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Assistant Professor email
VH G094
(205) 996-0826

Visit Dr. Rosa-Garrido's Research Website

Research and Teaching Interests: Epigenetics, Chromatin Structure, Heart Disease

Office Hours: By appointment

Education:

  • B.S. Biology, University of Jaen (Spain)
  • B.S. Biochemistry, University of Granada (Spain)
  • Ph.D. Biomedicine, University of Cantabria (Spain)
  • Post-Doc, University of California Los Angeles

Dr. Rosa-Garrido received his Ph.D. from the University of Cantabria (Spain) for his work studying the role of the epigenetic chromatin organizer CTCF in leukemia, lymphoma, and skin cancer. During his post-doctoral training at UCLA, Dr. Rosa-Garrido sought to apply what he learned from the cancer field to heart disease. During this stage, he demonstrated how the modulation of chromatin structure plays an essential role in the development of cardiac disease. In 2022 Dr. Rosa Garrido was recruited by the Department of Bioengineering, where he leads a research group focused on defining the direct and indirect role that chromatin structure plays in mediating cardiac pathology.

Research interest:

Dr. Rosa-Garrido investigates the functional role of chromatin reorganization in the setting of heart failure by combining his expertise in epigenomics and cardiac physiology. His group performs chromosome conformation capture (Hi-C), chromatin accessibility (ATAC-seq), bisulfite sequencing and gene expression profiling in different cardiac disease models to identify pathological structural patterns that can be used as predictive markers and targets of epigenetic therapies. To study the translational implications of his research, Dr. Rosa-Garrido’s lab also uses human heart tissue to compare chromatin remodeling dynamics at early and late stages of chronic cardiac disease and before and after clinical intervention.

  • Select Publications

    Select Publications

    • Chapski DJ, Cabaj M, Morselli M, Mason RJ, Soehalim E, Ren S, Pellegrini M, Wang Y, Vondriska TM, Rosa-Garrido M. Early adaptive chromatin remodeling events precede pathologic phenotypes and are reinforced in the failing heart. Journal of Molecular and Cellular Cardiology. July 15, 2021. PMID: 34273410.
    • Karbassi E, Rosa-Garrido M, Chapski DJ, Wu Y, Ren S, Wang Y, Stefani E, Vondriska TM. Direct visualization of cardiac transcription factories reveals regulatory principles of nuclear architecture during pathological remodeling. Journal of Molecular and Cellular Cardiology. February 8, 2019. PMID: 30742811.
    • Chapski DJ, Rosa-Garrido M, Hua N, Alber F, Vondriska TM. Spatial Principles of Chromatin Architecture Associated With Organ-Specific Gene Regulation. Frontiers in Cardiovascular Medicine. January 15, 2019. PMID: 30697540.
    • Rosa-Garrido M, Chapski DJ, Schmitt AD, Kimball TH, Karbassi E, Monte E., Balderas E, Pellegrini M, Shih TT, Soehalim E, Liem DA, Ping P, Galjart NJ, Ren S, Wang Y, Ren B, Vondriska TM. High Resolution Mapping of Chromatin Conformation in Cardiac Myocytes Reveals Structural Remodeling of the Epigenome in Heart Failure. Circulation. August 11, 2017. PMID: 28802249.
    • *Monte E., *Rosa-Garrido M., Karbassi E, Chen H, Rau C, Wang J, Wu Y, Stefani E, Weiss JN, Lusis AJ, Wang Y, Kurdistani K, Franklin S, Vondriska TM. Reciprocal regulation of cardiac chromatin by HMGB and CTCF: implications for transcriptional regulation in pathologic hypertrophy. The Journal of Biological Chemistry. May 16, 2016. (*Authors with equal contribution). PMID:27226577.
    • Ubil E, Duan J, Pillai I, Rosa-Garrido M, Wu Y, Bargiacchi F, Lu Y, Huang J, Rojas M, Vondriska TM, Stefani E, Stanbouly S, Deb A. Mesenchymal-endothelial-transition contributes to neovascularization after heart injury. Revista: October 30, 2014. PMID: 25317562.
    • Batlle A, Cortiguera M, Rosa-Garrido M, del Cerro E, Torrano V, Blanco R, Wagner SD, Delgado MD. Novel CTCF binding at a site in exon1A of BCL6 is associated with active histone marks and a transcriptionally active locus. Oncogene. December 23, 2013. PMID: 24362533.
  • Academic Distinctions and Professional Societies

    Academic Distinctions and Professional Societies

    • Louis N. and Arnold M. Katz Basic Science Research Prize for Early Career Investigators. AHA Scientific Sessions (Finalist). November 2020.
    • College of Medicine Tucson Award to attend the Eureka Translational Medicine Course 2020.
    • American Heart Association Career Development Award. 2019.
    • Outstanding Early Career Investigator Award. Basic Cardiovascular Sciences Scientific Sessions. August 2018.
    • 8th Edition Andalusian of the Future Prize. Scientific discipline (Finalist). December 2015.
    • 7th Edition Andalusian of the Future Prize. Scientific discipline (Finalist). December 2014.
    • Member of the JMCC editorial board. Special issue entitled "Cardiac Epigenetics: Driving signals to the cardiac epigenome in development and disease."
    • Member of the North American Section of the International Society (ISHR)
    • Member of the American Heart Association (AHA).