056/NEJMoa1908639. Epub 2019 Oct 31. PMID: 31697873.

    Wells JM, Xing D, Viera L, Burkes RM, Wu Y, Bhatt SP, Dransfield MT, Couper DJ, O'Neal W, Hoffman EA, Gaggar A, Barjaktarevic I, Curtis JL, Labaki WW, Han MLK, Freeman CM, Putcha N, Schlange T, Blalock JE; SPIROMICS Investigators,. Respir Res. 2019 Nov 12;20(1):254. doi: 10.1186/s12931-019-1230-8. The matrikine acetyl-proline-glycine-proline and clinical features of COPD: findings from SPIROMICS.

    Middleton PG, Mall MA, Dřevínek P, Lands LC, McKone EF1, Polineni D, Ramsey BW, Taylor-Cousar JL, Tullis E, Vermeulen F, Marigowda G, McKee CM, Moskowitz SM, Nair N, Savage J, Simard C, Tian S, Waltz D, Xuan F, Rowe SM, Jain R; VX17-445-102 Study Group.N Engl J Med. 2019 Nov 7;381(19):1809-1819. doi: 10.1056/NEJMoa1908639. Elexacaftor-Tezacaftor-Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele.

    Heijerman HGM, McKone EF, Downey DG, Van Braeckel E, Rowe SM, Tullis E, Mall MA, Welter JJ, Ramsey BW, McKee CM, Marigowda G, Moskowitz SM, Waltz D, Sosnay PR, Simard C, Ahluwalia N, Xuan F, Zhang Y, Taylor-Cousar JL, McCoy KS; VX17-445-103 Trial Group. Lancet. pii: S0140-6736(19)32597-8. doi: 10.1016/S0140-6736(19)32597-8. [Epub ahead of print] Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial.

    Lin VY, Kaza N, Birket SE, Kim H, Edwards LJ, LaFontaine J, Liu L, Mazur M, Byzek SA, Hanes J, Tearney GJ, Raju SV, Rowe SM.Eur Respir J. . pii: 1900419. doi: 10.1183/13993003.00419-2019. [Epub ahead of print]Excess mucus viscosity and airway dehydration impact COPD airway clearance.

    Sharifov OF, Denney TS Jr, Wells JM, Payne GA, Gulati S, Gupta H, Dransfield MT, Lloyd SG. Int J Chron Obstruct Pulmon Dis. 2019 Dec 2;14:2753-2757. doi: 10.2147/COPD.S220868. eCollection 2019. Velocity Transfer Function In The Right Pulmonary Artery And Impaired Cardiopulmonary Reserve In COPD.

    Larson-Casey JL, Vaid M, Gu L, He C, Cai GQ, Ding Q, Davis D, Berryhill TF, Wilson LS, Barnes S, Neighbors JD, Hohl RJ, Zimmerman KA, Yoder BK, Longhini ALF, Hanumanthu VS, Surolia R, Antony VB, Carter AB J Clin Invest. 2019 Nov 1;129(11):4962-4978. doi: 10.1172/JCI127959. Increased flux through the mevalonate pathway mediates fibrotic repair without injury.

    Lowe KE, Regan EA, Anzueto A, Austin E, Austin JHM, Beaty TH, Benos PV, Benway CJ, Bhatt SP, Bleecker ER, Bodduluri S, Bon J, Boriek AM, Boueiz AR, Bowler RP, Budoff M, Casaburi R, Castaldi PJ, Charbonnier JP, Cho MH, Comellas A, Conrad D, Costa Davis C, Criner GJ, Curran-Everett D, Curtis JL, DeMeo DL, Diaz AA, Dransfield MT, Dy JG, Fawzy A, Fleming M, Flenaugh EL, Foreman MG, Fortis S, Gebrekristos H, Grant S, Grenier PA, Gu T, Gupta A, Han MK, Hanania NA, Hansel NN, Hayden LP, Hersh CP, Hobbs BD, Hoffman EA, Hogg JC, Hokanson JE, Hoth KF, Hsiao A, Humphries S, Jacobs K, Jacobson FL, Kazerooni EA, Kim V, Kim WJ, Kinney GL, Koegler H, Lutz SM, Lynch DA, MacIntye NR Jr, Make BJ, Marchetti N, Martinez FJ, Maselli DJ, Mathews AM, McCormack MC, McDonald MN, McEvoy CE, Moll M, Molye SS, Murray S, Nath H, Newell JD Jr, Occhipinti M, Paoletti M, Parekh T, Pistolesi M, Pratte KA, Putcha N, Ragland M, Reinhardt JM, Rennard SI, Rosiello RA, Ross JC, Rossiter HB, Ruczinski I, San Jose Estepar R, Sciurba FC, Sieren JC, Singh H, Soler X, Steiner RM, Strand MJ, Stringer WW, Tal-Singer R, Thomashow B, Vegas Sánchez-Ferrero G, Walsh JW, Wan ES, Washko GR, Michael Wells J, Wendt CH, Westney G, Wilson A, Wise RA, Yen A, Young K, Yun J, Silverman EK, Crapo JD.COPDGene® 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease. Chronic Obstr Pulm Dis. 2019 Nov;6(5):384-399. doi: 10.15326/jcopdf.6.5.2019.0149.

    October 2019

    Dransfield MT, Voelker H, Bhatt SP, Brenner K, Casaburi R, Come CE, Cooper JAD, Criner GJ, Curtis JL, Han MK, Hatipoğlu U, Helgeson ES, Jain VV, Kalhan R, Kaminsky D1, Kaner R, Kunisaki KM, Lambert AA, Lammi MR, Lindberg S, Make BJ, Martinez FJ, McEvoy C, Panos RJ, Reed RM, Scanlon PD, Sciurba FC, Smith A, Sriram PS, Stringer WW, Weingarten JA, Wells JM, Westfall E, Lazarus SC, Connett JE; BLOCK COPD Trial Group. N Engl J Med. 2019 Oct 20. doi: 10.1056/NEJMoa1908142. Metoprolol for the Prevention of Acute Exacerbations of COPD.

    Oelsner EC, Balte PP, Bhatt SP, Cassano PA, Couper D, Folsom AR, Freedman ND, Jacobs DR Jr, Kalhan R, Mathew AR, Kronmal RA, Loehr LR, London SJ, Newman AB, O'Connor GT, Schwartz JE, Smith LJ, White WB, Yende S.Lancet Respir Med. 2019 Oct 9. pii: S2213-2600(19)30276-0. doi: 10.1016/S2213-2600(19)30276-0. [Epub ahead of print]Lung function decline in former smokers and low-intensity current smokers: a secondary data analysis of the NHLBI Pooled Cohorts Study.

    Kulkarni T, Yuan K, Tran-Nguyen TK, Kim YI, de Andrade JA, Luckhardt T, Valentine VG, Kass DJ, Duncan SR.PLoS One. 2019 Oct 4;14(10):e0221905. doi: 10.1371/journal.pone.0221905. eCollection 2019.Decrements of body mass index are associated with poor outcomes of idiopathic pulmonary fibrosis patients.

    Hodges AL, Konicki AJ, Talley MH, Bordelon CJ, Holland AC, Galin FS.J Am Assoc Nurse Pract. 2019 Oct 3. doi: 10.1097/JXX.0000000000000327. [Epub ahead of print]Competency-based education in transitioning nurse practitioner students from education into practice.

    Janz DR, Casey JD, Semler MW, Russell DW, Dargin J, Vonderhaar DJ, Dischert KM, West JR, Stempek S, Wozniak J, Caputo N, Heideman BE, Zouk AN, Gulati S, Stigler WS, Bentov I, Joffe AM, Rice TW; PrePARE Investigators; Pragmatic Critical Care Research Group.Effect of a fluid bolus on cardiovascular collapse among critically ill adults undergoing tracheal intubation (PrePARE): a randomised controlled trial. Lancet Respir Med. 2019 Oct 1. pii: S2213-2600(19)30246-2. doi: 10.1016/S2213-2600(19)30246-2. [Epub ahead of print]

    September 2019

    Bell SC, Mall MA, Gutierrez H, Macek M, Madge S, Davies JC, Burgel PR, Tullis E, Castaños C, Castellani C, Byrnes CA, Cathcart F, Chotirmall SH, Cosgriff R, Eichler I, Fajac I, Goss CH, Drevinek P, Farrell PM, Gravelle AM, Havermans T, Mayer-Hamblett N, Kashirskaya N, Kerem E, Mathew JL, McKone EF, Naehrlich L, Nasr SZ, Oates GR, O'Neill C, Pypops U, Raraigh KS, Rowe SM, Southern KW, Sivam S, Stephenson AL, Zampoli M, Ratjen F.Lancet Respir Med. 2019 Sep 27. pii: S2213-2600(19)30337-6. doi: 10.1016/S2213-2600(19)30337-6. [Epub ahead of print]The future of cystic fibrosis care: a global perspective.

    Rana T, Jiang C, Liu G, Miyata T, Antony V, Thannickal VJ, Liu RM.Am J Respir Cell Mol Biol. 2019 Sep 12. doi: 10.1165/rcmb.2019-0071OC. [Epub ahead of print]PAI-1 Regulation of TGF-β1-induced ATII Cell Senescence, SASP Secretion, and SASP-mediated Activation of Alveolar Macrophages.

    Hartley B, Criner GJ, Dransfield MT, Halpin DMG, Han MK, Jones CE, Kilbride S, Lange P, Lipson DA, Lomas DA12, Martin N, Martinez FJ, Singh D, Wise RA, Lettis S.Eur Respir J. 2019 Sep 5;54(3). pii: 1900634. doi: 10.1183/13993003.00634-2019. Print 2019 Sep. Misinterpretation of time-to-first event curves can lead to inappropriate treatment.

    Oates GR, Niranjan SJ, Ott C, Scarinci IC, Schumann C, Parekh T, Dransfield MT.J Cardiopulm Rehabil Prev. 2019 Sep;39(5):344-349. doi: 10.1097/HCR.0000000000000436.Adherence to Pulmonary Rehabilitation in COPD: A QUALITATIVE EXPLORATION OF PATIENT PERSPECTIVES ON BARRIERS AND FACILITATORS.

    Gu L, Larson Casey JL, Andrabi SA, Lee JH, Meza-Perez S, Randall TD, Carter AB.Redox Biol. 2019 Sep;26:101307. doi: 10.1016/j.redox.2019.101307. Mitochondrial calcium uniporter regulates PGC-1α expression to mediate metabolic reprogramming in pulmonary fibrosis.

    August 2019

    Bhatt SP. Ann Am Thorac Soc. 2019 Aug;16(8):975-977. doi: 10.1513/AnnalsATS.201903-231ED.Imaging Small Airway Disease: Probabilities and Possibilities.

    Maselli DJ, Bhatt SP, Anzueto A, Bowler RP, DeMeo DL, Diaz AA, Dransfield MT, Fawzy A, Foreman MG, Hanania NA, Hersh CP, Kim V, Kinney GL, Putcha N, Wan ES, Wells JM, Westney GE, Young KA, Silverman EK, Han MK, Make BJ. Chest. 2019 Aug;156(2):228-238. doi: 10.1016/j.chest.2019.04.135. Clinical Epidemiology of COPD: Insights From 10 Years of the COPDGene Study.

    He C, Larson-Casey JL, Davis D, Hanumanthu VS, Longhini ALF, Thannickal VJ, Gu L, Carter AB. JCI Insight. 2019 Aug 22;4(16). pii: 126551. doi: 10.1172/jci.insight.126551.NOX4 modulates macrophage phenotype and mitochondrial biogenesis in asbestosis.

    Mkorombindo T, Dransfield MT. Respirology. 2019 Aug 21. doi: 10.1111/resp.13683. [Epub ahead of print]COPD exacerbations and MACE: More than a chance encounter?

    McCormick JP, Weeks CG, Rivers NJ, Owen JD, Kelly DR, Rowe SM, Solomon GM, Woodworth BA, Cho DY. Int Forum Allergy Rhinol. 2019 Aug 20. doi: 10.1002/alr.22414. [Epub ahead of print]Prevalence of chronic rhinosinusitis in bronchiectasis patients suspected of ciliary dyskinesia.

    Bhatt SP, Dransfield MT.Am J Respir Crit Care Med. 2019 Aug 6. doi: 10.1164/rccm.201907-1486LE. [Epub ahead of print]Reply to: Video Telehealth and Pulmonary Rehabilitation: Need for a Better Understanding.

    Mkorombindo T, Dransfield M. Lancet Respir Med. 2019 Aug;7(8):647-648. doi: 10.1016/S2213-2600(19)30179-1. Epub 2019 May 20.Eosinophil-guided treatment of COPD exacerbations: unfinished business.

    July 2019

    Xing D, Wells JM, Giordano SS, Feng W, Gaggar A, Yan J, Hage FG, Li L, Chen YF, Oparil S. J Appl Physiol (1985). 2019 Aug 1;127(2):444-456. doi: 10.1152/japplphysiol.00587.2018. Induced pluripotent stem cell-derived endothelial cells attenuate lipopolysaccharide-induced acute lung injury.

    Washko GR, Colangelo LA, Estépar RSJ, Ash SY, Bhatt SP, Okajima Y, Liu K, Jacobs, Iribarren C, Thyagarajan BT, Lewis CE, Kumar R, Han MK, Dransfield MT, Carnethon, Kalhan R.Am J Med. 2019 Jul 29. pii: S0002-9343(19)30600-X. doi: 10.1016/j.amjmed.2019.06.049. [Epub ahead of print]Adult Life-Course Trajectories of Lung Function and the Development of Emphysema: The CARDIA Lung Study.

    Bhatt SP, Dransfield MT.Am J Respir Crit Care Med. 2019 Jul 25. doi: 10.1164/rccm.201907-1287LE. [Epub ahead of print]Reply to: Not all Home-Based Exercise Programs are Home-Based Pulmonary Rehabilitation Programs.

    Lyu X, Hu M, Peng J, Zhang X, Sanders YY.Ther Adv Chronic Dis. 2019 Jul 18;10:2040622319862697. doi: 10.1177/2040622319862697. eCollection 2019.HDAC inhibitors as antifibrotic drugs in cardiac and pulmonary fibrosis.

    Rusanov V, Fridman V, Wille K, Kramer MR.Transplant Proc. 2019 Jul - Aug;51(6):2029-2034. doi: 10.1016/j.transproceed.2019.04.036. Lung Transplantation for Cystic Fibrosis and Non-cystic Fibrosis Bronchiectasis: A Single-Center Experience.

    Johns JD, Rowe SM.BMC Gastroenterol. 2019 Jul 11;19(1):123. doi: 10.1186/s12876-019-1044-7.The effect of CFTR modulators on a cystic fibrosis patient presenting with recurrent pancreatitis in the absence of respiratory symptoms: a case report.

