Luz M. Reyes, Ph.D.Assistant Professor

Areas of Interest
genetic characterization, genome editing

Biography

Dr. Luz M. Reyes obtained her Master’s degree in Genetics at the National University of Colombia in Bogota, Colombia. She completed her Ph.D. in Molecular Genetics at the North Carolina State University, Raleigh, NC.

Genetics, Cell Biology, and Molecular Biology constitute the main areas that Dr. Reyes has explored as a scientist. Her research has been focused on the genetic characterization of the swine class I and class II MHC complex. Currently she is working in the creation of knockout pigs using Cas 9 nuclease and guide RNAs system.

Prior to coming to the University of Alabama at Birmingham, she worked as a Research Assistant Professor at the Department of Surgery, School of Medicine at Indiana University.

Selected Publications

Butler JR, Martens GR, Estrada JL, Reyes LM, Ladowski JM, Galli C, Perota A, Cunningham CM, Tector M, Joseph Tector A. 2016. Silencing porcine genes significantly reduces human-anti-pig cytotoxicity profiles: an alternative to direct complement regulation. Transgenic Res. 25(5):751-9.

Paris LL, Estrada JL, Li P, Blankenship RL, Sidner RA, Reyes LM, Montgomery JB, Burlak C, Butler JR, Downey SM, Wang Z-Y, Tector M, Tector AJ. 2015. Reduced Human platelet uptake by pig livers deficient in the asialoglycoprotein receptor 1 protein. Xenotransplantation 22(3): 203-210.

Reyes LM, Estrada JL, Wang ZY, Blosser RJ, Smith RF, Sidner RA, Paris LL, Blankenship RL, Ray CN, Miner AC, Tector MF, Tector AJ. 2014. Creating Class I MHC-null pigs using guide RNA and the Cas 9 endonuclease. J. Immunol. Dec 1; 193(11): 5751-5757.

Reyes LM, Blosser RJ, Smith RF, Miner AC, Paris LL, Blankenship RL, Tector MF, Tector AJ. 2014. Characterization of swine leucocyte antigen alleles in a crossbred pig to be used in xenotransplant studies. Tissue Antigens. 2014 Nov; 84(5):484-8.

Luz M. Reyes, PhD, Jose L. Estrada, DVM,PhD, Bess Ivary, BS, Richard A. Sidner, PhD, Leela L. Paris, PhD, A. Joseph Tector, MD, PhD. Efficient selection of Gal-knockout pig cells for somatic cell nuclear transfer. J. Of Surgical Research. 2013 Oct; 184(2) e37-e42.

  • Note: Commentary of this paper by Ryan W. Bradstreet, BS, and Luis H. Toledo-Pereyra, MD, PhD. Mechanisms of Gal-knockout pig cell selection for somatic cell nuclear transfer. J. Of Surgical Research. 2014 Jan; 186(1) 107-108.

Lutz AJ, Li P, Estrada JL, Sidner RA, Chihara RK, Downey SM, Burlak C, Wang ZY, Reyes LM, Ivary B, Yin F, Blankenship RL, Paris LL, Tector AJ. Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose 1,3-Galactose reduce the humoral barrier to xenotransplantation. Xenotransplantation. 2013 Jan; 20(1): 27-35.

Paris LL, Chihara RK, Reyes LM, Sidner RA, Estrada JL, Downey SM, Milgrom DP, Tector AJ, Burlak C. ASGR1 expressed by porcine enriched liver sinusoidal endothelial cells mediates human platelet phagocytosis in vitro. Xenotransplantation. 2011 Jul-Aug;18(4):245-51. Erratum in: Xenotransplantation. 2012; Jul-Aug; 19(4):269.

Chihara RK, Paris LL, L.M. Reyes, Sidner RA, Estrada JL, Downey SM, Wang ZY, Tector AJ, Burlak C. Primary porcine Kupffer cell phagocytosis of human platelets involves the CD18 receptor. Transplantation. 2011 Oct 15; 92(7): 739-44.

Waghmare S.K., J.L. Estrada, L.M. Reyes, B. Ivary, R.A. Sidner, C. Burlak, and A. J. Tector. 2011. Gene Targeting and Cloning in Pigs Using Fetal Liver Derived Cells. J. Of Surgical Research. 2011 Dec; 171(2): e223–e229.

Burlak C, Paris LL, Chihara RK, Sidner RA, L.M. Reyes, Downey SM, Tector AJ. The fate of human platelets perfused through the pig liver: implications for xenotransplantation. Xenotransplantation. 2010 Sep-Oct; 17(5):350-61.

Education

B.S. Biology and Chemistry
Teaching University of Colombia, Bogota, Colombia

M.Sc. Genetics and Plant Breeding
National University of Colombia, Bogota, Colombia

Ph.D. Horticultural Science-Molecular Genetics
North Carolina State University, Raleigh, North Carolina

Contact

Campus Address
Tinsley Harrison Tower
Room 848

Phone
205-934-9277

E-mail
luzreyes@uab.edu