clinicalresearch

Clinical research informatics entails all manner of activities but often focuses on retrospective historical studies and prospective clinical trials. Clinical research informatics pursues the development of methods and tools that support clinical researchers, whether that is reusing previously collected data or collecting new data in studies of their own. Clinical research informaticians seek to improve not only data collection but also the entire research process, from hypothesis generation, through study design and approval, to study execution and finally the analysis of study data. Clinical data repositories and clinical trials data management systems are major areas of focus in clinical research informatics. 

Clinical Research Informatics at UAB

The i2b2 (Intergrating Informatics for Biology to the Bedside) data repository at UAB provides researchers with self-service access to patient data from a variety of sources for use in clinical research. While i2b2ā€™s basic functionality is quite powerful, Dr. James Cimino and colleagues at the Informatics Institute are working with the UAB Center for Clinical and Translational Science to further improve the system to make it more useful and usable. This includes changes to the user interface, the search ontology, text processing (including indexing and de-identification), data download capabilities, and data analysis tools.

Infobuttons are context-aware links, typically inserted into clinical information systems to anticipate and address the information needs of clinicians and patients using such systems.  Researchers at UAB are examining the information needs of clinical researchers, in particular those working with the i2b2 system (see above).  Referred to as ā€œi3b3ā€ (Infobuttons for i2b2), we are developing methods for embedding links into i2b2 that will help users with questions about the terminologies encountered in i2b2, the biomedical concepts underlying these terms, and the use of i2b2 itself. For more information on infobuttons, contact Dr. James Cimino

The UAB Foundational Ontology (UFO) is an enterprise terminology management system, currently under development, that brings together controlled terminologies use for capturing clinical and research data at UAB. In the UFO, terminologies are merged to support system interoperability. The UFO will also include additional classification (new classes and multiple classification), improved term naming, synonyms, and other knowledge to improve the usability and usefulness of controlled terminologies in clinical and research systems, such as i2b2 (see above).

The Phenotype Detection Registry System (PheDRS) is a tool for clinical phenotyping at UAB. It is designed to support the identification of reportable cancers, patients suffering from COPD exacerbations, and other phenotypes of interest using machine learning and natural language processing (NLP).  A current area of interest is to improve natural language processing tools for information extraction using deep recurrent and convolutional neural networks (Deep Learning) focusing on such tasks as concept normalization, semantic role labeling and de-identification.