The Trial Innovation Network (TIN)​ is a platform for multi-center trials and studies that encompass a wide-range of disciplines. Investigators do not need to apply for a specific RFA, but should propose a multi-center trial or study. The Network will prioritize proposals for multi-center clinical trials and studies with patient-oriented endpoints with potential for impact on clinical practice and operational innovation as well as proposals that foster collaborations with other NIH ICs over proposals seeking funding from NCATS.​​
The TIN established three Network Central IRBs (CIRBs): Johns Hopkins University School of Medicine, The University of Utah, and Vanderbilt University Medical Center. The Network CIRBs use the SMART IRB Reliance Agreement through the IRB Reliance Exchange (IREx; formally SMART IRB Exchange).
What Makes a Good Proposal for the Trial Innovation Network?
- An optimal submission includes:
- Principal Investigator willing to partner with the TIN through the life cycle of the project
- Opportunity to study an innovative operational approach to improve quality, efficacy, or cost of clinical research
- More than 60 days allotted for consultation prior to planned grant submission with substantial project development
- Includes a multi-center study design (3 or more institutions)
- Fosters broad collaboration within the CTSA Program and NIH Institutes and Centers
- Includes all populations affected by the health condition being studied
- Opportunity to provide academic evidence to improve clinical trial designs, conduct, and reportability