The NIH PF5 Collaborative International Research Project mechanism introduces new structures and requirements for multi-component and international research awards.
This page provides key guidance, frequently asked questions, and resources to help investigators and collaborators navigate the application process successfully. You can also learn more about this project on the NIH website. You can also watch a recorded overview session, "NIH PF5: Shifting from the Traditional Foreign Subaward Model to the New Multi-Component Structure."
Key Questions and Guidance
How will international components be evaluated separately from domestic components?
While the research strategy section for international project components has a 6-page limit, the research project component strategy section can include detailed scientific content, and the entire application is reviewed collectively, though components can be funded separately.
Can multiple research projects can be included in one PF5 application?
Yes, multiple research projects can be included in one PF5 application, but the mechanism is not intended for restructuring existing awards.
What are some challenges for foreign collaborators?
Foreign collaborators may face language barriers and other requirements; NIH has provided some guidance, but many details will be clarified through early experience as adopters navigate the system.
How should research proposals with international components be structured under the new 12-page research strategy requirement?
International collaborators and foreign sites should be included in the overall research component discussion, similar to multi-component projects. When appropriate, one human subjects section in the overall or research component may suffice across the entire PF5 to avoid duplication.
How should multi-country projects be presented in the PF5?
Each foreign component that meets the traditional definition of a subaward requires its own international project component with a 6-page research strategy.
How are foreign organizations and sites structured for awards?
Each foreign organization and site receives its own component and award (RF2). Foreign collaborators can serve as MPIs if they meet the NIH definition, and MPI leadership plans must be uploaded to the overall project component.
How are credit and funding allocated to UAB for international components?
UAB receives recognition for having international components, but the funding does not flow through UAB's reporting numbers. UAB receives no IDC from RF2/international component awards.
When should foreign entities obtain UEI numbers and eRA Commons registration?
It is recommended that foreign institutions have eRA Commons registration and UEI numbers prior to submission. However, if the UEI number is pending at the time of submission, PF5 applications can be submitted using a placeholder UEI number (see PA-26-002). eRA Commons registration is required for institutional personnel to obtain an eRA Commons ID which is required by all Key Personnel at the time of submission. All registrations must be complete in order to receive a RF2 notice of award.