    June 2019 Patel NM, Kulkarni T, Dilling D, Scholand MB; Interstitial and Diffuse Lung Disease Network Steering Committee.Chest. 2019 Jun 29. pii: S0012-3692(19)31240-1. doi: 10.1016/j.chest.2019.05.028. [Epub ahead of print]Preoperative Evaluation of Patients With Interstitial Lung Disease.

    Bhatt SP, Balte PP, Schwartz JE, Cassano PA, Couper D, Jacobs DR Jr, Kalhan R, O'Connor GT, Yende S, Sanders JL, Umans JG, Dransfield MT, Chaves PH, White WB, Oelsner EC.JAMA. 2019 Jun 25;321(24):2438-2447. doi: 10.1001/jama.2019.7233.Discriminative Accuracy of FEV1:FVC Thresholds for COPD-Related Hospitalization and Mortality.

    Rangarajan S, Thannickal VJ.Am J Respir Crit Care Med. 2019 Jun 17. doi: 10.1164/rccm.201906-1101ED. [Epub ahead of print] Remember Me? The Bone Marrow in Pulmonary Fibrosis.

    Barnes J, Krick S.Ann Am Thorac Soc. 2019 Jun;16(6):674-675. doi: 10.1513/AnnalsATS.201901-095ED.How to Detect Tobacco-related Vasculopathy: Are We There Yet?

    Bernard K, Thannickal VJ.Methods Mol Biol. 07 Jun 2019;1982:487-496. doi: 10.1007/978-1-4939-9424-3_29. NADPH Oxidases and Aging Models of Lung Fibrosis.

    May 2019

    McDonald MN, Wouters EFM, Rutten E, Casaburi R, Rennard SI, Lomas DA, Bamman M, Celli B, Agusti A, Tal-Singer R, Hersh CP, Dransfield M, Silverman EK.Respir Res. 2019 May 22;20(1):100. doi: 10.1186/s12931-019-1073-3.It's more than low BMI: prevalence of cachexia and associated mortality in COPD.

    Chanda D, Thannickal VJ.Am J Respir Cell Mol Biol. 2019 May 15. doi: 10.1165/rcmb.2019-0153ED. [Epub ahead of print]Modeling Fibrosis in 3D Organoids Reveals New Epithelial Restraints on Fibroblasts.

    Parekh TM, Wu C, McClure LA, Howard VJ, Cushman M, Malek AM, Harrington KF, Cherrington AL, Dransfield MT, Bhatia S. BMJ Open. 2019 May 10;9(5):e027175. doi: 10.1136/bmjopen-2018-027175.Determinants of cigarette smoking status in a national cohort of black and white adult ever smokers in the USA: a cross-sectional analysis of the REGARDS study.

    Gulati S, Wells JM, Urdaneta GP, Balestrini K, Vital I, Tovar K, Barnes JW, Bhatt SP, Campos M, Krick S.Int J Mol Sci. 2019 May 9;20(9). pii: E2292. doi: 10.3390/ijms20092292.Fibroblast Growth Factor 23 is Associated with a Frequent Exacerbator Phenotype in COPD: A Cross-Sectional Pilot Study.

    Towards eradication of chronic obstructive pulmonary disease: a Lancet Commission. Lancet. 2019 May 4;393(10183):1786-1788. doi: 10.1016/S0140-6736(19)30950-X.

    April 2019

    Surolia R, Li FJ, Wang Z, Li H, Dsouza K, Thomas V, Mirov S, Perez-Sala D, Athar M, Thannickal V, Antony V.Vimentin intermediate filament assembly regulates fibroblast invasion in fibrogenic lung injury. JCI Insight. 2019;4(7):e123253. https://doi.org/10.1172/jci.insight.123253.

    Yuan T, Volckaert T, Hopkins S, Klinkhammer K, Yuan J, Thannickal VJ, De Langhe SP. FGF10-FGFR2B Signaling Generates Basal Cells and Drives Alveolar Epithelial Regeneration by Bronchial Epithelial Stem Cells after Lung Injury. Stem Cell Reports. 2019 Apr 16. pii: S2213-6711(19)30125-0. doi: 10.1016/j.stemcr.2019.04.003. [Epub ahead of print]

    Sgalla G, Kulkarni T, Antin-Ozerkis D, Thannickal VJ, Richeldi L. Update in Pulmonary Fibrosis 2018. Am J Respir Crit Care Med. 2019 Apr 24. https://doi.org/10.1164/rccm.201903-0542UP

    Bhatt SP, Patel SB, Anderson EM, Baugh D, Givens T, Schumann C, Sanders JG, Windham ST, Cutter GR, Dransfield MT. Video Telehealth Pulmonary Rehabilitation Intervention In COPD Reduces 30-day Readmissions.Am J Respir Crit Care Med. 2019 Apr 12. doi: 10.1164/rccm.201902-0314LE. [Epub ahead of print]

    Yan Z, Yang W, Parkitny L, Gibson SA, Lee KS, Collins F, Deshane JS, Cheng W, Weinmann AS, Wei H, Qin H, Benveniste EN. Deficiency of Socs3 leads to brain-targeted EAE via enhanced neutrophil activation and ROS production. JCI Insight. 2019 Apr 2;5. pii: 126520. doi: 10.1172/jci.insight.126520.

    March 2019

    Hough KP, Deshane JS. Exosomes in Allergic Airway Diseases. Curr Allergy Asthma Rep. 2019 Mar 22;19(5):26. doi: 10.1007/s11882-019-0857-3.

    Iyer AS, Holm KE, Bhatt SP, Kim V, Kinney GL, Wamboldt FS, Jacobs MR, Regan EA, Armstrong HF, Lowe KE, Martinez CH, Dransfield MT, Foreman MG, Shinozaki G, Hanania NA, Wise RA, Make BJ, Hoth KF; COPDGene Investigators.Symptoms of anxiety and depression and use of anxiolytic-hypnotics and antidepressants in current and former smokers with and without COPD - A cross sectional analysis of the COPDGene cohort. J Psychosom Res. 2019 Mar;118:18-26. doi: 10.1016/j.jpsychores.2019.01.002. Epub 2019 Jan 7.

    February 2019

    Vestbo J, Dransfield M, Anderson JA, Brook RD, Calverley PMA, Celli BR, Cowans NJ, Crim C, Martinez F, Newby DE, Yates J, Lange P. Impact of pre-enrolment medication use on clinical outcomes in SUMMIT. ERJ Open Res. 2019 Feb 25;5(1). pii: 00203-2018. doi: 10.1183/23120541.00203-2018. eCollection 2019 Feb.

    Press VG, Au DH, Bourbeau J, Dransfield MT, Gershon AS, Krishnan JA, Mularski RA, Sciurba FC, Sullivan J, Feemster LC. Reducing Chronic Obstructive Pulmonary Disease Hospital Readmissions. An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc. 2019 Feb;16(2):161-170. doi: 10.1513/AnnalsATS.201811-755WS.

    Ejike CO, Dransfield MT, Hansel NN, Putcha N, Raju S, Martinez CH, Han MK. Chronic Obstructive Pulmonary Disease in America's Black Population. Am J Respir Crit Care Med. 2019 Feb 21. doi: 10.1164/rccm.201810-1909PP. [Epub ahead of print]

    Casey JD, Janz DR, Russell DW, Vonderhaar DJ, Joffe AM, Dischert KM, Brown RM, Zouk AN, Gulati S, Heideman BE, Lester MG, Toporek AH, Bentov I, Self WH, Rice TW, Semler MW; PreVent Investigators and the Pragmatic Critical Care Research Group.Bag-Mask Ventilation during Tracheal Intubation of Critically Ill Adults. N Engl J Med. 2019 Feb 18. doi: 10.1056/NEJMoa1812405. [Epub ahead of print]

    Wells AU, Brown KK, Flaherty KR, Kolb M, Thannickal VJ; IPF Consensus Working Group;Idiopathic interstitial pneumonia or idiopathic interstitial pneumonitis: what's in a name? Eur Respir J. 2019 Feb 14;53(2). pii: 1801939. doi: 10.1183/13993003.01939-2018. Print 2019 Feb.

    Washko GR, Nardelli P, Ash SY, Vegas Sanchez-Ferrero G, Rahaghi FN, Come CE, Dransfield MT, Kalhan R, Han MK, Bhatt S, Wells JM, Aaron CP, Diaz AA, Ross JC, Cuttica MJ, Labaki WW, Querejeta Roca G, Shah AM, Young K, Kinney GL, Hokanson JE, Agusti A, San José Estépar R; COPDGene Investigators.Arterial Vascular Pruning, Right Ventricular Size and Clinical Outcomes in COPD. Am J Respir Crit Care Med. 2019 Feb 13. doi: 10.1164/rccm.201811-2063OC. [Epub ahead of print]

    January 2019

    Criner RN, Labaki WW, Regan EA, Bon JM, Soler X, Bhatt SP, Murray S, Hokanson JE, Silverman EK, Crapo JD, Curtis JL, Martinez FJ, Make BJ, Han MK, Martinez CH; COPDGene® Investigators. Mortality and Exacerbations by Global Initiative for Chronic Obstructive Lung Disease Groups ABCD: 2011 Versus 2017 in the COPDGene® Cohort. Chronic Obstr Pulm Dis. 2019 Jan 10;6(1):64-73. doi: 10.15326/jcopdf.6.1.2018.0130.

    Bhatt, SP. It’s Time to Rehabilitate Pulmonary Rehabilitation. Annals of the American Thoracic Society. Vol. 16, No. 1 | Jan 01, 2019 https://doi.org/10.1513/AnnalsATS.201809-641ED PubMed: 30592449

    Genschmer KR, Russell DW, Lal C, Szul T, Bratcher PE, Noerager BD, Roda MA, Xu X, Rezonzew G, Viera L, Dobosh BS, Margaroli C, Abdalla TH, King RW, McNicholas CM, Wells JM, Dransfield MT, Tirouvanziam R, Gaggar A, Blalock JE. Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung. Cell. Volume 176, ISSUE 1, P113-126.e15, 2019 Jan 10.

    Kurundkar D, Kurundkar AR, Bone NB, Becker EJ, Jr., Liu W, Chacko B, Darley-Usmar V, Zmijewski JW, Thannickal VJ. SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury. JCI Insight. 2019 Jan 10.

  • 2018 Publications

    March 2019

    Anand S.Iyer, Kristen E.Holm, Surya P.Bhatt, Victor Kim, Gregory L.Kinney, Frederick S.Wamboldt, Michael R.Jacobs, Elizabeth A.Regan, Hilary F.Armstrong, Katherine E.Lowe, Carlos H.Martinez, Mark T.Dransfield, Marilyn G.Foreman, Gen Shinozaki, Nicola A.Hanania, Robert A.Wise, Barry J.Make, Karin F.Hoth. Symptoms of anxiety and depression and use of anxiolytic-hypnotics and antidepressants in current and former smokers with and without COPD - A cross sectional analysis of the COPDGene cohort. Journal of Psychosomatic Research Volume 118, Pages 18-26

    February 2019

    Jonathan D. Casey, M.D., David R. Janz, M.D., Derek W. Russell, M.D., Derek J. Vonderhaar, M.D., Aaron M. Joffe, D.O., Kevin M. Dischert, M.D., Ryan M. Brown, M.D., Aline N. Zouk, M.D., Swati Gulati, M.B., B.S., Brent E. Heideman, M.D., Michael G. Lester, M.D., Alexandra H. Toporek, M.D., Itay Bentov, M.D., Ph.D., Wesley H. Self, M.D., Todd W. Rice, M.D., and Matthew W. Semler, M.D. for the PreVent Investigators and the Pragmatic Critical Care Research Group. Bag-Mask Ventilation during Tracheal Intubation of Critically Ill Adults. February 18, 2019. DOI: 10.1056/NEJMoa1812405. https://www.nejm.org/doi/full/10.1056/NEJMoa1812405?query=featured_home

    January 2019

    J Michael Wells, Douglas A Arenberg, Igor Barjaktarevic, Surya P Bhatt, Russell P Bowler, Stephanie A Christenson, David J Couper, Mark T Dransfield, MeiLan K Han, Eric A. Hoffman, Robert J Kaner, Victor Kim, Eric Kleerup, Fernando J. Martinez, Wendy C Moore, Sarah L O'Beirne, Robert Paine III, Nirupama Putcha; Sanjeev M Raman, R. Graham Barr, Stephen I Rennard, Prescott G Woodruff, and Jeffrey L Curtis. Safety and Tolerability of Comprehensive Research Bronchoscopy in COPD: Results from the SPIROMICS Bronchoscopy Sub-Study. https://doi.org/10.1513/AnnalsATS.201807-441OC. PubMed: 30653926. Received: July 01, 2018. Accepted: January 16, 2019. Published Online: January 17, 2019.

    Bhatt, SP. It’s Time to Rehabilitate Pulmonary Rehabilitation. Annals of the American Thoracic Society. Vol. 16, No. 1 | Jan 01, 2019 https://doi.org/10.1513/AnnalsATS.201809-641ED PubMed: 30592449

    Genschmer KR, Russell DW, Lal C, Szul T, Bratcher PE, Noerager BD, Roda MA, Xu X, Rezonzew G, Viera L, Dobosh BS, Margaroli C, Abdalla TH, King RW, McNicholas CM, Wells JM, Dransfield MT, Tirouvanziam R, Gaggar A, Blalock JE. Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung. Cell. Volume 176, ISSUE 1, P113-126.e15, 2019 Jan 10.

    Kurundkar D, Kurundkar AR, Bone NB, Becker EJ, Jr., Liu W, Chacko B, Darley-Usmar V, Zmijewski JW, Thannickal VJ. SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury. JCI Insight. 2019 Jan 10.

    November 2018

    J. Michael Wells, Margaret M. Parker, Robert A. Oster, Russ P. Bowler, Mark T. Dransfield, Surya P. Bhatt, Michael H. Cho, Victor Kim, Jeffrey L. Curtis, Fernando J. Martinez, Robert Paine III, Wanda O’Neal, Wassim W. Labaki, Robert J. Kaner, Igor Barjaktarevic, MeiLan K. Han, Edwin K. Silverman, James D. Crapo, R. Graham Barr, Prescott Woodruff, Peter J. Castaldi, Amit Gaggar, and the SPIROMICS and COPDGene Investigators. Elevated circulating MMP-9 is linked to increased COPD exacerbation risk in SPIROMICS and COPDGene. JCI Insight.

    October 2018

    Davies JC, Moskowitz SM, Brown C, Horsley A, Mall MA, McKone EF, Plant BJ, Prais D, Ramsey BW, Taylor-Cousar JL, Tullis E, Uluer A, McKee CM, Robertson S, Shilling RA, Simard C, Van Goor F, Waltz D, Xuan F, Young T, Rowe SM; VX16-659-101 Study Group. VX-659-Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles.

