Every Friday
10:15 - 11:30 a.m.
Shelby Biomedical Research Building
515 Seminar Room
Overview
This seminar series is developed and sponsored by the UAB informatics Institute. It educates individuals on research innovations in biomedical informatics.
There are two tracks: Clinical Informatics (1st and 3rd Fridays) and Bioinformatics (2nd and 4th Fridays).
Clinical informatics seminars focus on the application of informatics for improving healthcare delivery and using health data for research. It includes diverse topics such as design, implementation, and clinical decision support.
Bioinformatics seminars present late-breaking computational techniques, tools and applications. It includes genomics and other -omics.
Some areas of informatics, such as precision medicine, natural language processing and image processing, span clinical informatics and bioinformatics and have greater crossover appeal. Presentations in these areas may be held in either 1st/3rd or 2nd/4th Fridays.
In addition to educating, we also strive to make these seminars social gathering places for the UAB clinical informatics and bioinformatics communities. We encourage you to attend to learn more about biomedical informatics and related disciplines and discover new opportunities for collaboration.
Organizer
Jake Chen- Chair
Amy Wang-Moderator for 2018-2019 series
Bioinformatics Steering Committee
Jake Chen
Zechen Chong
David Crossman
Curtis Hendrickson
Elliot Lefkowitz
Merry-Lynn McDonald
Hemant Tiwari
Clinical Informatics Steering Committee
Eta Berner
James Cimino
Tiago Colicchio
Tony Fargason
Wayne Liang
Jacqueline Moss
Bunyamin Ozaydin
Marisa Wilson
Amy Y. Wang
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Upcoming Informatics Institute PowerTalk Seminars
Clinical Informatics
Friday, February 15 | "Population Genomics and Gene Expression Data Analysis"
Linyong Mao, Ph.D.
Assistant Professor
Department of Biochemistry and Molecular Biology
Howard University
This seminar will be a webinar through Zoom. Attendees may join us in the THT Vault for viewing or join from their own computer. Zoom meeting information to follow.
Bioinformatics
Friday, February 22 | "Keeping the ‘Bio’ in Bioinformatics: Optimizing Analytical Approaches to Support Biological Understanding"
Elliot Lefkowitz, Ph.D.
Professor, Department of Microbiology
Director of Informatics, Center for Clinical and Translational Science
Director, Molecular and Genetic Bioinformatics Facility, Center for AIDS Research
Director, Bioinformatics Core, Microbiome Facility
This seminar will be in the Finley Conference Center
Clinical Informatics
Friday, March 1 | “Gamification, patient reported outcomes and patient based metrics”
James, Willig, M.D., MSPH
Associate Professor
Division of Infectious Diseases
UAB Department of Medicine
Clinical Informatics
Friday, March 15 | "Toward Designing Smarter Electronic Clinical Documentation Systems"
Tiago Colicchio, Ph.D.
Assistant Professor
Department of Medicine
Informatics Institute
UAB
Bioinformatics Seminar Archive
2019
February 8, 2019
Topic: "Privacy-preserving Techniques for Sharing and Analyzing Human Genomic Data"
Speaker: Haixu Tang, Ph.D.
Affiliation: Director, Data Science Academic Programs, Professor of Informatics and Computing, Indiana University Bloomington
January 25, 2019
Topic: "Biological discoveries through bioinformatics analysis and research"
Speaker: Sheng Liu, Ph.D.
Affiliation: Junior Faculty, Indiana University Department of Medical & Molecular Genetics
January 11, 2019
Topic: "L-2-Hydroxyglutarate in Renal Cancer: Epigenetic Mechanisms and Liabilities"
Speaker: Sunil Sudarshan, M.D.
Affiliation: Associate Professor, UAB Department of Urology
2018
December 14, 2018
Topic: "The UAB Undiagnosed Diseases Program: Bioinformatic Applications in Rare Disorders"
Speaker: Bruce Korf, M.D., Ph.D.
Affiliation: Wayne H. and Sara Crews Finley Chair in Medical Genetics, Chief Genomics Officer, UAB Medicine, Co-Director, UAB-HudsonAlpha Center for Genomic Medicine, Associate Director for Rare Diseases, Hugh Kaul Personalized Medicine Institute
November 16, 2018
Topic: “From linear organization to the 3D genome architecture”
Speaker: Yichao Li, Ph.D.
Affiliation: Research Assistant, Ohio University School of Engineering and Computer Science
October 26, 2018
Topic: "Exploring the -Omics of Glioblastoma Using Patient-Derived Models of Cancer"
Speaker: Christopher Willey, M.D., Ph.D.
