Precision High-Intensity Training Through Epigenetics

The PHITE program will explore the link between physical training and epigenetics and will use that understanding to (1) identify training methodologies that modify epigenetics responses; (2) characterize epigenetic regulation of physiological processes, pathways, and mechanisms associated with moderate and high-intensity physical training: and (3) produce real-time biomarkers of cardiorespiratory and neuromuscular performance that predict physical training outcomes. 

Funding: Department of Defense MURI
Principal Investigators: Timothy J. Broderick, MD (Wright State), Marcas M. Bamman, PhD (UAB)
Institutions: Wright State University Boonshoft School of Medicine, Wright State University, The Salk Institute, UAB identifier: NCT03380923


Molecular Transducers of Physical Activity in Humans

MoTrPAC is a national research consortium designed to discover and perform preliminary characterization of the range of molecular transducers (the "molecular map") that underlie the effects of physical activity in humans. The program's goal is to study the molecular changes that occur during and after exercise and ultimately to advance the understanding of how physical activity improves and preserves health. The six-year program is the largest targeted NIH investment of funds into the mechanisms of how physical activity improves health and prevents disease.

Funding: The MoTrPAC program is supported by the NIH Common Fund and is managed by a trans-agency working group representing multiple NIH institutes and centers, led by the NIH Office of Strategic Coordination, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute on Aging, and National Institute of Biomedical Imaging and Bioengineering. identifier: NCT03960827

ACES Trial

Antihypertensives Combined with Exercise for Seniors with Hypertension

The purpose of this project is to conduct a randomized, controlled trial (RCT) to determine if choice of antihypertensive medication influences changes in functional status and other cardiovascular risk factors among older persons with hypertension. Sedentary men and women > 60 years of age with functional limitations and hypertension will be recruited from two sites to participate in a longitudinal intervention trial. Participants will be randomly assigned to one of three first-line antihypertensive agents and participate in a structured aerobic exercise intervention. This study is expected to differentiate beneficial effects of three FDA-approved antihypertensive medications on established and emerging cardiovascular risk factors in a clinically-relevant population.

Funding: NIH R01AG056769
Principal Investigators: Thomas Buford, PhD; Wendy Kohrt, PhD; Bret Goodpaster, PhD
Institutions: UAB, University of Colorado and Translational Research Institute, Advent Health.


Overcoming TWEAK Signaling to Restore Muscle and Mobility after Joint Replacement

This randomized clinical trial was designed to test the central hypothesis that progressive resistance training plus functional mobility training after total hip replacement or total knee replacement will more effectively restore muscle mass and mobility function to healthy standards than usual care and, because individuals with abnormally high muscle TWEAK signaling are predicted to suffer failed muscle recovery and persistent dismobility under usual care, the impact of the intervention will be greatest among these patients.

Funding: NIH R01HD084124
Principal Investigators: Marcas Bamman, PhD; Lou Bridges, MD, PhD
Institutions: UAB and UAMS Identifier: NCT02628795


Metformin to Augment Strength Training Effective Response in Seniors

Strength exercise training is the most effective intervention identified to combat loss of muscle function with advancing age; however, the response to exercise is blunted and highly variable in older adults. This randomized, placebo-controlled trial - a collaboration between two major academic medical centers (University of Kentucky and University of Alabama at Birmingham) - was designed to determine if the addition of a medication (Metformin) will improve the effectiveness of strength training in older adults.

Results: This clinical trial dispelled the hypothesis that the diabetes drug metformin could help exercising seniors gain more muscle mass. The double-blind trial found that older adults who took metformin while performing rigorous resistance exercise training had smaller gains in muscle mass than did the placebo group.

Funding: NIH R01AG046920
Principal Investigators: Charlotte Peterson, PhD; Phil Kern, MD; Marcas Bamman, PhD
Institutions: University of Kentucky and UAB Identifier: NCT02308228

The Effects of a High Intensity Exercise Training Program in Patients With Parkinson's Disease

The Effects of a High Intensity Exercise Training Program on Sleep and Vigilance in Patients With Parkinson's Disease (The Effect of Low Frequency STN DBS on Sleep and Vigilance in PD Patients)

The purpose of this randomized, controlled interventional study was to determine the effects of a high intensity exercise training program on objective sleep measures, daytime sleepiness, mobility, and brain health/functional connectivity in patients with Parkinson's disease.

Study Groups: All participants in this study were randomly assigned to one of two groups: the exercise group or a sleep hygiene group.

All participants received a free membership to The Lakeshore Foundation for the second half of the study.
Total Study Duration: 34 weeks
Study Visits: Participation in the study involved a screening visit and three sets of study assessments, each of which involved 3-4 study visits to the University of Alabama at Birmingham (UAB). The sets of study assessments occured at the beginning of the study, at week 18, and at week 34. Identifier: NCT02593955