Case of the Week
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Case History
A 41-year-old female with a right breast circumscribed mass in the middle upper outer region.
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Case History
A 59-year-old female with a history of ESRD attributed to hypertension, a renal transplant in 2004 on maintenance immunosuppression. Admission for E. coli sepsis with severe AKI a month prior; now with uremic symptoms, creatinine 6.0 mg/dL (baseline 1.9), normal renal ultrasound. Allograft biopsy shown.
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Case History
26-year-old man presents with pericardial, right atrial and ventricular masses.
Past medical history was positive for a mediastinal tumor resected 6 years prior followed by radiotherapy. He had several mediastinal and pericardial relapses, treated surgically.
Immunohistochemistry of this biphasic tumor showed diffuse and strong expression of pan-cytokeratin (AE1/AE3), CK5/6 and p63 in the spindle and glandular cells. D2-40 was patchy and focally strong and MOC-31 and EMA showed focal and weak expression. Nuclear INI-expression was retained. Negative markers included CK7, CK20, calcitonin, calretinin, mesothelin, WT1, CD5, CD34, STAT-6, S100, myogenin, C-KIT (CD117), alpha-fetoprotein, placental alkaline phosphatase (PLAP) and glypican-3. The admixed lymphocytes did not express TdT.
No genomic alterations were found that matched with Strata affiliated clinical trial. Two pathogenic variants in KMT2D gene were seen.
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Case History
A female in her mid-40s was admitted for splenectomy due to splenomegaly. The resected spleen weighed 655 grams and sections showed multiple tan, plaque-like lesions ranging in size 0.1-0.7 cm. Figures show microscopic findings of the lesion.
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Case History
A 32-year-old male presents with abdominal pain and bloating. He undergoes a distal subtotal gastrectomy for a 6 cm ulcerated mass located in the pylorus.
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Case History
60 yo female with a 28.7 cm solid, hemorrhagic, and degenerated uterine mass. Pelvic soft tissue was involved. The sections show heterogeneous morphology. Mitosis is up to 4 mitosis/10 hpf. Focal tumor necrosis is identified. IHC stains were performed on multiple representative sections that show the tumor is diffusely and strongly positive for desmin, SMM, BCL1, ER, negative for CK, SOX10, S100, SF1, CD10. HMB45 is very focally positive. Solid tumor cancer panel shows no clinically significant sequence variants, fusion genes or copy number alterations. MDM2 FISH testing shows non-amplified.
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Case History
29 yo P1001 di/di twins at 33 weeks. Pre-eclampsia, selective IUGR baby B, PPROM.
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Case History
60 yr old male with a mandibular mass and lymphadenopathy. CBC showed marked absolute eosinophilia (60%; 6.06 x 10^3/cm). The mass is CD34+, CD45+, CD33+, patchy + for CD43, MPO. A) mandibular mass, B) submandibular lymph node, C) CD34, D) bone marrow bx
