Stacey Harbour, Ph.D., Scientist I, Anatomic Pathology, in the lab of Casey Weaver, M.D., Professor, Anatomic Pathology, published an article on T cell differentiation in the July issue of Science Immunology, titled, "TH17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity."
Research conducted by the group showed that the molecule IL-6, a common target of various disease therapies, was indispensable for maintaining the inflammatory effects of T helper 17 cells that are implicated in diseases like IBD and psoriasis.
The article is published with co-authors Robin Hatton, Ph.D., Associate Professor, Anatomic Pathology; Daniel DiToro, Ph.D., Graduate Student, Anatomic Pathology; Steven Witte, Ph.D., Consultant, Anatomic Pathology; Carlene Zindl, Scientist I, Anatomic Pathology; Min Gao, Ph.D., Assistant Professor, Medicine; Trenton Schoeb, Ph.D., Professor, Genetics.
UAB News article, July 8, 2020
Expansion stress can have an alarming impact on breast cancer cells by creating conditions that could lead to dangerous acceleration of the disease, an interdisciplinary team of University of Alabama at Birmingham researchers has found.
As breast tumors grow, biomechanical forces in the tumor microenvironment, or TME, cause elevated compression at the tumor interior, tension at the periphery and altered interstitial fluid flow — promoting aggressive growth, invasion and metastasis. Biomechanical forces also may modulate the immune response through cancer cell-immune cell crosstalk.
UAB medical student Hannah Cutshall has been awarded a 2020 AΩA Carolyn L. Kuckein Student Research Fellowship, designed to foster the development of the next generation of medical researchers. Cutshall conducts research in the laboratory of Elizabeth Brown, Ph.D., M.P.H., Professor, Molecular and Cellular Pathology. Cutshall's award-winning proposal is titled, "Transcriptomatic Characterization of Multiple Myeloma." She will receive $5,000 to support her research project and up to $1,000 in travel reimbursement over a period of 1-2 years.
UAB medical student Vincent A. Laufer, M.D., Ph.D., was awarded the William Boyd Medal at the School of Medicine Dean's Awards Zoom ceremony earlier this month. The Boyd Medal is given every year to the UAB medical student whose performance in all aspects of their pathology education has been most outstanding.
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