    September 2018

    Sandeep Bodduluri, Abhilash S. Kizhakke Puliyakote, Sarah E. Gerard, Joseph M. Reinhardt, Eric A. Hoffman, John D. Newell Jr., Hrudaya P. Nath, MeiLan K. Han, George R. Washko, Raúl San José Estépar, Mark T. Dransfield, Surya P. Bhatt, and COPDGene Investigators. Airway fractal dimension predicts respiratory morbidity and mortality in COPD. The Journal of Clinical Investigation. September 26, 2018.

    Matthew AR, Bhatt SP, Colangelo LA, Allen NB, Jacobs DR Jr, Auer R, Dransfield MT, Hitsman B, Washko GR, Kalhan R.Life-course Smoking Trajectories and Risk of Emphysema in Middle Age: The CARDIA Lung Study. Am J Respir Crit Care Med. 2018 Sep 14. doi: 10.1164/rccm.201808-1568LE. [Epub ahead of print]

    Bodduluri S, Kizhakke Puliyakote AS, Gerard SE, Reinhardt JM, Hoffman EA, Newell JD Jr, Nath HP, Han MK, Washko GR, San José Estépar R, Dransfield MT, Bhatt SP. Airway Fractal Dimension Predicts Respiratory Morbidity and Mortality in COPD.J Clin Invest. 2018 Sep 17. pii: 120693. doi: 10.1172/JCI120693. [Epub ahead of print]

    July 2018

    Gulati S, Zouk AN, Kalehoff JP, Wren CS, Davison PN, Kirkpatrick DP, Bhatt SP, Dransfield MT, Wells JM. The use of a standardized order set reduces systemic corticosteroid dose and length of stay for individuals hospitalized with acute exacerbations of COPD: a cohort study. 27 July 2018 Volume 2018:13 Pages 2271—2278

    Hough KP, Wilson LS, Trevor JL, Strenkowski JG, Maina N, Kim YI, Spell ML, Wang Y, Chanda D, Dager JR, Sharma NS, Curtiss M, Antony VB, Dransfield MT, Chaplin DD, Steele C, Barnes S, Duncan SR, Prasain JK, Thannickal VJ, Deshane JS.Unique Lipid Signatures of Extracellular Vesicles from the Airways of Asthmatics. Sci Rep. 2018 Jul 9;8(1):10340. doi: 10.1038/s41598-018-28655-9.

    June 2018

    Hough KP, Trevor JL, Strenkowski JG, Wang Y, Chacko BK, Tousif S, Chanda D, Steele C, Antony VB, Dokland T, Ouyang X, Zhang J, Duncan SR, Thannickal VJ, Darley-Usmar VM, Deshane JS.Exosomal transfer of mitochondria from airway myeloid-derived regulatory cells to T cells. Redox Biol. 2018 Jun 25;18:54-64. doi: 10.1016/j.redox.2018.06.009. [Epub ahead of print]

    Bhatt SP, Kazerooni EA, Newell JD Jr, Hokanson JE, Budoff MJ, Dass CA, Martinez CH, Bodduluri S, Jacobson FL, Yen A, Dransfield MT, Fuhrman C, Nath H; COPDGene Investigators. Visual estimate of coronary artery calcium predicts cardiovascular disease in COPD. Chest. 2018 Jun 8. pii: S0012-3692(18)30888-2. doi: 10.1016/j.chest.2018.05.037. [Epub ahead of print]

    Larson-Casey JL, Gu L, Jackson PL, Briles DE, Hale JY, Blalock JE, Wells JM, Deshane JS, Wang Y, Davis D, Antony VB, Massicano AVF, Lapi SE, Carter AB. Macrophage Rac2 Is Required to Reduce the Severity of Cigarette Smoke-induced Pneumonia. Am J Respir Crit Care Med. 2018 Jun 13. doi: 10.1164/rccm.201712-2388OC. [Epub ahead of print]

    Iyer AS, Benzo RP, Bakitas MA. Easing the Tension Between Palliative Care and Intensive Care in Chronic Obstructive Pulmonary Disease. J Palliat Care. 2018 Jul;33(3):123-124. doi: 10.1177/0825859718782505.

    Ash SY, Harmouche R, Ross JC, Diaz AA, Rahaghi FN, Sanchez-Ferrero GV, Putman RK, Hunninghake GM, Onieva JO, Martinez FJ, Choi AM, Bowler RP, Lynch DA, Hatabu H, Bhatt SP, Dransfield MT, Wells JM, Rosas IO, San Jose Estepar R, Washko GR; COPDGene Investigators. Interstitial Features at Chest CT Enhance the Deleterious Effects of Emphysema in the COPDGene Cohort. Radiology. 2018 Jun 5:172688. doi: 10.1148/radiol.2018172688. [Epub ahead of print]

    May 2018

    Criner GJ, Sue R, Wright S, Dransfield M, Rivas-Perez H, Wiese T, Sciurba FC, Shah PL, Wahidi MM, de Oliveira HG, Morrissey B, Cardoso PFG, Hays S, Majid A, Pastis N Jr, Kopas L, Vollenweider M, McFadden PM, Machuzak M, Hsia DW, Sung A, Jarad N, Kornaszewska M, Hazelrigg S, Krishna G, Armstrong B, Shargill NS, Slebos DJ; LIBERATE Study Group. A Multicenter RCT of Zephyr Endobronchial Valve Treatment in Heterogeneous Emphysema (LIBERATE). Am J Respir Crit Care Med. 2018 May 22. doi: 10.1164/rccm.201803-0590OC. [Epub ahead of print]

    Wells AU, Brown KK, Flaherty KR, Kolb M, Thannickal VJ; IPF Consensus Working Group. What's in a name? That which we call IPF, by any other name would act the same. Eur Respir J. 2018 May 17;51(5). pii: 1800692. doi: 10.1183/13993003.00692-2018. Print 2018 May.

    Shi R, Cao Z, Li H, Graw J, Zhang G, Thannickal VJ, Cheng G.Peroxidasin contributes to lung host defense by direct binding and killing of gram-negative bacteria. PLoS Pathog. 2018 May 18;14(5):e1007026. doi: 10.1371/journal.ppat.1007026. [Epub ahead of print]

    Huilgol P, Bhatt SP, Biligowda N, Wright NC, Wells JM. Association of e-cigarette use with oral health: a population-based cross-sectional questionnaire study. J Public Health (Oxf). 2018 May 18. doi: 10.1093/pubmed/fdy082. [Epub ahead of print]

    Dodi AE, Ajayi IO, Chang C, Beard M, Ashley SL, Huang SK, Thannickal VJ, Tschumperlin DJ, Sisson TH, Horowitz JC. Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuli. Respir Res. 2018 May 10;19(1):91. doi: 10.1186/s12931-018-0801-4.

    Wang Y, Schafer CC, Hough KP, Tousif S, Duncan SR, Kearney JF, Ponnazhagan S, Hsu HC, Deshane JS. Myeloid-Derived Suppressor Cells Impair B Cell Responses in Lung Cancer through IL-7 and STAT5. J Immunol. 2018 May 11. pii: ji1701069. doi: 10.4049/jimmunol.1701069. [Epub ahead of print]

    Krick S, Grabner A, Baumlin N, Yanucil C, Helton S, Grosche A, Sailland J, Geraghty P, Viera L, Russell DW, Wells JM, Xu X, Gaggar A, Barnes J, King GD, Campos M, Faul C, Salathe M. Fibroblast Growth Factor 23 and Klotho Contribute to Airway Inflammation. Eur Respir J. 2018 May 10. pii: 1800236. doi: 10.1183/13993003.00236-2018. [Epub ahead of print]

    April 2018

    Guimbellot J, Solomon GM, Baines A, Heltshe SL, VanDalfsen J, Joseloff E, Sagel SD, Rowe SM, GOALe(2) Investigators.Effectiveness of ivacaftor in cystic fibrosis patients with non-G551D gating mutations.J Cyst Fibros. 2018 Apr 20. pii: S1569-1993(18)30090-0. doi: 10.1016/j.jcf.2018.04.004. [Epub ahead of print]

    Cui H, Banerjee S, Guo S, Xie N, Liu G. IFN Regulatory Factor 2 Inhibits Expression of Glycolytic Genes and Lipopolysaccharide-Induced Proinflammatory Responses in Macrophages. J Immunol. 2018 May 1;200(9):3218-3230. doi: 10.4049/jimmunol.1701571. Epub 2018 Mar 21.

    Zhou Z, Qu J, He L, Peng H, Chen P, Zhou Y. α6-Integrin alternative splicing: distinct cytoplasmic variants in stem cell fate specification and niche interaction. Stem Cell Res Ther. 2018 May 2;9(1):122. doi: 10.1186/s13287-018-0868-3.

    Zhou Y. Most Good, Least Harm: Isoform-Specific Targeting of ROCK in Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2018 Apr;58(4):421-422. doi: 10.1165/rcmb.2017-0426ED.

    Bernard K. Collagen Biosynthesis in Pulmonary Fibrosis: Unraveling the Metabolic Web. Am J Respir Cell Mol Biol. 2018 May;58(5):545-546. doi: 10.1165/rcmb.2017-0350ED.

    Thannickal VJ, Antony VB. Is personalized medicine a realistic goal in idiopathic pulmonary fibrosis? Expert Rev Respir Med. 2018 Apr 19:1-3. doi: 10.1080/17476348.2018.1464913. [Epub ahead of print]

    Lipson DA, Barnhart F, Brealey N, Brooks J, Criner GJ, Day NC, Dransfield MT, Halpin DMG, Han MK, Jones CE, Kilbride S, Lange P, Lomas DA, Martinez FJ, Singh D, Tabberer M, Wise RA, Pascoe SJ; IMPACT Investigators.Once-Daily Single-Inhaler Triple versus Dual Therapy in Patients with COPD. N Engl J Med. 2018 Apr 18. doi: 10.1056/NEJMoa1713901. [Epub ahead of print]

    Bhatt SP. Am J Respir Crit Care Med. 2018 Apr 13. doi: 10.1164/rccm.201802-0257LE. [Epub ahead of print]Early COPD Or Early Detection of Mild Disease?

    Putcha N, Paul GG, Azar A, Wise RA, O'Neal WK, Dransfield MT, Woodruff PG, Curtis JL, Comellas AP, Drummond MB, Lambert AA, Paulin LM, Fawzy A, Kanner RE, Paine R 3rd, Han MK, Martinez FJ, Bowler RP, Barr RG, Hansel NN; SPIROMICS investigators. PLoS One. 2018 Apr 12;13(4):e0194924. doi: 10.1371/journal.pone.0194924. eCollection 2018. Lower serum IgA is associated with COPD exacerbation risk in SPIROMICS.

    Reyfman PA, Washko GR, Dransfield MT, Spira A, Han MK, Kalhan R. Am J Respir Crit Care Med. 2018 Apr 6. doi: 10.1164/rccm.201801-0120PP. [Epub ahead of print] Defining Impaired Respiratory Health: A Paradigm Shift for Pulmonary Medicine.

    March 2018

    Peabody JE, Shei RJ, Bermingham BM, Phillips SE, Turner B, Rowe SM, Solomon GM. Am J Physiol Lung Cell Mol Physiol. 2018 Mar 1. doi: 10.1152/ajplung.00556.2017. [Epub ahead of print] Seeing Cilia: Imaging Modalities for Ciliary Motion and Clinical Connections.

    February 2018

    Guimbellot JS, Acosta EP, Rowe SM. Sensitivity of ivacaftor to drug-drug interactions with rifampin, a cytochrome P450 3A4 inducer. Pediatr Pulmonol. 2018 Feb 28. doi: 10.1002/ppul.23971. [Epub ahead of print]

    Payne GA, Wells JM.Deciphering COPD and associated cardiovascular impairment. Lancet Respir Med. 2018 Feb 21. pii: S2213-2600(18)30047-X. doi: 10.1016/S2213-2600(18)30047-X. [Epub ahead of print]

    Garcia BA, Carden JL, Goodwin DL, Smith TA, Gaggar A, Leon K, Antony VB, Rowe SM, Solomon GM. Implementation of a successful eradication protocol for Burkholderia Cepacia complex in cystic fibrosis patients. BMC Pulm Med. 2018 Feb 14;18(1):35. doi: 10.1186/s12890-018-0594-8.

    Kunisaki KM, Dransfield MT, Anderson JA, Brook RD, Calverley PMA, Celli BR, Crim C, Hartley BF, Martinez FJ, Newby DE, Pragman AA, Vestbo J, Yates JC, Niewoehner DE; SUMMIT Investigators. Exacerbations of Chronic Obstructive Pulmonary Disease and Cardiac Events: A Cohort Analysis.Am J Respir Crit Care Med. 2018 Feb 14. doi: 10.1164/rccm.201711-2239OC. [Epub ahead of print]

    Dransfield MT, McAllister DA, Anderson JA, Brook RD, Calverley PMA, Celli BR, Crim C, Gallot N, Martinez FJ, Scanlon PD, Yates J, Vestbo J, Newby DE; SUMMIT Investigators.Beta-blocker Therapy and Clinical Outcomes in Patients with Moderate COPD and Heightened Cardiovascular Risk: An Observational Sub-study of SUMMIT. Ann Am Thorac Soc. 2018 Feb 6. doi: 10.1513/AnnalsATS.201708-626OC. [Epub ahead of print]

    Iyer, AS, Dransfield, MT. The "Obesity Paradox" in Chronic Obstructive Pulmonary Disease: Can It Be Resolved? Ann Am Thorac Soc. 2018 Feb;15(2):158-159. doi: 10.1513/AnnalsATS.201711-901ED.

    Bhatt, SP. Diagnosis of Chronic Obstructive Pulmonary Disease: Breathing New Life Into an Old Debate. Ann Am Thorac Soc. 2018 Feb;15(2):163-165. doi: 10.1513/AnnalsATS.201709-733ED.

    Askari K, Sneij W, Krick S, Alvarez RA. Reply: We Did This, and the Patient Improved: True, True, and Unrelated? Ann Am Thorac Soc. 2018 Feb;15(2):269. doi: 10.1513/AnnalsATS.201711-865LE.

    January 2018

    Kalhan R, Dransfield MT, Colangelo LA, Cuttica MJ, Jacobs DR Jr, Thyagarajan B, San Jose Estepar R, Harmouche R, Onieva Onieva J, Ash SY, Okajima Y, Iribarren C, Sidney S, Lewis CE, Mannino DM, Liu K, Smith LJ, Washko GR.Respiratory Symptoms in Young Adults and Future Lung Disease: The CARDIA Lung Study. Am J Respir Crit Care Med. 2018 Jan 25. doi: 10.1164/rccm.201710-2108OC. [Epub ahead of print]

    Bhatt SP, Anderson JA, Brook RD, Calverley PMA, Celli BR, Cowans NJ, Crim C, Martinez FJ, Newby DE, Vestbo J, Yates JC, Dransfield MT. Cigarette smoking and response to inhaled corticosteroids in COPD. Eur Respir J. 2018 Jan 18;51(1). pii: 1701393. doi: 10.1183/13993003.01393-2017. Print 2018 Jan.

