Case of the Week
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Case History
A 35 y/o male, with a pathological fracture of the left humerus and a 6.5 cm marrow-replacing lesion.
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Case History
A 60-year-old woman presents with urinary symptoms, abdominal distension and bloating. A CT scan shows a large pelvic mass. A bilateral salpingo-oophorectomy with omentectomy is performed and reveals a 27.5 x 22.5 x 17.9 cm white, firm, and solid mass in the left ovary. Immunohistochemical staining shows positivity with pan-cytokeratin, CAM5.2, ER, PR, WT1, and PAX8 (patchy). Beta-catenin shows nuclear patchy staining. Calretinin, inhibin, and SF-1 are negative in neoplastic cells. The neoplastic cells are negative for GATA3, TTF-1, CDX2, INSM1, chromogranin, and synaptophysin.
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Case History
A 61-year-old female with erythematous vulvar lesion and previous history of invasive high-grade utothelial carcinoma.
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Case History
A 53-year-old female with acute hypoxic respiratory failure and pancytopenia. Imaging showed pulmonary infiltrates and lymphadenopathy. The morphology of a right axillary lymph node and immunohistochemical stains are shown.
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Case History
A 66-year-old female presented due to a cystic lesion of the pancreatic head approximately 5.6 cm. A Whipple procedure was performed and 5.7 cm-sized ill-defined multiloculated cystic mass involving the main pancreatic duct was identified by gross examination. Figures include H&Es, immunohistochemical stain (HepPar-1), and albumin mRNA in situ hybridization (ISH).
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Case History
35-year-old male with excisional biopsy of left cervical lymph node.
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Case History
A 51-year-old female presented with extensive microcalcification in the left breast. The morphology of the partial mastectomy is shown in the figures. ER was positive in 50% of the lesional cells.
What is the diagnosis?
A. Apocrine ductal carcinoma in situ
B. Apocrine metaplasia
C. Cystic hypersecretory intraductal carcinoma
D. Secretory carcinoma
Correct Answer: C. Cystic hypersecretory intraductal carcinoma
Case contributed by: Xiao Huang, M.D., Ph.D., Assistant Professor, Anatomic Pathology, UAB Pathology