4x 10x SMAS 100

Case history:

This is a biopsy from the olfactory cleft (skull base) in a 71-year-old woman with rhinorrhea. Endoscopically there is a small nodule.

What is the diagnosis?

  1. Reactive stromal spindle cell proliferation
  2. Respiratory epithelial adenomatoid hamartoma
  3. Biphenotypic sinonasal sarcoma
  4. Solitary fibrous tumor

Case contributed by Tom Winokur, M.D., Professor, Anatomic Pathology, UAB Department of Pathology

     OS 1  OS2 SATB2

Case history:

A 14-year-old girl presented with left hip pain. Imaging studies show a heterogeneous infiltrative lesion occupying the left hemipelvis. A biopsy was performed. (Brief History)

  1.       Conventional osteosarcoma
  2.       Conventional chondrosarcoma
  3.       Mesenchymal chondrosarcoma
  4.       Ewing sarcoma

       Stevens 1 Stevens 2 Stevens 3 Stevens 4

Case history:

Teenager with thyroid mass.

Diagnosis:

  1. Poorly differentiated thyroid carcinoma
  2. Aveolar rhabdomyosarcoma
  3. Adamantinoma-like Ewing sarcoma
  4. NUT carcinoma

       BM Bx 1 BM Bx 2 SC18 28248 DB .A.003

Case history:

The patient is a 64 year-old female with clinical history of relapsing/remitting multiple myeloma. CBC data: WBC 5.9 cells/microliter with a differential of 70% segs, 20.5% lymphs, 8.5% monos, 0.3% eos and 0.2% basos. PLT 144,000 /microliter, MCV 99 fL, Hemoglobin 8.9 gram/deciliter and HCT 28%. A surveillance bone marrow performed at OSH and showed increase of plasma cells and additional finding on the biopsy as illustrated.

Diagnosis:

A. Protein (Ig) deposits
B. Amyloid
C. Platelet clumps
D. Marrow necrosis

       1 2 3

Case history:

40-year-old male with rapidly growing thyroid tumor.

Diagnosis:

  1.         Angiosarcoma
  2.         Follicular thyroid carcinoma
  3.         Anaplastic thyroid carcinoma
  4.         Medullary carcinoma

       case83 question figures    

Case history:

A 37-year-old male with left neck mass. No significant medical history. Additional stains: ALK-, CD30, CD3-. 

What is the diagnosis?

  1. Anaplastic large T-cell lymphoma
  2. Lymphocyte depleted Classical Hodgkin lymphoma
  3. DLBCL, anaplastic variant
  4. Peripheral T-cell lymphoma

     FIG1 DIFFUSE HIGRD VUE w DVSCL BASAL and MIDDL LOPOW 2  HE 20x  HE 40x  

Case history:

238g (409 - 589 g) placenta w 3-vessel UC from delivery of IUGR briefly viable infant at 38.6 wkG.  Maternal hx: IgM + for HSV 1 & 2; IgG+ for HSV2. No travel hx but patient makes her own yogurt.

Which of the following is the correct diagnosis for the placental pathology?

  1. Herpes Simplex Virus villitis
  2. Massive chronic intervillositis
  3. High grade diffuse chronic villitis of unknown etiology with vascular obliteration and avascular villi
  4. Toxoplasma gondii villitis
  5. Listeria monocytogenes

     DM18 327FISH2 small  HE 10x SC18 8092HE 20x  HE 40x

Case history: The patient is a 62 year old female with right kidney mass, who underwent partial nephrectomy. FISH image with TFE3 break apart probe.

What is the diagnosis?

  1. Clear cell papillary renal cell carcinoma.
  2. Papillary renal cell carcinoma.
  3. Clear cell renal cell carcinoma.
  4. Metastatic carcinoma from ovary.
  5. MiT family translocation renal cell carcinoma

     Image 191 1 Image 195

Case history: 17-year-old female with large, solid adnexal mass.

What is the diagnosis?

  1. Germ cell tumor
  2. Carcinoid tumor arising in mature teratoma.
  3. Sex cord-stromal tumor.
  4. Endometrioid carcinoma arising in endometriosis.

 Picture1   Picture2 Picture3 Picture4

Case history:

A 33 year-old female with ESRD 2/2 DM and simultaneous renal and pancreas transplant 4 years ago. Now with fever, hematuria, diarrhea and bloating. Noted to have a creatinine of 6.7 (baseline 1.1). Renal biopsy.

What is the diagnosis:

  1. Acute cellular rejection
  2. Acute humoral rejection
  3. Polyoma virus nephropathy
  4. Adenovirus nephritis