Adults

Researchers at UAB are recruiting adults with Type 2 Diabetes for a clinical research study focused on weight loss and metabolic health. You may qualify if you: are an adult with Type 2 Diabetes are interested in weight loss meet additional study criteria Study-related care and compensation may be provided. To learn more or see if you qualify contact: Christie Kirchoff ckirchof@uab.edu 205-975-7494

We are currently recruiting participants aged 18-30 with normal or corrected to normal vision and participants aged 18-89 with Macular Degeneration/Stargardt's Disease for a clinical research study that aims to understand how individuals learn to use their peripheral vision following the loss of central vision. This study is being conducted in the Civitan International Research Center and involves a total of 27 in-person visits over the course of 1.5 to 3 months. There are 2 MRI visits (1 at the beginning of the study and one at the end), 5 assessment visits (3 baseline assessments and 2 post assessments), and a total of 20 training sessions (in between the baselines and the post assessments). Compensation for full participation in this study is $350. This is a great opportunity for all to gain experience participating in a clinical research study. All participation would not only contribute to advancing our understanding of perceptual learning and how the brain processes vision, but also holds the potential to improve outcomes for those with central vision loss. If you or someone you know may be interested, please consider participating. For more information or to express interest, please text or call 205-410-4041, or visit go.uab.edu/brainstudy to sign up! Thank you for your time and consideration!

Are you still suffering from Generalized Anxiety Disorder (GAD)? Have you tried prescribed medication but are still experiencing anxiety symptoms? If so, please consider participating in our research study of an investigational drug for GAD. To join this study, potential study participants: Must be at least 18 years of age Must have taken at least 2 of the following treatments without adequate symptom relief: Paroxetine Venlafaxine XR Duloxetine Escitalopram Buspirone There is no charge for study-related tests or drugs. For more information, please email lalexander@uabmc.edu or call 205-996-5987.

Have you been on antiretrovirals (ART) for at least 3 months? Are you between 18-70 years old? Are you not currently taking antidepressants, or has it been at least four weeks since your last dose? Do you have a viral load under 200 copies/mL? You may be eligible for our study! Compensation for time and travel provided. Contact: To find out more, please email klbass@uabmc.edu or call 205-975-6206.  

The University of Alabama at Birmingham (UAB) School of Optometry is conducting a research study to find out how well the eye drop Vevye® (cyclosporine 0.1% ophthalmic solution) works in a subtype of dry eye disease called meibomian gland dysfunction (MGD), a common condition where the glands in your eyelids don’t make enough oil to keep your eyes healthy and comfortable. You will be asked to visit UAB School of Optometry 5 times over approximately 6 months (26 weeks). Each visit is expected to last between 50 to 90 minutes. If you are eligible for the study, you will be paid at the conclusion of each completed visit based on the following payment schedule: $80 after Visit 1, $50 after Visit 2, $40 after Visit 3, $40 after Visit 4, and $40 after Visit 5. The total payment you will receive if you are eligible and complete all study tasks and visits is $250. For more information, contact study team at SOeyes@uab.edu or at 205-934-6734.

The UAB Department of Nutrition Sciences is conducting a 95-week study to see how an investigational drug works in lowering body weight in people with Type 2 Diabetes. Eligible participants must be at least 18 years old. In addition to study medication, participants will receive diet and exercise counseling. Participants will be compensated for study visits. For more information contact Christie Kirchoff at ckirchof@uab.edu or 205-975-7494.

What is the study about? The goal of this study is to understand how executive functioning skills, such as working memory and inhibition, are related to everyday adaptive behaviors in youth with intellectual disability. The study aims to improve understanding and practical support in daily life. What does the study involve? Two remote meetings via Zoom of 1.5h each (3h total) Computer-based tasks and questionnaires for youth Caregiver questionnaires about their child’s everyday skills Who can participate? Youth ages 6-21 Diagnosed with intellectual disability Caregiver available to participate Compensation Participants will receive $15 via a clincard upon completion as compensation. For more information about the study, please visit the UAB Science of Child Development and Neurodiversity (STARS) Lab website. To see if you are eligible and to sign up, complete this Qualtrics Survey.

