Pittet LabFrom left to right: Brant Wagener, M.D., Ph.D.; Jean-Francois Pittet, M.D.; Angela Brandon; Cilina Rodriguez. Not pictured: Clarissa (Sarah) Christiaans, M.D, M.Sc.; Naseem Anjum.The Pittet-Wagener Lab is co-directed by Jean-Francois Pittet, M.D., the David Hill Chestnut Endowed Professor of Anesthesiology and editor-in-chief of Anesthesia & Analgesia, and Brant Wagener, M.D., Ph.D. 

The laboratory focuses on the basic, clinical and translational mechanisms of acute respiratory distress syndrome (ARDS), coagulopathy and lung infection after acute trauma. After acute trauma, there is a direct interplay between the onset of coagulopathy and ARDS that increases a patient’s opportunity to acquire a nosocomial lung infection. We study these pathophysiologic and molecular mechanisms using animal models, cellular techniques and human clinical data. Our animal work consists of a trauma-hemorrhage-resuscitation model, a Pseudomonas aeruginosa model of lung infection, a stroke/TIA model and a blunt head-trauma model. Our molecular work entails use of flow cytometry, confocal microscopy, FRET, short-circuit current studies with Ussing chambers, Western blotting, ELISA and much more. 

See PubMed for Dr. Pittet's publications.

See PubMed for Dr. Wagener's publications.

Active Research projects include:

Assessment of Oxidant-Antioxidant Status in the Bronchoalveolar Lavage Fluid of Patients with Either Acute Lung Injury or No Pulmonary Disease

Retrospective Study on Coagulopathy and Nosocomial Pneumonia After Severe Trauma

Importance of the Type III Secretion (T3SS) Toxin ExoY in the Severity of P. Aeruginosa Pneumonia in ICU Patients

Effect of Autonomic Nervous System Activity and Early Coagulation Abnormalities on the Development of Systemic Immunosuppression and Noscomial Pneumonia in Patients with Vascular or Traumatic Brain Injury

Coagulopathy and Nosocomial Pneumonia After Severe Trauma

Coagulopathy in Severe Pediatric Trauma with and without Head Injury

Coagulation Abnormalities in Pediatric Trauma Patients and Secondary Outcomes

The Role of Exo-Induced Tau Phosphorylation in the Development of Cognitive Dysfunction in ICU Patients after Nosocomial Pneumonia.

A Clinical Proof-of-Concept Study for the Perioperative Surgical Home