Are you still suffering from Generalized Anxiety Disorder (GAD)? Have you tried prescribed medication but are still experiencing anxiety symptoms? If so, please consider participating in our research study of an investigational drug for GAD. To join this study, potential study participants: must be at least 18 years of age must have taken at least 2 of the following treatments without adequate symptom relief: Paroxetine Venlafaxine XR Duloxetine Escitalopram Buspirone There is no charge for study-related tests or drugs. For more information, please email lalexander@uabmc.edu or call 205-996-5987.

Learn more about a clinical trial examining a potential new treatment for depression in adult patients. Managing symptoms of depression can feel overwhelming, but you are not alone. If you experience symptoms such as sadness, diminished interest or pleasure in things that you once enjoyed, appetite changes, sleep changes, fatigue, feelings of worthlessness or guilt, or thoughts of suicide or harming yourself, you may qualify for a clinical trial examining a new treatment option for depression. The Vitalize Clinical Study is evaluating a new type of investigational treatment for patients with depression that works differently than traditional antidepressants. The study will include a total of 9 visits with the study doctor, over a period of 14 weeks. If you are qualified to participate, you will receive either the study drug, or placebo, as an oral tablet administered one time per week in the study clinic. As a study participant, you will also receive once-weekly evaluations of your depression and other symptoms, physical examinations and tests of your blood, urine, heart, and brain activity at no cost. This study may be an option for you if you: are a healthy adult aged 18-64 with no other major illnesses have a diagnosis of depression are currently experiencing a major depressive episode that has lasted at least 3 weeks but no longer than 18 months are interested in trying a new treatment option, administered as an oral tablet once per week are interested in receiving thorough evaluations of your depression and health monitoring during your participation in the study are interested in contributing to the growing body of research about depression and new treatment options. For more information on how to qualify for the Vitalize Clinical Study, please email lalexander@uabmc.edu or danagreen@uabmc.edu.

Continuing to experience the effects of depression? You could participate in a research study for adults who have depression. The purpose of the study is to evaluate the safety, efficacy, and maintenance of effect of an investigational medication in people with depression. You may be eligible to participate if you: are 18-74 years of age have been diagnosed with depression have taken antidepressants in the past that did not work well for you are currently taking an antidepressant medication but still have symptoms of depression If you are interested, additional eligibility criteria will be assessed by the study doctor or staff. The study consists of Part 1 and Part 2. In Part 1, you will received the investigational medication or placebo (contains no active medication) for 6 weeks. If you complete Part 1, you will have the option to participate in Part 2. In Part 2, you could receive the investigational medication for up to 16 weeks or more. Qualified patients may receive study-required medical care and investigational study medication at no cost. The study will not pay for other medical care or current medication(s) needed to support your daily health care routine. To learn more about this study, please email lalexander@uabmc.edu or kristinepike@uabmc.edu.

We are currently looking for adults between the ages of 18-60 who are depressed and experienced a happy childhood. Have you been: feeling sad, down, hopeless? experiencing increased/decreased appetite? having difficulty concentrating? feeling weary of life? If so, you may be eligible for our Non-treatment study. Participants will be compensated for participating. If you are interested or have any questions, please visit https://tinyurl.com/UABpsychiatricresearch or call (205) 975-2484.

Are you or is your child between the ages of 11-19? The UAB Office of Psychiatric Research is actively recruiting participants for an Adolescent Depression Study and wants to connect with you on our research! Whether you are needing someone to talk to, or even have no history of mental health conditions and are just wanting to further knowledge within the medical and mental health field, we would love to get you involved! Our Adolescent Study is a Non-Treatment Study. Our Non-Treatment Studies do NOT involve testing a new medication or intervention. Instead, these studies focus on understanding behaviors and experiences of mental health conditions via interviews, tests, or surveys. COMPENSATION IS PROVIDED FOR BOTH PARENT AND CHILD! For more information, please reach out to the UAB Office of Psychiatric Research at (205) 934-2484 or go to https://tinyurl.com/UABpsychiatricresearch and our team will be in contact with you shortly.

Are you at least 18 years old and have been previously diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD) and would like or are in need of a comprehensive psychological evaluation? If so, you may be eligible to participate in a research study where you will receive a free comprehensive psychological evaluation involving a diagnostic interview, cognitive testing such as achievement and intelligence testing, and a personality assessment. Participation involves approximately 7 to 8 hours of a full psychological evaluation to assess you for ADHD and other potential mental health concerns. The assessment may occur over either one or multiple days, depending on your preference. In exchange for participation, all participants will receive a full comprehensive psychological report detailing the findings of your evaluation. This report will be a standard medical report that can be utilized to seek mental health treatment, academic or work accommodations, or meet other needs. If you are interested in participating, please visit the following survey link: https://uab.co1.qualtrics.com/jfe/form/SV_72jKfhVIiFdZKyW If you have any questions, please reach out to either Drew Whittington at whitdrew@uab.edu or Dr. Nicholas Borgogna at borgogna@uab.edu.

