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2005 Case #9 | ![]() |
Diagnosis: Actinomycosis. |
![]() Primary cutaneous actinomycosis is an uncommon entity [Trans R Soc Trop Med Hyg. 2004 Jan;98(1):3-11]. Actinomycetes are generally thought to be an endogenous human organism colonizing the oro-pharynx, gastrointestinal, and female genitourinary tracts, and producing disease via local extension from these foci. Periodic case reports of primary cutaneous infection appear and this is the second such case seen during the Gorgas Course in Peru in the past 5 years [see Gorgas Case 2001-09]. The main and important differential diagnosis in this case is maduramycosis (e.g., Madura foot) [see Gorgas Case 2002-04]. Other diagnoses in the differential include TB, botrymycosis (chronic staphylococcal infection) [see Gorgas Case 2003-04], and malignancy. Maduromycosis is a common subcutaneous mycosis in the tropics and is caused by a wide variety of fungal organisms. In maduromycosis, the granules usually come to the surface spontaneously, unlike in this case, where there was copious drainage from the fistulous tracts without granules. In contrast to bacteria and actinomycosis (which is responsive to Penicillin and other antibiotics), they are poorly responsive to medical therapy and usually require aggressive surgery or amputation. Other subcutaneous mycoses to think of in the tropics include sporotrichosis, chromomycosis, and lobomycosis (phaeohyphomycosis). Our patient was begun on TMP-SXT and amikacin prior to obtaining the microbiological diagnosis of actinomycosis. In general, high dose intravenous penicillin for 6 weeks followed on chronic oral therapy for at least one year is the treatment of choice for subcutaneous actinomycosis. The patient also received thiabendazole for his strongyloidiasis. |