Displaying items by tag: department of microbiology
Lung-resident memory B cells produced during influenza are long-living immune cells that migrate to the lungs from draining lymph nodes and lie in wait as early responders that can quickly react to future infections. They are key sentinels against subsequent viral variants.
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This is the first direct evidence that resident microbiota can have a significant impact on the establishment and pathology of infection by two different human-specific pathogens.
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Some PD-1+CXCR5+CD4+ T cells will become germinal center-Tfh cells that are essential for B cells to become high-affinity antibody-producing cells. Others do not take that path, instead becoming memory T cells.
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Periodontal disease is one of the leading causes of tooth loss in adults and may be a risk factor in the development of Alzheimer’s disease.
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Knowledge of this previously unrecognized mechanism may aid therapy for patients with interleukin-6 signaling mutations and hyper-IgE Syndrome, or HIES.
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Researchers identify a new target to fight infections caused by the opportunistic lung pathogen Streptococcus pneumoniae — interference with the bacteria’s fermentation metabolism.
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These effector memory B cells appear poised for a rapid serum antibody response upon secondary challenge one year later, and evidence shows that the cells in this subset differ from all previously described memory B cell subsets.
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Having a bacterial infection at the same time as COVID-19 is a greater risk factor for COVID-19 severity and mortality than previously described risk factors such as advanced age, male sex or various comorbidities.
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- release
- school of medicine
- department of medicine
- department of microbiology
- department of anesthesiology and perioperative medicine
- department of pediatrics
- division of pulmonary allergy and critical care medicine
- division of neonatology
- division of pediatric critical care medicine
- division of infectious diseases
- hugh kaul personalized medicine institute
- uab medical scientist training program
The clinical trial focused on very young children, who have a more rapid loss of the pancreatic beta cells than do adolescents. The trial was constrained to a low-dose level, but showed safety and tolerability and reduced serum glucagon, a secondary outcome.
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Basic research in bacteria has led Michael Niederweis and Moon Nahm to 17 U.S. patents and various new technologies with real impacts on the welfare of society.
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ohn Kearney, Ph.D., Distinguished Professor of Microbiology at the University of Alabama at Birmingham, has been named a 2023 Distinguished Fellow of the American Association of Immunologists.
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High-resolution knowledge of structure is a key link between viral biology and potential therapeutic use of the virus to quell bacterial infections.
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Insights that are not possible with conventional two-dimensional platforms include characterization of obliterated airways in tuberculosis and hemorrhage from ruptured blood vessels in COVID-19 lungs, at near-microscopic levels.
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At their annual Innovation Awards, UAB’s Bill L. Harbert Institute for Innovation and Entrepreneurship celebrated innovators from all corners of campus for their accomplishments, inventions and ingenuity.
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- release
- college of arts and sciences
- school of engineering
- school of medicine
- department of medicine
- uab medicine
- collat school of business
- barefield entrepreneurship program
- department of physics
- department of pediatrics
- department of dermatology
- division of pulmonary allergy and critical care medicine
- comprehensive diabetes center
- department of materials science and engineering
- department of computer science
- department of ophthalmology and visual sciences
- department of mechanical engineering
- department of microbiology
- division of gerontology geriatrics and palliative care
- harbert institute for innovation and entrepreneurship
A novel activity against hypothiocyanite has been found for an E. coli enzyme and homologs enzymes in Streptococcus, Staphylococcus and Bacteroides species, with implications for diseases like cystic fibrosis and inflammatory bowel disease.
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This monoclonal antibody cocktail is deliverable via a nasal dose, and it is also effective against SARS, MERS and several coronavirus cold viruses. The antibodies are engineered for long-acting effectiveness, potentially lasting a year or more when used in humans.
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X-ray crystallography revealed the structure of the HIV-1 matrix protein at 2.1 angstroms resolution, advancing understanding of key mechanisms of viral assembly.
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This discovery validates siderophore secretion as a drug target in tuberculosis and reveals a new mechanism for putative drugs. Many tuberculosis bacteria are highly resistant to multiple antibiotics.
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Nearly all of the 344 residents in Panola, Alabama, received vaccination shots.
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Researchers show how two types of immune cells — one a part of the innate immune system and the other a part of the adaptive immune system — play distinct and indispensable roles in the colon to defend against pathogenic bacteria.
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