You may be eligible to participate in a research study about the effects of Sacubitril/Valsartan or Valsartan on your body’s 24-hour rhythm of a hormone in your blood called natriuretic peptides. This hormone and the study medications are related to the heart. Eligible participants must be obese (BMI: 30-45 kg/m2) men and women and have no history of diabetes, heart problems, or kidney problems. The study involves consuming prepared meals, wearing a blood pressure monitor for 24-hours, a 24-hour inpatient stay, and collecting blood and urine samples. The meals will be provided at no cost. Participants will be compensated $560 for completing the study visits. Please e-mail Nehal at PRECISION-BPSTUDY@uabmc.edu if you are interested.

Overweight/Obese adult volunteers needed for study If you are between the ages of 18 -89 yrs and have a body mass index > 30 kg/m2 you may be eligible to participate in a study exploring the reason why individuals who have high BMI have an increased risk of forming calcium oxalate kidney stones. Participation involves eating study-provided meals for 4 days, providing urine and blood samples. Study meals are provided free of charge and additional compensation up to $140 is offered. For more information call 205-934-5712 or email kidneystone@uabmc.edu or kidneystoneresearch@uabmc.edu

Adults with Type 2 Diabetes needed for a study If you are between the ages of 18 -89 yrs and have type 2 diabetes you may be eligible to participate in a study exploring the reason why individuals who have diabetes have an increased risk of forming calcium oxalate kidney stones. Individuals who are obese, overweight, or normal weight are all welcome to the study. Participation involves eating study-provided meals for 4 days, providing urine and blood samples. Study meals are provided free of charge and additional compensation up to $140 is offered. For more information, call 205-934-5712 or email kidneystone@uabmc.edu or kidneystoneresearch@uabmc.edu.

Are you struggling with Opioid addiction? If so, you may be eligible to participate in a research study at UAB that focuses on biomarkers in people with opioid addiction. The study includes 1 visit and takes up to 2 hours to complete. For more information, please call the UAB Office of Psychiatric Research at (205) 934-8336. You will be compensated $20 for your time and efforts.

You may be eligible to participate in a research study about the effects of sacubitril/valsartan on how your body handles insulin and glucose. This medication is related to the heart. Eligible participants must be healthy men and women, African American, and have no history of diabetes, heart problems, or kidney problems. The study involves performing some exercise, taking sacubitril/valsartan, and collecting blood samples. Participants will be compensated. To participate, please contact Nehal at 205-934-7173 or email us at nauticalstudy@uabmc.edu.

You may be eligible to participate in a research study about the effects of Exercise and Metoprolol (a blood pressure pill) on a protein in your blood. This protein is related to heart disease. Eligible participants must be Healthy men and women, African American or Caucasians, and have no history of diabetes, heart problems, or kidney problems. The study involves performing the exercise, taking metoprolol, consuming prepared meals, and collecting blood samples. Participants will be compensated. Please e-mail Nehal Vekariya at exercisebetastudy@uabmc.edu or call us at 205-934-7173 if you are interested.

Clinical trial evaluating a novel, non-invasive radiation treatment for ventricular tachycardia refractory to medication and catheter ablation The UAB Departments of Radiation Oncology and Cardiology are looking for patients with ventricular tachycardia (VT) not controlled by medications and catheter ablation. The trial will allow patients suffering from VT despite standard of care regimens to undergo non-invasive cardiac radioablation (CRA; a type of stereotactic body radiotherapy) to the area of the heart responsible for their symptoms. Stereotactic body radiotherapy is delivered with a device called the linear accelerator, which is primarily used to treat patients with cancer. UAB is one of the first centers in the U.S. to obtain a Food and Drug Administration (FDA) investigational device exemption for use of the linear accelerator in this capacity on a phase I/II trial. The study is being conducted in collaboration with the Washington University School of Medicine in St. Louis, a center which pioneered this promising technique in the U.S. For more information on the RAD 1901 trial, please contact Adelyn Gillon, clinical research coordinator, at 205.975.3019 or agillon@uabmc.edu" contenteditable="false">agillon@uabmc.edu.

If you have asthma, are at least 18 years of age, in the Los Angeles Region, (California) haven’t had oral steroids in at least 4 weeks, and are willing to donate 30 mL of blood, equivalent to two tablespoons, please contact Racheal Ogbebor at email Rachealogbebor@gmail.com.

