Case of the Week
- Details
Case History
80-year-old female with post-menopausal bleeding and 5.5 cm polypoidal mass in the endometrium.
What is the best diagnosis?
- Endometrial stromal sarcoma
- Serous carcinoma
- Mixed Mullerian tumor/carcinosarcoma
- Leiomyosarcoma
- Details
Case History
Gastric biopsy in an 80-year-old female.
What is the best diagnosis?
- H. pylori gastritis
- Autoimmune gastritis
- Iron-pill gastritis
- Doxycycline-associated gastritis
- Details
Case History
A 95 y/o male, non-smoker, with hx of ocular pemphigoid on immunosuppressants. 4 cm left level 4 mass, firm and fixed without tenderness to palpation.
What is the best diagnosis?
- Metastatic squamous cell carcinoma
- Metastatic prostatic adenocarcinoma
- Metastatic papillary thyroid carcinoma
- Metastatic renal cell carcinoma
- Details
Case History
A 67-year-old male presents with a parotid mass associated with facial pain and cervical adenopathy. Fine-needle aspiration and core needle biopsy are performed and representative sections are shown.p63 immunostain is negative.
Which stain is expected to be diffusely positive?
- SOX10
- Androgen receptor
- p40
- Calponin
- Details
Case History
A 58-year-old woman presents with a new left upper quadrant breast mass. The tumor cells show SOX10 positivity.
What additional stain would help reach the diagnosis?
- Pancytokeratin; IDC grade 3
- P63; Metaplastic Carcinoma
- Melan-A; Metastatic Melanoma
- CK7; Adenoid Cystic Carcinoma
- Details
Case History
A 56-year-old female with a right upper lobe lung nodule.
Which of the following is true regarding this lung neoplasm?
- Usually centrally located
- It has a bad prognosis
- EGFR mutation and ALK rearrangement are usually absent
- CDX2 and CK20 are negative
- Details
Case History
A 48-year-old man presents with an incidental 3 cm right adrenal mass, undergoes right adrenalectomy. The tubular and canalicular structures are positive for calretinin.
- Adrenal cortical adenoma
- Metastatic signet ring cell carcinoma
- Adenomatoid tumor
- Composite adrenal cortical adenoma and adenomatoid tumor
- Details
Case History
A 7 y/o M with pancytopenia and splenomegaly. Which one of the following is NOT included in DDx:
- Gaucher disease.
- MAC infection.
- Mast cell disorder
- Whipple disease
- Details
Case History
The patient is a 35-year-old-female with leukocytosis. Peripheral blood findings showed increased blasts consistent with acute leukemia. The morphology is suggestive of which genetic abnormality?
A. RUNX1-RUNX1T1
B. MLLT3-MLL
C. PML-RARA
D. CBFB-MYH11
