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Case History

A 48-year-old male with facial flushing was found to have atypical cells in both the peripheral blood (<1%) and bone marrow (50% on aspirate differential). Based on the provided photos and flow cytometry, which of the following is the best diagnosis?

  1.       AML with t(8;21)
  2.       CML
  3.       AML with inv(16)
  4. Mast cell leukemia (aleukemia variant)

Blood.jpgBlood    Aspirate.jpgAspirate

Flow.pngFlow    MarrowBiopsy.pngMarrow Biopsy

Answer: D 
Case contributed by: David Dorn, M.D., Fellow