Assistant Professor
Research Areas
Synaptic and cellular organization and processing in the neocortex and thalamus, with an emphasis on sensory systems
Publications
Two dynamically distinct circuits drive inhibition in the sensory thalamus, RI Martinez-Garcia, B Voelcker, JB Zaltsman, SL Patrick, TR Stevens, BW Connors, SJ Cruikshank, Nature 583 (7818), 813-818; 2020
A corticothalamic switch: controlling the thalamus with dynamic synapses, SR Crandall, SJ Cruikshank, BW Connors, Neuron 86 (3), 768-782; 2015
Thalamic control of layer 1 circuits in prefrontal cortex, SJ Cruikshank, OJ Ahmed, TR Stevens, SL Patrick, AN Gonzalez, ..., Journal of Neuroscience 32 (49), 17813-17823; 2012
Pathway-specific feedforward circuits between thalamus and neocortex revealed by selective optical stimulation of axons, SJ Cruikshank, H Urabe, AV Nurmikko, BW Connors, Neuron 65 (2), 230-245; 2010
Synaptic basis for intense thalamocortical activation of feedforward inhibitory cells in neocortex, SJ Cruikshank, TJ Lewis, BW Connors, Nature neuroscience 10 (4), 462-468; 2007
Auditory thalamocortical synaptic transmission in vitro, SJ Cruikshank, HJ Rose, R Metherate, Journal of neurophysiology 87 (1), 361-384; 2002
For a full list of publications:
https://scholar.google.com/citations?hl=en&user=qup9WlQAAAAJ
Biography
Dr. Cruikshank received his Ph.D. and postdoctoral training from the University of California, Irvine. Before coming to UAB in 2019, he was a research track professor in the Department of Neuroscience at Brown University.
Research
Dr. Cruikshank studies synaptic and sensory processing in neural circuits of the neocortex and thalamus. Clarifying how these structures bidirectionally control one another will be an important part of understanding mammalian information processing. His work involves neurophysiology in intact animals and in vitro, pharmacology, anatomy, behavior and optogenetics. He often combines whole-cell recordings from genetically-identified neurons with optical control. An overarching goal is to identify basic principles of cortical-thalamic processing, including interactions with brain state.
Contact
Email
sjc@uab.edu
Telephone
205-996-6247