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Dr James Mobley

Director of the UAB Heersink School of Medicine & O'Neal CCC Mass Spectrometry & Proteomics Shared Resource (MSP-SR)

Department of Anesthesiology and Perioperative Medicine
Division of Molecular and Translational Biomedicine


E-mail: mobleyja@uab.edu
Telephone: (205) 996-6363

Biomedical Research Building II, 227
901 19th Street South
Birmingham, AL 35294-2186

Full CV


Dr. Mobley has over 30 years of experience spanning both academia and industry, where analytical chemistry, spectroscopy, and mass spectrometry have been an intricate part of his work experience and studies throughout. Dr. Mobley worked in the polymer industry at Evanite Fiber Corporation, currently Hollingsworth & Vose as an analytical technician from 1985-1988. He then received his B.S. in Chemistry in 1991 from Oregon State University (OSU). Throughout that time, he worked as a Lab Technician, as a Teaching Assistant, and as a Research Assistant for the Chemistry Department at OSU. As a Research Assistant Dr. Mobley researched the electrochemical and spectroscopic characteristics of redox active metal complexes. He then went on to work full-time as an analytical Chemist at Roxane Laboratories, Inc. (now Hikma Labs Inc.) and Boehringer Ingelheim Roxane Inc. (now West-Ward Columbus Inc), which overlapped with a volunteer position in the Clinical Chemistry lab at The Ohio State University (OSU, 1992-1995).


In 1995, Dr. Mobley went on to become a Graduate Research Fellow funded through a training grant that he conceived and wrote, going on to receive a Ph.D. in Medicinal Chemistry and Pharmacology from OSU under Dr. Robert Brueggemeier where he studied hormone-induced carcinogenesis of the breast. His thesis involved the design, chemical synthesis, characterization, and determination of biological activities for small molecule ER agonists (1995-2000). Following his doctoral work, Dr. Mobley joined the faculty at the University of Massachusetts Medical School. In this role he initiated and operated a biomarker and small molecule discovery lab focused on 1) developing cellular assays for small molecule screening, 2) statistical & preprocessing analysis of MALDI-TOF generated spectra, and 3) developing MS driven protein characterization applications (2000-2004). He then took a position within the laboratory of Dr. Richard Caprioli at Vanderbilt University in 2004, where he mastered more sophisticated MS technologies, including, spectral pre-processing and tissue Imaging-MS. He was then recruited to the University of Alabama at Birmingham (UAB) in 2006, where his research interests have focused on MS driven biomarker discovery applications in cancer research.


In 2007, Dr. Mobley became Director of his newly formed CCC Clinical Proteomics Shared Facility, due to the success of that facility he was asked to expand in 2009 to encompass a single campus wide MS/ Proteomics Shared Resource (MSP-SR). This facility is extremely well equipped, and well-funded, with a focus on clinical based discovery projects that are driven by informatics applications. It is the successful incorporation of informatics tools used to carry out data pre-processing, statistics, and systems biology that make the facility highly successful and competitive. In this new structure, Dr. Mobley has worked very closely with dozens of investigators on projects that include targeted and global proteomics through funded mechanisms that include PPGs, UO1s, RO1s, and the UAB Pancreatic SPORE. Dr. Mobley is highly qualified for his current position, with nearly 30 years of experience in the field of Chemistry, covering Analytical, Organic, and Medicinal. He is considered an expert in Proteomics by his peers, and continues to focus on clinical/ translational proteomics applications, which include statistical analysis of high density 'omics driven data sets, and the use of systems biology applications to uncover biologically relevant pathways.