Case History

53-year-old female with uterine mass.

What is the diagnosis?

A. Endometrial stromal sarcoma, low grade
B. Epithelioid leiomyoma
C. Adenosarcoma
D. PEComa

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Case contributed by Todd Stevens, M.D., Assistant Professor, Anatomic Pathology, UAB Department of Pathology

Case History

A 73-year-old female with a left parotid mass. Fine needle aspirate. What is the best cytomorphologic diagnosis?

  1.       Pleomorphic adenoma
  2.       Adenoid cystic carcinoma
  3.       High-grade mucoepidermoid carcinoma 
  4.       Mammary analogue secretory carcinoma

Picture1Picture2Picture3 Picture4

Case History

The patient is a 29 year-old female with clinical history of shortness of breath and fevers. Routine imaging studies showed multiple pleural nodules. CBC and routine chemistries are within normal limits with mild increase of LDH. Open biopsy of the nodules obtained.

What is the diagnosis?

  1. Mesothelioma
  2. Germ cell tumor
  3. Anaplastic large cell lymphoma
  4. Thymoma

Thy 02 Thy 03 Thy 04 Thy 04

Case History

56-year-old female with left floor of mouth erythematous lesion

What is the diagnosis:

  1.        Melanoma
  2.        Myoepithelioma
  3.        Epithelioid Schwannoma
  4.        Ectomesenchymal Chondromyxoid Tumor (ECMT)

1 2

Case History

66-year-old male with mild splenomegaly. HB: 17.5 g/dL; HCT: 52%; WBC: 10.1 10^3/cm; PLT: 948 10^3/cm. Blasts <1% in bone marrow. JAK2+

1 question 2 question

What is the diagnosis:

  1.         PMF, prefibrotic stage
  2.         PMF, fibrotic stage
  3.         ET
  4.         PV

Case History

A 62 year-old man presenting with jaundice, pancreatic duct/common bile duct dilation and ampullary mass.

 What is the most appropriate diagnosis?

    1.        Nondiagnostic specimen
    2.        Negative for malignant cells
    3.        Atypical cells present
    4.        Neoplastic cells present
    5.        Adenocarcinoma

Figure 1 Figure 2 Figure 3 Figure 4

Case History

A 55-year-old female with a pelvic mass, laterality unknown; surgeon favors that the mass involves both adnexa and not sure which side it originated from. On gross examination there is a 17-cm complex, multilocular cyst with notable foci that show cystic, solid and papillary structures.

  1.        What is the most appropriate diagnosis?
    1.        High-grade serous carcinoma with clear cell change
    2.        Renal cell carcinoma
    3.        Yolk sac tumor
    4.        Clear cell carcinoma of the ovary

CCC HP CCC HP3 NapsinA pos

  1.        What entity is commonly associated with this lesion?
    1.        Endometriosis
    2.        Endosalpingiosis
    3.        Endocervicosis
    4.        Paratubal cysts
  1.         These tumors can present with …
    1.        Abdominal pain and swelling
    2.        Symptoms related to endometriosis
    3.        Asymptomatic
    4.        All of the above

Case History

42-year-old woman with two non-ulcerated skin nodules on right arm. The lymphoid infiltrate was CD20(-), CD8(+)/CD4(-), CD56(-), CD30(-), granzyme-B(+).

What is the diagnosis?

 TCOTM


Case History

A 76-year-old male with acute renal insufficiency and a recent diagnosis of multiple myeloma presents with hematuria, urine protein 15g/24 hours, creatinine 4.96, and a positive M spike. Which stain would you order next?

  1. Oil red O
  2. GMS
  3. Congo Red
  4. Colloidal Iron

EMpic HandEpic Kappapic Lambdapic

 Case History

A 50-year-old male presents with a 9 cm retroperitoneal mass who had a resection of 16 cm fatty retroperitoneal mass 10 years prior.

Which of the following will show diffuse positivity in this tumor?

  1.       S100
  2.       SMA
  3.       MDM2
  4.       Desmin

Figure 1 Figure 2 Figure 3 Figure 4