Dr. Jayme Locke

Associate Professor
Director, Incompatible Kidney Transplant Program
Director, Transplant Analytics, Informatics & Quality

Areas of Interest
abdominal transplantation, incompatible organ transplantation, transplantation of HIV-infected end-stage patients, outcomes and behavioral research focused on health disparities

Biography

Dr. Locke completed her undergraduate degree in biology and chemistry at Duke University and her medical degree at East Carolina University prior to matriculating to Johns Hopkins Hospital where she received training in general surgery and multi-visceral abdominal transplantation.  Dr. Locke completed her Master of Public Health degree with an emphasis in biostatistics and epidemiology at the Johns Hopkins Bloomberg School of Public Health. She joined the surgical faculty at UAB upon completion of her training at Johns Hopkins Hospital. Dr. Locke is a well-funded investigator, and currently holds an NIH K23 Career Development Award and a Clinical Science Faculty Development Grant through the American Society of Transplantation. She has authored 52 articles in peer-reviewed journals and 11 book chapters. Dr. Locke is frequently invited to present her research as a visiting professor at many prestigious academic centers around the US and at international transplant meetings, including the World Transplant Congress, the British Transplantation Society, the American Transplant Congress, and the National Kidney Foundation. In addition, Dr. Locke is an Associate Editor for Transplantation and is a regular peer reviewer for several journals, including the American Journal of Transplantation and the Journal of the American Society of Nephrology to name a few. She is an invited member of the ASTS Providing Better Access to Organs Task Force and Diversity Affairs Committee, the AST Kidney-Pancreas Committee, The Transplantation Society Young Member Committee, and the United Network for Organ Sharing Pediatric Transplant Committee. Dr. Locke is the recipient of numerous honors and has most recently received the American Transplant Congress Young Investigator Award, the Birmingham Business Journal’s Top 40 under 40 Award, and was named one of AL.com’s 2015 Women Who Shape the State. 

Dr. Locke is an abdominal transplant surgeon who specializes in innovative strategies for the transplantation of incompatible organs, disparities in access to and outcomes after solid organ transplantation, and transplantation of HIV-infected end-stage patients. Her research interests include complex statistical analysis and modeling of transplant outcomes and behavioral research focused on health disparities.


Selected Publications


Donnelly JP, Wang HE, Locke JE, Mannon RB, Safford MM, Baddley JW. Hospital-onset Clostridium difficile infection among solid organ transplant recipients. American Journal of Transplantation, 2015; 15(11): 2970-2977. PMID: 26484839

Locke JE, Durand C, Reed RD, MacLennan PA, Mehta S, Massie A, Nellore A, DuBay D, Segev DL. Long-term outcomes after liver transplantation among human immunodeficiency virus infected recipients. Transplantation, 2015; [Epub ahead of print]. PMID 26177090

Locke JE, Reed RD, Mehta SG, Durand C, Mannon RB, MacLennan PA, Shelton B, Martin MY, Qu H, Shewchuk R, Segev DL. Center-level experience and kidney transplant outcomes in HIV-infected recipients. American Journal of Transplantation, 2015; 15(8): 2096-2104. PMID: 25773499

Locke JE, Mehta S, Reed RD, MacLennan PA, Massie A, Nellore A, Durand C, Segev DL. A national study of outcomes among HIV-infected kidney transplant recipients. Journal of the American Society of Nephrology, 2015; 26(9): 2222-2229. PMID: 25791727

Locke JE, Qu H, Shewchuk R, Mannon RB, Gaston R, Segev DL, Mannon EC, Martin MY.  Identification of strategies to facilitate organ donation among African Americans using the nominal group technique. Clinical Journal of the American Society of Nephrology, 2015; 10(2): 286-93. PMID: 25635038

DuBay DA, MacLennan PA, Reed RD, Fouad M, Martin M, Meeks CB, Taylor G, Kilgore M, Tankersley M, Gray SH, White JA, Eckhoff DE, Locke JE. The impact of proposed changes in liver allocation policy on cold ischemia times and organ transportation costs. American Journal of Transplantation, 2015; 15(2): 541-546. PMID: 25612501

