You may be eligible to participate in a research study about the effects of Sacubitril/Valsartan or Valsartan on your body’s 24-hour rhythm of a hormone in your blood called natriuretic peptides. This hormone and the study medications are related to the heart. Eligible participants must be obese (BMI: 30-45 kg/m2) men and women and have no history of diabetes, heart problems, or kidney problems. The study involves consuming prepared meals, wearing a blood pressure monitor for 24-hours, a 24-hour inpatient stay, and collecting blood and urine samples. The meals will be provided at no cost. Participants will be compensated $560 for completing the study visits. Please e-mail Nehal at PRECISION-BPSTUDY@uabmc.edu if you are interested.

Overweight/Obese adult volunteers needed for study If you are between the ages of 18 -89 yrs and have a body mass index > 30 kg/m2 you may be eligible to participate in a study exploring the reason why individuals who have high BMI have an increased risk of forming calcium oxalate kidney stones. Participation involves eating study-provided meals for 4 days, providing urine and blood samples. Study meals are provided free of charge and additional compensation up to $140 is offered. For more information call 205-934-5712 or email kidneystone@uabmc.edu or kidneystoneresearch@uabmc.edu

Adults with Type 2 Diabetes needed for a study If you are between the ages of 18 -89 yrs and have type 2 diabetes you may be eligible to participate in a study exploring the reason why individuals who have diabetes have an increased risk of forming calcium oxalate kidney stones. Individuals who are obese, overweight, or normal weight are all welcome to the study. Participation involves eating study-provided meals for 4 days, providing urine and blood samples. Study meals are provided free of charge and additional compensation up to $140 is offered. For more information, call 205-934-5712 or email kidneystone@uabmc.edu or kidneystoneresearch@uabmc.edu.

Do you experience urine leakage with a strong and sudden urge and you leak before reaching the toilet? You may be eligible to participate in this important study if you are female and 21 years of age or older, if you are experiencing urine leakage with the feeling of urgency, coughing, sneezing, or laughing. For more information, contact our research team at 205-934-5498. Compensation is provided.

Do you experience accidental bowel leakage? You may qualify for a bowel leakage research study if you are female, 18 years or older, and have had accidental bowel leakage for at least 6 months. For more information contact 205-934-5498. Compensation is provided.

Healthy Volunteers Needed If you are: • 18-50 years of age • Can read and write in English • Are generally healthy • And have no history of mental illness or psychiatric disorders For more information and to determine eligibility, please call UAB Office of Psychiatric Research at (205) 934-8203. **Compensation is provided**

Are you struggling with Opioid addiction? If so, you may be eligible to participate in a research study at UAB that focuses on biomarkers in people with opioid addiction. The study includes 1 visit and takes up to 2 hours to complete. For more information, please call the UAB Office of Psychiatric Research at (205) 934-8336. You will be compensated $20 for your time and efforts.

You may be eligible to participate in a research study about the effects of sacubitril/valsartan on how your body handles insulin and glucose. This medication is related to the heart. Eligible participants must be healthy men and women, African American, and have no history of diabetes, heart problems, or kidney problems. The study involves performing some exercise, taking sacubitril/valsartan, and collecting blood samples. Participants will be compensated. To participate, please contact Nehal at 205-934-7173 or email us at nauticalstudy@uabmc.edu.

You may be eligible to participate in a research study about the effects of Exercise and Metoprolol (a blood pressure pill) on a protein in your blood. This protein is related to heart disease. Eligible participants must be Healthy men and women, African American or Caucasians, and have no history of diabetes, heart problems, or kidney problems. The study involves performing the exercise, taking metoprolol, consuming prepared meals, and collecting blood samples. Participants will be compensated. Please e-mail Nehal Vekariya at exercisebetastudy@uabmc.edu or call us at 205-934-7173 if you are interested.

Clinical trial evaluating a novel, non-invasive radiation treatment for ventricular tachycardia refractory to medication and catheter ablation The UAB Departments of Radiation Oncology and Cardiology are looking for patients with ventricular tachycardia (VT) not controlled by medications and catheter ablation. The trial will allow patients suffering from VT despite standard of care regimens to undergo non-invasive cardiac radioablation (CRA; a type of stereotactic body radiotherapy) to the area of the heart responsible for their symptoms. Stereotactic body radiotherapy is delivered with a device called the linear accelerator, which is primarily used to treat patients with cancer. UAB is one of the first centers in the U.S. to obtain a Food and Drug Administration (FDA) investigational device exemption for use of the linear accelerator in this capacity on a phase I/II trial. The study is being conducted in collaboration with the Washington University School of Medicine in St. Louis, a center which pioneered this promising technique in the U.S. For more information on the RAD 1901 trial, please contact Adelyn Gillon, clinical research coordinator, at 205.975.3019 or agillon@uabmc.edu" contenteditable="false">agillon@uabmc.edu.

