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The Metabolism Core was designed to provide state-of-the-art assessments of human energy expenditure, substrate metabolism, body composition, body fat distribution, and bone quality; to provide cost-effective, centralized analytical services to ongoing funded and pilot research projects; to promote multi-disciplinary research and training in clinical nutrition and obesity across the UAB campus; and to offer training, advice, and instruction to students, fellows, and investigators.


The Cost of Nutrition Sciences established the “Energy Metabolism Research Unit” (EMRU) in 1994 to provide a comprehensive assessment of human body composition, energy expenditure, and substrate metabolism. Services offered were body composition by dual-energy X-ray absorptiometry (DXA); body volume/density by underwater weighting; free-living energy expenditure by doubly-labeled water; 24-h energy metabolism using whole-room indirect calorimetry; and resting and exercise energy metabolism by the portable metabolic monitor (indirect calorimetry). In 2000, the EMRU became the “Energy Metabolism / Body Composition Core” of the NIDDK-funded Clinical Nutrition Research Center (CNRC). During the 2005 CNRC renewal, the name was changed to the “Metabolism Core.” The DXA was updated to a wider scanning bed and a table that could accommodate patients up to 450 lbs. In 2011, the Metabolism Core continued under the newly funded Nutrition Obesity Research Center (NORC). A PeaPod was added for assessment of infant body composition, and a Peripheral Quantitative Computed Tomography (pQCT) instrument was added for assessment of bone quality and fat infiltration of leg muscle.

Services (Research only)

Energy Expenditure/Substrate Metabolism:

  • Total energy expenditure by doubly-labeled water
  • Resting energy expenditure by indirect calorimetry
  • 24-h energy expenditure by whole-room indirect calorimetry
  • Design consultation

Body Composition:

  • Dual-energy X-ray absorptiometry
  • Body density by PeaPod (Infant)
  • Total body water by isotope dilution
  • Multi-compartment models
  • Bone/muscle quality by pQCT
  • MRI/CT scan analysis

Exercise and Physical Activity:

  • Maximal and submaximal oxygen consumption during exercise
  • Strength testing
  • Functional testing
  • Accelerometry


  • Isotope Ratio Mass Spectrometer (IRMS)

    The Core is equipped with two IRMS (Optima and Delta-V) for measurement of enrichment of deuterium and oxygen-18 in biological samples. Stable isotope dilution and metabolism can be used to assess body composition and free-living energy expenditure.

  • Indirect Calorimetry (resting)

    Two open-circuit metabolic monitors are available for assessment of resting energy expenditure (REE) and substrate oxidation (fat, carbohydrate) (Vmax ENCORE 29N Systems, SensorMedics Corporation, Yorba Linda, CA).

  • Indirect Calorimetry (whole-room)

    Room indirect calorimetry is used for evaluation of 24-h energy metabolism. The calorimeter has a gross volume of 17,500 liters (3.4m long, 2.1m wide, and 2.6m high). It is equipped with a fold-out bed, desk, chair, refrigerator, toilet, sink, television, video player, telephone, and airlock for the passage of food and materials in and out of the room. Data can be collected for sleeping energy expenditure, resting energy expenditure, physical activity-related energy expenditure, and diet-induced thermogenesis. Activity is monitored by a short-range, precision microwave motion detector.

  • PeaPod

    The PeaPod can analyze body composition in infants aged 0-6 months.The PeaPod can analyze body composition in infants aged 0-6 months.

    The portable PeaPod® (LMI) consists of a two-chamber plethysmograph. Infant body volume and density are used to calculate body composition. The test requires ~30 minutes.

  • Dual-Energy X-ray Absorptiometry (DXA)

    DXA for determination of total and regional body compositionDXA for determination of total and regional body composition

    The Core houses two iDXA instruments (GE-Lunar Radiation Corp. Madison, WI) for assessment of total and regional body composition. The new CoreScan software includes an estimate of visceral fat that is produced by subtracting measured subcutaneous abdominal fat from measured total abdominal fat. Bone density of the spine and hip also can be assessed. Whole-body scans require ~10-15 min. Additional hip or spine scans require re-positioning and re-scanning.

