Noha Sharafeldin, MBBCh, Ph.D., of the Institute for Cancer Outcomes and Survivorship, used UAB’s supercomputer to identify biomarkers linked with cognitive impairment in patients who received a blood or marrow transplant. She’s also testing a way to repair the damage.
The UAB Department of Dermatology is seeking people for a clinical study looking into ultraviolet light induced effects on the skin immune responses. This study may provide clues for the prevention of skin cancer. We are seeking 18-35 year old individuals, without a history of skin cancer, who are capable of being sunburned and who are not currently pregnant or planning to become pregnant the next 2 months. Participants may receive up to $500 in compensation. Please contact 205-801-8841 or UVstudy@uabmc.edu for more information.
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The UAB Department of Dermatology is seeking people for a clinical study looking into ultraviolet light induced effects on the skin immune responses. This study may provide clues for the prevention of skin cancer. We are seeking 18-35 year old individuals, without a history of skin cancer, who are capable of being sunburned and who are not currently pregnant or planning to become pregnant the next 2 months. Participants may receive up to $500 in compensation. Please contact 205-801-8841 or UVstudy@uabmc.edu for more information.
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Clinical trial evaluating a novel, non-invasive radiation treatment for ventricular tachycardia refractory to medication and catheter ablation The UAB Departments of Radiation Oncology and Cardiology are looking for patients with ventricular tachycardia (VT) not controlled by medications and catheter ablation. The trial will allow patients suffering from VT despite standard of care regimens to undergo non-invasive cardiac radioablation (CRA; a type of stereotactic body radiotherapy) to the area of the heart responsible for their symptoms. Stereotactic body radiotherapy is delivered with a device called the linear accelerator, which is primarily used to treat patients with cancer. UAB is one of the first centers in the U.S. to obtain a Food and Drug Administration (FDA) investigational device exemption for use of the linear accelerator in this capacity on a phase I/II trial. The study is being conducted in collaboration with the Washington University School of Medicine in St. Louis, a center which pioneered this promising technique in the U.S. For more information on the RAD 1901 trial, please contact Adelyn Gillon, clinical research coordinator, at 205.975.3019 or agillon@uabmc.edu" contenteditable="false">agillon@uabmc.edu.
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BAPS is a new Breast Cancer Recovery study opening at the O’Neal Comprehensive Cancer Center. As part of our focus on healthy recovery from cancer and its treatment, we try to offer programs that will support women in their recovery. We are studying a new program that is designed to help women find ways to be active and productive in all areas of life including managing work and employment, taking care of their home and family, and doing healthy activities such as exercise, leisure, hobbies, and socializing. The 9-session program happens over the telephone, at times that are convenient for you. If you would like to learn more about the study, please call 205-996-0384
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The ROME study is designed to discover how exercise affects the gut microbiome and fatigue in breast cancer survivors. This study includes 10 weeks of supervised, individual exercise sessions with exercise specialists. The study is funded by the National Cancer Institute. Participants must be between the ages of 18 and 70 with a history of stage I, II or III breast cancer within the last five years. For more information, contact the Cancer Lifestyle Team at (205) 934-8821 or email moveforward@uab.edu. All information is confidential and participation is free.
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The wisdom Study wants to apply modern medical science to breast cancer screening by determining if personalized screening is better than annual mammography and learning how to improve detection while reducing over-diagnosis and false-positive readings. Women ages 40-74, with no history of breast cancer or ductal carcinoma in situ (DCIS), are asked to join. Participation can mostly be done from home, and there are no additional medical visits outside routine visits required. Please register at www.wisdomstudy.org
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We are conducting a study to examine the naturally occurring bacteria in the gut of women and how behaviors like diet and stress may affect the presence of bacteria in the gut. Participation includes completing questionnaires, basic body measurements, and providing samples of blood, stool, and saliva. Compensation is provided. For more information contact Sh’Nese Townsend at 205-934-1715 or stownsend@uabmc.edu
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Are you a breast cancer survivor having difficulty walking? Do you have any lower-body pain that is restricting your mobility? If so, you may be interested in taking part in an exercise training intervention. UAB researchers are looking for overweight women - age 18-70 with a body mass index between 30-45 kg/m2 - with a history of breast cancer to participate in a novel exercise training study. Volunteers will be asked to attend two assessment sessions: an initial assessment and after 8 weeks of exercise to collect information about your health status. Further eligibility screening will be conducted by telephone. Volunteers must reside in or near Jefferson County. The study will evaluate a novel exercise training strategy designed to mimic exercise at higher altitude to support improved health and mobility among breast cancer survivors. Contact Dr. Stephen J. Carter, 205-975-0269 or carters@uab.edu; or the UAB Exercise and Cancer Research Team, 205.934.5466 or moveforward@uab.edu; to learn more.
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If you are experiencing extreme tiredness and fatigue even after your cancer treatment ends, you may be eligible to participate in a new mind/body research study. To qualify for this study, you must be a Stage II, Stage III or Stage IV cancer survivor who has completed all cancer treatment at least 6 months ago and within the last 10 years. Compensation for time and travel will be provided. For more information, please call 205-934-6326.
