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Study testing drug to protect lung cells from ARDS in COVID-19
With funding from UAB’s urgent COVID-19 research grants, researchers are testing penehyclidine to halt the acute respiratory distress syndrome seen in seriously ill patients by defending crucial cell barriers.
‘High-risk, high-reward’ NIH grant expands researcher’s work predicting cancer immunotherapy successBenjamin Larimer, Ph.D., has received a five-year, $1.5-million New Innovator Award grant to develop a PET imaging test that identifies patients most likely to benefit from immunotherapy.
Your ZIP code is a risk factor for COVID-19: Study will identify where testing, therapies are needed mostUsing extensive testing, diagnosis and clinical data from across the Deep South, this project will be the first to analyze multiple dimensions of inequality to clarify contributions to COVID-19 disparities.
Could NET-wielding neutrophils be driving respiratory distress and death in COVID-19 patients?The immune system’s first responders are implicated in acute respiratory distress syndrome, which greatly increases mortality in patients with COVID-19. With pilot funding from UAB’s urgent COVID-19 research initiative, investigators are exploring a potentially powerful new form of treatment.
Better tests, cheaper vaccines: Antibody expert turns to COVID-19Moon Nahm, M.D., has identified the crucial antibodies for pneumococcal vaccines and helped lower prices from $100 per dose to $2. With pilot funding from UAB’s urgent COVID-19 research initiative, Nahm is adapting his proven techniques to SARS-CoV-2.
How UAB became a national leader in clinical trialsAlabamians have early access to potentially life-saving vaccines and treatments for COVID-19 through UAB. Why? The same reasons that clinical trials activity at UAB has more than doubled in the past five years. Here's how it happened.
This glow-in-the-dark Trojan horse makes cancer cells build their own self-destruct switchA bioluminescent one-two punch targets mitochondria in cancer cells and evades the blood-brain barrier for a potential new treatment for neuroendocrine cancers, triple-negative breast cancer and brain cancers.
Studying an alternative steroid treatment to calm cytokine storms in COVID-19In a new trial funded through UAB’s urgent COVID-19 research program, investigators are comparing the widely available steroid methylprednisolone with dexamethasone, which lowered risk of dying by one-third in a U.K. trial this summer.
Chronotypes and cigarettes: New study explores strategies to help ethnic minorities get better rest and quit smokingWith a nearly $3 million grant from the NIH, researchers are studying interactions among sleep, nicotine and race.
Project aims to address HIV and substance use in Jefferson County youthProject LEAP will make novel use of integrated patient navigation and student champions to help high-risk young residents.
Data wizards join fight against COVID-19 in UAB hackathonThis summer’s COVID-19 Data Science Hackathon spurred many creative applications and several ongoing projects, including an automated genomic epidemiology pipeline and a machine-learning based viral transmission simulator.
New addiction and pain prevention center aims to rally researchers and communityInterdisciplinary center is focused on cutting-edge research that can be developed into better treatments — and helping junior faculty develop their own research programs.
Study testing behavioral intervention to prevent CMV, major cause of hearing loss in young childrenA $2.9 million study aims to lower the risk of pregnant women becoming infected with cytomegalovirus, a virus that can lead to long-term health problems for babies.
BMT survivor study finds significant breast cancer risk in young women who received total body irradiationWomen who had total body irradiation to prepare for blood or marrow transplantation before age 30 had a 4.5-fold increase in their risk of developing breast cancer later in life.
Which beach will bust? A high-tech flood forecaster predicts water’s next move like no one elsePrecision mapping using drones, light aircraft and lasers enables Rouzbeh Nazari, Ph.D., to pinpoint homes at highest risk in hurricanes and other disasters.
New weight-loss study focusing on stress — the diet killerA $2.9 million, NIH-funded trial aimed at Black women with high stress will examine whether culturally relevant stress-management strategies can improve weight-loss outcomes.
Radiology is investing in innovation and spinning off startups. What’s the secret?Department creates environment for entrepreneurial activity that fuels advances in artificial intelligence, cancer prediction and patient safety.
Hijacked mitochondria could induce COVID-19, study saysIn a new paper, Keshav Singh, Ph.D., outlines the case for the “powerhouse of the cell” as a hideout and unwitting ally for SARS-CoV-2.
Machine-learning tools find targets old drugs can exploit against COVID-19Researchers from UAB’s Precision Medicine Institute have used AI to identify hundreds of potential treatments, which are now being tested through the COVID-19 research fund that the institute helped launch.