  • Magnetic Resonance Imaging (MRI)

    MRI results showing thigh muscle
and adipose tissueMRI results showing thigh muscle and adipose tissue MRI scanning is conducted on clinical scanners in the Departments of Radiology and Cardiology at UAB. The Department of Radiology offers MRI scans on a Philips 1.5 Tesla Ingenia Omega HP; Cardiology uses a Philips Intera 3 Tesla scanner (Philips Medical Systems, Best, The Netherlands). Scanning is not offered as a NORC Core service; rather, each investigator makes his/her own arrangements with the appropriate departmental personnel, and arranges for faculty in Radiology/Cardiology to provide assistance with determining appropriate acquisition parameters. The Core provides scan analysis, and assistance with making necessary contacts.

  • Peripheral Quantitative Computed Tomography (pQCT)

    The XCT 3000® (Stratec, Germany) is a fully automated X-ray system for the determination of bone density and muscle composition. The pQCT offers an alternative to computed tomography (CT) and MRI for investigators who do not wish to, or cannot accommodate, the time constraints, expense, subject burden, or radiation exposure associated with CT or MRI. Study participants insert either the distal forearm (radius) or the lower leg (tibia) into the instrument. Scan time differs per location, but is typically 3 min.

  • Parvo Medics TrueOne® 2400

    The TrueOne 2400 is a computerized, integrated metabolic measurement system for cardiopulmonary stress testing, indirect calorimetry, and maximal O2 consumption measurement.

  • LODE Cycle Ergometer

    The Lode Corival ergometer has a digital interface and can be controlled easily by the Parvo Medics TrueOne for obtaining timely, accurate measurements.The workload is adjustable in a range of 7 to 1000 watts.

  • Actigraph GT3X-BT accelerometers with ActiLife software

    The ActiGraph wGT3X-BT captures and records high resolution raw acceleration data, which is converted into a variety of objective activity and sleep measures.

  • Hypoxico HYP-123

    The HYP-123 hypoxicator can assist in boosting the body’s oxygen transport systems through enhanced ventilation, naturally increased EPO production and increased mitochondrial efficiency.

  • CR 2000

    Produced by Hypertension Diagnostics, this equipment uses non-invasive radial artery pulse wave analysis for measurement of arterial elasticity.

  • Treadmills

    Our treadmills sync with the TrueOne 2400 for timely, accurate measurements.


DLW (IRMS analysis/calculations) $220 per patient
REE (core staff performs test) $100 per patient
REE (investigator performs test) $75 per patient
Room calorimeter $500 per patient
DXA $75 (whole-body)
$75 (hip and spine) per patient
Total body water (IRMS analysis /calculations) $60 per patient
MRI/CT scan analysis Based on slice number and location
Seca mBCA $15 per patient
Ultrasound $5 per day
VO2max $80 per patient
Submaximal exercise test $75 per patient
Strength testing $50 per patient
Functional testing $65 per patient
Accelerometry with data analysis (4 days) $50 per patient
Accelerometry without data analysis (4 days) $25 per patient

All Core users are asked to complete and submit a “Core Use Request Form” when applying for Core services. This form requests information concerning investigator funding, and the types and numbers of services requested.



Barbara A. Gower, PhD

Department of Nutrition Sciences

Robert Petri

Nutrition Sciences Research

Zhaojing Zeng

Scientist I
Nutrition Sciences Research

Heather Hunter

Scientist I
Nutrition Sciences Research

David Bryan

Clinical Research Coordinator III
Nutrition Obesity Research Center

Lia Puzzo

Nutrition Sciences Clinical Services



Barbara A. Gower, Ph.D.
Director, Metabolism Core

Department of Nutrition Sciences
School of Health Professions
Phone: (205) 934-4087
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

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