Participants between the ages of 35 and 65 are needed for this study. The purpose of the study is to fill in what we don’t know about how schizophrenia affects people as they get older. We want to find out what we can do to help older individuals with schizophrenia live better lives. The study includes 4 visits over the course of two weeks. The screening visit will take 2 hours. The first study visit will take 3 hours. The second study visit will take 2 hours. The third study visit will take 9 hours. This study will include: a clinical interview, cognitive batteries, questionnaires and assessments related to your daily and psychiatric functioning, two 90 minute MRI scans of your brain, a fasting blood draw, and a urine drug screen and pregnancy test (for females). Compensation is up to $310. TO SEE IF YOU QUALIFY PLEASE CONTACT (205) 934-8203 OR EMAIL nlsb.uab@gmail.com.

Do you struggle with anxiety, depression, or feel that your quality of life has suffered due to your HIV diagnosis? Researchers in the Department of Psychology at The University of Alabama at Birmingham are conducting a clinical trial of Acceptance and Commitment Therapy for the treatment of mental health concerns among men who have sex with men and are living with HIV. Volunteers will attend 8 weekly roughly 1 hour sessions of psychotherapy delivered via HIPAA-compliant Zoom by a doctoral student in Medical/Clinical Psychology at University of Alabama at Birmingham. Participants will receive $10 upon completion of initial intake session and an additional $15 upon completion of final therapy session. To participate, you must be an active patient of UAB's 1917 clinic. Complete this online screener to indicate interest: https://uab.co1.qualtrics.com/jfe/form/SV_8H8oWPLXTK532DQ Reach out to uabACThivtrial@gmail.com with any questions.

Study includes up to 12 in-person sessions of weekly counseling for free Remuneration in the form of up to three distributions of $25 for completing three surveys over the course of the study ($75 total) To be included: You must be an adult (18 or older) Identify as LGBTQ+ Our study is a counseling intervention designed to address mental health concerns related to identity-related minority stress. However, there are a few conditions that we do not think would be a good fit. If you are experiencing severe drug addiction, past year history of suicide attempt/self-injury, eating disorder problems, or struggling with psychosis you would not be eligible for this study. Please email Drew Whittington if interested in participating: whitdrew@uab.edu.

Are you between the ages of 18-60? The UAB Office of Psychiatric Research is actively recruiting participants for our studies and wants to connect with you on our research! Whether you are needing someone to talk to, or even have no history of mental health conditions and are just wanting to further knowledge within the medical and mental health field, we would love to get you involved!Our studies can be broken down into two different categories:1) TREATMENT STUDIES – Our Treatment Studies are designed to evaluate the effectiveness of new antidepressants on individuals living with Major Depressive Disorder or Treatment-Resistant Depression.2) NON-TREATMENT STUDIES – Our Non-Treatment Studies do NOT involve testing a new medication or intervention. Instead, these studies focus on understanding behaviors and experiences of mental health conditions via interviews, tests, or surveys.COMPENSATION IS PROVIDED!For more information, please reach out to the UAB Office of Psychiatric Research at (205) 934-2484 or go to: https://tinyurl.com/UABpsychiatricresearch and our team will be in contact with you shortly!

Do you experience mild to moderate anxiety?Want to learn calligraphy?Help us explore the effects of guided calligraphy training on mental health!Check eligibility and sign up here: https://sites.uab.edu/calligraphyresearchBENEFITSLearn calligraphy with live instructor • Free online calligraphy training course • Free calligraphy supplies • Drawings for gift cards • Improve manual dexterityPURPOSEThis is a pilot study to assess the feasibility of performing virtually administered art therapy research, as well as a preliminary study to explore whether calligraphy training affects anxiety levels in healthy individuals with mild to moderate anxiety.TIME & LOCATIONAll meetings and training sessions will be held on Zoom. Participation includes up to a total of 15 hours of time over 12 calendar weeks—an intro meeting, 4 training sessions, a debriefing meeting, and 15 minutes a day of practice--5 days a week for 4 weeks. Pending full recruitment, training classes will be held in January-February 2025.HOW TO ENROLLTo learn more, check eligibility and sign up, click here: https://sites.uab.edu/calligraphyresearch

If you are currently taking antidepressant medications but still struggle with depression, you may qualify for a new clinical research study. The study is evaluating an oral investigational medication for depression that can be taken with your current antidepressant medication. For more information and to see if you're eligible to participate, please call 205-975-8542 or 205-934-2484.

