Case of the Week
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Case history:
This is a biopsy from the olfactory cleft (skull base) in a 71-year-old woman with rhinorrhea. Endoscopically there is a small nodule.
What is the diagnosis?
- Reactive stromal spindle cell proliferation
- Respiratory epithelial adenomatoid hamartoma
- Biphenotypic sinonasal sarcoma
- Solitary fibrous tumor
Case contributed by Tom Winokur, M.D., Professor, Anatomic Pathology, UAB Department of Pathology
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Case history:
A 14-year-old girl presented with left hip pain. Imaging studies show a heterogeneous infiltrative lesion occupying the left hemipelvis. A biopsy was performed. (Brief History)
- Conventional osteosarcoma
- Conventional chondrosarcoma
- Mesenchymal chondrosarcoma
- Ewing sarcoma
- Details
Case history:
Teenager with thyroid mass.
Diagnosis:
- Poorly differentiated thyroid carcinoma
- Aveolar rhabdomyosarcoma
- Adamantinoma-like Ewing sarcoma
- NUT carcinoma
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Case history:
The patient is a 64 year-old female with clinical history of relapsing/remitting multiple myeloma. CBC data: WBC 5.9 cells/microliter with a differential of 70% segs, 20.5% lymphs, 8.5% monos, 0.3% eos and 0.2% basos. PLT 144,000 /microliter, MCV 99 fL, Hemoglobin 8.9 gram/deciliter and HCT 28%. A surveillance bone marrow performed at OSH and showed increase of plasma cells and additional finding on the biopsy as illustrated.Diagnosis:
A. Protein (Ig) deposits
B. Amyloid
C. Platelet clumps
D. Marrow necrosis
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Case history:
40-year-old male with rapidly growing thyroid tumor.
Diagnosis:
- Angiosarcoma
- Follicular thyroid carcinoma
- Anaplastic thyroid carcinoma
- Medullary carcinoma
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Case history:
A 37-year-old male with left neck mass. No significant medical history. Additional stains: ALK-, CD30, CD3-.
What is the diagnosis?
- Anaplastic large T-cell lymphoma
- Lymphocyte depleted Classical Hodgkin lymphoma
- DLBCL, anaplastic variant
- Peripheral T-cell lymphoma
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Case history:
238g (409 - 589 g) placenta w 3-vessel UC from delivery of IUGR briefly viable infant at 38.6 wkG. Maternal hx: IgM + for HSV 1 & 2; IgG+ for HSV2. No travel hx but patient makes her own yogurt.
Which of the following is the correct diagnosis for the placental pathology?
- Herpes Simplex Virus villitis
- Massive chronic intervillositis
- High grade diffuse chronic villitis of unknown etiology with vascular obliteration and avascular villi
- Toxoplasma gondii villitis
- Listeria monocytogenes
- Details
Case history: The patient is a 62 year old female with right kidney mass, who underwent partial nephrectomy. FISH image with TFE3 break apart probe.
What is the diagnosis?
- Clear cell papillary renal cell carcinoma.
- Papillary renal cell carcinoma.
- Clear cell renal cell carcinoma.
- Metastatic carcinoma from ovary.
- MiT family translocation renal cell carcinoma
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Case history: 17-year-old female with large, solid adnexal mass.
What is the diagnosis?
- Germ cell tumor
- Carcinoid tumor arising in mature teratoma.
- Sex cord-stromal tumor.
- Endometrioid carcinoma arising in endometriosis.
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Case history:
A 33 year-old female with ESRD 2/2 DM and simultaneous renal and pancreas transplant 4 years ago. Now with fever, hematuria, diarrhea and bloating. Noted to have a creatinine of 6.7 (baseline 1.1). Renal biopsy.
What is the diagnosis:
- Acute cellular rejection
- Acute humoral rejection
- Polyoma virus nephropathy
- Adenovirus nephritis