Influence of Obesity on Endogenous Oxalate Synthesis

Principal Investigator: Dean Assimos, MD
ClinicalTrials.gov Identifier: NCT03704350

There is increasing evidence that obesity is associated with increased urinary oxalate excretion, an important risk factor for calcium oxalate stone formation. By the administration of a controlled low oxalate diet the investigators will estimate endogenous oxalate synthesis in both non-obese and obese non-kidney-stone forming adults. This study seeks to increase the understanding of the relationships between obesity and endogenous oxalate synthesis to serve as a platform to develop novel therapies for stone prevention.

Influence of Obesity on Oxalate Metabolism and Handling in Calcium Oxalate Stone Formers

Principal Investigator: Dean Assimos, MD
ClinicalTrials.gov Identifier: NCT04333745

The primary goals of this study are to determine the contribution of dietary oxalate absorption, renal oxalate handling, and endogenous oxalate synthesis to urinary oxalate excretion in normal Body Mass Index (BMI) and obese calcium oxalate kidney stone formers.

Effect of Weight Loss on Urinary Oxalate Excretion in Obese Calcium Oxalate Kidney Stone Formers

Principal Investigator: Dean Assimos, MD
ClinicalTrials.gov Identifier: NCT04633811

This protocol seeks to determine if weight reduction with the Optifast VLCD program leads to reduced contribution of endogenous oxalate synthesis to the urinary oxalate pool in obese calcium oxalate stone formers.

Oxalate Formation From Ascorbic Acid

Principal Investigator: John Knight, PhD
ClinicalTrials.gov Identifier: NCT04603898

The purpose of this basic research study is to determine the contribution of endogenous ascorbic acid (AA) turnover to urinary oxalate excretion in both lean and obese adult non-stone formers and calcium oxalate stone formers. The studies proposed will use diets of known nutrient composition, a stable isotope of ascorbic acid (13C6-AA) and mass spectrometric techniques to quantify ascorbic acid turnover to oxalate.

Dietary Oxalate and Innate Immunity in Kidney Stone Disease

Principal Investigator: Tanecia Mitchell, PhD
ClinicalTrials.gov Identifier: NCT04051346

This study will test whether oxalate stimulates urinary crystals and impacts the immune system in healthy subjects using two controlled diets (low and high oxalate). 

Oxalate-Driven Host Responses in Kidney Stone Disease

Principal Investigator: Tanecia Mitchell, PhD
ClinicalTrials.gov Identifier: NCT05417568

This study is looking to understand the role of oxalate on kidney stone development and immunity. The purpose of this longitudinal study is to examine the effects of dietary oxalate on nanocrystalluria and the immune system.

Assessment of Endogenous Oxalate Synthesis

Principal Investigator: Sonia Fargue, PhD
ClinicalTrials.gov Identifier: NCT0522995

This study aims to determine the daily rate of endogenous synthesis of oxalate using carbon 13 oxalate isotope tracer technique and a low-oxalate controlled diet.

Renal Metabolism of Glycolate to Oxalate

Principal Investigator: Sonia Fargue, PhD
ClinicalTrials.gov Identifier: NCT04437225

This study will determine the contribution of glycolate metabolism to urinary oxalate excretion in healthy subjects, using carbon 13 isotope glycolate tracer technique and a low-oxalate controlled diet.

Obesity and Endogenous Oxalate Synthesis

Principal Investigator: Kyle Wood, MD
ClinicalTrials.gov Identifier: NCT03808090

The goal of this proposal is to determine the contribution and significance of obesity to urinary oxalate excretion and thus calcium oxalate kidney stone disease.

Dietary Oxalate and Immune Cell Function

Principal Investigator: Tanecia Mitchell, PhD
ClinicalTrials.gov Identifier: NCT03877276

The purpose of this study is to evaluate mitochondrial function in white blood cells and platelets from healthy individuals following dietary oxalate intake.