Displaying items by tag: department of microbiology

Lund is the fifth Distinguished Fellow from UAB named since 2019, a sign of the strength of immunology research at UAB.
Vaccination of neonatal mice with group A Streptococcus promotes clonal expansion of B cells that produce antibody against GlcNAc. The association of reduced Type 1 diabetes risk after group A Streptococcus infection is dependent on these GlcNAc-specific B cells.
Tuberculosis, the world’s leading infectious disease killer, caused 1.6 million deaths in 2021, along with 10 million new cases of tuberculosis every year.
Lung-resident memory B cells produced during influenza are long-living immune cells that migrate to the lungs from draining lymph nodes and lie in wait as early responders that can quickly react to future infections. They are key sentinels against subsequent viral variants.
This is the first direct evidence that resident microbiota can have a significant impact on the establishment and pathology of infection by two different human-specific pathogens.
Some PD-1+CXCR5+CD4+ T cells will become germinal center-Tfh cells that are essential for B cells to become high-affinity antibody-producing cells. Others do not take that path, instead becoming memory T cells.
Researchers identify a new target to fight infections caused by the opportunistic lung pathogen Streptococcus pneumoniae — interference with the bacteria’s fermentation metabolism.
These effector memory B cells appear poised for a rapid serum antibody response upon secondary challenge one year later, and evidence shows that the cells in this subset differ from all previously described memory B cell subsets.
The clinical trial focused on very young children, who have a more rapid loss of the pancreatic beta cells than do adolescents. The trial was constrained to a low-dose level, but showed safety and tolerability and reduced serum glucagon, a secondary outcome.
Basic research in bacteria has led Michael Niederweis and Moon Nahm to 17 U.S. patents and various new technologies with real impacts on the welfare of society.
ohn Kearney, Ph.D., Distinguished Professor of Microbiology at the University of Alabama at Birmingham, has been named a 2023 Distinguished Fellow of the American Association of Immunologists.
High-resolution knowledge of structure is a key link between viral biology and potential therapeutic use of the virus to quell bacterial infections.
Insights that are not possible with conventional two-dimensional platforms include characterization of obliterated airways in tuberculosis and hemorrhage from ruptured blood vessels in COVID-19 lungs, at near-microscopic levels.
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