Center for Exercise Medicine

The UAB Center for Exercise Medicine is focused on improving the health and well-being of children and adults of all ages through interdisciplinary research, the training of future leaders in science and healthcare, and community education based on clinical research findings. The UCEM interdisciplinary team brings together more than 160 investigators, 32 departments, and 10 schools for a multi-disciplinary approach. UAB is among the first of major academic medical centers to establish such a center. Among its activities, the Center sponsors an annual symposium.  

NIH Common Fund launches physical activity research program

Molecular Transducers of Physical Activity in Humans is the largest targeted NIH investment of funds into the mechanisms of how physical activity improves health and prevents disease. Through the program, investigators at research institutions across the United States will receive $170 million over five years, pending availability of funds. The National Institutes of Health's Common Fund launched this program with the aim to catalogue extensively the biological molecules that are affected by physical activity in people, identify some of the key molecules that underlie the systemic effects of physical activity, and characterize the functions of these key molecules.

Many NExTNet members including Dr. Marcas Bamman, Director of the UAB Center for Exercise Medicine, played key roles in laying the groundwork for this game-changing program. To view the videocast of the NIH workshop on October 30, 2014 click here. To read "Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits", recently published in the journal Cell Metabolism, click here.  


Current Research

1R01AG046920
Novel Actions of Metformin to Augment Resistance Training Adaptations in Older Adults (aka MASTERS Trial)

The overall goal of the MASTERS trial is to test the central hypothesis that adjuvant metformin may improve the responses to progressive resistance training in the elderly by altering the muscle tissue inflammatory environment, thereby enhancing mechanisms that drive myofiber regrowth and associated improvements in muscle function. For more information on the study or to submit an interest form click below.

MASTERS Trial Team:
PIs: Marcas Bamman, PhD (UAB), Phillip Kern, MD (UK), Charlotte Peterson, PhD (UK)
Co-investigators: Fernando Ovalle, MD (UAB), Samuel T. Windham, MD (UAB)

 
MASTERS trial


1R01HD084124
Overcoming TWEAK Signaling to Restore Muscle and Mobility after Joint Replacement

This randomized clinical trial is designed to test the central hypothesis that progressive resistance training plus adjunctive functional mobility training after THA/TKA will more effectively restore muscle mass and mobility function to healthy standards than usual care and, because individuals with abnormally high muscle TWEAK signaling are predicted to suffer failed muscle recovery and persistent dismobility under usual care, the impact of the intervention will be greatest among these patients.

TWEAK Trial Team
PIs: Marcas Bamman, PhD (UAB), Lou Bridges, MD, PhD (UAB)
Co-investigators: ChiChi Aban, MS, PhD (UAB), C. Scott Bickel, PhD (UAB), K. David Moore, MD (UAB), Samuel T. Windham, MD (UAB), Jasvinder Singh, MD, MPH (UAB)