Affiliation: Director, UAB Kinome Core, Associate Professor, UAB Radiation Oncology
October 12, 2018
Topic: "Unraveling the meiotic recombination landscape in individual human genomes"
Speaker: Peng Xu, Ph.D.
Affiliation: Postdotoral Fellow, UAB Informatics Institute
September 28, 2018
Topic: "From chaos, DRAMA: Data-driven Research for Advanced Modeling and Analysis"
Speaker: Jeremy Blackburn, Ph.D.
Affiliation: Assistant Professor, UAB Department of Computer Science
September 14, 2018
Topic: “Computational prediction and modeling for protein-drug and protein-protein interactions”
Speaker: Daisuke Kihara, Ph.D.
Affiliation: Professor, Department of Biological Sciences and Department of Computer Sciences, Purdue University
August 24, 2018
Topic: "Deep Learning and Clustering Algorithms for Protein Scoring"
Speaker: Debswapna Bhattacharya, PhD
Affiliation: Assistant Professor, Auburn University
August 10, 2018
Topic: "Context fear memory formation is regulated by hippocampal lncRNA-mediated histone methylation changes"
Speaker: Anderson Butler
Affiliation: Ph.D. candidate in GBS Cell, Molecular & Developmental Biology Program and Graduate student in Lubin Lab
July 27, 2018
Topic: "HLA Population Genetics and Informatics to Optimize the Kidney Allocation System"
Speaker: Loren Gragert, Ph.D.
Affiliation: Assistant Professor, Tulane University
July 22, 2018
Topic: "Predicting regulatory variants with large-scale multi-omics data"
Speaker: Li Chen, Ph.D.
Affiliation: Assistant Professor, Auburn University
July 13, 2018
Topic: "Implementation of Next Generation Sequencing (NGS) Testing in Precision Oncology Advantages and Challenges"
Speaker: Shuko Harada, MD
Affiliation: Associate Professor, UAB Pathology
May 25, 2018
Topic: "Towards the ultimate diagnostics: NGS of immune repertoire"
Speaker: Jian Han, MD, PhD
Affiliation: Faculty Investigator, HudsonAlpha Institute for Biotechnology
May 11, 2018
Topic: "Comparative and evolutionary genomics of allelic imbalance in mammals"
Speaker: Xu Wang, Ph.D.
Affiliation: Assistant Professor, Auburn University
April 27, 2018
Topic: "Integrating high-throughput drug screening with targeted deep sequencing reveals novel treatment strategies for chemoresistant acute myeloid leukemia"
Speaker: Miranda Burnette, Ph.D.
Affiliation: T32 Fellow, UAB Department of Microbiology
March 23, 2018
Topic: "An Introduction to Applied Longitudinal Data Analysis"
Speaker: Lloyd J. Edwards, PhD
Affiliation: Professor and Chair, Deparment of Biostatistics School of Public Health
Abstract: Longitudinal studies, in which outcomes are measured repeatedly over time on the same subject, are widely conducted in various applications and often provide better insights about the processes of interest than cross-sectional studies. Longitudinal studies allow addressing questions about changes over time in the response and changes in the relationship of the response to subjects' characteristics. We present an introduction to applied longitudinal data analysis that is meant to introduce features of longitudinal data and available statistical techniques for analyzing the data.
March 9, 2018
Topic: "Roles of Alternative Splicing in Complex Diseases"
Speaker: Yunlong Liu, Ph.D.
Affiliation: Professor, Indiana University School of Medicine
February 23, 2018
Topic: Integrating multidimensional data to catalyze translation of GWAs finds to biology and therapeutics
Speaker: Bingshan Li,PhD
Affiliation: Associate Professor, Vanderbilt University
Bio: Dr. Bingshan Li is Associate Professor at Vanderbilt Genetics Institute. Dr. Li’s research is focused on developing statistical methods and computational tools to understand genetics of human complex traits. Dr. Li is a pioneer in the development of gene-based collapsing methods for analyzing rare variants (almost 10 years ago), which laid a foundation for sequencing data analysis for complex traits. As a result, he received the C.W. Cotterman Award by the American Society of Human Genetics in 2009. He is now focused on developing methods for analyzing noncoding rare variants in whole genome sequencing (WGS) data. Dr. Li is a PI of one of the three Analysis Centers for the Genome Sequencing Program, which is to carry out whole genome sequencing over >100,000 samples across multiple complex diseases.
