Upcoming Events

2nd Bioethics Conference on Minority Health and Health Disparities Research
January 23-25, 2019
Tuskegee University
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Partnering Institutions

Morehouse School of Medicine (MSM)
Tuskegee University (TU)
University of Alabama at Birmingham (UAB)


Contact - PI

 MSM: James Lillard, PhD
   TU: Roberta Troy, PhD
 
UAB: Upender Manne, PhD


Program Managers

 MSM: Jennifer Creighton
 TU: Chiquita Lee
UAB: Suzanne Byan-Parker

 

 

 

 

 

 

 

 

 

 

 

Pre-Pilot Project: Novel Nanoformulation for Prostate Cancer Treatment

MSM Lead: Rajesh Singh, PhD
UAB Lead: Santosh Katiyar, PhD

The proposed studies will evaluate a new method and combination for targeted delivery (using folate) of curcumin or docetaxel at desired rates of release that will overcome the clinical barrier that curcumin and docetaxel have faced due to its poor bioavailability and lack of prostate tumor cell specificity. We will test the hypothesis that targeted delivery of curcumin and docetaxel-loaded PBM nanoparticles will enhance the efficacy to improve PCa treatment.

  Pre-Pilot Project: A Multi-Cancer Platform for Selective Photo-Nano-Therapy of Malignant Tumors

TU Lead: Hidiyah-Nicole Green, PhD
TU Lead: Clayton Yates, PhD

Proposal focuses on evaluating the potential use of photo-nano-therapy to induce tumor regression in cancers requiring greater depth penetrance than oral squamous carcinoma (for which the therapy has proven successful). This project will explore use of near infrared (NIR) photo-nano-therapy (PNT) in combination with gold nano rods that convert laser light energy to therapeutic thermal heat. In vivo studies will examine efficacy of the combined laser/nano rod therapy by evaluating tumor regression in primary tumor models (via orthotopic implants).

  Pre-Pilot Project: Role of TTP-Lin28-let-7-axis in Colorectal Cancer Treatment Responses

TU Lead:Amit Tiwari, PhD
UAB Lead: Esther Suswam, PhD

The proposed study will assess the importance of the TTP-Lin28-let-7 signaling pathway in the regulation of chemotherapy responses in colorectal cancers (CRCs). The proposal will evaluate the TTP/Lin28/let-7 pathway (which may be inactivated in CRCs – allowing deregulation of oncogenes such as Lin28B) in CRC primary tumors based on p53 status and assess the importance of this pathway in modulating tumor progression and responses to chemotherapy.

  Pre-Pilot Project: Association of CD24 and Progression of Prostate Cancer in African-Americans

MSM Lead:James Lillard, PhD
UAB Lead: Lizhong Wang, PhD

This proposal focuses on exploring the role CD24 expression (gene and subsequent protein expression) have in prostate cancer (PCa) among African American, Caucasian, and Asian men. The application is based on hypothesis that CD 24 is linked to risk and progression of PCa (as CD24 is over-expressed in many cancer types) and preliminary applicant data indicates growth, progression, and metastasis is reduced via CD24 mutation in murine models).