Case History
The patient is a 33-year-old female with large suprasellar mass.
What is a supplemental IHC that can be done to help predict possible post-op complications?
- GFAP
- IDH-1
- BRAF V600E
- TTF-1
Answer: D. TTF-1
Dx: Adamantinomatous craniopharyngioma, WHO Grade 1
-Aggressive clinical course - invasive and recurrent
-Post-op complications can include chemical meningitis from keratin spillage into the CSF and diabetes insipidus from resection of post pituitary. Fragments of post pituitary can be identified with a TTF-1 stain where the glial cells will demonstrate nuclear positivity.
-Molecular: CTNNB part of the WNT pathway nuclear (+) for beta catenin
-3 micro features – wet keratin, basal palisading and loose reticulum
Case contributed by: Astin Powers, M.D., Neuropathology Fellow