If you have asthma, are at least 18 years of age, in the Los Angeles Region, (California) haven’t had oral steroids in at least 4 weeks, and are willing to donate 30 mL of blood, equivalent to two tablespoons, please contact Racheal Ogbebor at email Rachealogbebor@gmail.com.

Rural Research Participants Needed FSU College of Nursing invites individuals with heart failure and their care partners who live in rural areas to participate in a research project under the direction of Lucinda J. Graven, Ph.D., APRN. Care teams will partner with a registered nurse to manage daily challenges related to heart failure self-care by telephone. Compensation up to $200 per care team who complete the telehealth program. Please contact Joan Grant Keltner, Ph.D., RN at (205) 934-6527 or grantj@uab.edu. For more information, you may also use: https://fsu.qualtrics.com/jfe/form/SV_3IPqQs7MAPmuHpH.

Participants between the ages of 65-89, and individuals diagnosed with Parkinson’s disease between the ages of 45-89 are needed for a research study on walking. This study is being done to assess how well individuals can modify walking patterns. If you qualify, we anticipate that your participation in the study will span a single study visit, with a total time commitment of 3 hours. You will be compensated for your time. Contact Christopher Hurt at cphurt@uab.edu or  at 205-934-8517, if you are interested.

Do you have a loved one with agitation associated with Alzheimer’s dementia? Is their agitation becoming overwhelming? Examples of some easily identifiable agitated behaviors are: restlessness, screaming, shouting, throwing things, resistiveness, constant unwarranted requests for attention or help, pacing/aimless wandering, kicking, hitting others or self, pushing people, hurting self or others, tearing things or destroying property. In this study, researchers want to find out if an investigational drug called AVP-786 is safe and effective (useful) in managing agitation in adults with Alzheimer’s dementia, when compared to a placebo. If you are a caregiver for a person with Alzheimer’s disease, please call (205) 996-5987 or email lalexander@uabmc.edu for more information.

We are enrolling opioid users without a history of psychosis, endocrine diseases, inflammatory diseases, or autoimmune diseases. If you meet these criteria you may be eligible to participate in a research study. Compensation provided up to $20. For more information, please call the UAB Office of Psychiatric Research at 205-934-8336.

You may be eligible to participate in a research study about the effects of Exercise and Metoprolol (a blood pressure pill) on a protein in your blood. This protein is related to heart disease. Eligible participants must be Healthy men and women, African American or Caucasians and have no history of diabetes, heart problems, or kidney problems. The study involves performing exercise, taking metoprolol, consuming prepared meals, and collecting blood samples. Participants will be compensated. Please e-mail Nehal Vekariya at nvekariya@uabmc.edu if you are interested.

You may be eligible to participate in a research study about the effects of sacubitril/valsartan on how your body handles insulin and glucose. This medication is related to the heart. Eligible participants must be healthy men and women, African American, and have no history of diabetes, heart problems, or kidney problems. The study involves performing some exercise, taking sacubitril/valsartan, and collecting blood samples. Participants will be compensated. Please e-mail Nehal Vekariya at nvekariya@uabmc.edu if you are interested.

UAB's Urogynecology and Pelvic Reconstructive Surgery is conducting a 3 month at-home non-invasive lower leg stimulation study. You may be eligible if you are female and 18 years of age and older, have a history of chronic Bowel Leakage for at least 6 months, and have tried at least 2 treatments, including medications, diet, and pelvic exercises. Compensation will be provided. If you would like more information about the study, please contact 205-934-5498.

You may be eligible for a research study if you are a female 18 or older and have been diagnosed with endometriosis. Study medication and clinic visits provided at no cost. Compensation provided for every visit. Please call 205-934-1322 or email slangan@uabmc.edu to hear more information.

The purpose of the study is to measure maximum walking speed and step length with virtual reality and customizable exercise games as feedback sources on a robotic treadmill. The targeted population is individuals with hemiparesis, in a chronic and stable stroke stage, who are able to follow instructions, and able to walk independently for at least three minutes. Based on a phone screening, eligible participants will attend up to two separate sessions at UAB Spain Rehabilitation Center. In each session, they will go into different walking or stepping performance conditions. The session will last about two hours, and participants will be paid 30$ per session for their time and effort. For more information please call Saleh Alhirsan at (205) 261-3853 or by email atalhirsan@uab.edu.