Orandi B, Zachary AA, Dagher N, Bagnasco S, Garonzik-Wang J, Arendonk K, Gupta N, Lonze B, Alachkar N, Kraus E, Desai N, Locke JE, Racusen L, Segev DL, Montgomery RA. Eculizumab and splenectomy as salvage therapy for severe antibody mediated rejection following HLA incompatible kidney transplantation. Transplantation, 2014; 98(8): 857-863. PMID:  25121475

Locke JE. To whom goes the kidney? Liver Transplantation, 2014, 20(9): 1017-1018. PMID:  25044428

Dubay DA, Redden DT, Bryant MK, Dorn DP, Fouad MN, Gray SH, White JA, Locke JE, Meeks CB, Taylor GC, Kilgore ML, Eckhoff DE.  Resource utilization associated with procurement of transplantable organs from donors that do not meet OPTN eligible death criteria. Transplantation, 2014; 97(10): 1043-1048. PMID:  24503760

Locke JE and Segev DL.  Is there a role for detection of complement binding antibodies in kidney transplantation?  American Journal of Kidney Disease, 2014; 63(4): 558-560.  PMID:  24480655

Locke JE, James N, Mannon RB, Mehta SG, Pappas PG, Baddley JW, Desai NM, Montgomery RA, and Segev DL.  Immunosuppression regimen and the risk of acute rejection in HIV-infected kidney transplant recipients.  Transplantation, 2014; 97(4): 446-450.  PMID:  24162248

Glueckert LN, Redden D, Thompson M, Haque A, Gray SH, Locke JE, Eckhoff DE, Fouad M, and DuBay DA.  What happens to liver transplant outcomes when the uninsured become insured?  Am J Transplant, 2013; 13(6):  1533-1540. PMID:  23659668

Lonze BE, Holzer HT, Knabel MK, Locke JE, DiCamillo GA, Karhadkar SS, Montgomery RA, Sun Z, Warrant DS, Cameron AM.  In vitro and ex vivo delivery of short hairpin RNAs for control of hepatitis C viral transcript expression.  Archives of Surgery, 2012; 147(4):  384-387.  PMID:  22508787

Dierberg KL, Marr KA, Subramanian A, Nace H, Desai N, Locke JE, Zang S, Diaz J, Chamberlain C, Neofytos D.  Donor-derived organ transplant transmission of coccidioidomycosis.  Clinical Infect Dis, 2011; 14(3):  300-304. PMID:  22176496

Van Arendonk K, James NT, Locke JE, Montgomery RA, Colombani PM, Segev DL.  Increase in late graft loss among pediatric recipients of DCD kidneys.  CJASN, 2011; 6(11):  2705-2711.  PMID:  21940839

Lonze BL, Dagher NN, Liu M, Kucirka LM, Simpkins CE, Locke JE, Desai NM, Cameron AL, Montgomery RA, Segev DL, Singer AL.  Outcomes of Renal Transplants from CDC High-Risk Donors with prospective recipient viral testing: a single center experience. Archives of Surgery, 2011; 146(11): 1261-1266.  PMID:  22106317

Montgomery RA, Lonze BE, King K, Kraus E, Kucirka L, Locke JE, Warren DS, Simpkins CE, Dagher NN, Singer AL, Zachary AA, Segev DL.  Desensitization in HLA-incompatible kidney recipients and survival. New Engl J Med, 2011; 365(4): 318-326.  PMID:  21793744

Mark AL, Sun Z, Warren DS, Lonze BE, Knabel MK, Williams GM, Locke JE, Montgomery RA, Cameron AM.  Stem cell mobilization is life saving in an animal model of acute liver injury.  Ann Surg, 2010; 252(4): 591-596.  PMID:  20881764

Lonze BE, Dagher NN, Simpkins CE, Locke JE, Singer AL, Segev DL, Zachary AA, Montgomery RA.  Eculizumab, bortezomib and kidney paired donation facilitate transplantation in a highly sensitized patient without vascular access.  Am J Transplant, 2010; 10(9): 2154-2160.  PMID:  20636451