    Bhatt SP, Kim YI, Harrington KF, Hokanson JE, Lutz SM, Cho MH, DeMeo DL, Wells JM, Make BJ, Rennard SI, Washko GR, Foreman MG, Tashkin DP, Wise RA, Dransfield MT, Bailey WC; COPDGene Investigators.Smoking duration alone provides stronger risk estimates of chronic obstructive pulmonary disease than pack-years. Thorax. 2018 Jan 11. pii: thoraxjnl-2017-210722. doi: 10.1136/thoraxjnl-2017-210722. [Epub ahead of print]

    Birket SE, Davis JM, Fernandez CM, Tuggle KL, Oden AM, Chu KK, Tearney GJ, Fanucchi MV, Sorscher EJ, Rowe SM.Development of an airway mucus defect in the cystic fibrosis rat. JCI Insight. 2018 Jan 11;3(1). pii: 97199. doi: 10.1172/jci.insight.97199. [Epub ahead of print]

    Copeland CR, Nath H, Terry NLJ, Wilson CG, Kim YI, Lynch DA, Bodduluri S, Wells JM, Dransfield MT, Díaz AA, Washko GR, Foreman MG, Bhatt SP; Genetic Epidemiology of COPD (COPDGene) Investigators. Paratracheal Paraseptal Emphysema and Expiratory Central Airway Collapse in Smokers.Ann Am Thorac Soc. 2018 Jan 3. doi: 10.1513/AnnalsATS.201709-713OC. [Epub ahead of print]

  • 2017 Publications

    December 2017

    Raju SV, Rowe SM. Not Simply the Lesser of Two Evils. Am J Physiol Lung Cell Mol Physiol. 2017 Dec 20. doi: 10.1152/ajplung.00534.2017. [Epub ahead of print]

    Martirossian A, Shah S, Carrete L, Valle J, Valentine V. Durability of Sirolimus for Lymphangioleiomyomatosis. Am J Med Sci. 2017 Dec;354(6):603-607. doi: 10.1016/j.amjms.2016.11.028. Epub 2016 Dec 5.

    Parekh, TM, Bhatt, SP, Westfall, AO, Wells JM, Kirkpatrick, DN, Iyer, AS, Mugavero M, Willig, JH, Dransfield, MT; Implications of DRG Classification in a Bundled Payment Initiative for COPD, The American Journal of Accountable Care, December 2017

    Heltshe SL, Rowe SM, Skalland M, Baines A, Jain M; GOAL Investigators of the Cystic Fibrosis Foundation Therapeutics Development Network.Ivacaftor-treated CF Patients Derive Long-term Benefit Despite No Short-term Clinical Improvement. Am J Respir Crit Care Med. 2017 Dec 19. doi: 10.1164/rccm.201710-2046LE. [Epub ahead of print]

    McNeil JB, Shaver CM, Kerchberger VE, Russell DW, Grove BS, Warren MA, Wickersham NE, Ware LB, McDonald WH, Bastarache JA. Novel Method for Non-Invasive Sampling of the Distal Airspace in Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2017 Dec 18. doi: 10.1164/rccm.201707-1474OC. [Epub ahead of print]

    McDonald MN, Diaz AA, Rutten E, Lutz SM, Harmouche R, San Jose Estepar R, Kinney G, Hokanson JE, Gower BA, Wouters EFM, Rennard SI1, Hersh CP, Casaburi R, Dransfield MT, Silverman EK, Washko GR. Chest Computed Tomography-Derived Low Fat-Free Mass Index and Mortality in COPD. Eur Respir J. 2017 Dec 14;50(6). pii: 1701134. doi: 10.1183/13993003.01134-2017. Print 2017 Dec.

    Bernard K, Logsdon NJ, Benavides GA, Sanders Y, Zhang J, Darley-Usmar VM, Thannickal VJ. Glutaminolysis is required for TGF-β1-induced myofibroblast differentiation and activation. J Biol Chem. 2017 Dec 8. pii: jbc.RA117.000444. doi: 10.1074/jbc.RA117.000444. [Epub ahead of print]

    Lutful Kabir F, Ambalavanan N, Liu G, Li P, Solomon GM, Lal CV, Mazur M, Halloran B, Szul T, Gerthoffer WT, Rowe SM, Harris WT.microRNA-145 Antagonism Reverses TGF-β Inhibition of F508del CFTR Correction in Airway Epithelia. Am J Respir Crit Care Med. 2017 Dec 12. doi: 10.1164/rccm.201704-0732OC. [Epub ahead of print]

    Semler MW, Janz DR, Casey JD, Russell DW, Rice TW. Response. Chest. 2017 Dec;152(6):1351. doi: 10.1016/j.chest.2017.09.032.

    Lancaster LH, de Andrade JA, Zibrak JD, Padilla ML, Albera C, Nathan SD, Wijsenbeek MS, Stauffer JL, Kirchgaessler KU, Costabel U. Pirfenidone safety and adverse event management in idiopathic pulmonary fibrosis. Eur Respir Rev. 2017 Dec 6;26(146). pii: 170057. doi: 10.1183/16000617.0057-2017. Print 2017 Dec 31.

    Cho DY, Hoffman KJ, Gill GS, Lim DJ, Skinner D, Mackey C, Rowe SM, Woodworth BA.Protective and antifungal properties of Nanodisk-Amphotericin B over commercially available Amphotericin B. World J Otorhinolaryngol Head Neck Surg. 2017 Mar 7;3(1):2-8. doi: 10.1016/j.wjorl.2017.01.002. eCollection 2017 Mar.

    Butts B, Goeddel LA, George DJ, Steele C, Davies JE, Wei CC, Varagic J, George JF, Ferrario CM, Melby SJ, Dell'Italia LJ.Increased Inflammation in Pericardial Fluid Persists 48 Hours After Cardiac Surgery. Circulation. 2017 Dec 5;136(23):2284-2286. doi: 10.1161/CIRCULATIONAHA.117.029589.

    Liu G, Thannickal VJ. The Lung Likes the Little Fella miR-29. Am J Respir Cell Mol Biol. 2017 Dec;57(6):637-638. doi: 10.1165/rcmb.2017-0266ED.

    November 2017

    Stalvey MS, Havasi V, Tuggle KL, Wang D, Birket S, Rowe SM, Sorscher EJ. Reduced bone length, growth plate thickness, bone content, and IGF-I as a model for poor growth in the CFTR-deficient rat. PLoS One. 2017 Nov 30;12(11):e0188497. doi: 10.1371/journal.pone.0188497. eCollection 2017.

    Rangarajan S, Bernard K, Thannickal VJ. Mitochondrial Dysfunction in Pulmonary Fibrosis. Ann Am Thorac Soc. 2017 Nov;14(Supplement_5):S383-S388. doi: 10.1513/AnnalsATS.201705-370AW.

    Solomon GM, Fu L, Rowe SM, Collawn JF. The therapeutic potential of CFTR modulators for COPD and other airway diseases. Curr Opin Pharmacol. 2017 Nov 10;34:132-139. doi: 10.1016/j.coph.2017.09.013. [Epub ahead of print]

    Rowe SM, Daines C, Ringshausen FC, Kerem E, Wilson J, Tullis E, Nair N, Simard C, Han L, Ingenito EP, McKee C, Lekstrom-Himes J, Davies JC.Tezacaftor-Ivacaftor in Residual-Function Heterozygotes with Cystic Fibrosis. N Engl J Med. 2017 Nov 3. doi: 10.1056/NEJMoa1709847. [Epub ahead of print]

    October 2017

    Krick S, Baumlin N, Aller SP, Aguiar C, Grabner A, Sailland J, Mendes E, Schmid A, Qi L, David NV, Geraghty P, King G, Birket SE, Rowe SM, Faul C, Salathe M.Klotho Inhibits Interleukin-8 Secretion from Cystic Fibrosis Airway Epithelia. Sci Rep. 2017 Oct 30;7(1):14388. doi: 10.1038/s41598-017-14811-0.

    Kaza N, Raju SV, Cadillac JM, Trombley JA, Rasmussen L, Tang L, Dohm E, Harrod KS, Rowe SM.Use of ferrets for electrophysiologic monitoring of ion transport. PLoS One. 2017 Oct 27;12(10):e0186984. doi: 10.1371/journal.pone.0186984. eCollection 2017.

    Reed RM, Cabral H, Dransfield M, Eberlein M, Merlo C, Mulligan MJ, Netzer G, Sanchez PG, Scharf SM, Sin DD, Celli BR.Survival of Lung Transplant Candidates with COPD: BODE Reconsidered. Chest. 2017 Oct 17. pii: S0012-3692(17)32900-8. doi: 10.1016/j.chest.2017.10.008. [Epub ahead of print]

    Abston E, Comellas A, Reed RM, Kim V, Wise RA, Brower R, Fortis S, Beichel R, Bhatt S, Zabner J, Newell J, Hoffman EA, Eberlein M. Higher BMI is associated with higher expiratory airflow normalised for lung volume (FEF25-75/FVC) in COPD. BMJ Open Respir Res. 2017 Oct 13;4(1):e000231. doi: 10.1136/bmjresp-2017-000231. eCollection 2017.

    Oates GR, Hamby BW, Stepanikova I, Knight SJ, Bhatt SP, Hitchcock J, Schumann C, Dransfield MT.Social Determinants of Adherence to Pulmonary Rehabilitation for Chronic Obstructive Pulmonary Disease. COPD. 2017 Oct 11:1-8. doi: 10.1080/15412555.2017.1379070. [Epub ahead of print]

    Volckaert T, Yuan T, Chao CM, Bell H, Sitaula A, Szimmtenings L, El Agha E, Chanda D, Majka S, Bellusci S, Thannickal VJ, Fässler R, De Langhe SP. Fgf10-Hippo Epithelial-Mesenchymal Crosstalk Maintains and Recruits Lung Basal Stem Cells. Dev Cell. 2017 Oct 9;43(1):48-59.e5. doi: 10.1016/j.devcel.2017.09.003.

    McDonald ML. Multiomics Approach to Asthma: Navigating the Network. Am J Respir Cell Mol Biol. 2017 Oct;57(4):381-382. doi: 10.1165/rcmb.2017-0220ED.

    September 2017

    Raju SV, Rasmussen L, Sloane PA, Tang LP, Libby EF, Rowe SM. Roflumilast reverses CFTR-mediated ion transport dysfunction in cigarette smoke-exposed mice. Respir Res. 2017 Sep 18;18(1):173. doi: 10.1186/s12931-017-0656-0.

    Guimbellot J, Sharma J, Rowe SM.Toward inclusive therapy with CFTR modulators: Progress and challenges. Pediatr Pulmonol. 2017 Sep 7. doi: 10.1002/ppul.23773. [Epub ahead of print]

    Askari K, Sneij W, Krick S, Alvarez RA.Going with the Flow: Saddle Pulmonary Embolism Complicated by Severe Hypoxemia without Shock. Ann Am Thorac Soc. 2017 Sep;14(9):1479-1484. doi: 10.1513/AnnalsATS.201702-145CC

    Tipirneni KE, Grayson JW, Zhang S, Cho DY, Skinner DF, Lim DJ, Mackey C, Tearney GJ, Rowe SM, Woodworth BA.Assessment of acquired mucociliary clearance defects using micro-optical coherence tomography. Int Forum Allergy Rhinol. 2017 Sep;7(9):920-925. doi: 10.1002/alr.21975.

    Sailland J, Grosche A, Baumlin N, Dennis JS, Schmid A, Krick S, Salathe M. Role of Smad3 and p38 Signaling in Cigarette Smoke-induced CFTR and BK dysfunction in Primary Human Bronchial Airway Epithelial Cells. Sci Rep. 2017 Sep 5;7(1):10506. doi: 10.1038/s41598-017-11038-x.

    August 2017

    Shenoy AT, Brissac T, Gilley RP, Kumar N, Wang Y, Gonzalez-Juarbe N, Hinkle WS, Daugherty SC, Shetty AC, Ott S, Tallon LJ, Deshane J, Tettelin H, Orihuela CJ. Streptococcus pneumoniae in the heart subvert the host response through biofilm-mediated resident macrophage killing. PLoS Pathog. 2017 Aug 25;13(8):e1006582. doi: 10.1371/journal.ppat.1006582. eCollection 2017 Aug

    Bodduluri S, Reinhardt JM, Hoffman EA, Newell JD Jr, Bhatt SP. Recent Advances in CT Imaging in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2017 Aug 16. doi: 10.1513/AnnalsATS.201705-377FR. [Epub ahead of print]

    Garth JM, Reeder KM, Godwin MS, Mackel JJ, Dunaway CW, Blackburn JP, Steele C. IL-33 Signaling Regulates Innate IL-17A and IL-22 Production via Suppression of Prostaglandin E2 during Lung Fungal Infection. J Immunol. 2017 Aug 7. pii: ji1602186. doi: 10.4049/jimmunol.1602186. [Epub ahead of print]

    Li FJ, Surolia R, Li H, Wang Z, Kulkarni T, Liu G, de Andrade JA, Kass DJ, Thannickal VJ, Duncan SR, Antony VB. Autoimmunity to Vimentin Is Associated with Outcomes of Patients with Idiopathic Pulmonary Fibrosis. J Immunol. 2017 Jul 28. pii: ji1700473. doi: 10.4049/jimmunol.1700473. [Epub ahead of print]

    Sharma NS, Wille KM, Athira S, Zhi D, Hough KP, Diaz-Guzman E, Zhang K, Kumar R, Rangarajan S, Eipers P, Wang Y, Srivastava RK, Rodriguez Dager JV, Athar M, Morrow C, Hoopes CW, Chaplin DD, Thannickal VJ, Deshane JS. Distal airway microbiome is associated with immunoregulatory myeloid cell responses in lung transplant recipients. J Heart Lung Transplant. 2017 Jul 15. pii: S1053-2498(17)31898-3. doi: 10.1016/j.healun.2017.07.007. [Epub ahead of print]

    Luckhardt T, Thannickal VJ. Measures of Frailty in Chronic Lung Diseases. Ann Am Thorac Soc. 2017 Aug;14(8):1266-1267. doi: 10.1513/AnnalsATS.201706-420ED.

