We are excited to announce the arrival of a new faculty member, joining the Division of Anatomic Pathology led by Director Cristina Magi-Galluzzi, M.D. Ph.D., Professor, Anatomic Pathology, in the Cytopathology section, directed by Isam-Eldin Eltoum, M.D., Professor, Anatomic Pathology.
Dina Kokh, M.D., is a board certified anatomic and clinical pathologist and cytopathologist. She completed her residency in anatomic and clinical pathology at the University of Maryland, followed by a fellowship in cytopathology. Kokh subsequently a pursued fellowship in gynecologic pathology at Stanford University. Her research interests include gynecologic and breast pathology/cytopathology. Kokh joins the division as an assistant professor.
Please join the Department in welcoming Dr. Kokh!
The UAB Computational Biology & Bioinformatics Center is offering a new course, "CB2-101: Bioinformatics Computing," replacing the old introductory course "CB2-101: Introduction to Scientific Computing” offered under the umbrella of the CB2 initiative at UAB (http://www.uab.edu/cb2). The course is led by Malay Basu, M.Tech, Ph.D., Assistant Professor, Division of Informatics, Department of Pathology.
This free course will start on Thursday, November 1. It is a hands-on, rigorous, and fast-paced introduction to computational skills required for Bioinformatics research, modeled after the National Science Foundation "immersive learning" proposal (http://www.nsf.gov/pubs/2008/nsf08204/index.jsp).
UAB Pathology celebrated the 27th year of its Paulette Shirey Pritchett Endowed Lecture in Pathology with an outstanding lecture by Elaine Jaffe, M.D., Series Editor, World Health Organization Classification of Tumours. Jaffe's lecture, "Charting the Future of Lymphoma Classification: A Road Map for Disease Discovery and Treatment," took place before a full house on Monday, September September 17, with the Pritchett family in attendance.
From left to right: George Netto, M.D., Elaine Jaffe, M.D., Yabing Chen, Ph.D., and Robert Pritchett, M.D.
This endowed lecture series is named in honor of Dr. Paulette Shirey Pritchett, and is supported by Dr. Robert Pritchett, husband of Dr. Paulette Pritchett, and family. Dr. Pritchett was a highly respected, young member of the UAB Department of Pathology when she unexpectedly passed away on August 4, 1984.She was a native Alabamian who obtained her medical degree from the University of Alabama, where she was awarded the Stewart Graves Award and the William Boyd Medal for her demonstrated excellence in pathology.
Two papers featuring the results of research conducted in the laboratory of X. Long Zheng, M.D., Ph.D., related to the pathogenesis and novel therapeutics for immune-mediated thrombotic thrombocytopenic purpura (iTTP) are published recently.
The first, "Clinical Factors and Biomarkers Predicting Outcome in Patients with Immune-Mediated Thrombotic Thrombocytopenic Purpura" was featured in Haematologica, the journal of the European Haematology Association, online on August 23, 2018. Elizabeth Staley, M.D., Ph.D., Hemostasis Fellow of pathology, was first author on the paper, along with colleagues Wenjing Cao, M.D., Ph.D., Instructor, Pathology; Nicole Kocher, Researcher, TTP Lab; Lucy Zheng, senior of Indian Springs School, Huy Pham, M.D., M.P.H., and Robin Lorenz, M.D., Ph.D., former Assistant Professor and Professor of Pathology, respectively, Lance Williams, Associate Professor of Pathology, Marisa Marques, Ph.D., Professor, and X. Long Zheng, M.D., Ph.D., Professor of Pathology and Division Director, Laboratory Medicine.
The second, "Transfusion of platelets loaded with recombinant ADAMTS13 is efficacious for inhibiting arterial thrombosis in mice and in human," was published in the journal Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB), on September 13, 2018. First author Mohammed Abdelgawwad, M.D., Ph.D., a graduate student of pathobiology theme at UAB. Other contributors include Wenjing Cao, M.D., Ph.D., Nicole Kocher, B.S., Lance Williams, M.D., Liang Zheng, Ph.D. and X. Long Zheng, M.D., Ph.D.The findings suggest that transfusion of recombinant ADAMTS13-loaded platelets may be a novel and potentially effective therapeutic approach for arterial thrombosis, including congenital and immune-mediated thrombotic thrombocytopenic purpura.
Haematologica and ATVB are top journals in the field of Hematology, with an impact factor of 9.09 and 6.6, respectively.
The Zheng Lab is interested in understanding the biological mechanisms of iTTP, which is caused by a deficiency of plasma ADAMTS13, the enzyme responsible for cleaving von Willebrand factor (VWF). Dr. Zheng was among the first group of investigators who discovered and cloned the ADAMTS13 enzyme. The Zheng Lab has made many seminal contributions to the understanding of the structure-function relationship and regulation of ADAMTS13, by working to develop novel tools for the diagnosis and treatment of TTP.
Each year the Zheng Lab hosts the TTP Fair and Education Day, an event designed to create a conversation and a community between those affected by the disorder and the physicians and researchers who are working to improve the available treatments, outcomes, and recovery time. Visit the event website to learn more.
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