iStock 172212825Supported by the financial support of Dr. Robert Pritchett, husband of Paulette Pritchett, and family.

This endowed lecture series is named in honor of Dr. Paulette Shirey Pritchett. Dr. Pritchett was a highly respected, young member of the UAB Department of Pathology when she unexpectedly passed away on August 4, 1984. Dr. Pritchett was a native Alabamian who obtained her medical degree from the University of Alabama, where she was awarded the Stewart Graves Award and the William Boyd Medal for her demonstrated excellence in pathology.

This year's lecture will feature: 

EricOlson 2018
Eric N. Olson, Ph.D.
Chair, Department of Molecular Biology
UT Southwestern Medical Center
"Understanding Muscle Development, Disease, and Regeneration"

Wednesday, May 29, 2019

2 p.m.
Margaret Cameron Spain Auditorium

Biosketch for Dr. Eric N. Olson

Eric Olson is the founding Chair of the Department of Molecular Biology at The University of Texas Southwestern Medical Center. He also founded the Center for Regenerative Science and Medicine at UT Southwestern, which is advancing new strategies for organ regeneration.  In addition, Dr. Olson directs the Wellstone Clinical Research Center for Muscular Dystrophy Research at UT Southwestern.  He holds the Robert A. Welch Distinguished Chair, the Pogue Chair Distinguished Chair in Cardiac Birth Defects and the Annie and Willie Nelson Professorship in Stem Cell Research.

Dr. Olson and his trainees discovered many of the key genes and mechanisms responsible for development of the heart and other muscles. His laboratory also unveiled the signaling pathways responsible for pathological cardiac growth and heart failure. Olson’s discoveries at the interface of developmental biology and medicine have illuminated the fundamental principles of organ formation and have provided new concepts in the quest for cardiovascular therapeutics. His most recent work has provided a new strategy for correction of Duchenne muscular dystrophy using CRISPR gene editing. 

Dr. Olson is a member of the U.S. National Academy of Sciences, the Institute of Medicine, and the American Academy of Arts and Sciences. His work has been recognized by numerous awards, including the Basic Research Prize and Research Achievement Award from the American Heart Association, the Pasarow Medical Research Award, the Pollin Prize, the Passano Award, and the March of Dimes Prize in Developmental Biology. In 2009, the French Academy of Science awarded Dr. Olson the Lefoulon-Delalande Grand Prize for Science. He is among the most highly cited scientists in the world, with his work having been cited over 100,000 times (with an h-Index of 180) in the scientific literature.

Dr. Olson has co-founded multiple biotechnology companies to design new therapies for heart muscle disease. Most recently, he founded Exonics Therapeutics, which is advancing gene editing as a therapy for Duchenne muscular dystrophy.  In his spare time, he plays guitar and harmonica with The Transactivators, a rock band inspired by the Texas troubadour, Willie Nelson, who created the Professorship that supports his research.

Dr. Pritchett was appointed an assistant professor at UAB in 1975 and a surgical pathologist at UAB and later at Cooper Green Hospital. Dr. Robert Pritchett, her husband and a practicing dermatologist, provided financial support to the university in her name to establish this lectureship. We thank Dr. Pritchett and members of his family for making this lectureship possible.
 
Past lecturers for the Dr. Paulette Shirey Pritchett Lecture in Pathology include:
1992            Paul E. Lacy, M.D., Ph.D.
                        Robert L. Kroc Professor of Pathology
                        Washington University School of Medicine
                                    "Islet Transplantation in Diabetes Mellitus"

1993            Lance A. Liotta, M.D., Ph.D.
                        NIH Deputy Director for Intramural Research
                        Chief of the Laboratory of Pathology,
                        National Cancer Institute
                              "Cancer Invasion and Metastasis: From Molecule to Bedside",

1994            Ramzi S. Cotran, M.D.
                        F.B. Mallory Professor of Pathology
                        Harvard Medical School
                        Chair, Department of Pathology, 
                        Brigham and Women's Hospital and Children's Hospital Medical Center
                                    "Endothelial Activation: Its Role in Inflammatory and Immune injury"

1995            Leroy E. Hood, M.D., Ph.D.
                        William Gates II Professor and Chair
                        Department of Molecular Biotechnology
                        University of Washington
                                    "The Human Genome Project: Leading a Revolution in Medicine of the 21st Century"

1996            Russell Ross, D.D.S., Ph.D.
                        Professor of Pathology
                        Director, Center for Vascular Biology 
                        University of Washington
                                    "Cellular and Molecular Studies in Atherogenesis"

1997            Emil R. Unanue, M.D.
                        Mallinckrodt Professor and Chair, Department of Pathology
                        Washington University School of Medicine
                              “The Cellular and Biochemical Basis of Antigen processing for T Cell Recognition”     

1998             Michael A. Gimbrone, Jr., M.D.
                        Elsie T. Friedman Professor Pathology
                        Harvard Medical School        
                                “Vascular Endothelium: A Dynamic Interface in Health and Disease”