    July 2017

    Jiang C, Liu G, Luckhardt T, Antony V, Zhou Y, Carter AB, Thannickal VJ, Liu RM. Serpine 1 induces alveolar type II cell senescence through activating p53-p21-Rb pathway in fibrotic lung disease. Aging Cell. 2017 Jul 19. doi: 10.1111/acel.12643. [Epub ahead of print]

    Bodduluri S, Reinhardt JM, Hoffman EA, Newell JD Jr, Nath H, Dransfield MT, Bhatt SP; COPDGene Investigators. Signs of Gas Trapping in Normal Lung Density Regions in Smokers. Am J Respir Crit Care Med. 2017 Jul 14. doi: 10.1164/rccm.201705-0855OC. [Epub ahead of print]

    June 2017

    Zouk AN, Wells JM. In Rotterdam, size really does matter: implications of pulmonary artery enlargement on mortality. Eur Respir J. 2017 Jun 15;49(6). pii: 1700750. doi: 10.1183/13993003.00750-2017. Print 2017 Jun. No abstract available. PMID: 28619963

    Khauli S, Abston E, Sajjad H, Bolukbas S, Lopez JMA, Saad R Jr, Bhatt SP, Eberlein M.Incomplete fissures are associated with increased alveolar ventilation via spiracles in severe emphysema. Interact Cardiovasc Thorac Surg. 2017 Jul 6. doi: 10.1093/icvts/ivx220. [Epub ahead of print]

    May 2017

    Barnes JW, Dweik RA. Pulmonary Hypertension and Precision Medicine through the "Omics" Looking Glass. Am J Respir Crit Care Med. 2017 Jun 15;195(12):1558-1560. doi: 10.1164/rccm.201704-0750ED.

    Grabner A, Mazzaferro S, Cianciolo G, Krick S, Capelli I, Rotondi S, Ronco C, La Manna G, Faul C. Fibroblast Growth Factor 23: Mineral Metabolism and Beyond. Contrib Nephrol. 2017;190:83-95. doi: 10.1159/000468952. Epub 2017 May 23.

    Cuttica MJ, Bhatt SP, Rosenberg SR, Beussink L, Shah SJ, Smith LJ, Dransfield MT, Kalhan R.Pulmonary artery to aorta ratio is associated with cardiac structure and functional changes in mild-to-moderate COPD. Int J Chron Obstruct Pulmon Dis. 2017 May 12;12:1439-1446. doi: 10.2147/COPD.S131413. eCollection 2017.

    Berry RB, Brooks R, Gamaldo C, Harding SM, Lloyd RM, Quan SF, Troester MT, Vaughn BV. AASM Scoring Manual Updates for 2017 (Version 2.4). http://www.aasmnet.org/jcsm/ViewAbstract.aspx?pid=31007 J Clin Sleep Med. 2017 May 15;13(5):665-666. doi: 10.5664/jcsm.6576.

    Budinger GS, Kohanski RA, Gan W, Kobor MS, Amaral LA, Armanios M, Kelsey K7, Pardo A, Tuder R, Macian F, Chandel N, Vaughan D, Rojas M, Mora AL, Kovacs E, Duncan SR, Finkel T, Choi A, Eickelberg O, Chen D, Agusti A, Selman M, Balch WE, Busse P, Lin A, Morimoto R, Sznajder JI, Thannickal VJ.The Intersection Of Aging Biology and The Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop. J Gerontol A Biol Sci Med Sci. 2017 May 12. doi: 10.1093/gerona/glx090. [Epub ahead of print]

    Zhang X, Hu M, Lyu X, Li C, Thannickal VJ, Sanders YY. DNA Methylation Regulated Gene Expression in Organ Fibrosis. Biochim Biophys Acta. 2017 May 10. pii: S0925-4439(17)30147-3. doi: 10.1016/j.bbadis.2017.05.010. [Epub ahead of print]

    Bhatt SP, Bodduluri S, Hoffman EA, Newell JD Jr, Sieren JC, Dransfield MT, Reinhardt JM. CT Measure of Lung At-risk and Lung Function Decline in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2017 May 8. doi: 10.1164/rccm.201701-0050OC. [Epub ahead of print]

    Semler MW, Janz DR, Russell DW, Casey JD, Lentz RJ, Zouk AN, deBoisblanc BP, Santanilla JI, Khan YA, Joffe AM, Stigler WS, Rice TW; Check-UP Investigators; Pragmatic Critical Care Research Group. A Multicenter, Randomized Trial of Ramped Position versus Sniffing Position during Endotracheal Intubation of Critically Ill Adults. Chest. 2017 May 6. pii: S0012-3692(17)30881-4. doi: 10.1016/j.chest.2017.03.061. [Epub ahead of print]

    Chupp GL, Bradford ES, Albers FC, Bratton DJ, Wang-Jairaj J, Nelsen LM, Trevor JL, Magnan A, Ten Brinke A. Efficacy of mepolizumab add-on therapy on health-related quality of life and markers of asthma control in severe eosinophilic asthma (MUSCA): a randomized, double-blind, placebo-controlled, parallel-group, multicentre, phase 3b trial.Lancet Respir Med. 2017 May;5(5):390-400. doi: 10.1016/S2213-2600(17)30125-X. Epub 2017 Apr 5.

    Jenkins RG, Moore BB, Chambers RC, Eickelberg O, Königshoff M, Kolb M, Laurent GJ, Nanthakumar CB, Olman MA, Pardo A, Selman M, Sheppard D, Sime PJ, Tager AM, Tatler AL, Thannickal VJ, White ES; ATS Assembly on Respiratory Cell and Molecular Biology. An Official American Thoracic Society Workshop Report: Use of Animal Models for the Preclinical Assessment of Potential Therapies for Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2017 May;56(5):667-679. doi: 10.1165/rcmb.2017-0096ST.

    April 2017

    Solomon GM, Liu B, Sermet-Gaudelus I, Fajac I, Wilschanski M, Vermeulen F, Rowe SM.A multiple reader scoring system for Nasal Potential Difference parameters. J Cyst Fibros. 2017 Apr 29. pii: S1569-1993(17)30141-8. doi: 10.1016/j.jcf.2017.04.011. [Epub ahead of print]

    Li FJ, Surolia R, Li H, Wang Z, Liu G, Liu RM, Mirov SB, Athar M, Thannickal VJ, Antony VB. Low Dose Cadmium Exposure Induces Peribronchiolar Fibrosis through Site Specific Phosphorylation of Vimentin.Am J Physiol Lung Cell Mol Physiol. 2017 Apr 27:ajplung.00087.2017. doi: 10.1152/ajplung.00087.2017. [Epub ahead of print]

    Bhatt SP, Vegas-Sánchez-Ferrero G, Rahaghi FN, MacLean ES, Gonzalez-Serrano G, Come CE, Kinney GL, Hokanson JE, Budoff MJ, Cuttica MJ, Wells JM, San José Estépar R, Washko GR. Cardiac Morphometry on Computed Tomography and Exacerbation Reduction with β-blocker Therapy in COPD.Am J Respir Crit Care Med. 2017 Apr 25. doi: 10.1164/rccm.201702-0399LE. [Epub ahead of print]

    King CS, Valentine V, Cattamanchi A, Franco-Palacios D, Shlobin OA, Brown AW, Singh R, Bogar L, Nathan SD. Early postoperative management after lung transplantation: Results of an international survey. Clin Transplant. 2017 Apr 20. doi: 10.1111/ctr.12985. [Epub ahead of print]

    Gallardo Estrella L, Pompe E, Kuhnigk JM, Lynch DA, Bhatt SP, van Ginneken B, van Rikxoort EM. Computed tomography quantification of tracheal abnormalities in COPD and their influence on airflow limitation. Med Phys. 2017 Apr 17. doi: 10.1002/mp.12274. [Epub ahead of print]

    Chupp GL, Bradford ES, Albers FC, Bratton DJ, Wang-Jairaj J, Nelsen LM, Trevor JL, Magnan A, Ten Brinke A. Efficacy of mepolizumab add-on therapy on health-related quality of life and markers of asthma control in severe eosinophilic asthma (MUSCA): a randomized, double-blind, placebo-controlled, parallel-group, multicentre, phase 3b trial. Lancet Respir Med. 2017 Apr 5. pii: S2213-2600(17)30125-X. doi: 10.1016/S2213-2600(17)30125-X. [Epub ahead of print]

    March 2017

    Reed RM, Dransfield MT, Eberlein M, Miller M, Netzer G, Pavlovich M, Pollin TI, Scharf SM, Shuldiner AR, Sin D, Mitchell BD. Gender differences in first and secondhand smoke exposure, spirometric lung function and cardiometabolic health in the old order Amish: A novel population without female smoking. PLoS One. 2017 Mar 31;12(3):e0174354. doi: 10.1371/journal.pone.0174354. eCollection 2017.

    Ding Q, Subramanian I, Luckhardt TR, Che P, Waghray M, Zhao X, Bone N, Kurundkar AR4, Hecker L5, Hu M, Zhou Y, Horowitz JC, Vittal R, Thannickal VJ. Focal Adhesion Kinase Signaling Determines the Fate of Lung Epithelial Cells in Response to TGF-β. Am J Physiol Lung Cell Mol Physiol. 2017 Mar 30:ajplung.00121.2016. doi: 10.1152/ajplung.00121.2016. [Epub ahead of print]

    Gu L, Larson-Casey JL, Carter AB. Macrophages utilize the mitochondrial calcium uniporter for profibrotic polarization. FASEB J. 2017 Mar 28. pii: fj.201601371R. doi: 10.1096/fj.201601371R. [Epub ahead of print]

    Longhurst H, Cicardi M, Craig T, Bork K, Grattan C, Baker J, Li HH, Reshef A, Bonner J, Bernstein JA, Anderson J, Lumry WR, Farkas H, Katelaris CH, Sussman GL, Jacobs J, Riedl M, Manning ME, Hebert J, Keith PK, Kivity S, Neri S, Levy DS, Baeza ML, Nathan R, Schwartz LB, Caballero T, Yang W, Crisan I, Hernandez MD, Hussain I, Tarzi M, Ritchie B, Králíčková P, Guilarte M, Rehman SM, Banerji A, Gower RG, Bensen-Kennedy D, Edelman J, Feuersenger H, Lawo JP, Machnig T, Pawaskar D, Pragst I, Zuraw BL; COMPACT Investigators. Prevention of Hereditary Angioedema Attacks with a Subcutaneous C1 Inhibitor. N Engl J Med. 2017 Mar 23;376(12):1131-1140. doi: 10.1056/NEJMoa1613627.

    Gelfond D, Heltshe S, Ma C, Rowe SM, Frederick C, Uluer A, Sicilian L, Konstan M, Tullis E, Roach RN, Griffin K, Joseloff E, Borowitz D. Impact of CFTR Modulation on Intestinal pH, Motility, and Clinical Outcomes in Patients With Cystic Fibrosis and the G551D Mutation.Clin Transl Gastroenterol. 2017 Mar 16;8(3):e81. doi: 10.1038/ctg.2017.10.

    Solomon GM, Francis R, Chu KK, Birket SE, Gabriel G, Trombley JE, Lemke KL, Klena N, Turner B, Tearney GJ, Lo CW, Rowe SM.Assessment of ciliary phenotype in primary ciliary dyskinesia by micro-optical coherence tomography.JCI Insight. 2017 Mar 9;2(5):e91702. doi: 10.1172/jci.insight.91702.

    Benck LR, Currica MJ, Colangelo LA, Sidney S, Dransfield MT, Mannino DM, Jacobs DR, Jr, Lewis CE, Zhu N, Washko GR, Liu K, Camethon MR, Kalhan R, Association Between Cardiorespiratory Fitness and Lung Health from Young Adulthood to Middle Age. Am J Respir Crit Care Med. 2017, Mar. 1. doi: 10.1164/rccm.2016-2089OC.

    February 2017

    Martinez Ch, Freeman CM, Nelson JD, Murray S, Wang X, Budoff MJ, Dransfield MT, Hokansan JE, Kaserooni EA, Kinney GL, Regan EA, Wells JM, Martinez FJ, Han MK, Curtis JL, COPDGene Investigators. GDF-15 Plasma Levels in Chronic Obstructive Pulmonary Disease are Associated with Subclinical Coronary Artery Disease. Respir Res. 2017 Feb 28;18(1):42. doi 10.1186/s12931-017-052 1-1.

    Garth JM, Steele C. Innate Lung Defense During Invasive Aspergillosis: New Mechanisms. J Innate Immun. 2017 Feb 21. doi: 10.1159/000455125. [Epub ahead of print]

    Rahaghi FN, Vegas-Sanchez-Ferrero G, Minhas JK, Come CE, De La Bruere I, Wells JM, Conzales G, Bhatt SP, Fenster BE, Diaz AA, Kohli P, Ross JC, Lynch DA, Dransfield MT, Bowler RP, Ledesma-Carbayo MJ, San Jose Estepar R, Washko GR, COPDGene Investigators. Ventricular Geometry From Non-Contrast Non-ECG-Gated CT Scans: An Imaging Marker of Cardiopulmonary Disease In Smokers. Acad Radiol. 2017 Feb 15. pii: S1076-6332(17)30008-9. doi: 10.1016/j.acra.2016.12.007

    Heresi GA, Malin SK, Barnes JW, Tian L, Kirwan JP, Dweik RA. Abnormal Glucose Metabolism and High-Energy Expenditure in Idiopathic Pulmonary Arterial Hypertension. Ann Am Thorac Soc. 2017 Feb;14(2):190-199. doi: 10.1513/AnnalsATS.201608-605OC.

    Rowe SM, McColley SA, Rietschel E, Li X, Bell SC, Konstan MW, Marigowda G, Waltz D, Boyle MP; VX09-809-102 Study Group. Lumacaftor/Ivacaftor Treatment of Patients with Cystic Fibrosis Heterozygous for F508del-CFTR. Ann Am Thorac Soc. 2017 Feb;14(2):213-219. doi: 10.1513/AnnalsATS.201609-689OC.

    Bhatt SP, Han MK. Functional Small Airways Disease and FEV1 Decline in COPD: Authors' Response. Am J Respir Crit Care Med. 2017 Feb 7. doi: 10.1164/rccm.201701-0127LE. [Epub ahead of print]

    Stalvey MS, Pace J, Niknian M, Higgins MN, Tarn V, Davis J, Heltshe SL, Rowe SM. Growth in Prepubertal Children With Cystic Fibrosis Treated With Ivacaftor. Pediatrics. 2017 Feb;139(2). pii: e20162522. doi: 10.1542/peds.2016-2522.

    Russell DW, Janz DR, Emerson WL, May AK, Bernard GR, Zhao Z, Koyama T, Ware LB.Early exposure to hyperoxia and mortality in critically ill patients with severe traumatic injuries. BMC Pulm Med. 2017 Feb 3;17(1):29. doi: 10.1186/s12890-017-0370-1.

