The endoplasmic reticulum (ER) regulates protein folding and maintains proteostasis in cells- a process essential to maintaining cellular health. However, researchers at UAB have found that chronic reductive stress (RS) impairs the ER transcriptome in the hearts of mice. In fact, RS has been found in the pathophysiology of several diseases, notably cancer, neurodegeneration and metabolic disorders.
In a recent study published in Redox Biology, Rajasekaran Namakkal-Soorappan, Ph.D., an associate professor in the Division of Molecular and Cellular Pathology, found that prolonged moderate treadmill exercise mitigates the RS-induced ER dysfunction and cardiac remodeling in mice.
Dario Vitturi, Ph.D., an assistant professor in the Division of Molecular and Cellular Pathology, has been awarded $1.8 million in grant funding from the National Institutes of Health’s (NIH) National Institute of General Medical Sciences (NIGMS), for his study of, “Formation, metabolism and cell signaling actions of tryptophan catabolism-derived electrophiles.” The five-year award will run through May 2029.
The Community Pathology Practice Program, led by director William Bell, M.D., is pleased to welcome Teresa Venz-Williamson, M.D., as a clinical professor, starting July 15, 2024.
Transplantation is a complicated and delicate process that begins long before organs are surgically placed into the recipient. The doctors of UAB Pathology play a crucial role in that process, providing details of pathological findings in diagnostic biopsies throughout the transplant process.
Several members of the UAB Pathology clinical faculty will take part in the 2024 Transplant Games of America, a biennial event welcoming thousands of individuals involved with transplants and organ donation. During the event, which takes place July 5-10 at a variety of locations throughout the Greater Birmingham area, transplant recipients and living donor athletes compete in 20 athletic and recreational competitions.
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