The Pre-Clinical Studies of AKI Core (Core B) provides skills and expertise to:

1) Study murine models of AKI
             Check out the FAQ for the Small Animal Microsurgical Core
2) Small animal imaging
3) Determine renal physiological changes in AKI

This core specifically provides 
  • Expertise in development and training in the use of rodent models of AKI, specifically in the setting of ischemia/reperfusion (I/R) injury, sepsis and renal transplantation
  • Multi-modality small animal imaging sub-core that provides state-of-the-art molecular imaging (functional, structural and metabolic imaging)
    • MRI/ Spectroscopy
    • high frequency ultrasonography
    • microCT
    • gamma-ray imaging (gamma camera, microSPECT/CT, microPET/CT)
    • optical imaging (bioluminescence, fluorescnece)
  • Physiology sub-core that provides expertise and training for studying renal function on whole kidney and at the single nephron level
    • Micropuncture techniques
    • GFR
    • microanalysis of tubular fluid and reabsorbtion
    • renal hemodynamics (assessment of tubuloglomerular feedback)
    • metabolic assessments of kidney O2 consumption
  • Technical expertise in isolation of primary renal and vascular cell in culture


Sanders 2

Paul W. Sanders, MD
Professor of Medicine
Division of Nephrology



Kurt Zinn, DVM, PhD
Professor of Radiology

BlzntzRoland Blantz, MD
Professor of Medicine
Division of Nephrology
UCSD School of Medicine

GeorgeJames George, PhD
Professor of Medicine
Division of Surgery

VallonVolker Vallon, MD
Professor of Medicine
Division of Nephrology
UCSD School of Medicine