As part of the Southeastern SHRINE Network, the CCTS is collaborating with CTSA Hubs including Emory, University of Arkansas, University of Kentucky and Medical University of South Carolina, to federate available data at each institution for assessment of clinical trial feasibility, participant recruitment and comparative effectiveness research. All partnering institutions bring strong experience in the deployment, use and extension of i2b2, in federated query infrastructure, and in participation in the development of PCORnet-style data sharing. Together, the group has developed and is maintaining i2b2 and SHRINE instances with a common SHRINE ontology, focused on multiple testbed areas of care and has established a shared governance model to access from the data network.