Glow-in-the-dark coronavirus testing is first project of new hireNew microbiology faculty member Nicholas Lennemann is transforming the fluorescent virus assay he developed into a new tool against coronavirus in work supported through UAB’s urgent COVID-19 research fund.
Researchers model COVID-19 infection in 3D human lung tissueBioreactors built to offer new insights on lung cancer are being adapted to study coronavirus infection and test new treatments in this project supported through UAB’s urgent COVID-19 research fund.
Tackling his third pandemic, UAB researcher gets up close with coronaviruses in order to kill themVirologist Kevin Harrod, Ph.D., is the institution’s resident expert on SARS viruses. His lab is handling biological validation for innovative drug-repurposing studies supported by the School of Medicine’s Urgent COVID-19 research fund.
Researchers are creating a coronavirus showdown to settle pressing antibody problemsMicrobiologists Troy Randall and Frances Lund are building key proteins from several coronaviruses to study antibody cross-reactivity and other crucial questions in this project supported through UAB’s urgent COVID-19 research fund.
Where are the good antibodies against COVID-19? UAB project aims to find outIn this project supported through UAB’s urgent COVID-19 research fund, Professor Randall Davis aims to identify antibodies that block SARS-CoV-2 from entering human cells — information that could guide convalescent plasma therapy and more.
Discoveries on deck: Searching for a better fit for safety eyewearProtecting workers’ vision has become more challenging as a diverse workforce stretches the definition of a “typical” face. UAB researchers are going 3D to keep employees safe.
Helpful viruses may unlock the secrets of coronavirus antibodiesIn this project supported through UAB’s urgent COVID-19 research fund, Assistant Professor Benjamin Larimer, Ph.D., adapts his lab’s work on phage display — normally used to identify new cancer treatments — to overcome limitations of antibody and vaccine testing.
#Chinavirus study explores spread of COVID-19 related stigma on TwitterResearchers in the School of Public Health illustrate how tweets labeling the novel coronavirus as the “Chinese virus” exploded across the United States.
Cytokine storm treatment for coronavirus patients is focus of first-in-US studyTrial to rapidly identify and treat the immune overreaction that may be behind some cases of severe COVID-19 is made possible through UAB Medicine’s Urgent COVID-19 Clinical Research and Laboratory Research Fund.
Discoveries on deck: Strategic planning against opioid disordersEducating new primary care physicians about effective treatments for opioid use disorder in partnership with Cahaba Medical Care.
Is U-BRITE 2.0 right for you?Just in time to tackle COVID-19, the Informatics Institute launches a bigger, more capable version of its team-science data platform.
Growing heart cells in a lab — one beat at a timeLab-grown human heart tissue could mean better drug tests, faster transplants and more accurate models of disease. To get there, Palaniappan Sethu, Ph.D., is stretching ingenuity.
Discoveries on deck: Helping vulnerable patients quit smokingUAB algorithm offers doctors a step-by-step guide to connect patients with HIV to best smoking-cessation options.
As coronavirus dashboards enthrall millions, a mapping guru reflects on the power of visualizationAriann Nassel in the Lister Hill Center for Health Policy works with UAB researchers to reveal patterns in patient care, neighborhood features, dental practices and more.
Discoveries on deck: Equations + images against HER2+ breast cancerNew UAB research is combining mathematical modeling and advanced imaging to find the right mix of therapy for patients with a common subtype of breast cancer.
Discoveries on deck: Back pain, race and moneyAre there differences in the way that minority groups and people with low socioeconomic status experience chronic low back pain? Learn more about an ongoing study in this new series that looks behind the scenes of UAB’s latest grants and contracts.
Discoveries on deck: Predicting uncontrolled bleedingLearn how UAB researchers are taking on the most feared complication of the new generation of blood-thinning drugs.
Discoveries on deck: Accelerating HIV suppression in the Deep SouthAn innovative grant aims to speed up antiretroviral therapy initiation for patients in the Deep South newly diagnosed with HIV.
Genetics may predict cancer patients at highest risk of ‘chemo brain’ after blood or marrow transplantUAB-led study finds that genetic variations associated with cognitive decline after BMT identify high-risk patients more accurately than current methods.
Discoveries on deck: Exploring a new strategy against lupusGo behind the scenes of UAB’s latest grants and contracts in this new series to discover a fresh approach to treat an autoimmune disease and its mysterious double-negative B cells.
Discoveries on deck: Blocking fentanyl at the sourceGo behind the scenes of our latest grants and contracts in this new series — including a grant that is taking UAB investigators into the heart of the dark web of opioid trafficking.
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