Angiopoietin-like-4 (Angptl4), a secreted glycoprotein, is highly upregulated in the serum and in podocytes in minimal change disease (MCD), a common cause of nephrotic syndrome. These transgenic rats exhibit podocyte-specific transgenic overexpression of Angptl4 (NPHS2-Angptl4), which induces nephrotic-range, and selective, proteinuria (over 500-fold increase in albuminuria), loss of glomerular basement membrane (GBM) charge and foot process effacement. Rats have been published in:

Clement LC, Avila-Casado C, Macé C, Soria E, Bakker WW, Kersten S, Chugh SS. Podocyte-secreted angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome. Nature Medicine 17, 117-122. 2011

UAB Reference: U2010-0068

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Eve Vick, PhD
Licensing Manager
Phone: (205) 996-4740

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