1999             Oliver Smithies, Ph.D.
                        Excellence Professor of Pathology and Laboratory Medicine
                        The University of North Carolina at Chapel Hill
                        2007 Nobel Laureate for Physiology and Medicine
                                    “A Mouse View of Hypertension”

2000             Louis J. Ignarro, Ph.D.
                        Jerome J. Belzer, M.D. Distinguished Professor of Pharmacology
                        University of California at Los Angeles
                        1998 Nobel Laureate for Physiology and Medicine
                                    “Nitric oxide as a Unique Signaling Molecule in the Vascular System”

2001              William E. Paul, M.D.
                        Chief of the Laboratory of Immunology at the National Institute of Allergy and 
                        Infections Diseases, National Institutes of Health
                                    “Cytokine Biology: Lessons from IL-4”

 2002            Sir John E. Walker, D. Phil.
                        Director, The Medical Research Council’s
                        Dunn Human Nutrition 
                        1997 Nobel Laureate in Chemistry
                              “Power in Biology”

2003            Peter F. Davies, Ph.D.
                         Professor of Pathology and Laboratory Medicine
                         Director, Institute for Medicine and Engineering
                         University of Pennsylvania
                               “Flow-Mediated Endothelial Mechanotransduction: Spatial Structural and
                              Genomics Responses"

2004            Stanley J. Korsmeyer , M.D.
                        Sidney Farber Professor of Pathology
                        Harvard University
                        Dana Farber Cancer Institute
                             “Gateways to Apoptosis”

2005            Harvey Lodish, Ph.D.
                        Professor of Biology and Bioengineering
                        Massachusetts Institutes of Technology
                             “Hematopoietic Stem Cells: Regulation by novel surface proteins, growth factors, 
                              and micro RNAs”

2006            Douglas C. Wallace, Ph.D.
                        Professor, Department of Ecology & Evolutionary Biology
                        University of California at Irvine
                              “A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and
                              Cancer: a Dawn for Evolutionary Medicine”

2007          Harry C. Dietz, III, M.D.
                       Victor A. McKusick Professor of Medicine, Pediatrics, 
                      Molecular Biology & Genetics
                       Johns Hopkins University School of Medicine
                              “Marfan Syndrome and Related Disorders: from Molecules to Medicines”

2008            Phillip A. Sharp, Ph.D.
                        Professor of Biology
                        Massachusetts Institute of Technology
                        1993 Nobel Prize in Physiology or Medicine
                               “The Biology and Medical Promise of Small RNAs”

2009            Gregg L. Semenza, M.D., Ph.D.
                        C. Michael Armstrong Professor, Depts. Of Pediatrics, Medicine, Oncology,
                        Radiation Oncology, and the McKusick-Nathans Institute of Genetic Medicine
                        The Johns Hopkins University School of Medicine
                                    “Targeting Hypoxia-Inducible Factor I for Cancer Therapy”

2010            Mary J.C. Hendrix, Ph.D.
                        President and Scientific Director, 
                        Children’s Memorial Research Center
                        Professor, Robert H. Lurie Comprehensive Cancer Center
                        and the Feinburg School of Medicine at Northwestern University
                                    “Targeting a Novel Embryonic Pathway to Suppress the Metastatic
                                     Phenotype”

2011            Eric D. Green M.D., Ph.D.
                        Director, National Human Genome Research Institute
                        Senior Investigator & Head, Physical Mapping Section
                        Genome Technology Branch, Division of Intramural Research
                        National Institutes of Health
                                    “Charting a Course for Genomic Medicine”

2012            Professor Sir Salvador Moncada, M.D.
                        Professor of Experimental Biology and Therapeutics
                        Wolfson Institute for Biomedical Research
                        University College London
                                     “Discovery of the Mechanism that Enables the Provision of Nutrients to
                                     Proliferating Cells”

2013            Jeffrey I. Gordon, M.D.
                        Dr. Robert J. Glaser Distinguished University Professor
                        Director, Center for Genome Sciences
                        Department of Pathology and Immunology
                        Washington University School of Medicine
                                      “Exploring the Human Gut Microbiome: Dining in with Tens of Trillions of
                                       Fascinating Friends”

2014            Solomon Snyder, M.D.
                        Johns Hopkins Medical School
                        Department of Neuroscience
                                    “Molecular Mechanisms in Huntington’s Disease Pathogenesis”

2015            Anthony Atala, M.D.
                        Director, Wake Forest Institute for Regenerative Medicine
                        W.H. Boyce Professor and Chair of the Department of Urology
                        Wake Forest University
                                    “Regenerative Medicine: New Approaches to Healthcare”

2018           Elaine Jaffe, M.D.
                        Series Editor, World Health Organization 'Classification of Tumours"
                        Senior Investigator
                        Laboratory of Pathology 
                        Head, Hematopathology Section
                        National Cancer Institute
                                     "Charting the Future of Lymphoma Classification: A Road Map for Disease Discovery and Treatment"