Zachary AA, Montgomery RA, Locke JE, Leffell MS.  Proinflammatory events and HLA antibodies.  Am J Transplant, 2010; 10(4): 956.  PMID:  20148814

Allen G, Simpkins CE, Segev D, Warren D, King K, Taube J, Locke JE, Baldwin W, Haas M, Chivukula R, Montgomery RA. Rapid accommodation of an A1 renal allograft after preconditioning for ABO-incompatible transplantation. Contrib Nephrol. 2009;162:35-46.  PMID: 19001812

Stewart ZA, Locke JE, Segev DL, Cohen C, Singer AL, Montgomery RA, Maley WR, Cameron WR.  Hepatic artery thrombosis after liver transplantation is associated with utilization of older donors.  Liver Transplant.  2009; 15(12): 1688-1695.  PMID:  19938120

Melancon JK, Kucirka LM, Boulware LE, Powe NR, Locke JE, Montgomery RA, Segev DL.  Impact of Medicare coverage on disparities in access to simultaneous pancreas and kidney transplantation.  Am J Transplant.  2009; 9(12): 2785-2791.  PMID:  19845587

Locke JE, Zachary AA, Warren DS, Segev DL, Houp JA, Montgomery RA, Leffell MS.  Proinflammatory events are associated with significant increases in breadth and strength of HLA-specific antibody.  Am J Transplant.  2009; 9(9): 2136-2139.  PMID:  19663896

Stewart ZA, Locke  JE, Montgomery RA, Singer AL, Cameron AM, Segev DL.  ABO-incompatible deceased donor liver transplantation in the United States: a national registry analysis.  Liver Transplant.  2009; 15(8): 883-893.  PMID:  19642117

Montgomery RA, Locke JE, King KE, Segev DL, Warren DS, Kraus ES, Cooper M, Simpkins CE, Singer AL, Stewart ZA, Melancon JK, Ratner L, Zachary AA, Haas M.  ABO incompatible renal transplantation:  a paradigm ready for broad implementation.  Transplantation.  2009; 87(8): 1246-1255.  PMID:  19384174

Singer AL, Locke JE, Stewart ZA, Hamilton JP, Scudiere JR, Anders RA, Maley WR, Thuluvath PJ, Brodsky RA, Cameron AM.  Successful liver transplantation for Budd-Chiari Syndrome in a patient with paroxysmal nocturnal hemoglobinuria treated with the anti-complement antibody eculizumab.  Liver Transplant.  2009; 15(5): 540-543.  PMID:  19399743

Locke JE, Montgomery RA, Warren DS, Subramanian A, Segev DL.  Renal transplantation in HIV-positive recipients:  long-term outcomes and risk factors for graft loss.  Archives of Surgery.  2009; 144(1):  83-86.  PMID:  19153330

Locke JE, Singer AL, Segev DL, Haas M, Hillel AT, King KE, Kraus E, Lees LM, Melancon JK, Stewart ZA, Warren DS, Zachary AA, Montgomery RA.  The use of antibody to complement protein C5 for salvage treatment of severe antibody mediated rejection.  Am J Transplant.  2009; 9(1):  231-235.  PMID:  18976298

Sun Z, Zhang X, Locke JE, Zheng Q, Tachibana S, Diehl AM, Williams G.  Recruitment of host progenitor cells in rat liver transplants.  Hepatology.  2009; 49(2): 587-597.  PMID:  18972402

Haas M, Segev DL, Racusen LC, Bagnasco SM, Locke JE, Warren DS, Simpkins CE, Lepley D, King KE, Kraus ES, Montgomery RA.  C4d deposition without histologic changes of rejection correlates with reduced scarring after 1-year in ABO-incompatible renal allografts.  J Am Soc Nephrol.  2009; 20(1):  197-204.  PMID:  18776120

Segev DL, Thompson R, Locke JE, Simpkins CE, Thuluvath PJ, Montgomery RA, Maley WR.  Prolonged Waiting Times for Liver Transplantation in Obese Patients.  Annals of Surgery.  2008; 248(5): 863-870.  PMID: 18948816