Rural Research Participants Needed FSU College of Nursing invites individuals with heart failure and their care partners who live in rural areas to participate in a research project under the direction of Lucinda J. Graven, Ph.D., APRN. Care teams will partner with a registered nurse to manage daily challenges related to heart failure self-care by telephone. Compensation up to $200 per care team who complete the telehealth program. Please contact Joan Grant Keltner, Ph.D., RN at (205) 934-6527 or grantj@uab.edu. For more information, you may also use: https://fsu.qualtrics.com/jfe/form/SV_3IPqQs7MAPmuHpH.

Participants between the ages of 65-89, and individuals diagnosed with Parkinson’s disease between the ages of 45-89 are needed for a research study on walking. This study is being done to assess how well individuals can modify walking patterns. If you qualify, we anticipate that your participation in the study will span a single study visit, with a total time commitment of 3 hours. You will be compensated for your time. Contact Christopher Hurt at cphurt@uab.edu or  at 205-934-8517, if you are interested.

Do you have a loved one with agitation associated with Alzheimer’s dementia? Is their agitation becoming overwhelming? Examples of some easily identifiable agitated behaviors are: restlessness, screaming, shouting, throwing things, resistiveness, constant unwarranted requests for attention or help, pacing/aimless wandering, kicking, hitting others or self, pushing people, hurting self or others, tearing things or destroying property. In this study, researchers want to find out if an investigational drug called AVP-786 is safe and effective (useful) in managing agitation in adults with Alzheimer’s dementia, when compared to a placebo. If you are a caregiver for a person with Alzheimer’s disease, please call (205) 996-5987 or email lalexander@uabmc.edu for more information.

We are enrolling opioid users without a history of psychosis, endocrine diseases, inflammatory diseases, or autoimmune diseases. If you meet these criteria you may be eligible to participate in a research study. Compensation provided up to $20. For more information, please call the UAB Office of Psychiatric Research at 205-934-8336.

You may be eligible to participate in a research study about the effects of Exercise and Metoprolol (a blood pressure pill) on a protein in your blood. This protein is related to heart disease. Eligible participants must be Healthy men and women, African American or Caucasians and have no history of diabetes, heart problems, or kidney problems. The study involves performing exercise, taking metoprolol, consuming prepared meals, and collecting blood samples. Participants will be compensated. Please e-mail Nehal Vekariya at nvekariya@uabmc.edu if you are interested.

You may be eligible to participate in a research study about the effects of sacubitril/valsartan on how your body handles insulin and glucose. This medication is related to the heart. Eligible participants must be healthy men and women, African American, and have no history of diabetes, heart problems, or kidney problems. The study involves performing some exercise, taking sacubitril/valsartan, and collecting blood samples. Participants will be compensated. Please e-mail Nehal Vekariya at nvekariya@uabmc.edu if you are interested.

Are you taking Metformin alone or metformin with a sodium-glucose transport protein 2 (SGLT2) inhibitor to treat your diabetes? The University of Alabama at Birmingham, Department of Nutrition Sciences, is conducting a 39-week research study to see how two new study medicines work together on blood sugar levels in people with Type 2 diabetes. Qualified participants will receive study-drug free of charge and may be compensated for time and travel. For more information, and to check your eligibility to join, please contact co-investigator Tracie Thomas at (205) 996-4015 or email tthoma@uab.edu.

The purpose of the study is to measure maximum walking speed and step length with virtual reality and customizable exercise games as feedback sources on a robotic treadmill. The targeted population is individuals with hemiparesis, in a chronic and stable stroke stage, who are able to follow instructions, and able to walk independently for at least three minutes. Based on a phone screening, eligible participants will attend up to two separate sessions at UAB Spain Rehabilitation Center. In each session, they will go into different walking or stepping performance conditions. The session will last about two hours, and participants will be paid 30$ per session for their time and effort. For more information please call Saleh Alhirsan at (205) 261-3853 or by email atalhirsan@uab.edu.

We are looking for adults between 21-55 years old and diagnosed with Attention Deficit and Hyperactivity Disorder (ADHD), and use stimulant medication to participate in our study. We want to determine the role of ADHD stimulant medication on balance and other factors, such as physical activity in improving balance performance. We hypothesize that ADHD will improve balance performance in adults with ADHD. We also hypothesize that moderate to vigorous physical activity behaviors will positively influence balance performance in this population. Participants will be required to make two visits. Once on-medication; and on the second visit, we will ask participants to forgo ADHD medication 24 hours before the testing. For more information please contact Mansour at (205) 503-2977, or by email at amansour@uab.edu.

