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Areas of Interest 
progression from immune homeostasis that leads to permissive dysplasia in colitis-associated cancer and novel avenues for its prevention, diagnosis, and treatment

Biography

Bhuwan Giri, MBBS, is an assistant professor within the Division of Gastrointestinal Surgery.

Dr. Giri earned his medical degree from All India Institute of Medical Sciences in New Delhi, India. He was then a post-doctoral research associate at the University of Minnesota for one year, and at the University of Miami for two years. After his post-doc research, he completed his general surgery residency at Jackson Memorial Hospital in Miami. Following residency, Dr. Giri completed a colorectal surgery fellowship at Cleveland Clinic Foundation. He joined the faculty of the UAB Department of Surgery in January 2025.

Select Publications

Nationwide outcomes after neoadjuvant chemotherapy for locally advanced sigmoid colon cancer - A propensity score-matched analysis. Kodia, K., Alnajar A., Huerta, CT., Gupta, G., Giri, B., Dosch, A., Paluvoi N. 2024, The American Surgeon 90 (4), 866-874.

A complex presentation and successful management of fistulizing perianal Crohn’s disease extending to the mid-back. Vazquez, C., Kodia K., Giri, B., Paluvoi, N., 2023 Journal of Surgical Case Reports, 2023, 6, rjad364

Comparison of procedural outcomes between morning and afternoon colonoscopies performed by colorectal surgeons. Modi, S., Picado, O., Fiser, C., Lubarsky, M., Giri, B., Hui, V., Force, L., Marchetti, F., Sands, L.R. and Paluvoi, N.V., (2022). Surgical Endoscopy, pp.1-8.

Pirfenidone increases IL-10 and improves acute pancreatitis in multiple clinically relevant murine models. Bava, E.P., George, J., Tarique, M., Iyer, S., Sahay, P., Aguilar, B.G., Edwards, D.B., Giri, B.,... Dudeja, V., (2022) JCI Insight, 7(2).

Minnelide synergizes with conventional chemotherapy by targeting both cancer and associated stroma components in pancreatic cancer. Modi, S., Giri, B., Gupta, V.K., Lavania, S., Sethi, V., Sharma, N.S., Pandey, S., Vickers, S., Dudeja, V. and Saluja, A.K., (2022). Cancer Letters, p.215591.

Hsp70 modulates immune response in pancreatic cancer through dendritic cells. Giri, B., Sharma, P., Jain, T., Ferrantella, A., Vaish, U., Mehra, S., ... & Dudeja, V. (2021).. Oncoimmunology, 10(1), 1976952.

An immunocompetent model of pancreatic cancer resection and recurrence. Giri, B., Ferrantella, A., Sharma, P., Jain, T., Jacob, H. K., Modi, S., . . . Dudeja, V.. Journal of GI Surgery. 2021 May;25(5):1271-1279

Minnelide, a prodrug, inhibits cervical cancer growth by blocking HPV-induced changes in p53 and pRb. Ramakrishnan, V., de Haydu, C., Wilkinson, P., Hooda, U., Giri, B., ... Saluja, A., (2021). American Journal of Cancer Research, 11(5), p.2202.

Acute care surgery in the times of COVID-19 pandemic: Our experience at a large safety net hospital. Modi S., Giri B., Olvera R., … Pust, G. Panam J Trauma Crit Care Emerg Surg 2020;9(2): 142–146.

Pre-clinical evaluation of Minnelide as a therapy for acute myeloid leukemia. Giri, B., Gupta, V.K., Yaffe, B., Modi, S., Roy, P., Sethi, V., Lavania, S.P., Vickers, S.M., Dudeja, V., Banerjee, S. and Watts, J., 2019. Journal of Translational Medicine, 17(1), p.163.

Stromal NFKB1 reprograms tumor immune environment to protect pancreatic cancer cells from immune-mediated cytotoxicity. Garg B., Giri B., Modi S., Sethi V., Castro Iris., Umland O., Lavania S.P., Dawra R.K, Banerjee S., Vickers S., Merchant N.B., Ban Y., Ramakrishnan S., Saluja A., Dudeja V. Gastroenterology.155 (3), 880-891. e8

Targeting tumor intrinsic metabolic node in pancreatic cancer causes tumor regression, remodels extracellular matrix and sensitizes to anti-PD1 therapy Sharma NS, Gupta VK, Garrido VT, Hadad R, Durden BC, Kesh K, Giri, B. Ferrantella,A…Banerjee, S. Journal of Clinical Investigation 2019:519462.

Gut microbiota promotes tumor growth in mice by modulating immune response. Sethi, V., Kurtom, S., Tarique, M., Lavania, S., Malchiodi, Z., Hellmund, L., Zhang, L., Sharma, U., Giri, B., Garg, B. and Ferrantella, A.,. Gastroenterology, 155(1), pp.33-37.

Metastasis and chemoresistance in CD133 expressing pancreatic cancer cells are dependent on their lipid raft integrity. Gupta, V. K., N. S. Sharma, K. Kesh, P. Dauer, A. Nomura, B. Giri, V. Dudeja et al. Cancer letters 439 (2018): 101.

Delayed intra-abdominal complications of ventriculoperitoneal shunts. Shah, M., Giri, B., Capizzani, T. R., & Moorman, M. L. (2018). International Journal of Academic Medicine, 4(2), 153.of Academic Medicine 4, no. 2 (2018): 153.

Education

Medical School
All India Institute of Medical Sciences

Residency
Jackson Memorial Hospital

Fellowship
Cleveland Clinic Foundation

Contact

Phone
Patient Appointments and Questions: 205-975-3000

Email
bgiri@uabmc.edu