Dr. James Bibb

Vice Chair, Basic Research 
Dr. Champ Lyons Endowed Chair in General Surgery

Areas of Interest
cognition and synaptic plasticity, mental illness, addiction, neuronal injury, neuroendocrine cancer, intracellular signal transduction

James Bibb received bachelor’s and master’s degrees with honors from Murray State University and the University of Kentucky, respectively. He worked in the Cell Biology and Physiology Department at Washington University in St. Louis before completing his doctorate in cellular and developmental biology at the State University of New York at Stony Brook. His doctoral thesis characterized the poliovirus receptor protein in Eckard Wimmer’s laboratory. Dr. Bibb’s postdoctoral training was conducted in the Laboratory on Molecular and Cellular Neuroscience at the Rockefeller University under the direction of Paul Greengard. His work on the regulation of dopamine neurotransmission was cited in the Nobel Prize in Physiology for Medicine in 2000. From 2001 to 2015 Dr. Bibb was a principal investigator and tenured faculty in the Psychiatry and Neurology and Neurotherapeutics Departments The University of Texas Southwestern Medical Center in Dallas. His lab focuses on signal transduction as it pertains to cognition, neurological and neuropsychiatric disorders, and cancer.


Dr. Bibb's research is aimed broadly at understanding the mechanistic basis of cellular functions and disease with emphasis on features of intracellular signal transduction and protein phosphorylation/dephosphorylation. Multidisciplinary approaches and advanced technologies are combined to identify signaling mechanisms and characterize their physiological functions, from basic molecular interactions to behavior or disease. This research has revealed, for example, common features between brain circuitry function, neuronal injury and oncogenesis. His goals are to import clinical information and perspectives into the lab, model and explore disease causes and then return new treatment approaches and solutions to help patients.


Graduate School 
University of Kentucky

Graduate School
SUNY at Stony Brook


Campus Address
THT 1028

(205) 975-7917|