The purpose of the SCIPE study is to examine two 8-week remotely delivered exercise interventions: Movement-to-Music, and Standard Exercise Training. Enrolled participants will be randomized into one of three groups: M2M, SET, or attention control. The primary goal of this study is to examine changes in physical activity levels after the 8-week M2M and SET interventions. We hypothesize that M2M and SET participants will have significant increases in physical activity, sleep quality, quality of life, and decreases in pain compared to the Attention Control group after the 8-week intervention. The secondary aim is to examine the effects of the M2M and SET interventions on health and quality of life outcomes. Exercise enjoyment in M2M and SET participants will also be explored. The tertiary aim is to evaluate the demographic, clinical, and psychosocial variables of two participant groups: 1) compliant participants who completed ≥ 50% of the intervention, and 2) non-compliant participants who completed post-testing but only 50% of the intervention, or did not complete post-testing. The SCIPE study will take place entirely online. The exercise program will be delivered to you in a video format, so you can exercise anywhere that is convenient for you. For more information please contact (205) 209-2245 or email scipe@uab.edu.

If you are 18 years of age or older and currently taking the blood thinners Xarelto (rivaroxaban) or Eliquis (apixaban), you may be eligible to participate in a research study. This study is being done to determine how your kidney function affects how you metabolize Xarelto or Eliquis. The study involves keeping a medication log for one week and one (12 hour) visit to UAB where we will collect blood samples at different times during the day. Participants will be compensated $150 for completing the one-day study visit. If you are interested or for more information, please contact our research team at pkpdstudy@uabmc.eduor 205-917-9800.

You may be eligible to participate in a research study about the effects of Sacubitril/Valsartan on how your body handles insulin and glucose. This medication is related to the heart. Eligible participants must be healthy men and women, African American, and have no history of diabetes, heart problems, or kidney problems. The study involves exercising, taking sacubitril/valsartan or valsartan, and collecting blood samples. Participants will be compensated. Please e-mail Dr. Vibhu Parcha, vparcha@uabmc.edu if you are interested. 

You may be eligible to participate in a research study about the effects of exercise and Metoprolol, a blood pressure pill, on a protein in your blood. This protein is related to heart disease. Eligible participants must be healthy men and women, African American or Caucasian with no history of diabetes, heart problems, or kidney problems. The study involves exercising, taking metoprolol, consuming prepared meals, and collecting blood samples. Participants will be compensated. Please email Dr. Vibhu Parcha at vparcha@uabmc.edu if you are interested.

The RECOVER study will investigate the use of Vagus Nerve Stimulation (VNS) Therapy in up to 1,000 people across the United States. To join the RECOVER study you must be 18 years or older and: currently depressed, have bi-polar depression that has lasted for at least two years or recurred several times, and have tried at least four types of antidepressant treatments and not found them helpful. Please leave a voice message at (205) 975-0068 or email candacegreen@uabmc.edu for more information.

If you are at least 18 years of age, can read and write in English, are generally healthy, and have no history of mental illness or psychiatric disorders, please leave a voice message at (205) 934-2484 or email lalexander@uabmc.edu for more information.

You may be able to participate in this study if you: are 18 years of age or older, have been diagnosed with major depressive disorder, MDD, and have not adequately responded to at least 2 different antidepressant treatments. Please leave a voice message at (205) 934-2484 or email lalexander@uabmc.edu for more information.

If you have Major Depressive Disorder (MDD) that hasn’t responded to anti-depressant medication, learn about this research study of an investigational drug for MDD. As part of their study participation, patients will be regularly evaluated and closely monitored by a team of medical professionals. To pre-qualify for this study, you must: be 18 to 65 years of age; have been diagnosed with MDD; be in a current depressive episode for at least 8 weeks but not more than 12 months; and have been taking an antidepressant medication for at least the last 8 weeks. Additional criteria will apply. All study-related visits, tests, and study drugs will be provided at no cost. In addition, reimbursement for study-related travel may be provided. Please leave a voice message at (205) 934-2484 or email lalexander@uabmc.edu for more information.