    January 2017

    Surolia R, Li FJ, Wang Z, Li H, Liu G, Zhou Y, Luckhardt T, Bae S, Liu RM, Rangarajan S, de Andrade J, Thannickal VJ, Antony VB. 3D Pulmospheres Serve As A Personalized and Predictive Multicellular Model for Assessment of Antifibrotic Drugs. JCI Insight. 2017 Jan 26;2)2):e91377. doi: 10. 1172/jci.insight.91377

    Bhatt SP, Dransfield M, Cockcroft JR, Wang-Jairaj J, Midwinter DA, Rubin DB, Scott-Wilson CA, Crim C. A randomized trial of once-daily fluticasone furoate/vilanterol or vilanterol versus placebo to determine effects on arterial stiffness in COPD. Int J Chron Obstruct Pulmon Dis. 2017 Jan 19;12:351-365. doi: 10.2147/COPD.S117373. eCollection 2017.

    Bernard K, Logsdon NJ, Miguel V, Benavides GA, Zhang J, Carter AB, Darley-Usmar VM, Thannickal VJ. NADPH Oxidase 4 (Nox4) Suppresses Mitochondrial Biogenesis and Bioenergetics in Lung Fibroblasts via a Nuclear Factor Erythroid-Derived 2-like 2 (Nrf2)-dependent Pathway. J Biol Chem. 2017 Jan 3. pii: jcb. M116.752261. doi: 10.1074/jbc.M116.752261 [Epub ahead of print].

    Bodduluri S, Bhatt S, Hoffman EA, Newell JD, Jr. Martinez CH, Dransfield MT, Han MK, Reinhardt JM, COPDGene Investigators. Biomechanical CT Metrics Are Associated with Patient Outcomes in COPD. Thorax. 2017 Jan 2. pii:thoraxjnl-2016-209544 [Epub ahead of print].

    McDonald MN, Won S, Matteisen M, Castaldi PJ, Cho MH, Rutten E, Hardin M, Yip WK, Rennard SI, Lomas DA, Wouters EF, Agusti A, Casaburi R, Lange CP, O'Connor G, Hersh CP, Silverman EK. Body Mass Index Change In Gastrointestinal Cancer and Chronic Obstructive Pulmonary Disease is Associated with Dedicator of Cytokinesis. Ja Cachexia Sarcopenia Muscle. 2017 Jan 2. doi: 10.1002/jcsm. 12171 [Epub ahead of print]

    de Andrade, JA, Luckhardt T. What Is In A Pattern? That Which We Call Idiopathic Pulmonary Fibrosis by Any Other Pattern Would Behave Alike! Am J Respir Crit Care Med. 2017 Jan 1;195(1): 10-12. doi: 10.1164/rccm.201606-1277ED

  • 2016 Publications
    December 2016

    YK Kim, LaFon D, Nahm MH. Indirect Effects of Pneumococcal Conjugate Vaccines in National Immunization Programs for Children on Adult Pneumococcal Disease. Infect Chemother. 2016 Dec. doi: 10.397/ic.2016.48.4.257.

    Bhatt SP, Wells JM, Iyer AS, Kirkpatrick DP, Parekh TM, Leach LT, Anderson EM, Sanders JG, Nichols JK, Blackburn CC, Dransfield MT. Results of a Medicare Bundled Payments for Care Improvement Initiative for COPD Readmissions. Ann Am Thorac Soc. 2016 Dec 22. doi: 10.1513/AnnalsATS.201610-775BC. [Epub ahead of print]

    Rowe SM. A Little CFTR Can Change A Lot: Slowing Cystic Fibrosis Progression. Lancet Respir Med. 2016 Dec 20. pii: S2213-2600(16)30465-9 [Epub ahead of print]

    Cui H, Ge J, Xie N, Banerjee S, Zhou Y, Liu RM, Thannickal VJ, Liu G. miR-34a Promotes Fibrosis in Aged Lungs by Inducing Alveolar Epithelial Dysfunctions. Am J Physiol Lung Cell Mol Physiol. 2016 Dec 15:ajplung.00335.2016. doi: 10.1152/ajplung.00335.2016. [Epub ahead of print]

    Zhao XK, Che P, Cheng ML, Zhang Q, Mu M, Li H, Luo Y, Liang YD, Lou XH, Gao CQ, Jackson PL, Wells JM, Zhou Y, Hu M, Cai G, Thannickal VJ, Steele C, Blalock JE, Han X, Chen CY, Ding Q. Tristetraprolin Down-Regulation Contributes to Persistent TNF-Alpha Expression Induced by Cigarette Smoke Extract through a Post-Transcriptional Mechanism. PLoS One. 2016 Dec 2.;11(12):e0167451. doi: 10.1371/journal.pone.0167451. eCollection 2016.

    Wells JM, Estepar RS, McDonald MN, Bhatt SP, Diaz AA, Bailey WC, Jacobson FL, Dransfield MT, Washko GR, Make BJ, Casaburi R, van Beek EJ, Hoffman EA, Sciurba FC, Crapo JD, Silverman EK, Hersh CP, COPDGene Investigators. Clinical, Physiologic, and Radiographic Factors Contributing to Development of Hypoxemia in Moderate to Severe COPD: A Cohort Study. BMC Pulm Med. 2016 Dec 1;16(1):169

    Rahaghi FN, Wells JM, Come CE, De La Bruere IA, Bhatt SP, Ross JC, Vegas-Sánchez-Ferrero G, Diaz AA, Minhas J, Dransfield MT, San José Estépar R, Washko GR; and the COPDGene Investigators.Arterial and Venous Pulmonary Vascular Morphology and Their Relationship to Findings in Cardiac Magnetic Resonance Imaging in Smokers. J Comput Assist Tomogr. 2016 Nov/Dec;40(6):948-952.

    November 2016

    Chanda D, Kurundkar A, Rangarajan S, Locy M, Bernard K, Sharma NS, Logsdon NJ, Liu H, Crossman DK, Horowitz JC, De Langhe Thannickal VJ. Developmental Reprogramming in Mesenchymal Stromal Cells of Human Subjects with Idiopathic Pulmonary Fibrosis. Sci Rep. 2016 Nov 21;6:37445. doi: 10.1038/srep37445.

    Hough KP, Chanda D, Duncan SR, Thannickal VJ, Deshane JS. Exosomes in Immunoregulation of Chronic Lung Diseases. Allergy. 2016 Nov 15. doi: 10.111/all.13086. [Epub ahead of print].

    Mutyam V, Du M, Xue X, Keeling KM, White EL, Bostwick JR, Rasmussen L, Liu B, Mazur M, Hong JS, Falk Libby E, Liang F, Shang H, Mense M, Suto MJ, Bedwell DM, Rowe SM. Discovery of Clinically Approved Agents That Promote Suppression of Cystic Fibrosis Transmembrane Conductance Regulator Nonsense Mutations. Am J Respir Crit Care Med 2016 Nov 1;194(9): 1092-1103.

    Surolia R, Karki S, Wang Z, Kulkarni T, Li FJ, Vohra S, Batra H, Nick JA, Duncan SR, Thannickal VJ, Steyn AJ, Agarwal A, Antony VB. Attenuated Heme Oxygenase-1 Responses Predispose the Elderly to Pulmonary Nontuberculosis Mycobacterial Infections. Am J Physiol Lung Cell Mol Physiol. 2016 Nov 1;311(5):L928-L940. doi: 10.1152/ajplung.00397.105

    Roy B, Friesen WJ, Tomizawa Y, Leszyk JD, Shuo J, Johnson B, Dakka J, Trotta CR, Xue X, Mutyam V, Keeling KM, Mobley JA, Rowe SM, Bedwell DM, Welch EM, Jacobson A. Ataluren Stimulates Ribosomal Selection of Near-Cognate tRNAs to Promote Nonsense Suppression. Proc Natl Acad Sci U.S.A. 2016 Nov 1;113(44):12508-12513

    October 2016

    Bartoszewski R, Króliczewski J, Piotrowski A, Jasiecka AJ, Bartoszewska S, Vecchio-Pagan B, Fu L, Sobolewska A, Matalon S, Cutting GR, Rowe SM, Collawn JF. Codon bias and the folding dynamics of the cystic fibrosis transmembrane conductance regulator. Cell Mol Biol Lett. 2016 Oct 19;21:23. doi: 10.1186/s11658-016-0025-x. eCollection 2016.

    Richard K. Albert, M.D., David H. Au, M.D., Amanda L. Blackford, Sc.M., Richard Casaburi, M.D., Ph.D., J. Allen Cooper, Jr., M.D, Gerard J. Criner, M.D., Philip Diaz, M.D., Anne L. Fuhlbrigge, M.D., Steven E. Gay, M.D., Richard E. Kanner, M.D., Neil MacIntyre, M.D., Fernando J. Martinez, M.D., Ralph J. Panos, M.D., Steven Piantadosi, M.D., Ph.D., Frank Sciurba, M.D., David Shade, J.D., Thomas Stibolt, M.D., James K. Stoller, M.D., Robert Wise, M.D., Roger D. Yusen, M.D., James Tonascia, Ph.D., Alice L. Sternberg, Sc.M., and William Bailey, M.D. A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation. N Engl J Med. 2016 Oct 27;375(17):1617-1627.

    Martinez FJ, Vestbo J, Anderson JA, Brook RD, Celli BR, Cowans NJ, Crim C, Dransfield M, Kilbride S, Yates J, Newby DE, Niewoehner D, Calverley PM, SUMMIT Investigators. Effect of Fluticasone Furoate and Vilaneterol on Exacerbations of COPD in Patients with Moderate Airflow Obstruction. Am J Respir Crit Care Med. 2016 Oct 21. [Epub ahead of print]

    Schroff P, Hitchcock J, Schumann C, Wells JM, Dransfield MT, Bhatt SP. Pulmonary Rehabilitation Improves Outcomes in Chronic Obstructive Pulmonary Disease Independent of Disease Burden. Ann Am Thorac Soc. 2016 Oct. 14 [Epub ahead of print.]

    Chung WJ, Goeckeler-Fried JL, Havasi V, Chiang A, Rowe SM, Plyler ZE, Hong JS, Mazur M, Piazza GA, Keeton AB, White EL, Rasmussen L, Weissman AM, Denny RA, Drodsky JL, Sorscher EJ. Increasing the Endoplasmic Reticulum Poiol of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PLoS One. 2016 Oct 12;11(10):e0163615. doi: 10.1371/journal.pone.0163615. eCollection 2016.

    Roy B, Friesen WJ, Tomizawa Y, Leszyk JD, Zhuo J, Johnson B, Dakka J, Trotta CR, Xue X, Mutyam V, Keeling KM, Mobley JA, Rowe SM, Bedwell DM, Welch EM, Jacobson A. Ataluren Stimulates Ribosomal Selection of Near-Cognate tRNAs to Promote Nonsense Suppression. Proceedings of the National Academy of Sciences of the United States of America. Published online before print on October 4, 2016 doi: 10.1073/pnas.1605336113

    Mutyam V, Libby EF, Peng N, Hadjiliadis D, Bonk M, Solomon GM, Rowe SM. Therapeutic Benefit Observed with the CFTR Potentiator, Ivacaftor, in a CF Patient Homozygous for the W1282X CFTR Nonsense Mutation. J Cyst Fibros. 2016 Oct 1, pii: S1569-1993(16)30607-5. doi: 10.1016/j.jcf.2016.09.005 [Epub ahead of print.]

    September 2016

    Schaffer CC, Wang Y, Hough KP, Sawant A, Grant SC, Thannickal VJ, Zmijewski J, Ponnazhagan S, Deshane JS. Indoleamine 2,3-dioxygenase Regulates Anti-Tumor Immunity in Lung Cancer by Metabolic Reprogramming of Immune Cells in the Tumor Microenvironment. Oncotarget. 2016 Sep 26. doi: 10.18632/oncotarget.12249 [Epub ahead of print.]

    Raju SV, Kim H, Byzek SA, Tang LP, Tromble JE, Jackson P, Rasmussen L, Wells JM, Libby EF, Dohm E, Winter L, Samuel SL, Zinn KR, Blalock JE, Schoeb TR, Dransfield MT, Rowe SM. A Ferret Model of COPD-Related Bronchitis. JCI Insight. 2016 Sep 22; 1(15):e87536

    Cui H, Ge J, Xie N, Banerjee S, Zhou Y, Antony VB, Thannickal VJ, Liu G. miR-34 Inhibits Lung Fibrosis by Inducing Lung Fibroblast Senescence. Am J Respir Cell Mol Biol. 2016 Sep 16. [Epub ahead of Print]

    Bolton CE, Quint JK, Dransfield MT. Cardiovascular Disease in COPD: Time to Quash A Silent Killer. Lancet Respir Med. 2016 Sep;4(9):687-9. doi: 10.1016/S2213-2600(16)30243-0.

    Gaggar A. Weathington N. Bioactive Extracellular Matrix Fragments in Lung Health and Disease. J Clin Invest. 2016 Sep 1:126(9):3176-84. doi 10.1272/JCI83147. Epub 2016 Sep 1.

    Bhatt SP. Hidden in Plain Sight: Lung Impairment in Ischemic Heart Disease. Am J Respir Crit Care Med. 2016 Sep 1;194(5):528-30. doi: 10.1164/rccm.201607-1521ED.

    Raju SV, Lin VY, Liu L, McNicholas CM, Karki S, Sloane PA, Tang L, Jackson PL, Wang W, Wilson L, Macon KJ, Mazur M, Kappes J, DeLucas LJ, Barnes S, Kirk K, Tearney GT, Rowe SM. The CFTR Potentiator Ivacaftor Augments Mucociliary Clearance Abrogating CFTR Inhibition by Cigarette Smoke. Am J Respir Cell Mol Biol. 2016 Sep 1. [Epub ahead of print]

    August 2016

    Sanders YY, Liu H, Scruggs AM, Duncan SR, Huang SK, Thannickal VJ. Epigenetic Regulation of Caveolin-1 Gene Expression in Lung Fibroblasts. Am J Respir Cell Mol Biol. 2016 Aug 25 [Epub ahead of print]

    Dransfield MT, Kunisaki KM, Strand, MJ, Anzueto A, Bhatt SP, Bowler RP, Cringer GJ, Curtis JL, Hanania NA, Nath H, Putcha N, Roark SE, Wan ES, Washko GR, Wells JM, Wendt CH, Make BJ, COPDGene Investigators. Acute Exacerbations and Lung Function Loss in Smokers With and Without COPD. Am J Respir Crit Care Med. 2016 Aug 24 [Epub ahead of print].

    Gaggar A. Patel RP. There Is Blood in the Water: Hemolysis, Hemoglobin, and Heme in Acute Lung Injury. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 19: ajplung.00312.2016. doi:10.1152/ajplung.00312.2016

    Chen H, Qu J, Huang X, Kurundkar A, Zhu L, Yang N, Venado A, Ding Q, Liu G, Antony VB. Thannickal VJ, Zhou Y. Mechanosensing by the α6-integrin Confers an Invasive Fibroblast Phenotype and Mediates Lung Fibrosis. Nat. Commun. 2016 Aug 18;7:12564. doi: 10.1038/ncomms12564.

