MLS 10x 2   MLS 40x 2

Clinical History:

Resection of a 3.5 cm subcutaneous mass from the left hand of a middle-aged man is depicted. What is the most likely cytogenetic abnormality in this tumor? (Brief History)

  1. t(11;22)
  2. t(9;22)
  3. t(7;16)
  4. t(12;16)

Contributed by Dr. Shi Wei

Picture1Picture2Picture3   Picture4

Clinical History:
44 year old male with pleural rind biopsy

 Choose the correct diagnosis:

  1. Squamous metaplasia
  2. Poorly differentiated adnocarcinoma
  3. Adenosquamous carcinoma
  4. NUT midline carcinoma

HandE40XHandE400X

HandE400XB

Clinical History:

66 year old male s/p kidney transplant with pericardial effusion

 Choose the correct diagnosis:

  1. Candida pericarditis
  2. Cryptococcus pericarditis
  3. Blastomyces pericarditis
  4. Histoplasma pericarditis

Case63 Pic1Case63 Pic2

Clinical History:

41 year old pregnant female with invasive cervical squamous cell carcinoma underwent cesarean section delivery, hysterectomy and lymph node dissection. Sections from the cervix confirmed the presence of invasive squamous cell carcinoma. Right obturator lymph node shows the following.

 Choose the correct diagnosis:

  1. Squamous metaplasia
  2. Decidual reaction
  3. Squamous cell carcinoma, metastatic
  4. Mucinous carcinoma, metastatic

Case 20180315 4x 1Case 20180315 20x 1Case 20180315 20x 2
The patient is a 60 year old female with left breast mass, who underwent needle localized lumpectomy.

 What is the most likely diagnosis?

A. Invasive ductal carcinoma.
B.
Matrix-producing carcinoma.
C.
Chondrosarcoma.
D.
Metaplastic carcinoma with squamous elements.
E. Phyllodes tumor


S 16 9003 4XS 16 9003 20X
57 year-old male with varices. Gastric biopsy. 

 What is the most likely diagnosis?

A. Helicobacter Pylori-related peptic ulcer
B. 
Helicobacter Pylori-related  chronic active gastritis
C. 
Iron-related  ulcerative mucosal injury
D. 
Mucosal calcinosis.


2Uterine mass in a 45 year old woman.

 What is the most likely diagnosis?

A. Papillary squamous cell carcinoma
B. High grade squamous intraepithelial lesion (CIN3).
C. Invasive, well differentiated squamous cell carcinoma.
D. Condyloma with atypia.


OMFP CASE O WEEK 1 OMFP 2 14 18This placental lesion an example of (Figure 1)

 What is the most likely diagnosis?

A. 1⁰ placental choriocarcinoma
B. Chorangioma
C. Diffuse multifocal chorangiomatosis
D. Segmental localized chorangiomatosis.
E. Chorangiosis.


01A 58 Y/O male h/o HBV, HCV, decompensated alcoholic cirrhosis and renal dysfunction (unclear etiology) who presented for consideration of orthotopic liver transplant and deceased donor renal transplant. Most recent End-Stage Liver Disease (MELD) score at last clinic visit was 24. He No encephalopathy. Denies h/o kidney or liver biopsy. Abdominal MRI revealed cirrhotic liver without focal lesion identified within the limitations of this examination due to given large volume of ascites. Macroscopic examination of the native liver weighted 983 g and 19.7 x 18.3 x 8.3 cm. The external surface of the liver is tan-brown and nodular. The cut surface is tan-brown to red-brown and diffusely nodular (ranging from 0.1-0.3 cm). In the left lobe, there are numerous (>30) tan-yellow soft ovoid nodules ranging from 0.1-0.9 cm in greatest dimension.

 What is the most likely diagnosis?

A. Focal Nodular Hyperplasia (FNH).
B. Hepatic adenomas.
C. Scirrhous hepatocellular carcinoma
D. Cirrhotomimetic hepatocellular carcinoma (Diffuse HCC / Cirrhotic-like HCC).
E. Fibrolamellar hepatocellular carcinoma (FLC)


Case1 Fig1A 19-year-old female with a 7.8 cm heterogeneously enhancing mass that was found on imaging after patient was in MVC. No personal or family history of liver disease, contraceptive use, hepatitis, or other malignancy. No significant unintentional weight loss or jaundice. MRI of the abdomen showed 7.3 x 6.2 cm lesion with lobular margins and several punctate calcifications within the central aspect of this lesion Figure (1). The patient underwent partial hepatectomy. Macroscopic examination revealed 8 x 6.3 x 6 cm tan-yellow firm ovoid mass. The remaining cut surface of the liver is red-brown and soft.

 What is the most likely diagnosis?

A. Focal Nodular Hyperplasia (FNH)
B. Hepatic adenoma
C. Cirrhosis hepatocellular carcinoma.
D. Fibrolamellar hepatocellular carcinoma (FLC).