Case History

80-year-old female with post-menopausal bleeding and 5.5 cm polypoidal mass in the endometrium.

What is the best diagnosis?

  1.        Endometrial stromal sarcoma
  2.        Serous carcinoma
  3.        Mixed Mullerian tumor/carcinosarcoma
  4. Leiomyosarcoma

 Varma Case1 7.4.22 Varma Case2 7.4.22


Case contributed by: Kavita Varma, M.D., DNB, Assistant Professor, Anatomic Pathology

Case History

Gastric biopsy in an 80-year-old female. 

What is the best diagnosis?

  1.        H. pylori gastritis
  2.        Autoimmune gastritis
  3.        Iron-pill gastritis
  4. Doxycycline-associated gastritis

Case of the week gastric biopsy 1 Case of the week gastric biopsy 2

Case History

A 95 y/o male, non-smoker, with hx of ocular pemphigoid on immunosuppressants. 4 cm left level 4 mass, firm and fixed without tenderness to palpation. 

What is the best diagnosis?

  1.        Metastatic squamous cell carcinoma
  2.        Metastatic prostatic adenocarcinoma
  3.        Metastatic papillary thyroid carcinoma
  4. Metastatic renal cell carcinoma

Rosenblum 6.20.22 Case1 Rosenblum 6.20.22 Case3.1

Case History

A 67-year-old male presents with a parotid mass associated with facial pain and cervical adenopathy.  Fine-needle aspiration and core needle biopsy are performed and representative sections are shown.p63 immunostain is negative.

Which stain is expected to be diffusely positive?

  1.        SOX10
  2.        Androgen receptor
  3.        p40
  4. Calponin

salivary duct ca HE 40x salivary duct ca DQ 60x

Case History

A 58-year-old woman presents with a new left upper quadrant breast mass. The tumor cells show SOX10 positivity.

What additional stain would help reach the diagnosis?

  1.        Pancytokeratin; IDC grade 3
  2.        P63; Metaplastic Carcinoma
  3.        Melan-A; Metastatic Melanoma
  4. CK7; Adenoid Cystic Carcinoma

Case History

A 56-year-old female with a right upper lobe lung nodule.

Which of the following is true regarding this lung neoplasm?

  1.        Usually centrally located
  2.        It has a bad prognosis
  3.        EGFR mutation and ALK rearrangement are usually absent
  4. CDX2 and CK20 are negative

6.1.22 Case1 6.1.22 Case 2

Case History

A 48-year-old man presents with an incidental 3 cm right adrenal mass, undergoes right adrenalectomy. The tubular and canalicular structures are positive for calretinin.

  1.        Adrenal cortical adenoma
  2.        Metastatic signet ring cell carcinoma
  3.        Adenomatoid tumor
  4. Composite adrenal cortical adenoma and adenomatoid tumor

 collsion tumor collsion tumor.tif 2

Case History

A 7 y/o M with pancytopenia and splenomegaly. Which one of the following is NOT included in DDx:

  1.        Gaucher disease.
  2.        MAC infection.
  3.        Mast cell disorder
  4. Whipple disease

Question Photo 15.2.22 Case 2
Question Photo 3 pic4

Case History

The patient is a 35-year-old-female with leukocytosis. Peripheral blood findings showed increased blasts consistent with acute leukemia. The morphology is suggestive of which genetic abnormality?


Question Photo 15.2.22 Case 2Question Photo 3Question Photo 4