Participants between the ages of 35 and 65 are needed for this study. The purpose of the study is to fill in what we don’t know about how schizophrenia affects people as they get older. We want to find out what we can do to help older individuals with schizophrenia live better lives. The study includes 4 visits over the course of two weeks. The screening visit will take 2 hours. The first study visit will take 3 hours. The second study visit will take 2 hours. The third study visit will take 9 hours. This study will include: a clinical interview, cognitive batteries, questionnaires and assessments related to your daily and psychiatric functioning, two 90 minute MRI scans of your brain, a fasting blood draw, and a urine drug screen and pregnancy test (for females). Compensation is up to $310. TO SEE IF YOU QUALIFY PLEASE CONTACT (205) 934-8203.

If you’ve been feeling stuck and longing for relief, you may be eligible to receive dedicated medical attention, an investigational therapeutic and compensation for your involvement in an innovative research study. We're conducting clinical research in depression to learn how individuals’ brain biology impacts response to treatment, with the goal to help people find relief faster. You do not need to already have a diagnosis to participate. If you’re currently taking medication, you are likely still eligible for our studies and don’t have to stop your existing treatment regimen.For more information about this trial and to see if you qualify, please contact Kristine at kristinepike@uabmc.edu or 205-975-8542.

Major Depressive Disorder is a mental health condition characterized by periods of low mood, low self-esteem, and loss of interest or pleasure in normally enjoyable activities. The purpose of this clinical research study is to evaluate the safety and effectiveness of an investigational drug for Major Depressive Disorder, also known as Major Depression. Study participation may include several clinic visits over a period of up to 5 months with an opportunity to conduct some visits either virtually or in-clinic. Qualified participants will receive compensation for their time.For more information about this trial and to see if you qualify, please contact Kristine at kristinepike@uabmc.edu or 205-975-8542.

Are you: A woman who has ever been in jail, prison, or on probation or parole? A woman who has used drugs? Interested in learning about a way to protect yourself against HIV?   You may qualify for a paid research study at the University of Alabama at Birmingham, in partnership with Yale University. Participate in confidential study interviews at our research office. Earn $50 for each interview, up to $225 for participating in the study. Fill out our contact survey at: https://yalesurvey.ca1.qualtrics.com/jfe/form/SV_d7sAjr6GDsjiJng?Q_CHL=qr Or you may call 205-934-2851 or email AthenaStudy@uabmc.edu

University of Alabama at Birmingham is seeking cigarette smokers who would like to quit smoking for participation in a scientific research study. The research study involves free counseling and treatment provided in a comfortable, supportive setting. The study may involve ingestion of psilocybin, a psychoactive substance found in psychedelic mushrooms that have been used as a sacrament in various cultures. Some research studies have suggested that psychedelics, when administered under interpersonally supportive and well-prepared conditions, may be effective in helping people overcome addictions. Questionnaires, interviews, and biological measures of smoking will be used to assess the treatment's effects on mood and smoking. Participants will be compensated $50 per session. If you would like to discuss the possibility of volunteering, please call 205-996-1198, or go to www.quitsmokingbaltimore.org for more information about the study and to complete the online study prescreener for the UAB site. Confidentiality will be maintained for all applicants and participants.Volunteers must be 21 years of age or older, and must live within travel distance of the study site in Birmingham.

There is an ongoing psychedelic clinical research study evaluating the safety and efficacy of an intranasal study drug for patients with treatment resistant depression. To qualify patients need to be 18-75 years of age, failed to respond to an adequate dose & duration of at least 2 medicines for depression. If currently taking antidepressants, willing and able to discontinue. If eligible, study participants will be expected to abstain from illicit drugs for the duration of the trial & attend all study visits & follow instructions from the study doctor. Study examinations will be at no cost to you. For more information please contact 205-996-1198 or spremani@uab.edu

Healthy participants needed if you are: 18-75 years old No diagnosis of any neurological disorders or psychiatric problems No history of problematic drug/alcohol use in the last 3 months For more information and to determine eligibility, please call the Neuroscience Laboratory of Social Behavior at (205) 934-8203 or email nlsb.uab@gmail.com. **Compensation is provided**

If you’re being treated for MDD and your current antidepressant medication(s) is not working, the SAVITRI Study might interest you. The SAVITRI Study is researching a potential MDD therapy to improve symptoms of depression, and you may be able to participate. This research study is now enrolling adults diagnosed with MDD. Those who qualify will receive the investigational medication (or placebo), study-specific medical exams, and study-specific laboratory tests at no cost. Participants in the SAVITRI Study must: be 18 to 65 years of age; have a clinical diagnosis of MDD; be currently on antidepressant medication(s); have had inadequate response to up to 5 oral antidepressant medications; and fulfill other eligibility criteria. For more information, please call (205) 996-5987 or email lalexander@uabmc.edu. Please mention SAVITRI in your message.