Yuhua Song.

Associate Professor This email address is being protected from spambots. You need JavaScript enabled to view it.
Shelby 803
(205) 996-6939

Research and Teaching Interests: Integrated computational and experimental study, Computational biology, Computational biomechanics, Apoptosis, Apoptotic cell removal, Cell adhesion, Regenerative medicine, Breast cancer

Office Hours: By appointment

Education:

  • B.S., Jilin University of Technology, Materials Science & Engineering
  • M.S., Harbin University of Science and Technology, Materials Science & Engineering
  • Ph.D., Harbin Institute of Technology, Materials Science & Engineering
  • Post-Doc, Tsinghua University, Computational Mechanics
  • Post-Doc, University of Pittsburgh, Computational Biomechanics
  • Post-Doc, Washington University in St. Louis, Computational Biology

Yuhua Song is an Associate Professor in the Department of Biomedical Engineering. She joined the faculty in August 2006 after earning her Ph.D. in Materials Science and Engineering at Harbin Institute of Technology and completing post-doctoral fellowships at Tsinghua University, University of Pittsburgh School of Medicine, and Washington University in St. Louis School of Medicine.

Dr. Song’s research group uses integrated multiscale computational modelling and experimental approaches to investigate the fundamental structural and functional mechanisms of the biomolecular interactions underlying apoptosis, apoptotic cell removal, and cell adhesion; to identify molecular targets for modifying the aberrant apoptotic cell removal in tissue remodeling and tumor immunity; and for overcoming the drug resistance in breast cancer. Dr. Song has published in high profile journals including Journal of Biological Chemistry, Biophysical Journal, Biochemistry, Proteins, Journal of American Chemical Society, Journal of Cellular Biochemistry and Journal of Biomechanics, etc.

Dr. Song’s education goals are to inspire the students’ interest, motivate students to actively think and be committed in the course and research, teach them to critically read literatures, and help them to develop critical and independent thinking, problem solving and team working skills, and good working ethic that are important for their future academic and professional development. Dr. Song is the recipient of the Graduate Dean’s Excellence in Mentorship Award.

Download CV

Recent Courses

  • BME 333: Biomechanics of Solids
  • BME 680, 780: Biomolecular Modeling

Research Interests

Dr. Song’s research group uses integrated multiscale computational modelling and experimental approaches to investigate the fundamental structural and functional mechanisms of the biomolecular interactions underlying apoptosis, apoptotic cell removal, and cell adhesion, and to identify molecular targets for modifying the aberrant apoptotic cell removal in tissue remodeling and tumor immunity, and for overcoming the drug resistance in breast cancer.

Other focuses of the group include:

  • Multiscale modelling of the protein complexes in regulating cell adhesion and collagen expression in tissue remodelling.
  • Optimized design of biomaterials and small molecules/drugs for cell-based therapeutics, including the applications in immunoisolation nanotechnology.
  • Methodology development for multiscale modelling of complex biological systems.

Research projects in Dr. Song's group are described in detail at the Song reasearch group website.

Select Publications

  • Romone M. Fancy, Harrison Kim, Tong Zhou, Kurt R. Zinn, Donald J. Buchsbaum, Yuhua Song. Calmodulin Binding to Death Receptor 5-mediated Death-inducing Signaling Complex in Breast Cancer Cells. Journal of Cellular Biochemistry, 2017, Jan 16 [Epub ahead of print]. DOI:10.1002/jcb.25882.
  • Romone M. Fancy, Lingyun Wang, Thomas Schmid, Qinghua Zeng, Hong Wang, Tong Zhou, Donald J. Buchsbaum, and Yuhua Song. Characterization of the Interactions between Calmodulin and Death Receptor 5 in Triple-Negative and Estrogen Receptor Positive Breast Cancer Cells: An Integrated Experimental and Computational Study. The Journal of Biological Chemistry, 2016, 291(24):12862-70. PMCID: PMC5095404.
  • Hongyi Yang, Yuhua Song. Structural insight for roles of DR5 death domain mutations on oligomerization of DR5 death domain – FADD complex in the death-inducing signaling complex formation: a computational study. Journal of Molecular Modeling, 2016, 22 (4): 89, page 1-12. PMID: 26995783.
  • Lingyun Wang, Joanne E, Murphy-Ullrich, Yuhua Song. Molecular insight for the effect of lipid bilayer environments on thrombospondin-1 and calreticulin interactions. Biochemistry, 2014, 53 (40), pp 6309–6322. PMID: 25260145.
  • Romone Fancy, Lingyun Wang, Tiara Napier, Jiabei Lin, Gu Jing, Aaron Lucius, Jay M McDonald, Tong Zhou, Yuhua Song. Characterization of calmodulin and Fas death domain interaction: an integrated experimental and computational study. Biochemistry, 2014, 53 (16), pp 2680–2688. PMCID: PMC4007977.
  • Qi Yan, Jay M McDonald, Tong Zhou, Yuhua Song. Structural Insight for the Roles of Fas Death Domain Binding to FADD and Oligomerization Degree of the Fas - FADD complex in the Death Inducing Signaling Complex Formation: A Computational Study. Proteins: Structure, Function, and Bioinformatics, 2013, 81(3):377-85. PMCID: PMC3556372.
  • John T. Wilson, Wanxing Cui, Veronika Kozlovskaya, Eugenia Kharlampieva, Di Pan, Zheng Qu, Venkata R. Krishnamurthy, Joseph Mets1, Vivek Kumar1, Jing Wen, Yuhua Song, Vladimir V. Tsukruk, and Elliot L. Chaikof. Cell Surface Engineering with Polyelectrolyte Multilayer Thin Films. J Am Chem Soc, 2011, 133(18): 7054-7064. PMID: 21491937.
  • Qi Yan, Joanne E. Murphy-Ullrich, Yuhua Song. Molecular and Structural Insight for the Role of Key Residues of Thrombospondin-1 and Calreticulin in Thrombospondin-1- Calreticulin Binding. Biochemistry, 2011, 50(4): 566-573. PMCID: PMC3037594.
  • Di Pan, Yuhua Song. Role of Altered Sialylation of the I-like Domain of β1 Integrin in the Binding of Fibronectin to β1 Integrin: Thermodynamics and Conformational Analyses. Biophys J, 2010, 99 (1): 208-217. PMCID: PMC2895365.

Academic Distinctions and Professional Societies

  • Principal Investigator for NIH and NSF grants
  • Recipient of the Graduate Dean’s Excellence in Mentorship Award
Editorial Boards
  • MCB: Molecular & Cellular Biomechanics
  • Modelling and Simulation in Biotechnology
  • Journal of Bioprocessing & Biotechniques
  • Journal of Thermodynamics & Catalysis
Professional Societies
  • Biophysical Society
  • American Association for Cancer Research
  • American Heart Association
  • Society of Women Engineers at UAB
    • Dr. Song is active in advancing woman and minority student development. Dr. Song has served as faculty advisor for the Society of Women Engineers at UAB, advisory board for mentoring women in computing and technology, the School of Engineering representative on the UAB Commission on the Status of Women, and the Committee for Professional Opportunities for Women in Biophysical Society. Dr. Song has served as faculty advisor for more than 10 minority high school, undergraduate, master's and Ph.D. students.