Dr. ChakrabortiInstructor
Managing Director, UAB Behavioral Assessment Core

Areas of Interest 
Gut-Brain Axis and Mood Disorders, Sex differences in Stress related Disorders, Metabolic Syndrome and Neuropsychiatric comorbidities

Biography

Dr. Chakraborti is an instructor in the Division of Gastrointestinal Surgery at the UAB Department of Surgery. He also serves as the managing director of the UAB Behavioral Assessment Core. Dr. Chakraborti received his Ph.D. in pharmacology from University of Delhi, India and subsequently obtained postdoctoral training at National Institute on Drug Abuse (NIDA) and at the Department of Neurosurgery, University of California, San Francisco. He has also received advanced training in space radiation biology research at NASA. Dr. Chakraborti has previously worked as a Senior Lecturer at Jeffrey Cheah School of Medicine, Monash University, Malaysia and as an assistant consultant at the Innovation Labs, Tata Consultancy Services, India. Dr. Chakraborti’s current research interests involve understanding the mechanisms by which stress and gastrointestinal inflammation affect behavioral and brain function.

Honors and Awards

1.International Brain Research Organization (IBRO) Travel Fellowship to attend 7th World Congress of Neuroscience, Melbourne, Australia (2007)

2.Travel Award from Society of Neuroscience (SfN), USA to attend the Workshop on ‘Neurodegenerative diseases: different phenotypes, shared mechanisms of pathogenesis’, Melbourne, Australia (2007)

3.Postdoctoral Travel Award – University of California, San Francisco (2012)

4. Fellow- NASA Space Radiation Summer School (2011)

5. Certificate of recognition from American Gastroenterological Association for scientific accomplishment as an Early Career Investigator (2018)

Select Publications

1. Mickael, M.E., Bhaumik, S., Chakraborti, A., Umfress, A., van Groen, T., Macaluso, M., Totenhagen, J., Sorace, A.G., Bibb, J.A., Standaert, D.G. and Basu, R., RORγt-Expressing Pathogenic CD4+ T Cells Cause Brain Inflammation During Chronic Colitis. J Immunol. 2022 Apr 4:ji2100869.

2. Umfress A., Singh, S., Ryan, K.J., Chakraborti, A., Platner, F., Sonawane Y., Mallareddy J.R., Acosta, E.P., Natarajan, A., Bibb, J.A. Systemic Administration of a Brain Permeable Cdk5 Inhibitor Alters Neurobehavior. in Press Frontiers in Pharmacology. 2022 DOI: 10.3389/fphar.2022.863762

3. Chakraborti, A., Graham, C., Chehade, S., Vashi, B., Umfress, A., Kurup, P, Vickers B, Chen HA, Telange R, Berryhill T, vander Pol W, Powell M, Barnes S, Morrow C, Smith D, Mukhtar MS, Watts S, Kennedy G Bibb, JA. High Fructose Corn Syrup-Moderate Fat Diet Potentiates Anxio-Depressive Behavior and Alters Ventral Striatal Neuronal Signaling. 2021 Frontiers in neuroscience, 15.

4. Shaikh MF, Chakraborti A, Ravizza T, Vezzani A, O’Brien TJ, Abdullah JM. Experimental and clinical epilepsy and related comorbidities Frontiers in Pharmacology. 2020; 11(592448) 5. Chakraborti A, Shaikh MF, Vezzani A, Abdullah JM. Experimental models of epilepsy and related comorbidities Frontiers in Pharmacology 2019: 10(179).

6. Paudel,YN, Shaikh MF, Chakraborti A , Kumari Y , Serrano AA, , Aleksovska K, Alvim M, , Othman I HMGB1: A Common Biomarker and Potential Target for Traumatic Brain Injury, Neuroinflammation, Epilepsy and Cognitive Dysfunction Frontiers in Neuroscience 2018; 12(628).

7. Raber J, Allen A, Weber S, Chakraborti A, Sharma S, Fike JR Effect of behavioral testing on basal dendrites in the CA1 region of the hippocampus modulated by 56Fe irradiation Behav Brain Res 2016; 302:263-8.

8. Allen AR, Raber J, Chakraborti A, Sharma S, , Fike JR 56Fe irradiation alters spine density and dendritic complexity in the mouse hippocampus Radiat Res 2015; 184(6):586-94.

9. Gulati K, Chakraborti A , Ray A Gender based differences in stress induced gastric ulcer formation and its modulation by nitric oxide : an experimental study. Curr Pharm Des 2015; 21(23):3395-401.

10. Chakraborti A, Gulati K, Ray A. Possible role of nitric oxide (NO) in the regulation of gender related differences in stress induced anxiogenesis in rats. Nitric Oxide. 2014; 43:74-80.

11. Allen AR, Eilertson K, Chakraborti A, Sharma S, Baure J, Habdank-Kolaczkowski J, Allen B, Rosi S, Raber J, Fike JR. Radiation exposure prior to traumatic brain injury induces responses that differ as a function of animal age. Int J Radiat Biol. 2014; 90(3):214-23.

12. Zou Y, Corniola R, Leu D, Khan A, Sahbaie P, Chakraborti A, Clark DJ, Fike JR, Huang TT Extracellular superoxide dismutase is important for hippocampal neurogenesis and preservation of cognitive functions after irradiation. Proc. Natl Acad Sci USA 2012;109(52): 21522-7.

13. Chakraborti A, Allen A, Allen B, Rosi S, Fike JR Cranial irradiation alters dendritic spine density and morphology in the hippocampus.PLoS One 2012; 7(7): e40844.

14. Raber J, Rosi S, Chakraborti A, Fishman K, Dayger C, Davis MJ, Villasana L, Fike JR Effects of ⁵⁶Feparticle cranial radiation on hippocampus-dependent cognition depend on the salience of the environmental stimuli. Radiat Res. 2011; 176 (4): 521-6.

15. Chakraborti A, Gulati K, Ray A Involvement of nitric oxide in the protective effects of dehydroepiandrosterone sulphate on stress induced neurobehavioral suppression and brain oxidative injury in rats. Eur J Pharmacol. 2011; 652 (1-3): 55-9.

Education

Post Doctoral Fellowships

University of California, San Francisco
National Institute on Drug Abuse (NIDA), NIH

Post-Graduate

PhD, Pharmacology, University of Delhi, India

Graduate

Master of Science, Zoology, Tripura University, India

Contact

Email
achakraborti@uabmc.edu

Phone
(205)-975-9717

Office Address
THT 1028E