    Oh GY, Hamm J, Xu X, Genschmer K, Zhong M, Lebensburger J, Margues MB, Kerby JD, Pittet JF, Gaggar A, Patel RP. Absorbance and Redox-Based Approaches for Measuring Free Heme and Free Hemoglobin in Biological Matrices. Redox Biol. 2016 Aug 10;9:167-177. doi: 10.1016/j.redox.2016.08.003. [Epub ahead of print]

    July 2016

    Lewis WE, Malarkey ED, Tritschler D, Bower R, Pasek RC, Birket SE, Saunier S, Antignac C, Knowles ME, Leigh MW, Zariwala MA, Challa AK, Kesterson RA, Rowe SM, Drummond IA, Parant JM, Hildebrandt F, Porter ME, Yoder BK, Berbari NF. Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease. PLos Genet, 2016 Jul 29.

    Dilektasi AG, Porszasz J, Casaburi R, Stringer WW, Bhatt SP, Pak Y, Rossiter HB, Washko G, Castaldi PJ, San Jose Estepar R, Hansen JE, COPDGene Investigators. A Novel Spirometric Measure Identifies Mild Chronic Obstructive Pulmonary Disease Unidentified by Standard Criteria. Chest. 2016 Jul 21. [Epub ahead of print.]

    Srivastava RK, Li C, Wang Y, Weng Z, Elmets CA, Harrod KS, Deshane JS, Athar M. Activating Transcription Factor 4 Underlies the Pathogenesis of Arsenic-Mediated Impairment of Macrophage Innate Immune Functions. Toxicol Appl Pharmacol. 2016 Jun 13.

    Pascoe SJ, Lipson DA, Locantore N, Barnacle H, Brealey N, Mohindra R, Dransfield MT, Pavord I, Barnes N. A Phase III Randomized Controlled Trial of Single-Dose Triple Therapy in COPD: The IMPACT Protocol. Eur Respir J. 2016 Jul. 13.

    Lipworth B, Wedzicha J, Devereux G, Vestbo J, Dransfield MT. Beta-Blockers in COPD: Time for Reappraisal. Eur Respir J. 2016 Jul 7.

    June 2016

    Kurundkar A. Thannickal VJ. Redox Mechanisms in Age-Related Lung Fibrosis. Redox Biol. 2016 Jun 25.

    Mou H. Vinarsky V, Tata PR, Brazauskas K, Choi SH, Crooke AK, Zhang B, Solomon GM, Turner B, Bihler H, Harrington J, Lapey A, Channick C, Keyes C, Freund A, Artandi S, Mense M, Rowe S, Engelhart JF, Hsu YC, Rajagopal J. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells. Cell Stem Cell, 2016 Jun 15. pii: S1934-5909(16)300096-0. doi: 10.1016/j.stem.201605.012.

    Wells JM. Farris RF, Gosdin TA, Dransfield MT, Wood ME, Bell SC, Rowe SM. Pulmonary Artery Enlargement and Cystic Fibrosis Pulmonary Exacerbations: A Cohort Study. Lancet Respir Med. 2016 Jun 9. pii: S2213-2600(16)30105-9. doi: 10.1016/S213-2600(16)30105-9.

    Bhatt SP, Connett JE, Voelker H, Lindberg SM, Westfall E, Wells JM, Lazarus SC, Criner GJ, Dransfield MT. β-Blockers for the Prevention of Acute Exacerbations of Chronic Obstructive Pulmonary Disease (βLOCK COPD): A Randomized Controlled Study Protocol. BMJ Open. 2016 June 7;6(6);e012292. doi: 10.1136/bmjopen-2016-012292.

    May 2016

    Kulkarni T. de Andrade JA. Zhou Y. Luckhardt TR, Thannickal VJ. Alveolar Epithelial Disintegrity in Pulmonary Fibrosis. Am J Physiol Lung Cell Mol Physiol. 2016 May 27:ajplung.00115.2016. doi: 10.1152/ajplung.00115.2016 [Epub ahead of print]

    Han MK, Martinez CH, Au DH, Bourbeau J, Boyd CM, Branson R, Criner GJ, Kalhan R, Kallstron TJ, King A, Krishnan JA, Lareau SC, Lee TA, Lindell K, Mannino DM, Martinez FJ, Meldrum C, Press VG, Thomashow B, Tycon Lm Sullican JL, Walsh J, Wilson KC, Wright J, Yawn B, Zueger PM, Bhatt SP, Dransfield MT. Meeting the Challenge of COPD Care Delivery in the USA: A Multi Provider Perspective. Lancet Respir Med. 2016 May 12. pii: S2213-2600(16)00094-1. doi: 10.1016/S2213-2600(16)00094-1..

    Solomon GM, Hathorn H, Liu B, Raju SV, Reeves G, Acosta EP, Dransfield MT, Rowe SM. Pilot Evaluation of Ivacaftor for Chronic Bronchitis. Lancet Respir. Med. pii: S2213-2600(16)30047-9. doi: 10.1016/S2213-2600(16)30047-9.

    Kim V, Zhao H, Boriek AM, Anzueto A, Soler X, Bhatt SP, Rennard SI, Wise R, Comellas A, Ramsdell JW, Kinney GL, Han MK, Martinez CH, Yen A, Black-Shinn J, Porszasz J Criner GJ, Hanania NA, Sharafkhaneh A, Crapo JD, Make BJ, Silverman EK, Curtis JL, COPDGene Investigators. Persistent and Newly Developed Chronic Bronchitis Are Associated with Worse Outcomes in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2016 May 9.

    Yang Y. Shi R. Cao Z. Cheng G. VP01 Mediates Oxidation of LDL and Formation of Foam Cells. Oncotarget. 2016 May 5. doi: 10.18632/oncotarget.9193.

    Sciurba FC, Criner GJ, Strange C, Shah PL, Michaud G, Connolly TA, Deslee G, Delage A, Marquette CH, Krishna G, Kalhan R, Ferguson JS, Jantz M, Maldonado F, McKenna R, Majid A, Rai N, Gay S, Dransfield MT, Angel L, Maxfield R, Herth FJ, Wahidi MM, Mehta A, Slebos DJ, RENEW Research Group. Effect of Endobrochial Coils vs Usual Care on Exercise Tolerance in Patients with Severe Emphysema: The RENEW Randomized Clinical Trial. JAMA. 2016 May.

    April 2016

    Mutyam V, Du M, Xue X, Keeling KM, White EL, Bostwick JR, Rasmussen L, Liu B, Mazur M, Hong JS, Falk Libby E, Liang F, Shang H, Mense M, Suto MJ, Bedwell DM, Rowe SM. Discovery of Clinically Approved Agents That Promote Suppression of CFTR Nonsense Mutations. Am J Respir Crit Care Med. 2016 Apr 22.

    Solomon GM, Raju SV, Dransfield MT, Rowe SM. Therapeutic Approaches to Acquired Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction in Chronic Bronchitis. Ann Am Thorac Soc. 2016 Apr;13 Suppl 2:S169-76.

    Iyer AS, Dransfield MT. Serum Eosinophils as a COPD Biomarker: Ready for Prime Time? Lancet Respir Med. 2016 Apr 7.

    March 2016

    Quon BS. Rowe SM. New and Emerging Targeted Therapies for Cystic Fibrosis. BMJ. 2016 Mar 30;325:i859.

    Hecker L. Thannickal VJ. Getting to the Core of Fibrosis: Targeting Redox Imbalance in Aging. Ann Transl Med. 2016 Mar;4(5):93.

    Birket SE, Chu KK, Houser GH, Liu L, Fernandez Cm, Solomon GM, Lin V, Shastry S, Mazur M, Sloane P, Hanes J, Grizzle WE, Sorscher EJ, Teamey GJ, Rowe SM. Combination Therapy with Cystic Fibrosis Transmembrane Conductance Regulator Modulators Augment the Airway Functional Microanatomy. Am J Physiol Lung Cell Mol Physiol. 2016 Mar 11:ajplung.00395.2015.

    Raghu G, Scholand MB, de Andrade J, Lancaster L, Mageto Y, Goldin, Brown KK, Flaherty KR, Wencel M, Wanger J, Neff T, Valone F, Stauffer J, Porter S. FG-3019 Anti-Connective Tissue Growth Factor Monoclonal Antibody: Results of an Open-Label Clinical Trial in IPF. Eur Respir D. 2016 Mar. 10.

    Walker MM, Novak L, Widener R, Grubbs JA, King J, Hale JY, Ochs MM, Myers LE, Briles DE, Deshane J. PcpA Promotes Higher Levels of Infection and Modulates Recruitment of Myeloid-Derived Suppressor Cells during Pneumococcal Pneumonia. J Immunol. 2016 Mar 1;196(5):2239-48. doi: 10.4049/jimmunol.1402518.

    Rangarajan S, Locy ML, Luckhardt TR, Thannickal VJ. Targeted Therapy for Idiopathic Pulmonary Fibrosis: Where To Now? Drugs. 2016 Mar;76(3):291-300. doi: 10.1007/s40265-015-0523-6.

    February 2016

    Brown AT, Hitchcock J, Schumann C, Wells JM, Dransfield MT, Bhatt SP. Determinants of Successful Completion of Pulmonary Rehabilitation in COPD. Int J Chron Obstruct Pulmon Dis. 2016 Feb 25.

    Larson-Casey JL, Deshane JS, Ryan AJ, Thannickal VJ, Carter AB. Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis. Immunity. 2016 Feb 22. pii: S1074-7613(16)00002-9. doi: 10.1016/j.immuni.2016.01.001.

    Kurundkar AR, Kurundkar D, Rangarajan S, Locy ML, Zhou Y, Liu RM, Zmijewski J, Thannickal VJ. The matricellular protein CCN1 enhances TGF-β1/SMAD3-dependent profibrotic signaling in fibroblasts and contributes to fibrogenic responses to lung injury. FASEB J. 2016 Feb 16. pii: fj.201500173. [Epub ahead of print]

    Liu RM, Eldridge S, Watanabe N, Deshane J, Kuo HC, Jiang C, Wang Y, Liu G, Schwiebert L, Miyata T, Thannickal VJ. Therapeutic potential of an orally effective small molecule inhibitor of plasminogen activator inhibitor for asthma. Am J Physiol Lung Cell Mol Physiol. 2016 Feb 15;310(4):L328-36. doi: 10.1152/ajplung.00217.2015. Epub 2015 Dec 23.

    Bhatt SP. Increased Costs of the Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome. One Syndrome for the Price of Two? Ann Am Thorac Soc. 2016 Feb;13(2):158-9. doi: 10.1513/AnnalsATS.201512-795ED. No abstract available.

    Busch R, Han MK, Bowler RP, Dransfield MT, Wells JM, Regan EA, Hersh CPRisk factors for COPD exacerbations in inhaled medication users: the COPDGene study biannual longitudinal follow-up prospective cohort. ; COPDGene Investigators. BMC Pulm Med. 2016 Feb 10;16(1):28. doi: 10.1186/s12890-016-0191-7.

    Bhatt SP, Terry NL, Nath H, Zach JA, Tschirren J, Bolding MS, Stinson DS, Wilson CG, Curran-Everett D, Lynch DA, Putcha N, Soler X, Wise RA, Washko GR, Hoffman EA, Foreman MG, Dransfield MT;Association Between Expiratory Central Airway Collapse and Respiratory Outcomes Among Smokers. Genetic Epidemiology of COPD (COPDGene) Investigators.JAMA. 2016 Feb 2;315(5):498-505. doi: 10.1001/jama.2015.19431.

    January 2016

    Sharma NS, Peters T, Kulkarni T, Hoopes CW, Bellot SC, Wille KM, Diaz-Guzman E. Flexible Bronchoscopy Is Safe and Effective in Adult Subjects Supported With Extracorporeal Membrane Oxygenation. Respir Care. 2016 Jan 26. pii: respcare.04456. [Epub ahead of print]

    Bhatt SP, Soler X, Wang X, Murray S, Anzueto AR, Beaty TH, Boriek AM, Casaburi R, Criner GJ, Diaz AA, Dransfield MT, Curran-Everett D, Galbán CJ, Hoffman EA, Hogg JC, Kazerooni EA, Kim V, Kinney GL, Lagstein A, Lynch DA, Make BJ, Martinez FJ, Ramsdell JW, Reddy R, Ross BD, Rossiter HB, Steiner RM, Strand MJ, van Beek EJ, Wan ES, Washko GR, Wells JM, Wendt CH, Wise RA, Silverman EK, Crapo JD, Bowler RP, Han MK; COPDGene Investigators. Association Between Functional Small Airways Disease and FEV1 Decline in COPD. Am J Respir Crit Care Med. 2016 Jan 25. [Epub ahead of print]

    Bratcher PE, Rowe SM, Reeves G, Roberts T, Szul T, Harris WT, Tirouvanziam R, Gaggar A. Alterations in blood leukocytes of G551D-bearing cystic fibrosis patients undergoing treatment with ivacaftor. J Cyst Fibros. 2016 Jan;15(1):67-73. doi: 10.1016/j.jcf.2015.02.010. Epub 2015 Mar 11.

    Kulkarni T, O'Reilly P, Antony VB, Gaggar A, Thannickal VJ.Matrix Remodeling in Pulmonary Fibrosis and Emphysema. Am J Respir Cell Mol Biol. 2016 Jan 7. [Epub ahead of print]

    Bhatt SP, Wells JM, Kinney GL, Washko GR Jr, Budoff M, Kim YI, Bailey WC, Nath H, Hokanson JE, Silverman EK, Crapo J, Dransfield MT; COPDGene Investigators. β-Blockers are associated with a reduction in COPD exacerbations. Thorax. 2016 Jan;71(1):8-14. doi: 10.1136/thoraxjnl-2015-207251.

  • 2015 Publications

    December 2015

    Liu RM, Desai LP. Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis. Redox Biol. 2015 Dec;6:565-77. doi: 10.1016/j.redox.2015.09.009.

    He C, Larson-Casey JL, Gu L, Ryan AJ, Murthy S, Carter AB.Cu,Zn-SOD-mediated Redox Regulation of Jmjd3 Modulates Macrophage Polarization and Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2015 Dec 23. [Epub ahead of print]

    Raju SV, Solomon GM, Dransfield MT, Rowe SM. Acquired Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction in Chronic Bronchitis and Other Diseases of Mucus Clearance. Clin Chest Med. 2016 Mar;37(1):147-58. doi: 10.1016/j.ccm.2015.11.003. Epub 2015 Dec 24.

    He C, Carter AB. The Metabolic Prospective and Redox Regulation of Macrophage Polarization. J Clin Cell Immunol. 2015 Dec;6(6)

    Lutz SM, Cho MH, Young K, Hersh CP, Castaldi PJ, McDonald ML, Regan E, Mattheisen M, DeMeo DL, Parker M, Foreman M, Make BJ, Jensen RL, Casaburi R, Lomas DA, , Bakke P, Gulsvik A, Crapo JD, Beaty TH, Laird NM, Lange C, Hokanson JE, Silverman EK; ECLIPSE Investigators. A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. COPDGene Investigators. BMC Genet. 2015 Dec 3;16:138. doi: 10.1186/s12863-015-0299-4.

