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Check desired core resources for your project and any other pertinent information.
Biostatistical Core
Analysis of pilot data Design of epidemiological, clinical studies or clinical trials Sample size and/or power analysis Analyses of study results Database development Forms and/or instrument development
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Clinical Studies in AKI (Core A)
Study Planning and Design Study Initiation and Conduct Study Analysis and Interpretation (in Conjunction with Biostatistical Core) Biological Sample Repository UCSD/O'Connor TSP Resource in Hypertension Preparation of genomic DNA, with quality control Cloud-based database for AKI research studies Renal functional monitoring with Iohexol
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Pre-Clinical Studies of AKI (Core B)
Orthotopic Kidney Transplantation Heterotopic Heart Transplantation Orthotopic Abdominal aorta transplantation Renal ischemia/reperfusion Nephrotoxin-induced models of AKI Rhabdomyolysis model of AKI Other Procedures Use of Microsurgical Workstation Hands-on training of a surgical protocol Isolation and culture of primary cell lines Functional renal imaging analysis Ultrasound MicroCT Gamma Camera SPECT/CT PET/CT MRI Bioluminescence Fluorescence Whole Kidney Studies (eg clearance, blood flow, oxygen consumption) Tissue oxygen partial pressure determination in kidney Nitric oxide generation Invitro assessment of O2 consumption by isolated proximal tubule segments Single Nephron Function by Micropuncture (eg tubuloglomerular feedback, SNGFR) Metabolic cage experiments in mice Radioimmunoassay of angiotensin II Videometric flow velocitometry (VMFV)
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Bioanalytical Core (Core C)
Training in proteomics and mass spectrometry approaches Consultation for analysis of oxidative stress biomarkers in AKI Biomarkers for AKI Serum/plasma/urine creatinine determination by isotope dilution LC-MS/MS Assays for oxidative stress markers Oxidized fatty acid LC-MS/MS Bioenergetics and Mitochondrial Function Assessment for AKI Assays for post-translational modification of proteins Quantitative analysis of Krebs cycle and glycolytic intermediates by LC-MS/MS
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Please remember to cite the grant DK079337 and acknowledge UAB-UCSD O’Brien Center for support.
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