Locke JE, Warren DS, Dominici F, Cameron AM, Leffell MS, McRann DA, Melancon JK, Segev DL, Simpkins CE, Singer AL, Zachary AA, Montgomery RA.  The influence of donor ethnicity on outcomes following deceased donor kidney transplantation in black recipients.  J Am Soc Nephrol.  2008; 19(10): 2011-2019.  PMID:  18650478

Locke JE, Sun Z, Warren DS, Sheets TP, Holzer H, Shamblott MJ, Montgomery RA, Cameron AM.  Generation of humanized animal livers using stem cell transplant.  Annals of Surgery.  2008; 248(3): 487-493.  PMID:  18791369

Locke JE, Warren DS, Singer AL, Segev DL, Simpkins CE, Maley WR, Montgomery RA, Danovitch G, Cameron AM.  Declining outcomes in simultaneous liver kidney transplantation in the MELD era:  ineffective utilization of renal allografts.  Transplantation.  2008; 85(7): 935-942. PMID:  18408571

Segev DL, Kucirka LM, Nguyen GC, Cameron AM, Locke JE, Simpkins CE, Thuluvath PJ, Montgomery RA, Maley WR.  Effect modification in liver allografts with prolonged cold ischemic time.  Am J Transplant.  2008; 8:  658-666.  PMID:  18294162

Montgomery RA and Locke JE.  ABO-incompatible transplantation:  less may be more.  Transplantation.  2007; 84(12 Suppl): S8-9.  PMID:  18162992

Segev DL, Simpkins CE, Thompson RE, Locke JE, Warren DS, Montgomery RA.  Obesity impacts access to kidney transplantation.  J Am Soc Nephrol.  2007; 19(2): 349-355.  PMID:  18094366

Segev DL, Maley WR, Simpkins CE, Locke JE, Montgomery RA, Thuluvath PJ.  Minimizing risk associated with elderly liver donors by matching to preferred recipients.  Hepatology.  2007; 46(6):  1907-1918.

Segev DL, Nguyen GC, Locke JE, Simpkins CE, Montgomery RA, Maley WR, Thuluvath PJ.  20 years of liver transplantation for Budd-Chiari Syndrome:  a national registry analysis.  Liver Transplantation. 2007 13(9):  1285-1294.  PMID:  17763380

Locke JE, Segev DL, Warren DS, Dominici F, Simpkins CE, Montgomery RA.  Outcomes of kidneys from donors after cardiac death:  implications for allocation and preservation.  Am J Transplant.  2007 7(7): 1797-1807.  PMID:  17524076

Locke JE, Zachary AA, Haas M, Melancon JK, Warren DS, Simpkins CE, Segev DL, Montgomery RA.  The utility of splenectomy as rescue treatment for severe acute antibody mediated rejection.  Am J Transplant.  2007; 7(4): 842-846.  PMID:  17391127

Simpkins CE, Montgomery RA, Hawxby AM, Locke JE, Gentry SE, Warren DS, Segev DL.  Cold ischemic time and allograft outcomes in live donor renal transplantation:  is live donor organ transport feasible?  Am J Transplant.  2007; 7(1):  99-107.  PMID:  17227561

Lee KW, Simpkins CE, Montgomery RA, Locke JE, Segev DL, Maley WR.  Factors affecting graft survival after liver transplantation from donation after cardiac death donors.  Transplantation.  2006; 82(12):  1683-1688.  PMID:  17198260

Locke JE, Choti MA, Torbenson MS, Horton KM and Molmenti EP.  Inflammatory pseudotumor of the liver.  Journal of Hepatobiliary and Pancreatic Surgery.  2005; 12: 314-316.  PMID:  16133699


Education

Medical School
East Carolina University

Graduate School
Johns Hopkins University
MPH, Biostatistics and Epidemiology

Residency
Johns Hopkins University
General Surgery

Fellowship
Johns Hopkins University
Abdominal Transplantation


Contact

Campus Address
Lyons Harrison Research Building, Room 748

Phone
205-934-2131

E-mail
jlocke@uabmc.edu