Abstract: Genome-wide association studies (GWAS) have identified numerous variants associated with schizophrenia (SCZ). Translating GWAS findings to biological mechanisms, especially clinical applicability, however, remains a major challenge. In this talk, I will introduce a statistical framework that integrates multiple -omics data to identify SCZ risk genes based on GWAS findings. The risk genes identified are highly consistent with the leading pathophysiological hypotheses of SCZ, specifically expressed in brain tissues, and enriched in de novo mutations in a broader range of psychiatric disorders (e.g. autism, developmental diseases and intellectual disability). Furthermore, the risk genes are enriched in drug targets, providing candidate genes for therapeutic development. We further investigated the expression patterns of risk genes across multiple tissue- and cell type-specific transcriptomic data, and used machine learning approaches to build models to predict risk genes across the genome
February 9, 2018
Topic: Genomic disgnosis of developmental diabilities
Speaker: Greg Cooper, PhD
Affiliation: Faculty Investigator, HudsonAlpha Institute for Biotechnology
January 26, 2018
Topic: Impact of rare variants on eft ventrivular traits in African American using WGS
Speaker: Rafet Al-Tobasei, PhD
Affiliation: T32 Fellow, UAB Department of Biostatistics
January 12, 2018
Topic: Intergrative Anlaysis of Cancer Progression
Speaker: Sooryanarayana Varambally, PhD
Affiliation: Associate Professor, UAB Department of Pathology
2017
December 15, 2017
Topic: Hierarchical Models for Complex Molecular Data Analysis
Speaker: Nengjun Yi, PhD
Affiliation: Professor, UAB Department of Biostatistics
November 11, 2017
Topic: System for Big Data Analytics
Speaker: Da Yan, PhD
Affiliation: Assistant Professor, UAB Department of Computer Science
October 13, 2017
Topic: Framework for multidimensional data intergration in complex human diseases
Speaker: Brittany Lasseigne, Phd
Affiliation: Senior Scientist, HudsonAlpha Institute for Biotechnology
Clinical Informatics Seminar Archive
2019
February 1, 2019
Topic: “Clinical Bioinformatics Methods to Study Genomic Mutational Profiles in Cancer Disease”
Speaker: Yvonne Edwards, Ph.D.
Affiliation: Director of Bioinformatics, Program in Molecular Medicine and Research, Assistant Professor, University of Massachusetts Medical School
January 18, 2019
Topic: "Actually See Your Patient, Not Just Inside Them: A New Technology and Paradigm for Medical Imaging Care"
Speaker: Srini Tridandapani, M.D., Ph.D., MBA
Affiliation: Vice Chair, Imaging Informatics, Professor, Department of Radiology- Cardiopulmonary Section
January 4, 2019
Topic: “Incorporating CMS Medicare Cost Report data into Health Services Research Data Infrastructure”
Speaker: Bunyamin Ozaydin, Ph.D.
Affiliation: Assistant Professor, UAB School of Health Professions
2018
December 7, 2018
Topic: "Quality Improvement with CDW Mining, Graph-Network Analysis & Visualization: The INFECTALYTICS Project"
Speaker: Allen Bryan, M.D., Ph.D.
Affiliation: Assistant Professor, Department of Pathology, Division of Laboratory Medicine
November 30, 2018
Topic: "Investigating the Use of Patient Attributes to Predict False-Positive Medical Alerts"
Speaker: Tim Kennell
Affiliation: M.D./Ph.D. Student, UAB, GBS
November 9, 2018
Topic: "Biomedical Informatics Year in Review"
Speaker: James J. Cimino, M.D.
Affiliation: Director, UAB Informatics Institute, Professor of Medicine
November 2, 2018
Topic: "Informatics in Precision Medicine: When Data Is the Drug"
Speaker: Matthew Might, Ph.D.
Affiliation: Director, UAB Hugh Kaul Precision Medicine Institute, Professor of Medicine
October 19, 2018
Topic: “Beyond Patient Portals: Informatics Support for Patient Engagement in the Inpatient Setting”
Speaker: Wayne Liang, M.D.
Affiliation: Assistant Professor, UAB Department of Pediatrics, Division of Pediatric Hematology/Oncology
October 5, 2018
Topic: "Physician Performance and Preference for Clinical Data in Structured and Unstructured Formats."
Speaker: Eta Berner, Ed.D.
Affiliation: Professor, Director, Center for Health Informatics for Patient Safety/Quality UAB School of Health Professions
September 5, 2018
Topic:“Putting the “Why” in “EHR”: Toward the Development of an Ontology for Representing Clinical Reasoning in Clinical Notes”
Speaker: Jim Cimino, M.D., FACMI, FACP
Affiliation: Professor, Director-Informatics Institute, Co-Director-Center for Clinical and Translational Science