    Noerager BD, Xu X, Davis VA, Jones CW, Okafor S, Whitehead A, Blalock JE, Jackson PL.. A Potential Role for Acrolein in Neutrophil-Mediated Chronic Inflammation. Inflammation. 2015 Dec;38(6):2279-87. doi: 10.1007/s10753-015-0213-2.

    Baumann AW, Kohler C, Kim YI, Cheong J, Hendricks P, Bailey WC, Harrington KF. Differences in Electronic Cigarette Awareness, Use History, and Advertisement Exposure Between Black and White Hospitalized Cigarette Smokers. J Cancer Educ. 2015 Dec;30(4):648-54. doi: 10.1007/s13187-014-0767-y.

    November 2015

    Cui H, Banerjee S, Xie N, Ge J, Liu RM, Matalon S, Thannickal VJ, Liu G. miR-27a-3p is a Negative Regulator of Lung Fibrosis by Targeting Myofibroblast Differentiation. Am J Respir Cell Mol Biol. 2015 Nov 24. [Epub ahead of print]

    Pennathur S, Vivekanandan-Giri A, Locy ML, Kulkarni T, Zhi D, Zeng L, Byun J, de Andrade JA, Thannickal VJ. Oxidative Modifications of Protein Tyrosyl Residues are Increased in Plasma of Human Subjects with Interstitial Lung Disease. Am J Respir Crit Care Med. 2015 Nov 17. [Epub ahead of print] Xie N, Liu G. ncRNA-regulated immune response and its role in inflammatory lung diseases. Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15;309(10):L1076-87. doi: 10.1152/ajplung.00286.2015. Review. October 2015

    Wells JM, Jackson PL, Viera L, Bhatt SP, Gautney J, Handley G, King RW, Xu X, Gaggar A, Bailey WC, Dransfield MT, Blalock JE. A Randomized, Placebo-controlled Trial of Roflumilast. Effect on Proline-Glycine-Proline and Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2015 Oct 15;192(8):934-42. doi: 10.1164/rccm.201503-0543OC.

    September 2015

    Venado A, Wille K, Belott SC, Diaz-Guzman E. Unexplained hemolysis in patients undergoing ECMO: beware of hypertriglyceridemia. Perfusion. 2015 Sep;30(6):465-8. doi: 10.1177/0267659114557693.

    Hendricks PS, Cases MG, Thorne CB, Cheong J, , Kohler CL, Bailey WC. Hospitalized smokers' expectancies for electronic cigarettes versus tobacco cigarettes. Addict Behav. 2015 Feb;41:106-11. doi: 10.1016/j.addbeh.2014.09.031. Epub 2014 Sep 28.

    Teerapuncharoen K, Sharma NS, Barker AB, Wille KM, Diaz-Guzman E. Successful Treatment of Severe Carbon Monoxide Poisoning and Refractory Shock Using Extracorporeal Membrane Oxygenation. Respir Care. 2015 Sep;60(9):e155-60. doi: 10.4187/respcare.03990.

    Akhter H, Ballinger C, Liu N, van Groen T, Postlethwait EM, Liu RM. Cyclic Ozone Exposure Induces Gender-Dependent Neuropathology and Memory Decline in an Animal Model of Alzheimer's Disease.

    August 2015

    Murthy S, Larson-Casey JL, Ryan AJ, He C, Kobzik L, Carter AB. Alternative activation of macrophages and pulmonary fibrosis are modulated by scavenger receptor, macrophage receptor with collagenous structure. FASEB J. 2015 Aug;29(8):3527-36. doi: 10.1096/fj.15-271304.

    Surolia R, Karki S, Kim H, Yu Z, Kulkarni T, Mirov SB, Carter AB, Rowe SM, Matalon S, Thannickal VJ, Agarwal A, Antony VB. Heme oxygenase-1-mediated autophagy protects against pulmonary endothelial cell death and development of emphysema in cadmium-treated mice. Am J Physiol Lung Cell Mol Physiol. 2015 Aug 1;309(3):L280-92. doi: 10.1152/ajplung.00097.2015.

    Wheatley CM, Baker SE, Morgan MA, Martinez MG, Liu B, Rowe SM, Morgan WJ, Wong EC, Karpen SR, Snyder EM. Moderate intensity exercise mediates comparable increases in exhaled chloride as albuterol in individuals with cystic fibrosis. Respir Med. 2015 Aug;109(8):1001-11. doi: 10.1016/j.rmed.2015.05.018.

    July 2015

    Kong MY, Whitley RJ, Peng N, Oster R, Schoeb TR, Sullender W, Ambalavanan N, Clancy JP, Gaggar A, Blalock JE. Matrix Metalloproteinase-9 Mediates RSV Infection in Vitro and in Vivo. Viruses. 2015 Jul 30;7(8):4230-53. doi: 10.3390/v7082817.

    May 2015

    Eddens T, Elsegeiny W, Nelson MP, Horne W, Campfield BT, Steele C, Kolls JK. Eosinophils Contribute to Early Clearance of Pneumocystis murina Infection. J Immunol. 2015 Jul 1;195(1):185-93. doi: 10.4049/jimmunol.1403162. Epub 2015 May 20.

    Tan Z, Xie N, Cui H, Moellering DR, Abraham E, Thannickal VJ, Liu G. Pyruvate dehydrogenase kinase 1 participates in macrophage polarization via regulating glucose metabolism. J Immunol. 2015 Jun 15;194(12):6082-9. doi: 10.4049/jimmunol.1402469. Epub 2015 May 11. MMP generated matrikines. Wells JM, Gaggar A, Blalock JE. Matrix Biol. 2015 May-Jul;44-46:122-9. doi: 10.1016/j.matbio.2015.01.016.

    April 2015

    Wells JM, Iyer AS, Rahaghi FN, Bhatt SP, Gupta H, Denney TS, Lloyd SG, Dell'Italia LJ, Nath H, Estepar RS, Washko GR, Dransfield MT.Pulmonary artery enlargement is associated with right ventricular dysfunction and loss of blood volume in small pulmonary vessels in chronic obstructive pulmonary disease. Circ Cardiovasc Imaging. 2015 Apr;8(4). pii: e002546. doi: 10.1161/CIRCIMAGING.114.002546. J Pediatr. 2015 Mar;166(3):531-7.e13. doi: 10.1016/j.jpeds.2014.09.052.

    February 2015

    Sanders YY, Liu H, Liu G, Thannickal VJ. Epigenetic mechanisms regulate NADPH oxidase-4 expression in cellular senescence. Free Radic Biol Med. 2015 Feb;79:197-205. doi: 10.1016/j.freeradbiomed.2014.12.008.

    Deshane JS, Redden DT, Zeng M, Spell ML, Zmijewski JW, Anderson JT, Deshane RJ, Gaggar A, Siegal GP, Abraham E, Dransfield MT, Chaplin DD. Subsets of airway myeloid-derived regulatory cells distinguish mild asthma from chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2015 Feb;135(2):413-424.e15. doi: 10.1016/j.jaci.2014.08.040. Erratum in: J Allergy Clin Immunol. 2015 Apr;135(4):1092.

    January 2015

    Huang WT, Akhter H, Jiang C, MacEwen M, Ding Q, Antony V, Thannickal VJ, Liu RM. Plasminogen activator inhibitor 1, fibroblast apoptosis resistance, and aging-related susceptibility to lung fibrosis. Exp Gerontol. 2015 Jan;61:62-75. doi: 10.1016/j.exger.2014.11.018.

    Stein A, Kraus DW, Doeller JE, Bailey SM. Inhalation exposure model of hydrogen sulfide (H₂S)-induced hypometabolism in the male Sprague-Dawley rat. Methods Enzymol. 2015;555:19-35. doi: 10.1016/bs.mie.2014.11.019. Epub 2015 Jan 8.

  • 2014 Publications

    December 2014

    Honavar J, Doran S, Oh JY, Steele C, Matalon S, Patel RP.Nitrite therapy improves survival postexposure to chlorine gas.Am J Physiol Lung Cell Mol Physiol. 2014 Dec 1;307(11):L888-94. doi: 10.1152/ajplung.00079.2014.

    November 2014

    Harrington KF, Hull NC, Akindoju O, Kim YI, Hendricks PS, Kohler C, Bailey WC. Electronic cigarette awareness, use history, and expected future use among hospitalized cigarette smokers. Nicotine Tob Res. 2014 Nov;16(11):1512-7. doi: 10.1093/ntr/ntu054.

    Park DW, Jiang S, Liu Y, Siegal GP, Inoki K, Abraham E, Zmijewski JW. GSK3β-dependent inhibition of AMPK potentiates activation of neutrophils and macrophages and enhances severity of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2014 Nov 15;307(10):L735-45. doi: 10.1152/ajplung.00165.2014.

    Bratcher PE, Gaggar A. Factors influencing the measurement of plasma/serum surfactant protein D levels by ELISA. PLoS One. 2014 Nov 3;9(11):e111466. doi: 10.1371/journal.pone.0111466. eCollection 2014.

    Bhatt SP, Wells JM, Kim V, Criner GJ, Hersh CP, Hardin M, Bailey WC, Nath H, Kim YI, Foreman MG, Stinson DS, Wilson CG, Rennard SI, Silverman EK, Make BJ, Dransfield MT; COPDGene Investigators.Radiological correlates and clinical implications of the paradoxical lung function response to β₂ agonists: an observational study.Lancet Respir Med. 2014 Nov;2(11):911-8. doi: 10.1016/S2213-2600(14)70185-7.

    October 2014

    Hu M, Che P, Han X, Cai GQ, Liu G, Antony V, Luckhardt T, Siegal GP, Zhou Y, Liu RM, Desai LP, O'Reilly PJ, Thannickal VJ, Ding Q. Therapeutic targeting of SRC kinase in myofibroblast differentiation and pulmonary fibrosis. J Pharmacol Exp Ther. 2014 Oct;351(1):87-95. doi: 10.1124/jpet.114.216044

    Werner JL, Steele C. Innate receptors and cellular defense against pulmonary infections. J Immunol. 2014 Oct 15;193(8):3842-50. doi: 10.4049/jimmunol.1400978. Review.

    Bhatt SP, Wells JM, Dransfield MT.. Cardiovascular disease in COPD: a call for action.Lancet Respir Med. 2014 Oct;2(10):783-5. doi: 10.1016/S2213-2600(14)70197-3. No abstract available.

    August 2014

    Schwiebert LM, Estell K, Meadows T, Thannickal VJ, Rowe S, Sorscher EJ, Harris WT, Gaggar A, Dransfield M, de Andrade JA. Development and maintenance of a biospecimen repository for clinical samples derived from pulmonary patients. Clin Transl Sci. 2014 Aug;7(4):336-41. doi: 10.1111/cts.12161.

    Dransfield MT, Feldman G, Korenblat P, LaForce CF, Locantore N, Pistolesi M, Watkins ML, Crim C, Martinez FJ. Efficacy and safety of once-daily fluticasone furoate/vilanterol (100/25 mcg) versus twice-daily fluticasone propionate/salmeterol (250/50 mcg) in COPD patients.Respir Med. 2014 Aug;108(8):1171-9. doi: 10.1016/j.rmed.2014.05.008.

    July 2014

    Marques MB, Wille KM, Ren Z, Sheth M, McGiffin DC. Successful pulmonary thromboendarterectomy in a patient with sickle cell disease treated with a single preoperative red blood cell exchange.Transfusion. 2014 Jul;54(7):1901-2. doi: 10.1111/trf.12651. No abstract available.

    June 2014

    Desai LP, Zhou Y, Estrada AV, Ding Q, Cheng G, Collawn JF, Thannickal VJ. Negative regulation of NADPH oxidase 4 by hydrogen peroxide-inducible clone 5 (Hic-5) protein.J Biol Chem. 2014 Jun 27;289(26):18270-8. doi: 10.1074/jbc.M114.562249.

    Thannickal VJ, Henke CA, Horowitz JC, Noble PW, Roman J, Sime PJ, Zhou Y, Wells RG, White ES, Tschumperlin DJ. Matrix biology of idiopathic pulmonary fibrosis: a workshop report of the national heart, lung, and blood institute. Am J Pathol. 2014 Jun;184(6):1643-51. doi: 10.1016/j.ajpath.2014.02.003. Review.

    May 2014

    Abdul Roda M, Sadik M, Gaggar A, Hardison MT, Jablonsky MJ, Braber S, Blalock JE, Redegeld FA, Folkerts G, Jackson PL. Targeting prolyl endopeptidase with valproic acid as a potential modulator of neutrophilic inflammation. PLoS One. 2014 May 16;9(5):e97594. doi: 10.1371/journal.pone.0097594. eCollection 2014

    April 2014

    Bai G, Hock TD, Logsdon N, Zhou Y, Thannickal VJ. A far-upstream AP-1/Smad binding box regulates human NOX4 promoter activation by transforming growth factor-β.Gene. 2014 Apr 25;540(1):62-7. doi: 10.1016/j.gene.2014.02.026.

    March 2014

    Bhatt SP, Kim YI, Wells JM, Bailey WC, Ramsdell JW, Foreman MG, Jensen RL, Stinson DS, Wilson CG, Lynch DA, Make BJ, Dransfield MT. . FEV(1)/FEV(6) to diagnose airflow obstruction. Comparisons with computed tomography and morbidity indices. Ann Am Thorac Soc. 2014 Mar;11(3):335-41. doi: 10.1513/AnnalsATS.201308-251OC.

    February 2014

    Courville CA, Tidwell S, Liu B, Accurso FJ, Dransfield MT, Rowe SM. Acquired defects in CFTR-dependent β-adrenergic sweat secretion in chronic obstructive pulmonary disease.Respir Res. 2014 Feb 25;15:25. doi: 10.1186/1465-9921-15-25.

    Raju SV, Tate JH, Peacock SK, Fang P, Oster RA, Dransfield MT, Rowe SM. Impact of heterozygote CFTR mutations in COPD patients with chronic bronchitis.Respir Res. 2014 Feb 11;15:18. doi: 10.1186/1465-9921-15-18.

    January 2014

    Bhatt SP, Cole AG, Wells JM, Nath H, Watts JR, Cockcroft JR, Dransfield MT.Determinants of arterial stiffness in COPD. BMC Pulm Med. 2014 Jan 4;14:1. doi: 10.1186/1471-2466-14-1.

    Sharma NS, Wille KM, Hoopes CW, Diaz-Guzman E. Acute demyelinating polyneuropathy after lung transplantation: guillain-barré syndrome or tacrolimus toxicity? Case Rep Transplant. 2014;2014:685010. doi: 10.1155/2014/685010.