Participate in the PRECISION-BP research study investigating the best time to take blood pressure medication, morning or evening. In this study, participants will receive blood pressure medications for 28 days. Eligible participants must be obese (BMI: 30-45 kg/m2) men and women, have high blood pressure, and have no history of heart or kidney problems. The study involves wearing a blood pressure monitor for 24 hours, 24-hour inpatient visits at UAB Hospital, taking medications, and collecting blood and urine samples. Meals will be provided at no cost. Participants will be compensated $575 for completing the study visits. Please e-mail Amrita at PRECISION-BPSTUDY@uabmc.edu or call us at 205-934-0649 if you are interested.

This study, “The Energy Cost Related to Chronic Stress and Its Effect on Fat Accumulation in Adults Experiencing High Perceived Stress,” is investigating how stress affects metabolism, nutrient use, and hunger-related hormones. In one or two visits to UAB (about two hours total), you’ll have a body scan that shows your muscle, fat, and bone levels, and we’ll measure how much energy (calories) your body burns when you’re resting. Eligibility 25–50 years old Have high perceived stress Have a BMI ≥ 25 kg/m2 Do not have chronic medical conditions Are not taking medications that affect metabolism or body composition Exercise less than two hours per week Reimbursement Participants will receive $70 in compensation. Contact and registration Link: https://redcap.link/stresscost Phone: 205-934-9460 Yenni Cedillo, PhD, RD (Principal Investigator) Email: yennicj@uab.edu

Researchers want to learn how to help expecting mothers stay active throughout pregnancy through resistance training (exercises that make your muscles stronger, also known as strength training). The goal of this study is to understand how we can help you and women like you become more active through resistance training. We also want to get your feedback on how to best design a resistance training program for pregnant women. To participate: You must be 18-45 years old and currently pregnant (6-37 weeks gestation) Receiving prenatal care at UAB or planning to deliver at UAB Hospital AND At least one of these applies to you: Participate in public assistance programs such as Medicaid, WIC, SNAP, free or reduced-priced school meals, etc. Before pregnancy: Had obesity, high blood pressure, or diabetes For the first time during pregnancy: Had high blood sugar, or high blood pressure with or without signs of organ involvement Your baby was: Smaller or larger than expected in the womb, didn’t weigh enough at birth, or was born too early. Eligible participants will complete online questionnaires (one time, ≤30 minutes) and a 1-on-1 online interview with study staff (~1 hour). Compensation provided. Contact the study team at StrongRoots@uabmc.edu or 205-934-2872 for more information.

Join a clinical research study that seeks to improve the lives of those suffering from depression. We are looking for volunteers to participate in a clinical trial. Are you eligible to enroll in the Amplify Study? Must be between 18 and 65 years of age and meet the DSM-5 criteria for a diagnosis of MDD. You are experiencing a moderate or severe major depressive episode of up to 12 months. You have been using a SSRI or SNRI antidepressant for at least 6 weeks and are having an inadequate response. You do not have a history of obsessive-compulsive disorder (OCD), posttraumatic stress disorder (PTSD), panic disorder, or eating disorder, according to DSM-5 criteria. For more information, contact Dana Green at (205) 975-6426 or danagreen@uabmc.edu or Candace Green at (205) 975-0068 or candacegreen@uabmc.edu.

Millions of Americans struggle with bipolar depression. If you’ve tried seeking treatment and are still suffering, consider a research study. Local study doctors are studying how your brain's unique biology impacts treatment response in bipolar depression. To participate, you must be 18 years or older, have a diagnosis of bipolar depressive disorder (BPD), be experiencing a current depressive episode, and be taking a current bipolar medication. Contact us about the Alto Study: Candace Green: candacegreen@uabmc.edu or 205-934-2484

Participate in the PRISM-BP research study at UAB, investigating whether sharing personalized genetic risk scores can help people better control blood pressure. In this study, participants will attend 6 visits over 12 months. The study involves health checks, blood tests, urine samples, activity tracking, and wearing a 24-hour blood pressure monitor. Some participants will also receive their genetic risk score with counseling. Eligible participants must be 18–55 years old, have high blood pressure, and have no history of serious heart or kidney problems. Women cannot be pregnant or breastfeeding. Participants will be compensated up to $360 for completing study visits. Please e-mail Dr. Bal at harshvir6598@uabmc.edu or call us at 205-934-7936 if you are interested.

You may be eligible to participate in a research study looking at the effects of sacubitril/valsartan on how your body handles sugar. This medication is related to blood pressure and is safe to take with or without hypertension. Eligible participants must be healthy men and women, African American, and have no history of diabetes, heart disease or kidney problems. The study involves performing some exercise, taking sacubitril/valsartan, and collecting blood samples. Participants will be compensated $675 for completing all the visits. To participate, please contact Tiffany at 205-934-0534 or email us at nauticalstudy@uabmc.edu.