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We are inviting you to participate in the D.I.A.L. physical activity program for 12 weeks at no cost to you. What is it? Receive 12-weeks of physical activity information over the phone. Who can join? Any healthy adult age 21 or older and you do not have to currently be physically active to participate. Why be involved? Contribute to cancer prevention research and receive compensation for your involvement. Call 205-934-0504 to see if you qualify for the program.
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Unique study investigates what tools survivors need to engage in regular exercise after treatment
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3 UAB chemists break down their formulas for fighting cancerNew treatments emerging from the labs in the Department of Chemistry rely on split-second timing, tiny cargo bubbles and supercomputer-powered predictions.Researchers hack adaptive cruise control, then show how to make it safer
Driver assistance tech that comes standard on new vehicles can be tricked into causing accidents — but there is a way to alert humans in time. A UAB grad student and his mentor will share their findings this month at a global conference.
First-of-its-kind scan tracks immune invaders to explore puzzling brain diseasesPatients with multiple sclerosis, fibromyalgia and chronic fatigue syndrome will soon be able to enroll in the clinical trial of a PET agent that can capture evidence of brain infiltration by white blood cells and could eventually guide treatment.Salt boosts blood pressure for some people. UAB study asks: Who?By alternating high-salt and low-salt diets, a new clinical trial aims to find out how common salt sensitivity of blood pressure is in the general population. The researchers are also exploring whether the immune system plays a role.Researchers pioneering long-read sequencing studies explain why long reads matterNew technologies are filling in gaps in the human genome and opening major areas for discovery. Zechen Chong, Ph.D., and Robert Kimberly, M.D., explain the pros and cons and how they are using long reads at UAB.UAB study: Could this five-second obesity management strategy keep the pounds off?American adults tend to gain a pound or two per year. Researchers are testing a new approach to halt this creeping weight gain. They give participants a digital scale that graphs their weight over time and one job: step on it daily.This long-running study proves that nice people finish firstMore than 100 different UAB researchers have been first authors on papers based on the REGARDS study thanks to its innovative design — and a uniquely “friendly and welcoming team.”Exploring simulations, a philosopher finds clues to overcoming “failure of imagination”Lindsay Brainard, Ph.D., assistant professor in the Department of Philosophy, delves into the tools modern scientists use to generate new hypotheses in biology, medicine, astronomy — and philosophy.Feeling proud: UAB researcher’s work on touch cited in 2021 Medicine Nobel PrizeProfessor Jianguo Gu, Ph.D., was the first to publish direct evidence that the Piezo2 channel is the sensor for light touch in 2014. His lab continues to pioneer research that could ease the burden of chemotherapy, excruciating facial pain and other conditions.Researchers identify new phase of disaster during pandemic: the sandbarIn a new paper, UAB experts in counseling and health behavior adapt the widely used Phases of Disaster Model to help colleges and universities respond to unique needs during COVID.Hackathon yields AI-inspired ideas to fight cancerTwelve teams competed for cash and prizes across two action-packed days in the AI Against Cancer hackathon. This is the third iteration of the UAB-sponsored event, which applies big data and artificial intelligence techniques to fight disease.UAB trial studying diet composition — with no weight loss — to treat Type 2 diabetesClinical trial investigates diet as a way to remodel the body by re-partitioning energy away from metabolically harmful lipid stores.Researchers are learning how to understand stigma and bring people back from ‘social death’Fear and self-loathing play a role in conditions from cancer to HIV and COVID-19, spurring a flood of new NIH funding for stigma research. This summer, UAB researchers led — and participated in — a first-of-its-kind “crash course” to bring more investigators into the field.How many more COVID variants will we see?Two UAB researchers — a SARS-CoV-2 expert and a vaccine researcher — discuss the prospects for future mutations.
Virtually all Alabamians could benefit from gene-based drug prescribing, statewide study findsAnalyzing gene sequencing data and prescriptions for more than 3,300 participants in the Alabama Genomic Health Initiative, UAB researchers estimate 98.6% of Alabamians have actionable genotypes and “a significant proportion are currently prescribed affected medications.”Exercise, sleep and cognition are linked in Parkinson's disease. A new study aims to personalize prescriptions.Research by Amy Amara, M.D., Ph.D., explores the ways deep sleep improves cognition and resistance exercise boosts deep sleep. With a new grant, she is studying the best exercise prescription for people with Parkinson’s.Why doesn't weight loss work for me? Smarter studies aim for faster answers.Drew Sayer, Ph.D., is a pioneer in the use of sequential multiple-assignment, randomized trials, known as SMARTs, for weight-loss research. His studies test several interventions at once to speed the search for solutions tailored to specific groups.How an epidemiologist uses social media to build trust and communicateBertha Hidalgo, Ph.D., associate professor in the Department of Epidemiology, explains how she is using WhatsApp and Facebook in two current studies and shares advice on using social media for research.How does COVID-19 affect patients with cancer? Largest U.S. study shares first results.Assistant Professor Noha Sharafeldin, MBBCh, Ph.D., presented cancer-related findings from the massive N3C database of records from COVID-positive patients at 55 institutions nationwide, including UAB. Results — including a significant increase in risk of death among patients who recently had chemotherapy — were published simultaneously in the Journal of Clinical Oncology.
Preparing a new workforce to care for patients with cardiac implantsPatients with cardiac implantable electronic devices are at risk for complications when undergoing heart surgery. UAB’s multi-disciplinary team is creating a platform to train anesthesiologists to help.More research from UAB News