Do you have COPD? Are you 40 – 80 years old? Diagnosed with COPD for at least 1 year? Experienced at least 1 COPD flare-up last year? Weigh 99 pounds or more with a BMI in range of 16 - 35? Current/former smoker (1+ pack/day for 10+ years)? If you qualify and choose to participate, you may receive study-related care and study medication at no cost. You may also be compensated for your time and travel. Other criteria apply – ask your doctor about the Seabreeze study. Experimental medication has not been approved by US Food and Drug Administration. ClinicalTrials.gov ID NCT06940154 Call 205-975-5294 or email epkennedy@uabmc.edu.

Researchers at the University of Alabama at Birmingham are conducting a study on driving readiness and attentional control in teens and young adults who have not driven before. This study examines how attention, coordination, and reaction time relate to safe driving using a virtual driving simulator. Eligible participants are teens and young adults ages 13 to 21 who have never driven and do not have a developmental, neurological, or psychiatric diagnosis. Participants under 18 must have a parent or guardian available to provide consent. Participation involves a single 1.5 hour visit to the UAB Driving Simulator Lab, a brief overview of driving rules and safety procedures, a virtual driving simulation similar to a video game, and a short survey about the experience. Parents or guardians may observe the session. Participants who complete the driving simulator session will receive $50 for their time and effort. For more information about the study, please visit the UAB Science of Child Development and Neurodiversity (STARS) Lab website. To see if you are eligible and to sign up, complete this Qualtrics survey.

ZION is a clinical research study for adults with chronic obstructive pulmonary disease (COPD). This study will test a study drug injection to learn about its safety, effectiveness, and tolerability (side effects) in participants with COPD. Participation in the ZION study lasts about 32 weeks. Throughout the entire study, participants will continue to take their daily maintenance COPD medications. Who can join the ZION study? You may be able to join this study if you meet the following requirements: 40 to 75 years old Confirmed diagnosis of COPD for at least 12 months Currently taking 2 or more inhaled daily maintenance medications for COPD Other eligibility requirements will apply. Call 205-975-5294 or email epkennedy@uabmc.edu.

Do you experience leaks when you laugh, cough, or exercise? You’re not alone — it’s called Stress Urinary Incontinence (SUI), and there are solutions! RESTRAIN-SUI is a clinical research study from Eli Lilly and Company. It is testing how well and safely the investigational medicine can help female participants reduce their weekly frequency of stress urinary incontinence (SUI) compared to placebo. Can I join this study? Yes, you may be able to join the study if you: Are aged 18 years and over Are a woman (assigned female at birth) Have a BMI* of 27 or higher Have not lost or gained more than 5kg of your body weight in the last 3 months Have daily episodes of accidental leakage of urine onto your clothing, underwear, or pad during an activity such as coughing, sneezing, laughing, running, exercising, or lifting. Do not have diabetes Do not take any anti-obesity, stress urinary incontinence or overactive bladder medication. Compensation is provided. For more information about this study, please email Elizabeth at ekilpatrick@uabmc.edu or 205-934-5498 or visit https://e.lilly/44ze2QJ.

Do you or your child have one of the skin conditions listed below? If so, you may be able to get medical treatment while getting paid to help advance science! Alopecia (hair loss) Atopic Dermatitis (eczema) Psoriasis (scaly red rash) Hidradenitis Suppurativa (boils/abscesses) Vitiligo (depigmented spots) Pyoderma Gangrenosum (nonhealing wound) Lupus Erythematosus (round scaly rash) Benefits of participating in clinical trials: Frequent free dermatology evaluations Cutting edge treatment options Advancement of research Contact us to learn more about our clinical trials! Phone: 205-502-9967 | 205-502-9961Email: dermresearch@uabmc.edu

The UAB Department of Nutrition Sciences is conducting a nutrition and brain health study looking at whether an acute dose of a ketone supplement can improve cognitive function in individuals 60 and older. You may qualify if you are between the ages of 60-75 years, are healthy or have prediabetes, have NOT been diagnosed with Diabetes, are willing to consume a ketone supplement drink, and are willing to travel to UAB for 2 testing visits that include a PET-fMRI brain scan. Qualified participants will receive PET-fMRI scans upon request and monetary compensation for their time. For more information and to see if you qualify, please call or email sksweatt@uab.edu.